SK281807B6 - Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu - Google Patents
Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu Download PDFInfo
- Publication number
- SK281807B6 SK281807B6 SK1536-96A SK153696A SK281807B6 SK 281807 B6 SK281807 B6 SK 281807B6 SK 153696 A SK153696 A SK 153696A SK 281807 B6 SK281807 B6 SK 281807B6
- Authority
- SK
- Slovakia
- Prior art keywords
- reaction
- phenyl
- pyrimidin
- acetic acid
- cyanopyrazolo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 25
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 60
- FFNKBQRKZRMYCL-UHFFFAOYSA-N 5-amino-1h-pyrazole-4-carbonitrile Chemical compound NC1=NNC=C1C#N FFNKBQRKZRMYCL-UHFFFAOYSA-N 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 4
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 1
- -1 N-acetylaminophenyl Chemical group 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US785995P | 1995-12-01 | 1995-12-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK153696A3 SK153696A3 (en) | 1997-11-05 |
| SK281807B6 true SK281807B6 (sk) | 2001-08-06 |
Family
ID=21728482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1536-96A SK281807B6 (sk) | 1995-12-01 | 1996-11-29 | Spôsob výroby n-[3-(3-kyanopyrazolo[1,5-a]pyrimidin-7-yl)fenyl]- n-etyl-acetamidu |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5714607A (no) |
| EP (1) | EP0776898B1 (no) |
| JP (1) | JP4112032B2 (no) |
| KR (1) | KR100439282B1 (no) |
| CN (1) | CN1057525C (no) |
| AR (1) | AR004822A1 (no) |
| AT (1) | ATE227290T1 (no) |
| AU (1) | AU718310B2 (no) |
| BR (1) | BR9605760A (no) |
| CA (1) | CA2191647C (no) |
| CY (1) | CY2440B1 (no) |
| CZ (1) | CZ292253B6 (no) |
| DE (1) | DE69624657T2 (no) |
| DK (1) | DK0776898T3 (no) |
| ES (1) | ES2184844T3 (no) |
| HU (1) | HU226398B1 (no) |
| IL (1) | IL119710A (no) |
| MX (1) | MX9605974A (no) |
| NO (1) | NO307181B1 (no) |
| NZ (1) | NZ299848A (no) |
| PT (1) | PT776898E (no) |
| RU (1) | RU2178415C2 (no) |
| SK (1) | SK281807B6 (no) |
| TW (1) | TW382629B (no) |
| ZA (1) | ZA9610008B (no) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399621B1 (en) | 1999-08-10 | 2002-06-04 | American Cyanamid Company | N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| US20030091632A1 (en) * | 1999-08-26 | 2003-05-15 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| US6384221B1 (en) | 1999-09-02 | 2002-05-07 | Neurocrine Biosciences, Inc. | Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| CN1847244A (zh) * | 2000-08-03 | 2006-10-18 | Wyeth公司 | 扎来普隆多晶型物及其制备方法 |
| EP1526136A1 (en) * | 2000-08-03 | 2005-04-27 | Wyeth | Polymorphs of zaleplon and methods for the preparation thereof |
| AR029780A1 (es) | 2000-12-13 | 2003-07-16 | Gador Sa | Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida |
| US20050032818A1 (en) * | 2001-06-12 | 2005-02-10 | Entire Interest | N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon |
| KR20040007683A (ko) * | 2001-06-12 | 2004-01-24 | 비오갈 기오기스제르갸르 알티. | 잘레플론의 제조 방법 |
| SK472004A3 (en) | 2001-08-01 | 2004-12-01 | Biogal Gyogyszergyar | Purification and crystalline forms of zaleplon |
| ATE368667T1 (de) | 2002-02-14 | 2007-08-15 | Cilag Ag | Verfahren zur herstellung von n-ethyl-n-(3-(3- cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)- acetamid |
| CN101426504A (zh) * | 2002-02-15 | 2009-05-06 | 特瓦药厂私人有限公司 | 包含规定粒径分布的扎来普隆的粉末组合物和由其制得的药物制品 |
| PL207322B1 (pl) * | 2002-05-14 | 2010-11-30 | Adamed Społka Z Ograniczoną Odpowiedzialnością | Sposób wytwarzania zaleplonu |
| WO2005023813A1 (en) * | 2003-09-04 | 2005-03-17 | Cipla Limited | Zaleplon synthesis |
| ES2515092T3 (es) | 2003-12-11 | 2014-10-29 | Sunovion Pharmaceuticals Inc. | Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión |
| ATE458739T1 (de) * | 2004-01-14 | 2010-03-15 | Mallinckrodt Inc | Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine |
