SI20848A - Farmacevtska formulacija, ki vsebuje atorvastatin kalcij - Google Patents

Farmacevtska formulacija, ki vsebuje atorvastatin kalcij Download PDF

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Publication number
SI20848A
SI20848A SI200100069A SI200100069A SI20848A SI 20848 A SI20848 A SI 20848A SI 200100069 A SI200100069 A SI 200100069A SI 200100069 A SI200100069 A SI 200100069A SI 20848 A SI20848 A SI 20848A
Authority
SI
Slovenia
Prior art keywords
atorvastatin
pharmaceutical formulation
atorvastatin calcium
amorphous
calcium
Prior art date
Application number
SI200100069A
Other languages
English (en)
Slovenian (sl)
Inventor
Janez Ker
Mateja Salobir
Sa�a Bavec
Original Assignee
Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20432850&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI20848(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. filed Critical Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D.
Priority to SI200100069A priority Critical patent/SI20848A/sl
Priority to IL15753402A priority patent/IL157534A0/xx
Priority to BR0207880-5A priority patent/BR0207880A/pt
Priority to YU69603A priority patent/RS51746B/sr
Priority to RS20110313A priority patent/RS55021B1/sr
Priority to MEP-2008-845A priority patent/ME00517B/me
Priority to CA002440331A priority patent/CA2440331C/en
Priority to US10/471,906 priority patent/US7030151B2/en
Priority to SI200230945T priority patent/SI1499297T1/sl
Priority to HU0303434A priority patent/HU230213B1/hu
Priority to SK1136-2003A priority patent/SK287925B6/sk
Priority to RU2003130378/15A priority patent/RU2293555C2/ru
Priority to EP10183122.0A priority patent/EP2263655B1/en
Priority to ES02702654T priority patent/ES2361609T3/es
Priority to ES10183122T priority patent/ES2417881T3/es
Priority to CZ2003-2469A priority patent/CZ306128B6/cs
Priority to PCT/IB2002/000736 priority patent/WO2002072073A2/en
Priority to DE60239425T priority patent/DE60239425D1/de
Priority to PL371919A priority patent/PL211803B1/pl
Priority to PL396343A priority patent/PL217835B1/pl
Priority to AT02702654T priority patent/ATE500818T1/de
Priority to MXPA03008340A priority patent/MXPA03008340A/es
Priority to KR1020037011535A priority patent/KR100905730B1/ko
Priority to UA2003098317A priority patent/UA78201C2/xx
Priority to EP02702654A priority patent/EP1499297B1/en
Priority to JP2002571032A priority patent/JP4295988B2/ja
Priority to CN028064739A priority patent/CN1630510B/zh
Publication of SI20848A publication Critical patent/SI20848A/sl
Priority to IL157534A priority patent/IL157534A/en
Priority to ZA200306575A priority patent/ZA200306575B/en
Priority to HRP20030726AA priority patent/HRP20030726B1/hr
Priority to BG108175A priority patent/BG66339B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SI200100069A 2001-03-14 2001-03-14 Farmacevtska formulacija, ki vsebuje atorvastatin kalcij SI20848A (sl)

Priority Applications (31)

