SK279765B6 - Rmaceutický prípravok - Google Patents

Rmaceutický prípravok Download PDF

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Publication number
SK279765B6
SK279765B6 SK8804-85A SK880485A SK279765B6 SK 279765 B6 SK279765 B6 SK 279765B6 SK 880485 A SK880485 A SK 880485A SK 279765 B6 SK279765 B6 SK 279765B6
Authority
SK
Slovakia
Prior art keywords
epo
sequence
cells
erythropoietin
dna
Prior art date
Application number
SK8804-85A
Other languages
English (en)
Slovak (sk)
Other versions
SK880485A3 (en
Inventor
Edward Fritsch
Rodney M. Hewick
Kenneth Jacobs
Randal C. Kaufman
Original Assignee
Genetics Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27418329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK279765(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genetics Institute filed Critical Genetics Institute
Publication of SK880485A3 publication Critical patent/SK880485A3/sk
Publication of SK279765B6 publication Critical patent/SK279765B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK8804-85A 1984-12-04 1985-12-03 Rmaceutický prípravok SK279765B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67781384A 1984-12-04 1984-12-04
US68862285A 1985-01-03 1985-01-03
US69325885A 1985-01-22 1985-01-22

Publications (2)

Publication Number Publication Date
SK880485A3 SK880485A3 (en) 1999-03-10
SK279765B6 true SK279765B6 (sk) 1999-03-12

Family

ID=27418329

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1687-99A SK168799A3 (en) 1984-12-04 1985-12-03 Method for production of human erythropoetin
SK8804-85A SK279765B6 (sk) 1984-12-04 1985-12-03 Rmaceutický prípravok

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK1687-99A SK168799A3 (en) 1984-12-04 1985-12-03 Method for production of human erythropoetin

Country Status (24)

Country Link
EP (2) EP0411678B2 (fi)
JP (4) JPH0655144B2 (fi)
KR (1) KR890001011B1 (fi)
AT (2) ATE71408T1 (fi)
AU (1) AU621535B2 (fi)
CA (1) CA1341502C (fi)
CZ (3) CZ281756B6 (fi)
DE (3) DE3585161D1 (fi)
DK (4) DK172953B1 (fi)
ES (1) ES8800049A1 (fi)
FI (2) FI104261B (fi)
GE (1) GEP19970775B (fi)
GR (1) GR852890B (fi)
HK (2) HK105593A (fi)
HU (1) HU216079B (fi)
IL (1) IL77081A (fi)
LV (2) LV10505B (fi)
MD (1) MD1639C2 (fi)
NO (1) NO304469B1 (fi)
PL (2) PL157926B1 (fi)
PT (1) PT81590B (fi)
SK (2) SK168799A3 (fi)
UA (1) UA44882C2 (fi)
WO (1) WO1986003520A1 (fi)

