SI20511B - Izdelovanje trenutno raztopljivega peroralnega odmerka - Google Patents
Izdelovanje trenutno raztopljivega peroralnega odmerka Download PDFInfo
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- SI20511B SI20511B SI200000187A SI200000187A SI20511B SI 20511 B SI20511 B SI 20511B SI 200000187 A SI200000187 A SI 200000187A SI 200000187 A SI200000187 A SI 200000187A SI 20511 B SI20511 B SI 20511B
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- calcium silicate
- dosage form
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- pharmaceutical dosage
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- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008187 granular material Substances 0.000 claims abstract 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract 7
- 239000003814 drug Substances 0.000 claims abstract 7
- 239000011230 binding agent Substances 0.000 claims abstract 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 3
- 239000006185 dispersion Substances 0.000 claims abstract 2
- 238000009826 distribution Methods 0.000 claims abstract 2
- 239000000378 calcium silicate Substances 0.000 claims 26
- 229910052918 calcium silicate Inorganic materials 0.000 claims 26
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 26
- 239000002552 dosage form Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 7
- 239000007884 disintegrant Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 238000000465 moulding Methods 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229910021486 amorphous silicon dioxide Inorganic materials 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- 238000007580 dry-mixing Methods 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 238000003825 pressing Methods 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000005995 Aluminium silicate Substances 0.000 claims 1
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000005909 Kieselgur Substances 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 235000012211 aluminium silicate Nutrition 0.000 claims 1
- UWFFNDSXSPUNTR-UHFFFAOYSA-N aluminum magnesium silicic acid trihydroxy(oxido)silane silicate Chemical compound [Mg+2].[Al+3].O[Si](O)(O)O.O[Si](O)(O)[O-].[O-][Si]([O-])([O-])[O-] UWFFNDSXSPUNTR-UHFFFAOYSA-N 0.000 claims 1
- 229960004372 aripiprazole Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000001698 pyrogenic effect Effects 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
Podan je postopek priprave zrnc za izdelavo trenutno raztopljivih peroralnih farmacevtskih dozirnih oblik. Poleg enega ali večih zdravil, so zrnca sestavljena iz ekscipientne kombinacije, ki sestoji iz superdisintegranta, disperznega sredstva, distribucijskega oz. porazdelitvenega sredstva ter vezivnega sredstva. Prav tako vključujejo konvencionalne dodatke oz. primesi, kot so sladila in arome. Zrnca, ki so predmet obravnavanja, imajo to prednost, da so stabilna in da so lahko izdelana brez dodatka topil ne da bi bilo pri tem potrebno posebno okolje ali rokovanje. Dozirne oblike, posebno tablete, ki so iz njih izdelane na konvencionalni opremi, se razkrojijo v ustih v manj kot približno petindvajsetih sekundah.
Claims (23)
- -1 - Sl 20511 FORMULACIJA TRENUTNO RAZTOPLJIVEGA PERORALNEGA ODMERKA PATENTNI ZAHTEVKI 1. Trenutno raztopljiva farmacevtska dozirna oblika, ki se bo razkrojila v ustih v manj kot 25 sekundah, obsegajoča zdravilo in kombinacijo ekscipientov, ki obsega, na osnovi celotne mase dozirne oblike, a) od 4 do 8 % (masni delež) super-razgrajevalca, b) od 20 do 70 % (masni delež) disperzijskega sredstva, ki je kalcijev silikat, c) od 1 do 10 % (masni delež) porazdelitvenega sredstva, izbranega iz amorfnega silicijevega dioksida, pirogenega silicijevega dioksida, diatomejske zemlje, smukca, kaolina in magnezijvega aluminijevega trisilikata in d) od 10 do 50 % (masni delež) veziva.
- 2. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 1, ki obsega ne več kot 30 procentov (masni delež) zdravila in ne več kot 85 procentov (masni delež) skupne vsote kombinacije ekscipientov.
- 3. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 2, ki obsega, na osnovi celotne mase omenjene dozirne oblike, ne več kot okoli 30 procentov (masni delež) omenjenega zdravila, od 5 do 7 procentov (masni delež) omenjenega super-razgrajevalca, od 35 do 45 procentov (masni delež) omenjenega disperzijskega sredstva, od 1,5 do 3 procente (masni delež) omenjenega porazdelitvenega sredstva in od 12 do 20 procentov (masni delež) omenjenega veziva.
- 4. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, pri čemer je kalcijev silikat izbran iz orto, meta in alfa triklinskega kalcijevega silikata.
- 5. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 4, pri čemer je omenjeni kalcijev siilkat alfa triklinski kalcijev silikat. -2-
- 6. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, pri čemer je omenjeni super-razgrajevalec krospovidon, natrijeva kroskarmeloza, natrijev škrobni glikolat, nizko substituirana hidroksipropil celuloza ali predželatiniran škrob in omenjeno vezivo je mikrokristalna celuloza, hidroksipropil celuloza, etil celuloza, laktoza, manitol ali kalcijev fosfat.
- 7. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 1, pri čemer je omenjeni super-razgrajevalec krospovidon, omenjeni kalcijev silikat je kristalni alfa triklinski kalcijev silikat, omenjeno porazdelitveno sredstvo je amorfni silicijev dioksid in omenjeno vezivo je mikrokristalna celuloza.
