BR0207880A - Formulação farmacêutica, processo para preparação da mesma e uso de formulação sólida - Google Patents
Formulação farmacêutica, processo para preparação da mesma e uso de formulação sólidaInfo
- Publication number
- BR0207880A BR0207880A BR0207880-5A BR0207880A BR0207880A BR 0207880 A BR0207880 A BR 0207880A BR 0207880 A BR0207880 A BR 0207880A BR 0207880 A BR0207880 A BR 0207880A
- Authority
- BR
- Brazil
- Prior art keywords
- atorvastatin
- calcium
- formulation
- preparation
- amorphous
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 3
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 3
- 229960005370 atorvastatin Drugs 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- BWFCZHDTTAYGNN-CNZCJKERSA-N calcium;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound [Ca].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 BWFCZHDTTAYGNN-CNZCJKERSA-N 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 abstract 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 229960001770 atorvastatin calcium Drugs 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"FORMULAçãO FARMACêUTICA, PROCESSO PARA PREPARAçãO DA MESMA E USO DE FORMULAçãO SóLIDA". Atorvastatina cálcica, a substância conhecida pelo nome químico sal semi cálcio de [(R-(R*,R*)]-2-(4-fluorfenil)-<225>,<sym>dihidróxi-5- (1-metil-etil) -3-fenil-4- [(fenilamino) carbonil] 1H-pirrolo-1-ácido heptanóico, é conhecida como inibidora de HMG-CoA redutase e é usada como um agente antihipercolesterolêmico. A atorvastatina nas composições farmacêuticas disponíveis no mercado é normalmente preparada como seu sal de cálcio, uma vez que ele permite que a atorvastatina seja convenientemente formulada nas formulações farmacêuticas, por exemplo, comprimidos, cápsulas, pós e similares para administração oral. A atorvastatina cálcica pode existir em uma forma amorfa ou em uma de pelo menos quatro formas cristalinas conhecidas (Forma I, Forma II, Forma III e Forma IV). A atorvastatina cálcica é a substância que é muito ligeiramente solúvel em água, com pKa 4, 5, e concluiu-se que as formas cristalinas são menos solúveis do que a forma amorfa, o que pode causar problemas na biodisponibilidade de atorvastatina no corpo. A presente invenção resolve o problema de proporcionar equivalência terapêutica de formulação terapêutica de atorvastatina independentemente da forma (cristalina, amorfa ou mistura de ambas) da atorvastatina cálcica usada para sua preparação.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI200100069A SI20848A (sl) | 2001-03-14 | 2001-03-14 | Farmacevtska formulacija, ki vsebuje atorvastatin kalcij |
PCT/IB2002/000736 WO2002072073A2 (en) | 2001-03-14 | 2002-03-13 | Pharmaceutical formulation comprising atorvastatin calcium |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0207880A true BR0207880A (pt) | 2004-03-02 |
Family
ID=20432850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0207880-5A BR0207880A (pt) | 2001-03-14 | 2002-03-13 | Formulação farmacêutica, processo para preparação da mesma e uso de formulação sólida |
Country Status (25)
Country | Link |
---|---|
US (1) | US7030151B2 (pt) |
EP (2) | EP2263655B1 (pt) |
JP (1) | JP4295988B2 (pt) |
KR (1) | KR100905730B1 (pt) |
CN (1) | CN1630510B (pt) |
AT (1) | ATE500818T1 (pt) |
BG (1) | BG66339B1 (pt) |
BR (1) | BR0207880A (pt) |
CA (1) | CA2440331C (pt) |
CZ (1) | CZ306128B6 (pt) |
DE (1) | DE60239425D1 (pt) |
ES (2) | ES2361609T3 (pt) |
HR (1) | HRP20030726B1 (pt) |
HU (1) | HU230213B1 (pt) |
IL (2) | IL157534A0 (pt) |
ME (1) | ME00517B (pt) |
MX (1) | MXPA03008340A (pt) |
PL (2) | PL217835B1 (pt) |
RS (2) | RS55021B1 (pt) |
RU (1) | RU2293555C2 (pt) |
SI (2) | SI20848A (pt) |
SK (1) | SK287925B6 (pt) |
UA (1) | UA78201C2 (pt) |
WO (1) | WO2002072073A2 (pt) |
ZA (1) | ZA200306575B (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2382970T3 (da) | 2000-04-10 | 2013-03-25 | Teva Pharma | Stabile farmaceutiske sammensætninger, der indeholder 7-substitueret-3,5-dihydroxyheptansyrer eller 7-substitueret-3,5-dihydroxyheptensyrer |
USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
CA2622477A1 (en) | 2000-12-27 | 2002-07-04 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of atorvastatin |
PL367943A1 (en) | 2001-06-29 | 2005-03-07 | Warner-Lambert Company Llc | Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
AU2003245736A1 (en) * | 2002-02-14 | 2003-09-04 | Ranbaxy Laboratories Limited | Formulations of atorvastatin stabilized with alkali metal additions |
US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
AU2003298514A1 (en) * | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
CA2385529A1 (en) * | 2002-05-21 | 2003-11-21 | Bernard Charles Sherman | Stable dosage forms comprising atorvastatin calcium |
SI21302A (sl) * | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
SI21402A (sl) * | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Obloženi delci in farmacevtske oblike |
US7790197B2 (en) | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
CA2465565A1 (en) * | 2003-06-12 | 2004-12-12 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US20050271717A1 (en) * | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
CA2465693A1 (en) | 2003-06-12 | 2004-12-12 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
TR200301614A2 (tr) * | 2003-09-26 | 2005-10-21 | Bi̇ofarma İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Atorvastatin kalsiyum tablet formülasyonunun hazırlanması için yeni yöntem |
JP2007536373A (ja) | 2004-05-05 | 2007-12-13 | ファイザー・プロダクツ・インク | アトルバスタチンの塩形態 |
EP1771412A2 (en) * | 2004-07-20 | 2007-04-11 | Warner-Lambert Company LLC | Crystalline forms of [r-(r*)]-2-(4-fluorophenyl)-bet a,gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid calcium salt (2:1) |
EP1807055A1 (en) * | 2004-10-28 | 2007-07-18 | Warner-Lambert Company LLC | Process for forming amorphous atorvastatin |
AU2005305460B2 (en) * | 2004-11-22 | 2011-04-21 | Dexcel Pharma Technologies Ltd. | Stable atorvastatin formulations |
JP2008521878A (ja) * | 2004-12-02 | 2008-06-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 非晶質アトルバスタチンの医薬組成物及びその製造のための方法 |
ES2263370B1 (es) * | 2005-02-16 | 2007-12-01 | Ercros Industrial, S.A. | Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion. |
WO2006123358A2 (en) * | 2005-02-22 | 2006-11-23 | Sun Pharmaceutical Industries Limited | Stabilized atorvastatin-containing formulation |
JP5002904B2 (ja) * | 2005-04-04 | 2012-08-15 | ブラザー工業株式会社 | 無線タグ通信装置、その通信方法、及びその通信プログラム |
CA2547216A1 (en) | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
KR20080079646A (ko) * | 2005-11-21 | 2008-09-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토르바스타틴 제제 |
EP1923057A1 (en) * | 2005-11-21 | 2008-05-21 | Teva Pharmaceutical Industries Ltd | Atorvastatin pharmaceutical formulation |
US8084488B2 (en) | 2005-11-21 | 2011-12-27 | Pfizer Inc. | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium |
EP1810667A1 (en) * | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
US7772273B2 (en) * | 2006-02-10 | 2010-08-10 | Lifecycle Pharma A/S | Stabilized atorvastatin |
US20080038332A1 (en) * | 2006-08-10 | 2008-02-14 | Cai Gu Huang | Stable pharmaceutical formulation comprising atorvastatin calcium |
WO2008066179A1 (fr) * | 2006-12-01 | 2008-06-05 | Nitto Denko Corporation | Préparation d'absorption percutanée |
US20080131490A1 (en) * | 2006-12-01 | 2008-06-05 | Akinori Hanatani | Stabilized donepezil-containing patch preparation |
AR065670A1 (es) | 2007-03-09 | 2009-06-24 | Indigene Pharmaceuticals Inc | Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas |
US20090226516A1 (en) * | 2008-03-04 | 2009-09-10 | Pharma Pass Ii Llc | Sartan compositions |
US20090226515A1 (en) * | 2008-03-04 | 2009-09-10 | Pharma Pass Ii Llc | Statin compositions |
WO2009145269A1 (ja) * | 2008-05-30 | 2009-12-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 経皮吸収製剤 |
