MX9605974A - Proceso mejorado en la sintesis de n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacet amida. - Google Patents

Proceso mejorado en la sintesis de n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacet amida.

Info

Publication number
MX9605974A
MX9605974A MX9605974A MX9605974A MX9605974A MX 9605974 A MX9605974 A MX 9605974A MX 9605974 A MX9605974 A MX 9605974A MX 9605974 A MX9605974 A MX 9605974A MX 9605974 A MX9605974 A MX 9605974A
Authority
MX
Mexico
Prior art keywords
ethyl
cyanopyrazolo
pyrimidin
phenyl1
synthesis
Prior art date
Application number
MX9605974A
Other languages
English (en)
Other versions
MXPA96005974A (es
Inventor
Thurairajah Padmanathan
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of MXPA96005974A publication Critical patent/MXPA96005974A/es
Publication of MX9605974A publication Critical patent/MX9605974A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invencion describe un proceso mejorado para producir N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]- N-etil-acetamida, la cual es util como un agente ansiolítico, antiespiléptico, sedante-hipnotico y relajante del musculo esquelético. La invencion descrita comprende hacer reaccionar 3-dimetilamino-1-(3-N-etil-N-acetil-aminofenil)-2- propen-1-ona, o una sal adecuada de la misma, con 3-aminopirazol-4-carbonitrilo, o una sal adecuada del mismo, en una mezcla que comprende agua y ácido acético, más que en ácido acético solo.
MX9605974A 1995-12-01 1996-11-29 Proceso mejorado en la sintesis de n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacet amida. MX9605974A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/007,859 1995-02-01
US785995P 1995-12-01 1995-12-01

Publications (2)

Publication Number Publication Date
MXPA96005974A MXPA96005974A (es) 1998-04-01
MX9605974A true MX9605974A (es) 1998-04-30

Family

ID=21728482

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605974A MX9605974A (es) 1995-12-01 1996-11-29 Proceso mejorado en la sintesis de n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacet amida.

Country Status (25)

Country Link
US (1) US5714607A (es)
EP (1) EP0776898B1 (es)
JP (1) JP4112032B2 (es)
KR (1) KR100439282B1 (es)
CN (1) CN1057525C (es)
AR (1) AR004822A1 (es)
AT (1) ATE227290T1 (es)
AU (1) AU718310B2 (es)
BR (1) BR9605760A (es)
CA (1) CA2191647C (es)
CY (1) CY2440B1 (es)
CZ (1) CZ292253B6 (es)
DE (1) DE69624657T2 (es)
DK (1) DK0776898T3 (es)
ES (1) ES2184844T3 (es)
HU (1) HU226398B1 (es)
IL (1) IL119710A (es)
MX (1) MX9605974A (es)
NO (1) NO307181B1 (es)
NZ (1) NZ299848A (es)
PT (1) PT776898E (es)
RU (1) RU2178415C2 (es)
SK (1) SK281807B6 (es)
TW (1) TW382629B (es)
ZA (1) ZA9610008B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
CN1847244A (zh) * 2000-08-03 2006-10-18 Wyeth公司 扎来普隆多晶型物及其制备方法
EP1526136A1 (en) * 2000-08-03 2005-04-27 Wyeth Polymorphs of zaleplon and methods for the preparation thereof
AR029780A1 (es) 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
KR20040007683A (ko) * 2001-06-12 2004-01-24 비오갈 기오기스제르갸르 알티. 잘레플론의 제조 방법
SK472004A3 (en) 2001-08-01 2004-12-01 Biogal Gyogyszergyar Purification and crystalline forms of zaleplon
ATE368667T1 (de) 2002-02-14 2007-08-15 Cilag Ag Verfahren zur herstellung von n-ethyl-n-(3-(3- cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)- acetamid
CN101426504A (zh) * 2002-02-15 2009-05-06 特瓦药厂私人有限公司 包含规定粒径分布的扎来普隆的粉末组合物和由其制得的药物制品
PL207322B1 (pl) * 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
WO2005023813A1 (en) * 2003-09-04 2005-03-17 Cipla Limited Zaleplon synthesis
ES2515092T3 (es) 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
ATE458739T1 (de) * 2004-01-14 2010-03-15 Mallinckrodt Inc Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine
HUP0400325A3 (en) * 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
ES2337700T3 (es) 2004-02-18 2010-04-28 Sepracor, Inc. Terapia combinada de agonista de dopamina con sedantes para mejorar la calidad del sueño.
WO2006070244A2 (en) * 2004-11-22 2006-07-06 Bakulesh Mafatlal Khamar A process for the preparation of zaleplon
US7538107B2 (en) 2006-08-15 2009-05-26 Wyeth Oxazinan-2-one derivatives useful as PR modulators
US7649007B2 (en) * 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
US7652018B2 (en) * 2006-08-15 2010-01-26 Wyeth Llc Imidazolidin-2-one derivatives useful as PR modulators
TW200815428A (en) * 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
WO2008068600A2 (en) * 2006-12-06 2008-06-12 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of zaleplo
CZ301145B6 (cs) 2008-07-31 2009-11-18 Farmak, A. S. Zpusob prípravy N-(1-benzo[b]thien-2-ylethyl)-N-hydroxymocoviny
CN102816163A (zh) * 2012-08-20 2012-12-12 四川禾邦阳光制药股份有限公司 扎来普隆的新晶型及制备方法
CN112694336B (zh) * 2020-12-29 2021-11-16 哈尔滨工业大学 一种高纯α相氮化硅纤维毡的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
JPS62270584A (ja) * 1986-04-28 1987-11-24 Yoshitomi Pharmaceut Ind Ltd ４，７−ジヒドロピラゾロ〔１，５−ａ〕ピリミジン誘導体
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents

Also Published As

Publication number Publication date
AU7409196A (en) 1997-06-05
ZA9610008B (en) 1998-08-28
CY2440B1 (en) 2004-11-12
DK0776898T3 (da) 2003-02-24
EP0776898B1 (en) 2002-11-06
CA2191647C (en) 2005-01-25
NO307181B1 (no) 2000-02-21
ATE227290T1 (de) 2002-11-15
NO965084L (no) 1997-06-02
TW382629B (en) 2000-02-21
ES2184844T3 (es) 2003-04-16
NZ299848A (en) 1998-09-24
BR9605760A (pt) 1998-08-25
IL119710A0 (en) 1997-02-18
CN1163893A (zh) 1997-11-05
JPH09216885A (ja) 1997-08-19
DE69624657D1 (de) 2002-12-12
US5714607A (en) 1998-02-03
AU718310B2 (en) 2000-04-13
CN1057525C (zh) 2000-10-18
HU9603275D0 (en) 1997-01-28
PT776898E (pt) 2003-02-28
KR970042543A (ko) 1997-07-24
HUP9603275A3 (en) 1997-10-28
DE69624657T2 (de) 2003-08-21
AR004822A1 (es) 1999-03-10
CA2191647A1 (en) 1997-06-02
RU2178415C2 (ru) 2002-01-20
HUP9603275A2 (en) 1997-08-28
SK281807B6 (sk) 2001-08-06
KR100439282B1 (ko) 2004-08-31
SK153696A3 (en) 1997-11-05
CZ292253B6 (cs) 2003-08-13
HU226398B1 (en) 2008-11-28
EP0776898A1 (en) 1997-06-04
IL119710A (en) 1999-11-30
JP4112032B2 (ja) 2008-07-02
CZ350596A3 (en) 1997-09-17
NO965084D0 (no) 1996-11-28

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