SI20511B - Izdelovanje trenutno raztopljivega peroralnega odmerka - Google Patents
Izdelovanje trenutno raztopljivega peroralnega odmerka Download PDFInfo
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- SI20511B SI20511B SI200000187A SI200000187A SI20511B SI 20511 B SI20511 B SI 20511B SI 200000187 A SI200000187 A SI 200000187A SI 200000187 A SI200000187 A SI 200000187A SI 20511 B SI20511 B SI 20511B
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- calcium silicate
- dosage form
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- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008187 granular material Substances 0.000 claims abstract 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract 7
- 239000003814 drug Substances 0.000 claims abstract 7
- 239000011230 binding agent Substances 0.000 claims abstract 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 3
- 239000006185 dispersion Substances 0.000 claims abstract 2
- 238000009826 distribution Methods 0.000 claims abstract 2
- 239000000378 calcium silicate Substances 0.000 claims 26
- 229910052918 calcium silicate Inorganic materials 0.000 claims 26
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 26
- 239000002552 dosage form Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 7
- 239000007884 disintegrant Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 238000000465 moulding Methods 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 229910021486 amorphous silicon dioxide Inorganic materials 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- 238000007580 dry-mixing Methods 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 238000003825 pressing Methods 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000005995 Aluminium silicate Substances 0.000 claims 1
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000005909 Kieselgur Substances 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 235000012211 aluminium silicate Nutrition 0.000 claims 1
- UWFFNDSXSPUNTR-UHFFFAOYSA-N aluminum magnesium silicic acid trihydroxy(oxido)silane silicate Chemical compound [Mg+2].[Al+3].O[Si](O)(O)O.O[Si](O)(O)[O-].[O-][Si]([O-])([O-])[O-] UWFFNDSXSPUNTR-UHFFFAOYSA-N 0.000 claims 1
- 229960004372 aripiprazole Drugs 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000001698 pyrogenic effect Effects 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Podan je postopek priprave zrnc za izdelavo trenutno raztopljivih peroralnih farmacevtskih dozirnih oblik. Poleg enega ali večih zdravil, so zrnca sestavljena iz ekscipientne kombinacije, ki sestoji iz superdisintegranta, disperznega sredstva, distribucijskega oz. porazdelitvenega sredstva ter vezivnega sredstva. Prav tako vključujejo konvencionalne dodatke oz. primesi, kot so sladila in arome. Zrnca, ki so predmet obravnavanja, imajo to prednost, da so stabilna in da so lahko izdelana brez dodatka topil ne da bi bilo pri tem potrebno posebno okolje ali rokovanje. Dozirne oblike, posebno tablete, ki so iz njih izdelane na konvencionalni opremi, se razkrojijo v ustih v manj kot približno petindvajsetih sekundah.
Claims (23)
- -1 - Sl 20511 FORMULACIJA TRENUTNO RAZTOPLJIVEGA PERORALNEGA ODMERKA PATENTNI ZAHTEVKI 1. Trenutno raztopljiva farmacevtska dozirna oblika, ki se bo razkrojila v ustih v manj kot 25 sekundah, obsegajoča zdravilo in kombinacijo ekscipientov, ki obsega, na osnovi celotne mase dozirne oblike, a) od 4 do 8 % (masni delež) super-razgrajevalca, b) od 20 do 70 % (masni delež) disperzijskega sredstva, ki je kalcijev silikat, c) od 1 do 10 % (masni delež) porazdelitvenega sredstva, izbranega iz amorfnega silicijevega dioksida, pirogenega silicijevega dioksida, diatomejske zemlje, smukca, kaolina in magnezijvega aluminijevega trisilikata in d) od 10 do 50 % (masni delež) veziva.
- 2. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 1, ki obsega ne več kot 30 procentov (masni delež) zdravila in ne več kot 85 procentov (masni delež) skupne vsote kombinacije ekscipientov.