- 8. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od zahtevkov 1 do 3, pri čemer je omenjeni kalcijev silikat sestavljen iz kombinacije alfa triklinskega kalcijevega silikata in vsaj ene druge farmacevtske vrste kalcijevega silikata, pri čemer omenjeni alfa triklinski kalcijev silikat obsega od 10 % do 90 % (masni delež) omenjene kombinacije.
- 9. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od zahtevkov 1 do 4, pri čemer ima omenjeni kalcijev silikat površino 1,0 m2/g (m2/gm) do 210 m2/g (m2/gm), nasipno gostoto 0,075 g/ml_ (g/cc) do 0,90 g/mL (g/cc), pravo gostoto 1,70 g/mL (g/cc) do 2,90 g/mL (g/cc) in vsebnost hlapnih snovi manj kot 1 % do 14 % m/m.
- 10. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat alfa triklinski kalcijev silikat, ki ima površino 1,3 m2/g (m2/gm), nasipno gostoto 0,627g/mL (g/cc), pravo gostoto 2,934 g/mL (g/cc) in vsebnost hlapnih snovi 0,5 % m/m.
- 11. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat orto kristalen kalcijev silikat, ki ima površino 0,98 m2/g (m2/gm), nasipno gostoto 0,492 g/mL (g/cc), pravo gostoto 3,252 g/mL (g/cc) in vsebnost hlapnih snovi 0,02 % m/m.
- 12. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat meta kristalen kalcijev silikat, ki ima površino 2,5 m2/g (m2/gm), nasipno gostoto 0,867 g/mL (g/cc), pravo gostoto 2,940 g/mL (g/cc) in vsebnost hlapnih snovi 0,5 % m/m. -3-
- 13. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat kristalen kalcijev silikat, ki ima površino 90,4 m2/g (m2/gm), nasipno gostoto 0,094 g/ml_ (g/cc), pravo gostoto 2,598 g/mL (g/cc) in vsebnost hlapnih snovi 0,94 % m/m.
- 14. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat amorfni kalcijev silikat, ki ima površino 191,3 m2/g (m2/gm), nasipno gostoto 0,120 g/mL (g/cc), pravo gostoto 2,314 g/mL (g/cc) in vsebnost hlapnih snovi 5,11 % m/m.
- 15. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat amorfni kalcijev silikat, ki ima površino 103,0 m2/g (m2/gm), nasipno gostoto 0,130 g/mL (g/cc), pravo gostoto 1,702 g/mL (g/cc) in vsebnost hlapnih snovi 9,90 % m/m.
- 16. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat amorfni kalcijev silikat, ki ima površino 209 m2/g (m2/gm), nasipno gostoto 0,075 g/mL (g/cc), pravo gostoto 2,035 g/mL (g/cc) in vsebnost hlapnih snovi 13,8 % m/m.
- 17. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, pri čemer je omenjeno zdravilo aripiprazol.
- 18. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, ki je tableta.
- 19. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 1, ki se da dobiti s suhim mešanjem zdravila in kombinacije ekscipientov, kot je definirano v katerem koli od zahtevkov 1 do 18, v zmes, s stiskanjem zmesi skozi primeren kompaktor ali oblikovalno napravo, da nastanejo kompaktirani deli ali oblikovanci in s prehajanjem kompaktiranih delov ali oblikovancev skozi sito, da nastanejo zrnca.
- 20. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 19, ki se da dobiti z nadaljnjim stiskanjem zrnc. -4-
- 21. Postopek oblikovanja zrnc, primernih za stiskanje v trenutno raztopljive dozirne oblike, po katerem koli od zahtevkov 1 do 20, ki obsega suho mešanje zdravila in kombinacije ekscipientov, kot je definirano v katerem koli od zahtevkov 1 do 20, v zmes, s stiskanjem zmesi skozi primeren kompaktor ali oblikovalno napravo, da nastanejo kompaktirani deli ali oblikovanci in s prehajanjem kompaktiranih delov ali oblikovancev skozi sito, da nastanejo zrnca.
- 22. Postopek oblikovanja zrnc po zahtevku 21, ki dodatno obsega stopnjo mešanja omenjenih zrnc z dodatnimi količinami omenjenega super-razgrajevalca in veziva, da nastane končna zmes, primerna za direktno stiskanje v omenjene tablete.
- 23. Postopek po zahtevku 22, pri čemer omenjena zrnca obsegajo od okoli 80 % do okoli 99 % (masni delež) omenjene končne zmesi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54794800A | 2000-04-12 | 2000-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI20511A SI20511A (sl) | 2001-10-31 |
| SI20511B true SI20511B (sl) | 2008-08-31 |
Family
ID=24186805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200000187A SI20511B (sl) | 2000-04-12 | 2000-08-14 | Izdelovanje trenutno raztopljivega peroralnega odmerka |
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Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2311734C (en) | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
| US20020076437A1 (en) | 2000-04-12 | 2002-06-20 | Sanjeev Kothari | Flashmelt oral dosage formulation |
| US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| PE20030445A1 (es) * | 2001-09-25 | 2003-07-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| GB0123400D0 (en) * | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| BR0117147A (pt) * | 2001-10-09 | 2006-05-09 | Bristol Myers Squibb Co | preparado de dosagem oral de desintegração instantánea |
| US6610266B2 (en) * | 2001-11-28 | 2003-08-26 | Michael C. Withiam | Calcium metasilicates and methods for making |
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