Application Number Priority Date Filing Date Title
SI200100069A SI20848A (sl) 2001-03-14 2001-03-14 Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
IL15753402A IL157534A0 (en) 2001-03-14 2002-02-13 Atorvastatin calcium in a pharmaceutical form composition thereof, and pharmaceutical formulation comprising atorvastatin calcium
CN028064739A CN1630510B (zh) 2001-03-14 2002-03-13 药物形式的阿托伐他汀钙、其组合物和包含阿托伐他汀钙的药物制剂
ES10183122T ES2417881T3 (es) 2001-03-14 2002-03-13 Formulación farmacéutica que comprende atorvastatina cálcica
DE60239425T DE60239425D1 (de) 2001-03-14 2002-03-13 Kalziumatorvastatin enthaltende arzneiformulierung
RS20110313A RS55021B1 (sr) 2001-03-14 2002-03-13 Atorvastatin kalcijum u farmaceutskom obliku, njegovoj smeši i farmaceutskoj formulaciji, koja sadrži atorvastatin kalcijum
MEP-2008-845A ME00517B (me) 2001-03-14 2002-03-13 Atorvastati kalcijum u farmaceutskom obliku, njegovoj smješi i farmaceutskoj formulaciji, koja sadrži atorvastatin kalcijum
CA002440331A CA2440331C (en) 2001-03-14 2002-03-13 Atorvastatin calcium in a pharmaceutical form, composition thereof, and pharmaceutical formulation comprising atorvastatin calcium
US10/471,906 US7030151B2 (en) 2001-03-14 2002-03-13 Atorvastatin calcium in a pharmaceutical form composition thereof and pharmaceutical formulation comprising atorvastatin calcium
SI200230945T SI1499297T1 (sl) 2001-03-14 2002-03-13 Farmacevtska oblika, ki vsebuje atorvastatin kalcij
HU0303434A HU230213B1 (hu) 2001-03-14 2002-03-13 Atorvasztatin-kalciumot tartalmazó gyógyszerkészítmény
SK1136-2003A SK287925B6 (sk) 2001-03-14 2002-03-13 Pharmaceutical formulation comprising atorvastatin calcium, method for the preparation and use
RU2003130378/15A RU2293555C2 (ru) 2001-03-14 2002-03-13 Аторвастатин кальций в фармацевтической форме, его композиция и фармацевтическая рецептура, содержащая аторвастатин кальций
EP10183122.0A EP2263655B1 (en) 2001-03-14 2002-03-13 Pharmaceutical formulation comprising atorvastatin calcium
ES02702654T ES2361609T3 (es) 2001-03-14 2002-03-13 Formulación farmaceútica que comprende atorvastanina cálcica.
BR0207880-5A BR0207880A (pt) 2001-03-14 2002-03-13 Formulação farmacêutica, processo para preparação da mesma e uso de formulação sólida
CZ2003-2469A CZ306128B6 (cs) 2001-03-14 2002-03-13 Kalcium-atorvastatin ve farmaceutické formě, prostředky obsahující tuto sloučeninu a farmaceutické přípravky obsahující kalcium-atorvastatin
PCT/IB2002/000736 WO2002072073A2 (en) 2001-03-14 2002-03-13 Pharmaceutical formulation comprising atorvastatin calcium
YU69603A RS51746B (sr) 2001-03-14 2002-03-13 Atorvastatin kalcijum u farmaceutskom obliku, njegovoj smeši i farmaceutskoj formulaciji, koja sadrži atorvastatin kalcijum
PL371919A PL211803B1 (pl) 2001-03-14 2002-03-13 Preparat farmaceutyczny zawierający sól wapniową atorwastatyny, sposób wytwarzania tego preparatu i jego zastosowanie do leczenia hipercholesterolemii i hiperlipidemii
PL396343A PL217835B1 (pl) 2001-03-14 2002-03-13 Preparat farmaceutyczny zawierający sól wapniową atorwastatyny, sposób wytwarzania tego preparatu i jego zastosowanie do leczenia hipercholesterolemii i hiperlipidemii
AT02702654T ATE500818T1 (de) 2001-03-14 2002-03-13 Kalziumatorvastatin enthaltende arzneiformulierung
MXPA03008340A MXPA03008340A (es) 2001-03-14 2002-03-13 Calcio de atorvastatina en una forma farmaceutica, su composicion, y formulacion farmaceutica que comprende calcio de atorvastatina.
KR1020037011535A KR100905730B1 (ko) 2001-03-14 2002-03-13 약제학적 형태의 아토르바스타틴 칼슘, 이의 조성물 및아토르바스타틴 칼슘을 함유하는 약제학적 제형
UA2003098317A UA78201C2 (en) 2001-03-14 2002-03-13 Pharmaceutical formulation containing amorphous micronized atorvastatin calcium and method for preparation thereof
EP02702654A EP1499297B1 (en) 2001-03-14 2002-03-13 Pharmaceutical formulation comprising atorvastatin calcium
JP2002571032A JP4295988B2 (ja) 2001-03-14 2002-03-13 医薬形態のアトルバスタチンカルシウム、その構成物、及びアトルバスタチンカルシウムを含む医薬製剤
IL157534A IL157534A (en) 2001-03-14 2003-08-21 Atorvastatin calcium in a pharmaceutical form, composition thereof and pharmaceutical formulation comprising atorvastatin calcium
ZA200306575A ZA200306575B (en) 2001-03-14 2003-08-22 Atorvastatin calcium in a pharmaceutical form, composition thereof, and pharmaceutical formulation comprising atorvastatin calcium.
HRP20030726AA HRP20030726B1 (hr) 2001-03-14 2003-09-11 Atorvastatin kalcij u farmaceutskom obliku, njegova kompozicija i farmaceutska formulacija koja obuhvaä†a atorvastatin kalcij
BG108175A BG66339B1 (bg) 2001-03-14 2003-09-12 Фармацевтична форма съдържаща калциев аторвастатин