- 3. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 2, ki obsega, na osnovi celotne mase omenjene dozirne oblike, ne več kot okoli 30 procentov (masni delež) omenjenega zdravila, od 5 do 7 procentov (masni delež) omenjenega super-razgrajevalca, od 35 do 45 procentov (masni delež) omenjenega disperzijskega sredstva, od 1,5 do 3 procente (masni delež) omenjenega porazdelitvenega sredstva in od 12 do 20 procentov (masni delež) omenjenega veziva.
- 4. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, pri čemer je kalcijev silikat izbran iz orto, meta in alfa triklinskega kalcijevega silikata.
- 5. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 4, pri čemer je omenjeni kalcijev siilkat alfa triklinski kalcijev silikat. -2-
- 6. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, pri čemer je omenjeni super-razgrajevalec krospovidon, natrijeva kroskarmeloza, natrijev škrobni glikolat, nizko substituirana hidroksipropil celuloza ali predželatiniran škrob in omenjeno vezivo je mikrokristalna celuloza, hidroksipropil celuloza, etil celuloza, laktoza, manitol ali kalcijev fosfat.
- 7. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 1, pri čemer je omenjeni super-razgrajevalec krospovidon, omenjeni kalcijev silikat je kristalni alfa triklinski kalcijev silikat, omenjeno porazdelitveno sredstvo je amorfni silicijev dioksid in omenjeno vezivo je mikrokristalna celuloza.
- 8. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od zahtevkov 1 do 3, pri čemer je omenjeni kalcijev silikat sestavljen iz kombinacije alfa triklinskega kalcijevega silikata in vsaj ene druge farmacevtske vrste kalcijevega silikata, pri čemer omenjeni alfa triklinski kalcijev silikat obsega od 10 % do 90 % (masni delež) omenjene kombinacije.
- 9. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od zahtevkov 1 do 4, pri čemer ima omenjeni kalcijev silikat površino 1,0 m2/g (m2/gm) do 210 m2/g (m2/gm), nasipno gostoto 0,075 g/ml_ (g/cc) do 0,90 g/mL (g/cc), pravo gostoto 1,70 g/mL (g/cc) do 2,90 g/mL (g/cc) in vsebnost hlapnih snovi manj kot 1 % do 14 % m/m.
- 10. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat alfa triklinski kalcijev silikat, ki ima površino 1,3 m2/g (m2/gm), nasipno gostoto 0,627g/mL (g/cc), pravo gostoto 2,934 g/mL (g/cc) in vsebnost hlapnih snovi 0,5 % m/m.
- 11. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat orto kristalen kalcijev silikat, ki ima površino 0,98 m2/g (m2/gm), nasipno gostoto 0,492 g/mL (g/cc), pravo gostoto 3,252 g/mL (g/cc) in vsebnost hlapnih snovi 0,02 % m/m.
- 12. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat meta kristalen kalcijev silikat, ki ima površino 2,5 m2/g (m2/gm), nasipno gostoto 0,867 g/mL (g/cc), pravo gostoto 2,940 g/mL (g/cc) in vsebnost hlapnih snovi 0,5 % m/m. -3-
- 13. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat kristalen kalcijev silikat, ki ima površino 90,4 m2/g (m2/gm), nasipno gostoto 0,094 g/ml_ (g/cc), pravo gostoto 2,598 g/mL (g/cc) in vsebnost hlapnih snovi 0,94 % m/m.
- 14. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat amorfni kalcijev silikat, ki ima površino 191,3 m2/g (m2/gm), nasipno gostoto 0,120 g/mL (g/cc), pravo gostoto 2,314 g/mL (g/cc) in vsebnost hlapnih snovi 5,11 % m/m.
- 15. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat amorfni kalcijev silikat, ki ima površino 103,0 m2/g (m2/gm), nasipno gostoto 0,130 g/mL (g/cc), pravo gostoto 1,702 g/mL (g/cc) in vsebnost hlapnih snovi 9,90 % m/m.
