SI2578571T1 - Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto - Google Patents

Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto

Info

Publication number
SI2578571T1
SI2578571T1 SI200831546T SI200831546T SI2578571T1 SI 2578571 T1 SI2578571 T1 SI 2578571T1 SI 200831546 T SI200831546 T SI 200831546T SI 200831546 T SI200831546 T SI 200831546T SI 2578571 T1 SI2578571 T1 SI 2578571T1
Authority
SI
Slovenia
Prior art keywords
isoquinoline
atp
modulators
binding cassette
cassette transporters
Prior art date
Application number
SI200831546T
Other languages
English (en)
Slovenian (sl)
Inventor
Ruah Sara Hadida
Mark Miller
Jinglan Zhou
Brian Bear
Peter D. J. Grootenhuis
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of SI2578571T1 publication Critical patent/SI2578571T1/sl

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Gynecology & Obstetrics (AREA)
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  • Psychology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
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  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
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  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
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  • Heart & Thoracic Surgery (AREA)
SI200831546T 2007-11-16 2008-11-14 Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto SI2578571T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16
EP12181370.3A EP2578571B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of ATP-binding cassette transporters

Publications (1)

Publication Number Publication Date
SI2578571T1 true SI2578571T1 (sl) 2016-01-29

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SI200831546T SI2578571T1 (sl) 2007-11-16 2008-11-14 Izokinolinski modulatorji prenašalcev z atp-vezavno kaseto
SI200831147T SI2217572T1 (sl) 2007-11-16 2008-11-14 Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200831147T SI2217572T1 (sl) 2007-11-16 2008-11-14 Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto

Country Status (16)

Country Link
US (4) US8507524B2 (https=)
EP (3) EP2578571B1 (https=)
JP (3) JP5646338B2 (https=)
CN (2) CN101952254B (https=)
AU (1) AU2008322616B2 (https=)
CA (1) CA2705562C (https=)
CY (1) CY1115318T1 (https=)
DK (2) DK2217572T3 (https=)
ES (3) ES2658064T3 (https=)
HR (2) HRP20140103T1 (https=)
HU (1) HUE026334T2 (https=)
NZ (2) NZ585980A (https=)
PL (2) PL2217572T3 (https=)
PT (2) PT2578571E (https=)
SI (2) SI2578571T1 (https=)
WO (1) WO2009064959A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006111093A (ru) 2003-09-06 2007-10-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы атр-связывающих кассетных транспортеров
CN101675928A (zh) * 2003-11-14 2010-03-24 沃泰克斯药物股份有限公司 可用作atp-结合弹夹转运蛋白调控剂的噻唑和噁唑
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
BRPI0507278A (pt) * 2004-01-30 2007-06-26 Vertex Pharma moduladores dos transportadores do cassete de ligação ao atp
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