SK117399A3 - Pyrazine compounds, preparation method thereof, pharmaceutical composition containing them and their use - Google Patents

Pyrazine compounds, preparation method thereof, pharmaceutical composition containing them and their use Download PDF

Info

Publication number
SK117399A3
SK117399A3 SK1173-99A SK117399A SK117399A3 SK 117399 A3 SK117399 A3 SK 117399A3 SK 117399 A SK117399 A SK 117399A SK 117399 A3 SK117399 A3 SK 117399A3
Authority
SK
Slovakia
Prior art keywords
pyrazine
compound
formula
alkyl
compounds
Prior art date
Application number
SK1173-99A
Other languages
English (en)
Slovak (sk)
Inventor
Brian Cox
Dean David Edney
Michael Simon Loft
Malcolm Stuart Nobbs
Gita Punjabhai Shah
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9704275.8A external-priority patent/GB9704275D0/en
Priority claimed from GBGB9708183.0A external-priority patent/GB9708183D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SK117399A3 publication Critical patent/SK117399A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Detergent Compositions (AREA)
SK1173-99A 1997-03-01 1998-02-26 Pyrazine compounds, preparation method thereof, pharmaceutical composition containing them and their use SK117399A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9704275.8A GB9704275D0 (en) 1997-03-01 1997-03-01 Pharmacologically active compound
GBGB9708183.0A GB9708183D0 (en) 1997-04-23 1997-04-23 Pharmacologically active compound
PCT/EP1998/001077 WO1998038174A1 (en) 1997-03-01 1998-02-26 Pyrazine compounds

Publications (1)

Publication Number Publication Date
SK117399A3 true SK117399A3 (en) 2000-06-12

Family

ID=26311097

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1173-99A SK117399A3 (en) 1997-03-01 1998-02-26 Pyrazine compounds, preparation method thereof, pharmaceutical composition containing them and their use

Country Status (46)