- 16. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 9, pri čemer je omenjeni kalcijev silikat amorfni kalcijev silikat, ki ima površino 209 m2/g (m2/gm), nasipno gostoto 0,075 g/mL (g/cc), pravo gostoto 2,035 g/mL (g/cc) in vsebnost hlapnih snovi 13,8 % m/m.
- 17. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, pri čemer je omenjeno zdravilo aripiprazol.
- 18. Trenutno raztopljiva farmacevtska dozirna oblika po katerem koli od predhodnih zahtevkov, ki je tableta.
- 19. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 1, ki se da dobiti s suhim mešanjem zdravila in kombinacije ekscipientov, kot je definirano v katerem koli od zahtevkov 1 do 18, v zmes, s stiskanjem zmesi skozi primeren kompaktor ali oblikovalno napravo, da nastanejo kompaktirani deli ali oblikovanci in s prehajanjem kompaktiranih delov ali oblikovancev skozi sito, da nastanejo zrnca.
- 20. Trenutno raztopljiva farmacevtska dozirna oblika po zahtevku 19, ki se da dobiti z nadaljnjim stiskanjem zrnc. -4-
- 21. Postopek oblikovanja zrnc, primernih za stiskanje v trenutno raztopljive dozirne oblike, po katerem koli od zahtevkov 1 do 20, ki obsega suho mešanje zdravila in kombinacije ekscipientov, kot je definirano v katerem koli od zahtevkov 1 do 20, v zmes, s stiskanjem zmesi skozi primeren kompaktor ali oblikovalno napravo, da nastanejo kompaktirani deli ali oblikovanci in s prehajanjem kompaktiranih delov ali oblikovancev skozi sito, da nastanejo zrnca.
- 22. Postopek oblikovanja zrnc po zahtevku 21, ki dodatno obsega stopnjo mešanja omenjenih zrnc z dodatnimi količinami omenjenega super-razgrajevalca in veziva, da nastane končna zmes, primerna za direktno stiskanje v omenjene tablete.
- 23. Postopek po zahtevku 22, pri čemer omenjena zrnca obsegajo od okoli 80 % do okoli 99 % (masni delež) omenjene končne zmesi.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54794800A | 2000-04-12 | 2000-04-12 |
Publications (2)
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SI20511A SI20511A (sl) | 2001-10-31 |
SI20511B true SI20511B (sl) | 2008-08-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SI200000187A SI20511B (sl) | 2000-04-12 | 2000-08-14 | Izdelovanje trenutno raztopljivega peroralnega odmerka |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2311734C (en) | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
US20020076437A1 (en) | 2000-04-12 | 2002-06-20 | Sanjeev Kothari | Flashmelt oral dosage formulation |
US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
PE20030445A1 (es) * | 2001-09-25 | 2003-07-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
GB0123400D0 (en) * | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
BR0117147A (pt) * | 2001-10-09 | 2006-05-09 | Bristol Myers Squibb Co | preparado de dosagem oral de desintegração instantánea |
US6610266B2 (en) * | 2001-11-28 | 2003-08-26 | Michael C. Withiam | Calcium metasilicates and methods for making |
EP1453826A1 (en) * | 2001-12-10 | 2004-09-08 | Dr. Reddy's Laboratories Ltd. | Amorphous form of 2-n-butyl-3-[[2-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4,4'] non-1-en-4-one |
AU2003221326A1 (en) * | 2002-03-06 | 2003-09-16 | Kyowa Hakko Kogyo Co., Ltd. | Tablets quickly disintegrating in oral cavity |
AU2003238670A1 (en) * | 2002-04-05 | 2003-10-27 | Cadila Healthcare Limited | Fast disintegrating oral dosage forms |
TWI275392B (en) * | 2002-04-08 | 2007-03-11 | Bristol Myers Squibb Co | Low dose liquid entecavir formulations and use |
RU2342931C2 (ru) | 2002-08-20 | 2009-01-10 | Бристол-Маерс Сквибб Компани | Состав на основе комплекса арипипразола |
IN2012DN00604A (sl) * | 2002-12-11 | 2015-08-21 | Bristol Myers Squibb Co | |
JP3841804B2 (ja) | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
DE602005025755D1 (de) | 2004-06-04 | 2011-02-17 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
JP3996626B2 (ja) * | 2004-06-22 | 2007-10-24 | 塩野義製薬株式会社 | 口腔内速崩壊錠 |
CA2600533A1 (en) * | 2005-03-24 | 2006-09-28 | Daiichi Sankyo Company, Limited | Pharmaceutical composition |
WO2007081366A1 (en) | 2006-01-05 | 2007-07-19 | Teva Pharmaceutical Industries Ltd. | Wet granulation pharmaceutical compositions of aripiprazole |
PL1808165T3 (pl) * | 2006-01-05 | 2009-09-30 | Teva Pharma | Suche formulacje aripiprazolu |
DE602006013261D1 (de) * | 2006-01-09 | 2010-05-12 | Krka D D | Irbesartan enthaltende feste Zubereitung |
KR101324898B1 (ko) | 2006-03-31 | 2013-11-04 | 루비콘 리서치 피브이티. 엘티디. | 구강 붕해 정제 |
PL2487161T3 (pl) | 2007-02-23 | 2017-03-31 | Gilead Sciences, Inc. | Modulatory farmakokinetycznych właściwości środków terapeutycznych |
WO2008125388A1 (en) * | 2007-04-17 | 2008-10-23 | Ratiopharm Gmbh | Pharmaceutical compositions comprising irbesartan |
CA2686035C (en) * | 2007-05-08 | 2016-01-05 | Hercules Incorporated | Robust rapid disintegration tablet formulation |
CN101322709B (zh) * | 2007-06-12 | 2011-03-02 | 成都康弘药业集团股份有限公司 | 一种含有阿立哌唑的药物组合物及其制备方法 |
SG190618A1 (en) * | 2008-05-02 | 2013-06-28 | Gilead Sciences Inc | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
JP5296456B2 (ja) * | 2008-08-26 | 2013-09-25 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
JP5594285B2 (ja) * | 2009-03-16 | 2014-09-24 | ニプロ株式会社 | 口腔内崩壊錠 |
WO2010146551A2 (en) * | 2009-06-16 | 2010-12-23 | Ranbaxy Laboratories Limited | Orally disintegrating compositions comprising antihypertensive agents |
CA2773003A1 (en) | 2009-09-15 | 2011-03-24 | Ratiopharm Gmbh | Orally disintegrating pharmaceutical dosage form containing aripiprazole |
TR201000689A1 (tr) * | 2010-01-29 | 2011-08-22 | Bi̇lgi̇ç Mahmut | Sefprozil içeren katı dozaj formlar. |
CN103284968B (zh) * | 2010-04-13 | 2015-11-18 | 齐鲁制药有限公司 | 一种阿立哌唑组合物微晶的口腔崩解片及其制备方法 |
EP2384742A1 (en) | 2010-05-03 | 2011-11-09 | The Jordanian Pharmaceutical Manufacturing Co. | Pharmaceutical excipient, method for its preparation and use thereof |
DE102010019416A1 (de) * | 2010-05-04 | 2011-11-10 | Stada Arzneimittel Ag | Schmelztablette, umfassend ein Triptan oder ein atypisches Neuroleptikum |
HU1000278D0 (en) | 2010-05-28 | 2010-07-28 | Egis Gyogyszergyar Nyilvanosan | Novel pharmaceutical use uf silicic acid |
JP2012121850A (ja) * | 2010-12-09 | 2012-06-28 | Otsuka Pharmaceut Co Ltd | アリピプラゾールの経口速溶性組成物 |
CN103561746B (zh) | 2011-03-18 | 2018-05-29 | 奥克梅斯制药爱尔兰有限公司 | 包含脱水山梨糖醇酯的药物组合物 |
EP3854376A3 (en) * | 2011-03-21 | 2021-12-22 | Coloright Ltd. | Systems for custom coloration |
CN102846543B (zh) * | 2011-06-27 | 2014-11-19 | 上海中西制药有限公司 | 一种阿立哌唑药物制剂及其制备方法 |
CN102846564B (zh) * | 2011-06-28 | 2013-10-09 | 南京亿华药业有限公司 | 一种头孢丙烯片及其制法 |
CN102357086A (zh) * | 2011-11-01 | 2012-02-22 | 上海理工大学 | 一种头孢丙烯口腔崩解片 |
AU2012360935A1 (en) * | 2011-12-26 | 2014-07-17 | Novartis Ag | Tablets and dry-coated agents |
CA2867123C (en) | 2012-03-19 | 2021-02-16 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising water-insoluble antipsychotic agents and glycerol esters |
EP2827868B8 (en) | 2012-03-19 | 2019-12-18 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
WO2013175508A2 (en) | 2012-05-24 | 2013-11-28 | Medreich Limited | Stable pharmaceutical composition of aripiprazole |
CA2779052A1 (en) * | 2012-05-31 | 2013-11-30 | Pharmascience Inc. | Pharmaceutical composition of entecavir and process of manufacturing |
KR101571670B1 (ko) | 2012-08-08 | 2015-11-25 | 주식회사 씨엠지제약 | 아리피프라졸을 포함하는 경구용 속용 필름 제제 |
US20150224086A1 (en) * | 2012-08-23 | 2015-08-13 | Hetero Research Foundation | Pharmaceutical Formulations of Rufinamide |
CA2885196C (en) | 2012-09-19 | 2021-06-22 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
CN102885790B (zh) * | 2012-09-20 | 2013-12-25 | 中国人民解放军第三〇二医院 | 恩替卡韦分散片及其制备方法 |
ES2625613T3 (es) | 2013-04-30 | 2017-07-20 | Otsuka Pharmaceutical Co., Ltd. | Preparación sólida oral que comprende aripiprazol y método para producir una preparación sólida oral que comprende aripiprazol |
JP5714652B2 (ja) * | 2013-06-13 | 2015-05-07 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
EP3065700A1 (en) | 2013-11-07 | 2016-09-14 | Synthon B.V. | Orodispersible pharmaceutical compositions comprising aripiprazole |
CN110368360A (zh) | 2014-03-20 | 2019-10-25 | 奥克梅斯制药爱尔兰有限公司 | 具有增加的注射速度的阿立哌唑制剂 |
JP5978335B2 (ja) * | 2015-03-11 | 2016-08-24 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
KR20160139704A (ko) | 2015-05-28 | 2016-12-07 | 주식회사 씨엠지제약 | 아리피프라졸을 포함하는 경구용 속용 필름 제제, 및 이의 제조방법 |
JP2015172084A (ja) * | 2015-07-06 | 2015-10-01 | 大塚製薬株式会社 | アリピプラゾールの経口速溶性組成物 |
US9855227B2 (en) | 2015-12-18 | 2018-01-02 | The Procter & Gamble Company | Quick dissolving diphenhydramine oral dosage form |
TR201617675A2 (tr) | 2016-12-02 | 2018-06-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Ari̇pi̇prazole monohi̇drat formülasyonlarinin ağizda dağilan tablet formu |
JP6572257B2 (ja) * | 2017-05-16 | 2019-09-04 | 大塚製薬株式会社 | アリピプラゾールの経口速溶性組成物 |
JP2017141299A (ja) * | 2017-05-24 | 2017-08-17 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
CN112423754A (zh) | 2018-03-05 | 2021-02-26 | 奥克梅斯制药爱尔兰有限公司 | 阿立哌唑的给药策略 |
JP2018168185A (ja) * | 2018-07-05 | 2018-11-01 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
JP2019203031A (ja) * | 2019-09-06 | 2019-11-28 | 大日本住友製薬株式会社 | 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠 |
RU2732291C1 (ru) * | 2020-02-13 | 2020-09-15 | Открытое акционерное общество "Фармстандарт-Лексредства" (ОАО "Фармстандарт-Лексредства") | Лекарственный препарат на основе травы алтея лекарственного для лечения простудных и острых респираторных заболеваний |