| HUP0400325A3 (en) * | 2004-02-02 | 2005-11-28 | Richter Gedeon Vegyeszet | Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates |
| ES2337700T3 (es) | 2004-02-18 | 2010-04-28 | Sepracor, Inc. | Terapia combinada de agonista de dopamina con sedantes para mejorar la calidad del sueño. |
| WO2006070244A2 (en) * | 2004-11-22 | 2006-07-06 | Bakulesh Mafatlal Khamar | A process for the preparation of zaleplon |
| US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
| US7649007B2 (en) * | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
| US7652018B2 (en) * | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
| TW200815428A (en) * | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
| WO2008068600A2 (en) * | 2006-12-06 | 2008-06-12 | Orchid Chemicals & Pharmaceuticals Limited | An improved process for the preparation of zaleplo |
| CZ301145B6 (cs) | 2008-07-31 | 2009-11-18 | Farmak, A. S. | Zpusob prípravy N-(1-benzo[b]thien-2-ylethyl)-N-hydroxymocoviny |
| CN102816163A (zh) * | 2012-08-20 | 2012-12-12 | 四川禾邦阳光制药股份有限公司 | 扎来普隆的新晶型及制备方法 |
| CN112694336B (zh) * | 2020-12-29 | 2021-11-16 | 哈尔滨工业大学 | 一种高纯α相氮化硅纤维毡的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281000A (en) * | 1979-07-09 | 1981-07-28 | American Cyanamid Company | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents |
| US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
| NZ208554A (en) * | 1983-06-23 | 1987-06-30 | American Cyanamid Co | (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions |
| US4521422A (en) * | 1983-06-23 | 1985-06-04 | American Cyanamid Company | Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| JPS62270584A (ja) * | 1986-04-28 | 1987-11-24 | Yoshitomi Pharmaceut Ind Ltd | ４，７−ジヒドロピラゾロ〔１，５−ａ〕ピリミジン誘導体 |
| GB9321162D0 (en) * | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
-
1996
- 1996-11-25 US US08/758,132 patent/US5714607A/en not_active Expired - Lifetime
- 1996-11-28 DK DK96308630T patent/DK0776898T3/da active
- 1996-11-28 PT PT96308630T patent/PT776898E/pt unknown
- 1996-11-28 NO NO965084A patent/NO307181B1/no not_active IP Right Cessation
- 1996-11-28 ZA ZA9610008A patent/ZA9610008B/xx unknown
- 1996-11-28 IL IL11971096A patent/IL119710A/xx not_active IP Right Cessation
- 1996-11-28 EP EP96308630A patent/EP0776898B1/en not_active Expired - Lifetime
- 1996-11-28 DE DE69624657T patent/DE69624657T2/de not_active Expired - Lifetime
- 1996-11-28 HU HU9603275A patent/HU226398B1/hu unknown
- 1996-11-28 AT AT96308630T patent/ATE227290T1/de active
- 1996-11-28 ES ES96308630T patent/ES2184844T3/es not_active Expired - Lifetime
- 1996-11-29 CA CA002191647A patent/CA2191647C/en not_active Expired - Fee Related
- 1996-11-29 TW TW085114751A patent/TW382629B/zh not_active IP Right Cessation
- 1996-11-29 CZ CZ19963505A patent/CZ292253B6/cs not_active IP Right Cessation
- 1996-11-29 JP JP31909596A patent/JP4112032B2/ja not_active Expired - Fee Related
- 1996-11-29 NZ NZ299848A patent/NZ299848A/en not_active IP Right Cessation
- 1996-11-29 BR BR9605760A patent/BR9605760A/pt not_active Application Discontinuation
- 1996-11-29 RU RU96122857/04A patent/RU2178415C2/ru not_active IP Right Cessation
- 1996-11-29 AR ARP960105438A patent/AR004822A1/es active IP Right Grant
- 1996-11-29 KR KR1019960059652A patent/KR100439282B1/ko not_active IP Right Cessation
- 1996-11-29 AU AU74091/96A patent/AU718310B2/en not_active Ceased
- 1996-11-29 SK SK1536-96A patent/SK281807B6/sk not_active IP Right Cessation
- 1996-11-29 MX MX9605974A patent/MX9605974A/es unknown
- 1996-11-30 CN CN96118985A patent/CN1057525C/zh not_active Expired - Fee Related
-
2004
- 2004-05-06 CY CY0400035A patent/CY2440B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Expiry date: 20161129 |