AU2008322616B2 - Isoquinoline modulators of ATP-Binding Cassette transporters - Google Patents

Isoquinoline modulators of ATP-Binding Cassette transporters Download PDF

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Publication number
AU2008322616B2
AU2008322616B2 AU2008322616A AU2008322616A AU2008322616B2 AU 2008322616 B2 AU2008322616 B2 AU 2008322616B2 AU 2008322616 A AU2008322616 A AU 2008322616A AU 2008322616 A AU2008322616 A AU 2008322616A AU 2008322616 B2 AU2008322616 B2 AU 2008322616B2
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optionally substituted
aliphatic
heteroaryl
aryl
group
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AU2008322616A1 (en
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Brian Bear
Peter D. J. Grootenhuis
Sara Hadida Ruah
Mark Miller
Jinglan Zhou
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • A61K31/47Quinolines; Isoquinolines
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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AU2008322616A 2007-11-16 2008-11-14 Isoquinoline modulators of ATP-Binding Cassette transporters Active AU2008322616B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013231151A AU2013231151B2 (en) 2007-11-16 2013-09-23 Isoquinoline modulators of ATP-Binding Cassette transporters

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16
US60/988,559 2007-11-16
PCT/US2008/083517 WO2009064959A1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of atp-binding cassette transporters

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AU2013231151A Division AU2013231151B2 (en) 2007-11-16 2013-09-23 Isoquinoline modulators of ATP-Binding Cassette transporters

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AU2008322616A1 AU2008322616A1 (en) 2009-05-22
AU2008322616B2 true AU2008322616B2 (en) 2013-07-18

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EP (3) EP2578571B1 (https=)
JP (3) JP5646338B2 (https=)
CN (2) CN101952254B (https=)
AU (1) AU2008322616B2 (https=)
CA (1) CA2705562C (https=)
CY (1) CY1115318T1 (https=)
DK (2) DK2217572T3 (https=)
ES (3) ES2658064T3 (https=)
HR (2) HRP20140103T1 (https=)
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PL (2) PL2217572T3 (https=)
PT (2) PT2578571E (https=)
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Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006111093A (ru) 2003-09-06 2007-10-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы атр-связывающих кассетных транспортеров
CN101675928A (zh) * 2003-11-14 2010-03-24 沃泰克斯药物股份有限公司 可用作atp-结合弹夹转运蛋白调控剂的噻唑和噁唑
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
BRPI0507278A (pt) * 2004-01-30 2007-06-26 Vertex Pharma moduladores dos transportadores do cassete de ligação ao atp
RS56037B1 (sr) 2004-06-24 2017-09-29 Vertex Pharma Modulatori atp-vezujućih kasetnih transportera
US7999113B2 (en) 2005-08-11 2011-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
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