BRPI0913229A2 (pt) * | 2008-05-30 | 2016-01-19 | Nitto Denko Corp | preparação adesiva contendo donepezil e embalagem da mesma |
WO2010038688A1 (ja) * | 2008-09-30 | 2010-04-08 | アステラス製薬株式会社 | アトルバスタチン経口投与用粒子状医薬組成物 |
MY159533A (en) * | 2009-01-02 | 2017-01-13 | Univ Putra Malaysia | Porous bioceramic composition for bone repair |
JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
KR101248804B1 (ko) * | 2010-05-14 | 2013-03-29 | 한미사이언스 주식회사 | HMG-CoA 환원효소 억제제 및 이베살탄을 포함하는 이층정 약제학적 복합제제 |
KR20120011249A (ko) | 2010-07-28 | 2012-02-07 | 주식회사 경보제약 | 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법 |
US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
CN102755322B (zh) * | 2012-07-24 | 2013-12-11 | 兆科药业(广州)有限公司 | 一种乐卡地平和阿托伐他汀复方制剂 |
WO2014153509A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
CN104069502B (zh) * | 2013-03-29 | 2018-02-16 | 北京罗诺强施医药技术研发中心有限公司 | 复合骨架材料及其药物组合物 |
CN103705484B (zh) * | 2014-01-03 | 2015-05-20 | 华北制药集团新药研究开发有限责任公司 | 一种稳定的阿托伐他汀钙片及其制备方法 |
CN104013617A (zh) * | 2014-05-13 | 2014-09-03 | 万特制药(海南)有限公司 | 一种含有依折麦布和阿托伐他汀钙的组合物及其制备方法 |
US10413543B2 (en) * | 2015-09-01 | 2019-09-17 | Sun Pharma Advanced Research Company Ltd. | Stable multiparticulate pharmaceutical composition of rosuvastatin |
CN110339365A (zh) * | 2018-04-02 | 2019-10-18 | 强生化学制药厂股份有限公司 | 一种可提高口服他汀类药物生体可用率的医药组合物及其用途 |
CN109044989A (zh) * | 2018-10-09 | 2018-12-21 | 河南师范大学 | 一种阿托伐他汀钙胶囊制剂及其制备方法 |
KR102643099B1 (ko) | 2020-01-31 | 2024-03-05 | 주식회사 일원바이오 | 양춘사 및 백출 복합 추출물을 유효성분으로 함유하는 고지혈증 또는 동맥경화의 예방, 개선 또는 치료용 조성물 |
KR20210098059A (ko) | 2020-01-31 | 2021-08-10 | 주식회사 일원바이오 | 양춘사 추출물을 유효성분으로 함유하는 고지혈증 또는 동맥경화의 예방, 개선 또는 치료용 조성물 |
AU2021273936A1 (en) * | 2020-05-22 | 2022-12-08 | Durect Corporation | Treatment of non-alcoholic steatohepatitis (NASH) |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5216174A (en) | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
DE69324504T2 (de) * | 1993-01-19 | 1999-08-26 | Warner Lambert Co | Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren |
FR2700452B1 (fr) | 1993-01-20 | 1995-03-24 | Mgb | Structure transformable de réception du corps d'une personne, par exemple siège-berceau pour enfant. |
US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
HRP960312B1 (en) * | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
DE69616808T2 (de) | 1995-07-17 | 2002-05-29 | Warner Lambert Co | Kristallines (r-(r*,r*))-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrol-1-heptancarbonsäure hemi calcium salz (atorvastatin) |
US5874029A (en) | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US6372246B1 (en) | 1998-12-16 | 2002-04-16 | Ortho-Mcneil Pharmaceutical, Inc. | Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals |
SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
US6696086B1 (en) * | 1999-09-10 | 2004-02-24 | Lek Pharmaceuticals D.D. | Solid pharmaceutical formulation containing lovastatin and simvastatin, respectively, and its preparation |
SI20425A (sl) | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
DK2382970T3 (da) | 2000-04-10 | 2013-03-25 | Teva Pharma | Stabile farmaceutiske sammensætninger, der indeholder 7-substitueret-3,5-dihydroxyheptansyrer eller 7-substitueret-3,5-dihydroxyheptensyrer |
US6806290B2 (en) * | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
SI1292293T1 (en) * | 2000-06-09 | 2004-06-30 | LEK farmacevtska dru�ba d.d. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
-
2001
- 2001-03-14 SI SI200100069A patent/SI20848A/sl not_active IP Right Cessation
-
2002
- 2002-02-13 IL IL15753402A patent/IL157534A0/xx unknown
- 2002-03-13 SI SI200230945T patent/SI1499297T1/sl unknown
- 2002-03-13 PL PL396343A patent/PL217835B1/pl unknown
- 2002-03-13 HU HU0303434A patent/HU230213B1/hu unknown
- 2002-03-13 RS RS20110313A patent/RS55021B1/sr unknown
- 2002-03-13 RS YU69603A patent/RS51746B/sr unknown
- 2002-03-13 DE DE60239425T patent/DE60239425D1/de not_active Expired - Lifetime