Country Link
US (2) US6255307B1 (cs)
EP (1) EP0966448B1 (cs)
JP (1) JP3369189B2 (cs)
KR (1) KR100544263B1 (cs)
CN (1) CN1105111C (cs)
AP (1) AP9901632A0 (cs)
AR (1) AR011174A1 (cs)
AT (1) ATE251143T1 (cs)
AU (1) AU732915B2 (cs)
BG (1) BG103723A (cs)
BR (1) BR9807814B1 (cs)
CA (1) CA2282585C (cs)
CO (1) CO4950513A1 (cs)
CZ (1) CZ295618B6 (cs)
DE (1) DE69818643T2 (cs)
DK (1) DK0966448T3 (cs)
EA (1) EA002102B1 (cs)
EE (1) EE9900376A (cs)
ES (1) ES2205469T3 (cs)
GE (1) GEP20012555B (cs)
GT (1) GT199800046A (cs)
HK (1) HK1023116A1 (cs)
HN (2) HN1998000036A (cs)
HR (1) HRP980107A2 (cs)
HU (1) HU225852B1 (cs)
ID (1) ID22850A (cs)
IL (1) IL131293A (cs)
IS (1) IS5163A (cs)
JO (1) JO2035B1 (cs)
MA (1) MA26473A1 (cs)
MY (1) MY118612A (cs)
NO (1) NO313383B1 (cs)
NZ (1) NZ337121A (cs)
OA (1) OA11151A (cs)
PA (1) PA8448201A1 (cs)
PE (1) PE58299A1 (cs)
PL (1) PL192864B1 (cs)
PT (1) PT966448E (cs)
SI (1) SI0966448T1 (cs)
SK (1) SK117399A3 (cs)
SV (1) SV1998000029A (cs)
TR (1) TR199902082T2 (cs)
TW (1) TW513416B (cs)
UY (1) UY24911A1 (cs)
WO (1) WO1998038174A1 (cs)
YU (1) YU40799A (cs)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420354B1 (en) 1998-06-08 2002-07-16 Advanced Medicine, Inc. Sodium channel drugs and uses
GB9818881D0 (en) 1998-08-28 1998-10-21 Glaxo Group Ltd Compounds
GB9907965D0 (en) * 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
US6479498B1 (en) 1999-06-04 2002-11-12 Theravance, Inc. Sodium channel drugs and uses
KR20030031886A (ko) * 2000-02-16 2003-04-23 뉴로젠 코포레이션 치환된 아릴피라진
EP1500653A1 (en) * 2000-02-16 2005-01-26 Neurogen Corporation Substituted arylpyrazines
GB0010971D0 (en) * 2000-05-05 2000-06-28 Glaxo Group Ltd Process
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
SE0102439D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
SE0102438D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
US6992087B2 (en) 2001-11-21 2006-01-31 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
MXPA04004714A (es) * 2001-11-21 2004-08-19 Upjohn Co Derivados de aril 1,4-pirazina sustituidos.
SI1458386T1 (sl) 2001-12-27 2007-08-31 Ortho Mcneil Pharm Inc Aroil pirol heteroeril in metanoli, uporabni za zdravljenje motnje centralnega živčnega sistema
MXPA04008384A (es) * 2002-04-26 2004-11-26 Upjohn Co Derivados de pirazina sustituidos.
CA2496197A1 (en) 2002-08-20 2004-03-04 Neurogen Corporation 5-substituted-2-arylpyrazines as modulators of crf receptors
SE0203753D0 (sv) * 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
SE0203754D0 (sv) * 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
CA2514574A1 (en) 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Use of sodium channel modulators for treating gastrointestinal tract disorders
TW200510373A (en) * 2003-07-14 2005-03-16 Neurogen Corp Substituted quinolin-4-ylamine analogues
US8518950B2 (en) * 2005-01-25 2013-08-27 Synta Pharmaceuticals Corp. 2-amido pyrazines for inflammation and immune related uses
US20060182805A1 (en) * 2005-02-15 2006-08-17 Jazz Pharmaceuticals Dosage form and method for sustained release of substituted pyrazine compound
NL2000284C2 (nl) * 2005-11-04 2007-09-28 Pfizer Ltd Pyrazine-derivaten.
CA2633329A1 (en) * 2006-01-23 2007-07-26 Pfizer Limited Pyridine derivatives as sodium channel modulators
JP2010526051A (ja) * 2007-05-03 2010-07-29 ファイザー・リミテッド 疼痛を治療するためのｎａｖ１．８チャネルモジュレーターとしてのｎ−［６−アミノ−５−（フェニル）ピラジン−２−イル］−イソオキサゾール−４−カルボキサミド誘導体および関連化合物
GB0800741D0 (en) 2008-01-16 2008-02-20 Univ Greenwich Cyclic triazo and diazo sodium channel blockers
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
FR3001151B1 (fr) 2013-01-21 2016-04-08 Pf Medicament Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
JO3517B1 (ar) * 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
CA3023216A1 (en) 2016-06-14 2017-12-21 Novartis Ag Compounds and compositions for inhibiting the activity of shp2
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
CN108101857B (zh) * 2016-11-24 2021-09-03 韶远科技（上海)有限公司 制取2-氨基-3-溴-6-氯吡嗪的可放大工艺
CN107011273A (zh) * 2017-05-04 2017-08-04 无锡捷化医药科技有限公司 一种合成6‑碘‑3‑(2,3‑二氯苯基)吡嗪‑2‑胺的方法
JP7553453B2 (ja) 2019-03-01 2024-09-18 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
CN115611700B (zh) * 2022-10-11 2024-06-14 辽宁东大光明化工科技有限责任公司 一种1-溴-2,5-二氯-3-氟苯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402958A (en) * 1981-11-19 1983-09-06 American Cyanamid Company Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates
EP0288431B1 (de) 1987-04-07 1992-08-19 Ciba-Geigy Ag 3H-1,2,3-Triazolo[4,5-d]pyrimidine
JPH08238778A (ja) * 1995-03-07 1996-09-17 Brother Ind Ltd インク噴射装置の電極形成方法

Also Published As

Publication number Publication date
OA11151A (en) 2003-04-22
TR199902082T2 (xx) 2000-04-21
UY24911A1 (es) 2000-12-29
NO313383B1 (no) 2002-09-23
KR100544263B1 (ko) 2006-01-23
ES2205469T3 (es) 2004-05-01
US20020169172A1 (en) 2002-11-14
US6599905B2 (en) 2003-07-29
HK1023116A1 (en) 2000-09-01
AU732915B2 (en) 2001-05-03
PL192864B1 (pl) 2006-12-29
AR011174A1 (es) 2000-08-02
PE58299A1 (es) 1999-06-23
GT199800046A (es) 1999-08-20
HN1999000019A (es) 1999-08-23
EE9900376A (et) 2000-04-17
MA26473A1 (fr) 2004-12-20
JO2035B1 (en) 1999-05-15
WO1998038174A1 (en) 1998-09-03
PA8448201A1 (es) 2000-05-24
US6255307B1 (en) 2001-07-03
PT966448E (pt) 2004-02-27
NO994213L (no) 1999-10-29
DE69818643T2 (de) 2004-10-07
BR9807814A (pt) 2000-02-22
CN1253551A (zh) 2000-05-17
IL131293A (en) 2003-07-31
JP2000511203A (ja) 2000-08-29
GEP20012555B (en) 2001-10-25
HUP0001802A2 (hu) 2001-05-28
EA002102B1 (ru) 2001-12-24
CZ295618B6 (cs) 2005-09-14
CA2282585C (en) 2006-06-06
TW513416B (en) 2002-12-11
DK0966448T3 (da) 2004-02-02
SI0966448T1 (en) 2004-04-30
PL335441A1 (en) 2000-04-25
IL131293A0 (en) 2001-01-28
HUP0001802A3 (en) 2001-07-30
DE69818643D1 (de) 2003-11-06
BG103723A (bg) 2001-05-31
HN1998000036A (es) 1999-08-23
CN1105111C (zh) 2003-04-09
HRP980107A2 (en) 1998-12-31
CA2282585A1 (en) 1998-09-03
IS5163A (is) 1999-08-24
CZ311199A3 (cs) 2000-02-16
AP9901632A0 (en) 1999-09-30
EP0966448A1 (en) 1999-12-29
YU40799A (sh) 2001-09-28
AU6823798A (en) 1998-09-18
SV1998000029A (es) 1998-12-11
JP3369189B2 (ja) 2003-01-20
CO4950513A1 (es) 2000-09-01
ID22850A (id) 1999-12-09
EP0966448B1 (en) 2003-10-01
NO994213D0 (no) 1999-08-31
NZ337121A (en) 2001-03-30
HU225852B1 (en) 2007-11-28
MY118612A (en) 2004-12-31
BR9807814B1 (pt) 2009-01-13
ATE251143T1 (de) 2003-10-15
KR20000075859A (ko) 2000-12-26
EA199900687A1 (ru) 2000-04-24

Similar Documents

Publication Publication Date Title
SK117399A3 (en) Pyrazine compounds, preparation method thereof, pharmaceutical composition containing them and their use
EP1650205B1 (en) Cyclohexanecarboxylic acid compound
US6503909B1 (en) Pyrazine compounds
CN107438604B (zh) 新吡啶化合物
JP2002509930A (ja) ベンゾ複素環ジスタマイシン誘導体、その製造方法および抗腫瘍薬としてのそれの使用
EP3700890B1 (en) Alcoxyamino derivatives for treating pain and pain related conditions
SK9592000A3 (en) Triazine compounds for treatment of cns disorders
US4609659A (en) 2,6-disubstituted derivatives of 3-nitropyrazines useful as adjuncts to radiation therapy
JP2002517494A (ja) シンナモイルジスタマイシン類似誘導体、その製造方法及びその抗腫瘍剤としての使用
JPS59144765A (ja) ２−（１−ピペラジニル）ピリミジン、その製造方法およびそれを含む医薬組成物
EP0111151B1 (en) Substituted nitropyrazine compounds, process for their preparation and pharmaceutical compositions containing them
NZ233928A (en) 1,2,4-triazolo(4,3-a)pyrazine derivatives and anticonvulsant compositions
EP0792879A1 (en) Hydrate for medicinal use
JP2002308773A (ja) ピラジン化合物
JPH09132560A (ja) ２−シアノ−３−メルカプトクロトンアミド
CN117586204A (zh) 异硒唑酮类化合物、其合成方法及用途
CN112851599A (zh) 一种具有双阳离子季铵盐结构的化合物及其制备方法和用途
KR20050019935A (ko) 피라진 화합물을 포함하는 제약 조성물
MXPA01001983A (en) Pyrazine compounds