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KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
EP0236059B1 (en) * 1986-02-27 1994-04-27 Snow Brand Milk Products Co. Ltd. Preparation of erythropoietin-producing cells and production process of erythropoietin using same
DK173067B1 (da) * 1986-06-27 1999-12-13 Univ Washington Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
IE872455L (en) * 1986-09-12 1988-03-12 Lanstrase Ltd Improved recombinant expression
US4954437A (en) * 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5888774A (en) * 1994-12-19 1999-03-30 Cangene Corporation Recombinant DNA molecules and expression vectors for erythropoietin
ATE445705T1 (de) 1995-06-15 2009-10-15 Crucell Holland Bv Verpackungssysteme für humane rekombinante adenoviren zur gentherapie
EP0752474A1 (en) * 1995-07-07 1997-01-08 Boehringer Mannheim Gmbh Nucleic acid coding for CMP-N-acetyl-neuraminic acid hydroxylase and its use for the production of modified glycoproteins
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US20100272816A1 (en) 2009-04-27 2010-10-28 Wolfgang Rudinger Microcapsules comprising liver cells and erythropoietin, methods for preparing said microcapsules and methods for treating a patient comprising applying said microcapsules to the patient
KR20120117728A (ko) 2009-09-23 2012-10-24 바이오제너릭스 에이지 재조합 인간 에리트로포이에틴(ｅｐｏ)의 정제 방법, 이렇게 정제된 ｅｐｏ 및 이를 포함하는 약학적 조성물
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JPS6045849B2 (ja) * 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
JPS6043395A (ja) * 1983-08-19 1985-03-07 Sumitomo Chem Co Ltd エリスロポエチンの製造法
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IT1185503B (it) * 1984-01-11 1987-11-12 Univ New York Cloni di odna di eritropietina umana
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EP0411678B1 (en) 1992-01-08
HUT40706A (en) 1987-01-28
DK173254B1 (da) 2000-05-22
ATE63137T1 (de) 1991-05-15
MD940371A (en) 1996-06-28
CA1341502C (en) 2006-03-21
WO1986003520A1 (en) 1986-06-19
NO304469B1 (no) 1998-12-21
SK281799B6 (sk) 2001-08-06
SK168799A3 (en) 2001-08-06
LV10505A (lv) 1995-02-20
EP0205564B2 (en) 2000-06-21
EP0205564A4 (en) 1987-12-14
JPH0655144B2 (ja) 1994-07-27
EP0205564A1 (en) 1986-12-30
IL77081A0 (en) 1986-04-29
DK173293B1 (da) 2000-06-13
DK200000527A (da) 2000-03-29
FI863044A (fi) 1986-07-24
PL256589A1 (en) 1986-10-21
PT81590A (en) 1986-01-01
DE3582732D1 (de) 1991-06-06
ES549539A0 (es) 1987-10-16
EP0411678B2 (en) 2000-01-12
EP0205564B1 (en) 1991-05-02
DK172953B1 (da) 1999-10-18
CZ281756B6 (cs) 1997-01-15
HU216079B (hu) 1999-04-28
JPH07184681A (ja) 1995-07-25
LV10507A (lv) 1995-02-20
JPH02104284A (ja) 1990-04-17
LV10507B (lv) 1996-06-20
FI104261B1 (fi) 1999-12-15
DK199901147A (da) 1999-08-20
FI863044A0 (fi) 1986-07-24
AU621535B2 (en) 1992-03-19
KR870700099A (ko) 1987-02-28
FI104261B (fi) 1999-12-15
PL154180B1 (en) 1991-07-31
DE3585161D1 (de) 1992-02-20
SK880485A3 (en) 1999-03-10
LV10505B (en) 1996-04-20
HK105593A (en) 1993-10-15
PT81590B (pt) 1987-10-20
EP0411678A1 (en) 1991-02-06
CZ880485A3 (en) 1996-08-14
CZ287620B6 (cs) 2001-01-17
ATE71408T1 (de) 1992-01-15
DK175826B1 (da) 2005-03-14
CZ286557B6 (cs) 2000-05-17
KR890001011B1 (en) 1989-04-18
MD1639B2 (en) 2001-03-31
NO863050L (no) 1986-07-28
DK368786A (da) 1986-08-01
NO863050D0 (no) 1986-07-28
GR852890B (fi) 1986-04-03
GEP19970775B (en) 1997-01-27
DK368786D0 (da) 1986-08-01
JPH01257480A (ja) 1989-10-13
AU5313486A (en) 1986-07-01
CZ127496A3 (cs) 2000-02-16
FI19992064A (fi) 1999-09-27
DE411678T1 (de) 1991-10-17
MD1639C2 (ro) 2001-10-31
JPH02442A (ja) 1990-01-05
UA44882C2 (uk) 2002-03-15
FI105347B (fi) 2000-07-31
IL77081A (en) 1999-10-28
PL157926B1 (pl) 1992-07-31
ES8800049A1 (es) 1987-10-16
DK95197A (da) 1997-08-20
HK105693A (en) 1993-10-15

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