- 2002-03-13 JP JP2002571032A patent/JP4295988B2/ja not_active Expired - Lifetime
- 2002-03-13 ES ES02702654T patent/ES2361609T3/es not_active Expired - Lifetime
- 2002-03-13 ES ES10183122T patent/ES2417881T3/es not_active Expired - Lifetime
- 2002-03-13 RU RU2003130378/15A patent/RU2293555C2/ru active
- 2002-03-13 AT AT02702654T patent/ATE500818T1/de not_active IP Right Cessation
- 2002-03-13 CA CA002440331A patent/CA2440331C/en not_active Expired - Lifetime
- 2002-03-13 CN CN028064739A patent/CN1630510B/zh not_active Expired - Lifetime
- 2002-03-13 MX MXPA03008340A patent/MXPA03008340A/es active IP Right Grant
- 2002-03-13 US US10/471,906 patent/US7030151B2/en not_active Expired - Lifetime
- 2002-03-13 CZ CZ2003-2469A patent/CZ306128B6/cs not_active IP Right Cessation
- 2002-03-13 EP EP10183122.0A patent/EP2263655B1/en not_active Expired - Lifetime
- 2002-03-13 UA UA2003098317A patent/UA78201C2/xx unknown
- 2002-03-13 EP EP02702654A patent/EP1499297B1/en not_active Expired - Lifetime
- 2002-03-13 BR BR0207880-5A patent/BR0207880A/pt not_active Application Discontinuation
- 2002-03-13 KR KR1020037011535A patent/KR100905730B1/ko active IP Right Grant
- 2002-03-13 PL PL371919A patent/PL211803B1/pl unknown
- 2002-03-13 ME MEP-2008-845A patent/ME00517B/me unknown
- 2002-03-13 SK SK1136-2003A patent/SK287925B6/sk unknown
- 2002-03-13 WO PCT/IB2002/000736 patent/WO2002072073A2/en active IP Right Grant
-
2003
- 2003-08-21 IL IL157534A patent/IL157534A/en active IP Right Grant
- 2003-08-22 ZA ZA200306575A patent/ZA200306575B/en unknown
- 2003-09-11 HR HRP20030726AA patent/HRP20030726B1/hr not_active IP Right Cessation
- 2003-09-12 BG BG108175A patent/BG66339B1/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0207880A (pt) | Formulação farmacêutica, processo para preparação da mesma e uso de formulação sólida | |
BR0206637A (pt) | Processo para preparação de atorvastatina em forma não cristalina e de formulação farmacêutica | |
DK1276467T3 (da) | Formuleringer og tabletter til forhalet frigivelse af guaifenesin | |
HK1096034A1 (en) | A solid dosage form comprising a fibrate | |
SE8700499D0 (sv) | Novel pharmacologically active compounds | |
WO2003002136A3 (en) | Stable formulation of modified glp-1 | |
CO5390076A1 (es) | Composiciones farmaceuticas | |
WO2007014124A3 (en) | High drug load formulations and dosage forms | |
ES2110212T3 (es) | Composicion farmaceutica efervescente que contiene ibuprofeno y su procedimiento de preparacion. | |
ATE529097T1 (de) | Pharmazeutische zubereitung in form einer paste mit einem säurelabilen wirkstoff | |
DE60210552D1 (de) | Prozess zur Herstellung einer festen pharmazeutischen Zubereitung welche einen schwerlöslichen Wirkstoff enthält | |
SE9901573D0 (sv) | New compounds | |
HUP0301390A2 (hu) | Valzartánt tartalmazó orális gyógyászati készítmény | |
AU8268591A (en) | Codeine salt of a substituted carboxylic acid, processes for the preparation thereof, its use and pharmaceutical compositions | |
WO2005115346A3 (en) | Pharmaceutical composition containing risperidone | |
WO2000066550A8 (en) | New compounds | |
HUP0004701A2 (hu) | Új dezloratadin sók, az ezeket tartalmazó gyógyászati készítmények és eljárás azok előállítására | |
BR9917315A (pt) | Composições medicinais para liberação imediata para uso oral | |
KR930023338A (ko) | 데포우 제제 | |
SE8503109L (sv) | Cykliska forstadielekemedel till antiinflammatoriska oxikamer | |
HUP0004132A2 (hu) | Gyorsan oldódó gyógyászati készítmény | |
ATE270T1 (de) | Neue n1-benzoyl-n2-phenyl-1,3-diaminopropan-2-ole und ihre salze; verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel. | |
TH64687A (th) | สารผสมตามสูตรของอิแบนโดรเนทที่มีขนาดยาสูง | |
EP1825848A2 (de) | Stabile pharmazeutische Zusammensetzungen umfassend einen HMG-CoA-Reduktase Inhibitor | |
NO160258C (no) | Analogifremgangsmaate for fremstilling av farmakologisk aktive pyridazinonimin-derivater. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |