PT966448E - Compostos de pirazina - Google Patents
Compostos de pirazinaInfo
- Publication number
- PT966448E PT966448E PT98913592T PT98913592T PT966448E PT 966448 E PT966448 E PT 966448E PT 98913592 T PT98913592 T PT 98913592T PT 98913592 T PT98913592 T PT 98913592T PT 966448 E PT966448 E PT 966448E
- Authority
- PT
- Portugal
- Prior art keywords
- pyrazine compounds
- pyrazine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Detergent Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9704275.8A GB9704275D0 (en) | 1997-03-01 | 1997-03-01 | Pharmacologically active compound |
| GBGB9708183.0A GB9708183D0 (en) | 1997-04-23 | 1997-04-23 | Pharmacologically active compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT966448E true PT966448E (pt) | 2004-02-27 |
Family
ID=26311097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98913592T PT966448E (pt) | 1997-03-01 | 1998-02-26 | Compostos de pirazina |
Country Status (46)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6420354B1 (en) | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
| GB9818881D0 (en) | 1998-08-28 | 1998-10-21 | Glaxo Group Ltd | Compounds |
| GB9907965D0 (en) * | 1999-04-09 | 1999-06-02 | Glaxo Group Ltd | Medical use |
| US6479498B1 (en) | 1999-06-04 | 2002-11-12 | Theravance, Inc. | Sodium channel drugs and uses |
| EE200200453A (et) | 2000-02-16 | 2003-12-15 | Neurogen Corporation | Asendatud arüülpürasiinid |
| EP1500653A1 (en) * | 2000-02-16 | 2005-01-26 | Neurogen Corporation | Substituted arylpyrazines |
| GB0010971D0 (en) * | 2000-05-05 | 2000-06-28 | Glaxo Group Ltd | Process |
| GB0016040D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| BR0214309A (pt) * | 2001-11-21 | 2004-10-13 | Upjohn Co | Derivados aril-1,4-pirazina substituìdos |
| US6992087B2 (en) | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
| US6897319B2 (en) * | 2001-12-27 | 2005-05-24 | Ortho-Mcneil Pharmaceutical, Inc. | Useful aroyl pyrrole heteroaryl methanones and methanols |
| BR0309551A (pt) * | 2002-04-26 | 2005-02-09 | Upjohn Co | Derivados substituìdos de pirazina |
| JP2006509729A (ja) | 2002-08-20 | 2006-03-23 | ニューロジェン・コーポレーション | Ｃｒｆ受容体モジュレータとしての５−置換−２−アリールピラジン類 |
| SE0203754D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203753D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| JP2006515326A (ja) | 2003-01-30 | 2006-05-25 | ダイノジェン ファーマシューティカルズ， インコーポレイテッド | 胃腸管障害を処置するためのナトリウムチャネルモジュレーターの使用 |
| TW200510373A (en) * | 2003-07-14 | 2005-03-16 | Neurogen Corp | Substituted quinolin-4-ylamine analogues |
| JP5307402B2 (ja) * | 2005-01-25 | 2013-10-02 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫に関連する用途に用いる化合物 |
| AU2006214454B2 (en) * | 2005-02-15 | 2011-05-19 | Jazz Pharmaceuticals, Inc. | Dosage form and method for sustained release of a substituted pyrazine compound |
| NL2000284C2 (nl) * | 2005-11-04 | 2007-09-28 | Pfizer Ltd | Pyrazine-derivaten. |
| EP1984339A1 (en) * | 2006-01-23 | 2008-10-29 | Pfizer Limited | Pyridine derivatives as sodium channel modulators |
| CA2685952C (en) * | 2007-05-03 | 2012-03-13 | Pfizer Limited | N- [6-amino-5- (phenyl) pyrazin-2-yl] -isoxazole-4-carboxamide derivatives and related compounds as nav1.8 channel modulators for the treatment of pain |
| GB0800741D0 (en) | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
| GB201111712D0 (en) | 2011-07-08 | 2011-08-24 | Gosforth Ct Holdings Pty Ltd | Pharmaceutical compositions |
| FR3001151B1 (fr) | 2013-01-21 | 2016-04-08 | Pf Medicament | Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant |
| JO3517B1 (ar) * | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| MX2018015625A (es) | 2016-06-14 | 2019-03-06 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de shp2. |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| CN108101857B (zh) * | 2016-11-24 | 2021-09-03 | 韶远科技（上海)有限公司 | 制取2-氨基-3-溴-6-氯吡嗪的可放大工艺 |
| CN107011273A (zh) * | 2017-05-04 | 2017-08-04 | 无锡捷化医药科技有限公司 | 一种合成6‑碘‑3‑(2,3‑二氯苯基)吡嗪‑2‑胺的方法 |
| EP3930702A1 (en) | 2019-03-01 | 2022-01-05 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| CN115611700A (zh) * | 2022-10-11 | 2023-01-17 | 辽宁东大光明化工科技有限责任公司 | 一种1-溴-2,5-二氯-3-氟苯的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4402958A (en) * | 1981-11-19 | 1983-09-06 | American Cyanamid Company | Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates |
| ATE79624T1 (de) | 1987-04-07 | 1992-09-15 | Ciba Geigy Ag | 3h-1,2,3-triazolo(4,5-d>pyrimidine. |
| JPH08238778A (ja) * | 1995-03-07 | 1996-09-17 | Brother Ind Ltd | インク噴射装置の電極形成方法 |
-
1998
- 1998-02-23 MA MA24973A patent/MA26473A1/fr unknown
- 1998-02-24 PE PE1998000134A patent/PE58299A1/es not_active Application Discontinuation
- 1998-02-26 ES ES98913592T patent/ES2205469T3/es not_active Expired - Lifetime
- 1998-02-26 GE GEAP19984976A patent/GEP20012555B/en unknown
- 1998-02-26 KR KR1019997007937A patent/KR100544263B1/ko not_active IP Right Cessation
- 1998-02-26 AP AP9901632A patent/AP9901632A0/xx unknown
- 1998-02-26 PT PT98913592T patent/PT966448E/pt unknown
- 1998-02-26 BR BRPI9807814-3A patent/BR9807814B1/pt not_active IP Right Cessation
- 1998-02-26 IL IL13129398A patent/IL131293A/xx not_active IP Right Cessation
- 1998-02-26 CO CO98010500A patent/CO4950513A1/es unknown
- 1998-02-26 NZ NZ337121A patent/NZ337121A/xx not_active IP Right Cessation
- 1998-02-26 EE EEP199900376A patent/EE9900376A/xx unknown
- 1998-02-26 US US09/380,062 patent/US6255307B1/en not_active Expired - Fee Related
- 1998-02-26 DK DK98913592T patent/DK0966448T3/da active
- 1998-02-26 TR TR1999/02082T patent/TR199902082T2/xx unknown
- 1998-02-26 HU HU0001802A patent/HU225852B1/hu not_active IP Right Cessation
- 1998-02-26 AU AU68237/98A patent/AU732915B2/en not_active Ceased
- 1998-02-26 YU YU40799A patent/YU40799A/sh unknown
- 1998-02-26 EA EA199900687A patent/EA002102B1/ru not_active IP Right Cessation
- 1998-02-26 EP EP98913592A patent/EP0966448B1/en not_active Expired - Lifetime
- 1998-02-26 SI SI9830578T patent/SI0966448T1/xx unknown
- 1998-02-26 SK SK1173-99A patent/SK117399A3/sk unknown
- 1998-02-26 CZ CZ19993111A patent/CZ295618B6/cs not_active IP Right Cessation
- 1998-02-26 GT GT199800046A patent/GT199800046A/es unknown
- 1998-02-26 MY MYPI98000852A patent/MY118612A/en unknown
- 1998-02-26 ID IDW990951A patent/ID22850A/id unknown
- 1998-02-26 AT AT98913592T patent/ATE251143T1/de active
- 1998-02-26 CA CA002282585A patent/CA2282585C/en not_active Expired - Fee Related
- 1998-02-26 JO JO19982035A patent/JO2035B1/en active
- 1998-02-26 CN CN98804593A patent/CN1105111C/zh not_active Expired - Fee Related
- 1998-02-26 PL PL335441A patent/PL192864B1/pl unknown
- 1998-02-26 DE DE69818643T patent/DE69818643T2/de not_active Expired - Lifetime
- 1998-02-26 JP JP53731098A patent/JP3369189B2/ja not_active Expired - Fee Related
- 1998-02-26 WO PCT/EP1998/001077 patent/WO1998038174A1/en active IP Right Grant
- 1998-02-27 SV SV1998000029A patent/SV1998000029A/es not_active Application Discontinuation
- 1998-02-27 UY UY24911A patent/UY24911A1/es unknown
- 1998-02-27 PA PA19988448201A patent/PA8448201A1/es unknown
- 1998-02-27 HR HR9708183.0A patent/HRP980107A2/hr not_active Application Discontinuation
- 1998-02-27 HN HN1998000036A patent/HN1998000036A/es unknown
- 1998-02-27 AR ARP980100906A patent/AR011174A1/es active IP Right Grant
- 1998-03-03 TW TW087103079A patent/TW513416B/zh not_active IP Right Cessation
-
1999
- 1999-02-11 HN HN1999000019A patent/HN1999000019A/es unknown
- 1999-08-24 IS IS5163A patent/IS5163A/is unknown
- 1999-08-27 OA OA9900196A patent/OA11151A/en unknown
- 1999-08-31 NO NO19994213A patent/NO313383B1/no not_active IP Right Cessation
- 1999-09-09 BG BG103723A patent/BG103723A/bg unknown
-
2000
- 2000-04-10 HK HK00102173A patent/HK1023116A1/xx not_active IP Right Cessation
-
2001
- 2001-05-16 US US09/855,703 patent/US6599905B2/en not_active Expired - Fee Related
Also Published As
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