PL2578571T3 - Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP - Google Patents

Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

Info

Publication number
PL2578571T3
PL2578571T3 PL12181370T PL12181370T PL2578571T3 PL 2578571 T3 PL2578571 T3 PL 2578571T3 PL 12181370 T PL12181370 T PL 12181370T PL 12181370 T PL12181370 T PL 12181370T PL 2578571 T3 PL2578571 T3 PL 2578571T3
Authority
PL
Poland
Prior art keywords
isoquinoline
atp
modulators
binding cassette
cassette transporters
Prior art date
Application number
PL12181370T
Other languages
English (en)
Polish (pl)
Inventor
Ruah Sara Hadida
Mark Miller
Jinglan Zhou
Brian Bear
Peter D J Grootenhuis
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PL2578571T3 publication Critical patent/PL2578571T3/pl

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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PL12181370T 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP PL2578571T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16
EP12181370.3A EP2578571B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of ATP-binding cassette transporters
EP20080849242 EP2217572B1 (en) 2007-11-16 2008-11-14 Isoquinoline modulators of atp-binding cassette transporters

Publications (1)

Publication Number Publication Date
PL2578571T3 true PL2578571T3 (pl) 2016-03-31

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PL12181370T PL2578571T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP
PL08849242T PL2217572T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL08849242T PL2217572T3 (pl) 2007-11-16 2008-11-14 Modulatory izochinolinowe transporterów zawierających kasetę wiążącą ATP

Country Status (16)

Country Link
US (4) US8507524B2 (https=)
EP (3) EP2578571B1 (https=)
JP (3) JP5646338B2 (https=)
CN (2) CN102743385B (https=)
AU (1) AU2008322616B2 (https=)
CA (1) CA2705562C (https=)
CY (1) CY1115318T1 (https=)
DK (2) DK2217572T3 (https=)
ES (3) ES2658064T3 (https=)
HR (2) HRP20140103T1 (https=)
HU (1) HUE026334T2 (https=)
NZ (2) NZ598941A (https=)
PL (2) PL2578571T3 (https=)
PT (2) PT2217572E (https=)
SI (2) SI2217572T1 (https=)
WO (1) WO2009064959A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200602755B (en) 2003-09-06 2007-06-27 Vertex Pharma Modulators of ATP-binding cassette transporters
JP4869072B2 (ja) * 2003-11-14 2012-02-01 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセットトランスポーターのモジュレーターとして有用なチアゾールおよびオキサゾール
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
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US8674108B2 (en) 2012-04-20 2014-03-18 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AU2013270681A1 (en) 2012-06-08 2014-12-18 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of CFTR -mediated disorders
WO2014014841A1 (en) 2012-07-16 2014-01-23 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
LT3470063T (lt) 2012-11-02 2025-02-10 Vertex Pharmaceuticals Incorporated Farmacinės kompozicijos, skirtos cftr nulemtų ligų gydymui
US20140221424A1 (en) 2013-01-30 2014-08-07 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for use in the treatment of cystic fibrosis
ES2885181T3 (es) 2014-04-15 2021-12-13 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
TWI735416B (zh) 2014-10-06 2021-08-11 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
KR20170063954A (ko) 2014-10-07 2017-06-08 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정

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