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI200100069A SI20848A (sl) 2001-03-14 2001-03-14 Farmacevtska formulacija, ki vsebuje atorvastatin kalcij

Publications (1)

Publication Number Publication Date
SI20848A true SI20848A (sl) 2002-10-31

Family

ID=20432850

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200100069A SI20848A (sl) 2001-03-14 2001-03-14 Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
SI200230945T SI1499297T1 (sl) 2001-03-14 2002-03-13 Farmacevtska oblika, ki vsebuje atorvastatin kalcij

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200230945T SI1499297T1 (sl) 2001-03-14 2002-03-13 Farmacevtska oblika, ki vsebuje atorvastatin kalcij

Country Status (25)

Country Link
US (1) US7030151B2 (sk)
EP (2) EP2263655B1 (sk)
JP (1) JP4295988B2 (sk)
KR (1) KR100905730B1 (sk)
CN (1) CN1630510B (sk)
AT (1) ATE500818T1 (sk)
BG (1) BG66339B1 (sk)
BR (1) BR0207880A (sk)
CA (1) CA2440331C (sk)
CZ (1) CZ306128B6 (sk)
DE (1) DE60239425D1 (sk)
ES (2) ES2417881T3 (sk)
HR (1) HRP20030726B1 (sk)
HU (1) HU230213B1 (sk)
IL (2) IL157534A0 (sk)
ME (1) ME00517B (sk)
MX (1) MXPA03008340A (sk)
PL (2) PL211803B1 (sk)
RS (2) RS55021B1 (sk)
RU (1) RU2293555C2 (sk)
SI (2) SI20848A (sk)
SK (1) SK287925B6 (sk)
UA (1) UA78201C2 (sk)
WO (1) WO2002072073A2 (sk)
ZA (1) ZA200306575B (sk)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE524163T1 (de) 2000-04-10 2011-09-15 Teva Pharma Stabile pharmazeutische zusammensetzungen enthaltend 7-substituierte-3,5- dihydroxyheptansäuren oder 7-substituierte-3,5- dihydroxyheptensäuren
USRE44578E1 (en) 2000-04-10 2013-11-05 Teva Pharmaceutical Industries, Ltd. Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
CZ20032019A3 (cs) 2000-12-27 2003-10-15 Ciba Specialty Chemicals Holding Inc. Krystalické formy Atorvastatinu
EA005317B1 (ru) 2001-06-29 2004-12-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1h-пиррол-1-гептановой кислоты кальциевой соли (2:1) (аторвастатин)
EP1336405A1 (en) * 2002-02-14 2003-08-20 Ranbaxy Laboratories, Ltd. Formulations of atorvastatin stabilized with alkali metal additions
AU2003298514A1 (en) * 2002-05-17 2004-05-04 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
US20070053976A1 (en) * 2002-05-17 2007-03-08 Eisai R & D Management Co., Ltd. Novel combination of drugs as antidepressant
CA2385529A1 (en) * 2002-05-21 2003-11-21 Bernard Charles Sherman Stable dosage forms comprising atorvastatin calcium
SI21302A (sl) * 2002-10-11 2004-04-30 LEK farmacevtska dru�ba d.d. Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino
SI21402A (sl) * 2003-02-12 2004-08-31 LEK farmacevtska dru�ba d.d. Obloženi delci in farmacevtske oblike
US7790197B2 (en) 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
CA2465693A1 (en) 2003-06-12 2004-12-12 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
CA2465565A1 (en) * 2003-06-12 2004-12-12 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
TR200301614A2 (tr) * 2003-09-26 2005-10-21 Bi̇ofarma İlaç Sanayi̇ Ve Ti̇caret A.Ş. Atorvastatin kalsiyum tablet formülasyonunun hazırlanması için yeni yöntem
ES2739493T3 (es) 2004-05-05 2020-01-31 Pfizer Prod Inc Formas de sal de de atorvastatina con benetamina
CA2672554C (en) 2004-07-20 2012-01-03 Warner-Lambert Company Llc Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1)
AU2005298383A1 (en) * 2004-10-28 2006-05-04 Warner-Lambert Company Llc Process for forming amorphous atorvastatin
EP1814541A4 (en) * 2004-11-22 2009-10-28 Dexcel Pharma Technologies Ltd STABLE ATORVASTATIN FORMULATIONS
CA2589537A1 (en) * 2004-12-02 2006-06-08 Stephen Craig Dyar Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
ES2263370B1 (es) * 2005-02-16 2007-12-01 Ercros Industrial, S.A. Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion.
WO2006123358A2 (en) * 2005-02-22 2006-11-23 Sun Pharmaceutical Industries Limited Stabilized atorvastatin-containing formulation
JP5002904B2 (ja) * 2005-04-04 2012-08-15 ブラザー工業株式会社 無線タグ通信装置、その通信方法、及びその通信プログラム
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
DE602006014193D1 (de) 2005-11-21 2010-06-17 Warner Lambert Co Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure-magnesium
US20070116758A1 (en) * 2005-11-21 2007-05-24 Dafna Dlugatch Atorvastatin formulation
EP1923057A1 (en) * 2005-11-21 2008-05-21 Teva Pharmaceutical Industries Ltd Atorvastatin pharmaceutical formulation
EP1810667A1 (en) * 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
EP1818049A3 (en) * 2006-02-10 2008-11-19 LifeCycle Pharma A/S Stabilized Atorvastatin
US20080038332A1 (en) * 2006-08-10 2008-02-14 Cai Gu Huang Stable pharmaceutical formulation comprising atorvastatin calcium
CN101568340B (zh) * 2006-12-01 2011-06-15 日东电工株式会社 经皮吸收制剂
BRPI0719308A2 (pt) * 2006-12-01 2014-02-04 Nitto Denko Corp Método para supressão da coloração de preparação adesiva contendo donepzil e método para redução da quantidade de substâncias formadas relacionadas à donepezil.
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
US20090226516A1 (en) * 2008-03-04 2009-09-10 Pharma Pass Ii Llc Sartan compositions
US20090226515A1 (en) * 2008-03-04 2009-09-10 Pharma Pass Ii Llc Statin compositions
WO2009145177A1 (ja) * 2008-05-30 2009-12-03 日東電工株式会社 ドネペジル含有貼付製剤およびその包装体
CN102046171B (zh) * 2008-05-30 2013-06-19 日东电工株式会社 经皮吸收制剂
US20100151034A1 (en) * 2008-09-30 2010-06-17 Astellas Pharma Inc. Granular pharmaceutical composition of atorvastatin for oral administration
MY159533A (en) * 2009-01-02 2017-01-13 Univ Putra Malaysia Porous bioceramic composition for bone repair
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
KR101248804B1 (ko) * 2010-05-14 2013-03-29 한미사이언스 주식회사 ＨＭＧ-ＣｏＡ 환원효소 억제제 및 이베살탄을 포함하는 이층정 약제학적 복합제제
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
CN102755322B (zh) * 2012-07-24 2013-12-11 兆科药业（广州）有限公司 一种乐卡地平和阿托伐他汀复方制剂
US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
CN104069502B (zh) * 2013-03-29 2018-02-16 北京罗诺强施医药技术研发中心有限公司 复合骨架材料及其药物组合物
CN103705484B (zh) * 2014-01-03 2015-05-20 华北制药集团新药研究开发有限责任公司 一种稳定的阿托伐他汀钙片及其制备方法
CN104013617A (zh) * 2014-05-13 2014-09-03 万特制药(海南)有限公司 一种含有依折麦布和阿托伐他汀钙的组合物及其制备方法
US10413543B2 (en) * 2015-09-01 2019-09-17 Sun Pharma Advanced Research Company Ltd. Stable multiparticulate pharmaceutical composition of rosuvastatin
CN110339365A (zh) * 2018-04-02 2019-10-18 强生化学制药厂股份有限公司 一种可提高口服他汀类药物生体可用率的医药组合物及其用途
CN109044989A (zh) * 2018-10-09 2018-12-21 河南师范大学 一种阿托伐他汀钙胶囊制剂及其制备方法
KR102643099B1 (ko) 2020-01-31 2024-03-05 주식회사 일원바이오 양춘사 및 백출 복합 추출물을 유효성분으로 함유하는 고지혈증 또는 동맥경화의 예방, 개선 또는 치료용 조성물
KR20210098059A (ko) 2020-01-31 2021-08-10 주식회사 일원바이오 양춘사 추출물을 유효성분으로 함유하는 고지혈증 또는 동맥경화의 예방, 개선 또는 치료용 조성물
JP2023527153A (ja) * 2020-05-22 2023-06-27 デュレクト コーポレーション 非アルコール性脂肪性肝炎（ｎａｓｈ）の処置