GB2617603A (en) * | 2022-04-13 | 2023-10-18 | Univ Brunel | Compositions for preventing and treating infection |
CN115227661B (zh) * | 2022-09-22 | 2022-12-13 | 北京惠之衡生物科技有限公司 | 一种利格列汀片及其制备方法 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1912354B2 (de) * | 1969-03-12 | 1972-04-13 | Reimbold & Strick, 5000 Köln-Kalk | Synthetisches kristallines calciumsilikat und verfahren zu seiner herstellung |
US3622677A (en) * | 1969-07-07 | 1971-11-23 | Staley Mfg Co A E | Compressed tablets containing compacted starch as binder-disintegrant ingredient |
FR2234244B1 (sl) * | 1973-06-20 | 1978-02-17 | Rech Geolog Miniere | |
DE2556561C2 (de) | 1975-12-16 | 1983-04-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Herstellung von porösen Tabletten |
DE2845326C2 (de) * | 1978-10-18 | 1985-05-23 | Beiersdorf Ag, 2000 Hamburg | Verwendung einer spezifischen mikrodispersen, amorphen, porösen Kieselsäure zur Herstellung von Digoxin enthaltenden Tabletten mit stark beschleunigter Wirkstoff-Freisetzung |
DE2849494A1 (de) | 1978-11-15 | 1980-05-29 | Voss Gunter M | Verfahren zur herstellung von arzneimittel-formlingen |
US4327080A (en) * | 1981-07-13 | 1982-04-27 | E. R. Squibb & Sons, Inc. | Novel Bendroflumethiazide formulations and method |
ZA87279B (en) | 1986-01-17 | 1987-09-30 | Chugai Pharmaceutical Co Ltd | Method for production of stable nicorandil preparation |
AU7084587A (en) * | 1986-04-01 | 1987-10-20 | Upjohn Company, The | Methylprednisolone/sodium carboxymethyl starch tablet composition |
SE8601624D0 (sv) | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
US5032552A (en) * | 1988-07-04 | 1991-07-16 | Tdk Corporation | Biomedical material |
US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
US4906478A (en) * | 1988-12-12 | 1990-03-06 | Valentine Enterprises, Inc. | Simethicone/calcium silicate composition |
HU203041B (en) | 1989-03-14 | 1991-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin |
JPH06271744A (ja) * | 1993-03-22 | 1994-09-27 | Mizusawa Ind Chem Ltd | ポリアセタール系樹脂用帯電防止剤 |
US5393472A (en) * | 1993-06-30 | 1995-02-28 | Shaw; John D. | Method of producing wollastonite & ceramic bodies containing wollastonite |
IL110376A (en) * | 1993-08-02 | 1998-08-16 | Bristol Myers Squibb Co | Pharmaceutical preparations containing iftroban and methods for their preparation |
AU7407194A (en) * | 1993-08-03 | 1995-02-28 | Warner-Lambert Company | Pleasant tasting effervescent cold/allergy medications |
US5622719A (en) * | 1993-09-10 | 1997-04-22 | Fuisz Technologies Ltd. | Process and apparatus for making rapidly dissolving dosage units and product therefrom |
US5895664A (en) * | 1993-09-10 | 1999-04-20 | Fuisz Technologies Ltd. | Process for forming quickly dispersing comestible unit and product therefrom |
US5994348A (en) * | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
TW442301B (en) * | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
WO1997019033A1 (en) * | 1995-11-17 | 1997-05-29 | Vrije Universiteit Brussel | Inorganic resin compositions, their preparation and use thereof |
TW430561B (en) * | 1995-12-20 | 2001-04-21 | Gea Farmaceutisk Fabrik As | Rapid release tablet composition comprising tolfenamic acid or a pharmaceutically acceptable salt thereof as active ingredient and a method of preparing such tablet |
DK1166651T3 (da) * | 1996-02-29 | 2005-05-30 | Fujisawa Pharmaceutical Co | Hurtigt disintegrerende granulat af et syntetisk södemiddel indeholdende kiselsyre og/eller siliciumdioxid |
GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
EP1380308B1 (en) * | 1996-07-12 | 2008-07-09 | Daiichi Pharmaceutical Co., Ltd. | Quickly disintegrable compression-molded materials and process for producing the same |
CA2258917A1 (en) * | 1996-07-23 | 1998-01-29 | Fmc Corporation | Disintegrant composition for dispersible solids |
JPH10114655A (ja) | 1996-10-09 | 1998-05-06 | Kyowa Hakko Kogyo Co Ltd | 固形製剤 |
JPH10182436A (ja) | 1996-10-31 | 1998-07-07 | Takeda Chem Ind Ltd | 固形医薬製剤 |
AUPO446397A0 (en) | 1997-01-07 | 1997-01-30 | Rees Equipment Pty Ltd | Agricultural equipment direction control |
US6024981A (en) * | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
TW527195B (en) * | 1997-10-09 | 2003-04-11 | Ssp Co Ltd | Fast-soluble solid pharmaceutical combinations |
JPH11152220A (ja) * | 1997-11-19 | 1999-06-08 | Daiichi Yakuhin Kogyo Kk | 脂溶性薬物を含有した丸剤の製造方法 |
PL197989B1 (pl) * | 1997-12-19 | 2008-05-30 | Smithkline Beecham Corp | Sposób wytwarzania szybko rozpraszających się tabletek do podawania doustnego, szybko rozpraszający się preparat farmaceutyczny w postaci tabletek i szybko rozpraszająca się, farmaceutycznie dopuszczalna, tabletka do podawania doustnego |
US5914128A (en) * | 1997-12-22 | 1999-06-22 | Schering Corporation | Orally administrable solid dosage form |
EP1058538B9 (en) | 1998-03-06 | 2013-01-02 | Aptalis Pharma S.r.l. | Fast disintegrating tablets |
JP4027535B2 (ja) | 1998-05-26 | 2007-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 脂溶性薬物を含有した粉末 |
PE20000559A1 (es) * | 1998-05-27 | 2000-07-05 | Merck & Co Inc | Formulacion de tabletas comprimidas de efavirenz |
JP2000119014A (ja) | 1998-08-12 | 2000-04-25 | Fuji Chem Ind Co Ltd | 無晶形ケイ酸アルミン酸カルシウム複合酸化物及びその製造方法並びに制酸剤 |
JP2000086537A (ja) | 1998-09-11 | 2000-03-28 | Fuji Chem Ind Co Ltd | 無機化合物糖類組成物、賦形剤、速崩壊性圧縮成型物及びその製造方法 |
US6133378A (en) * | 1998-11-20 | 2000-10-17 | Bridgestone/Firestone, Inc. | EPDM-based roofing shingle compositions |
GB9914936D0 (en) | 1999-06-26 | 1999-08-25 | Cerestar Holding Bv | Directly compressible starch as enhancer of properties of excipients when used as binder and disintegrant for compression tablets |
US20020076437A1 (en) * | 2000-04-12 | 2002-06-20 | Sanjeev Kothari | Flashmelt oral dosage formulation |
CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
WO2003003522A2 (en) | 2001-06-29 | 2003-01-09 | Xanoptix, Inc. | High-precision female format multifiber connector |
TWI324074B (en) * | 2001-10-09 | 2010-05-01 | Bristol Myers Squibb Co | Flashmelt oral dosage formulation |
US6610266B2 (en) * | 2001-11-28 | 2003-08-26 | Michael C. Withiam | Calcium metasilicates and methods for making |
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