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245047A (en) 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5097045A (en) 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5124482A (en) 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5248793A (en) 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5103024A (en) 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
WO1994016693A1 (en) * 1993-01-19 1994-08-04 Warner-Lambert Company Stable oral ci-981 formulation and process of preparing same
FR2700452B1 (fr) 1993-01-20 1995-03-24 Mgb Structure transformable de réception du corps d'une personne, par exemple siège-berceau pour enfant.
US5298627A (en) 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
IL128862A (en) 1995-07-17 2007-12-03 Warner Lambert Co [R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate
HRP960312B1 (en) * 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
HRP960313B1 (en) * 1995-07-17 2002-08-31 Warner Lambert Co Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)
US5874029A (en) 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
SI20109A (sl) * 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stabilna farmacevtska formulacija
US6372246B1 (en) 1998-12-16 2002-04-16 Ortho-Mcneil Pharmaceutical, Inc. Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
US6696086B1 (en) * 1999-09-10 2004-02-24 Lek Pharmaceuticals D.D. Solid pharmaceutical formulation containing lovastatin and simvastatin, respectively, and its preparation
SI20425A (sl) 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
ATE524163T1 (de) * 2000-04-10 2011-09-15 Teva Pharma Stabile pharmazeutische zusammensetzungen enthaltend 7-substituierte-3,5- dihydroxyheptansäuren oder 7-substituierte-3,5- dihydroxyheptensäuren
US6806290B2 (en) * 2000-06-09 2004-10-19 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
JP2004501121A (ja) * 2000-06-09 2004-01-15 エルイーケー　ファーマシューティカルズ　ディー．ディー． 安定した医薬効果を有する合成物、及びそれを含む医薬製剤

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