SG189817A1 - Potent conjugates and hydrophilic linkers - Google Patents

Potent conjugates and hydrophilic linkers Download PDF

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Publication number
SG189817A1
SG189817A1 SG2013033188A SG2013033188A SG189817A1 SG 189817 A1 SG189817 A1 SG 189817A1 SG 2013033188 A SG2013033188 A SG 2013033188A SG 2013033188 A SG2013033188 A SG 2013033188A SG 189817 A1 SG189817 A1 SG 189817A1
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Singapore
Prior art keywords
bond
cell
antibody
conjugate
binding agent
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SG2013033188A
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English (en)
Inventor
Rajeeva Singh
Yelena Kovtun
Sharon D Wilhelm
Ravi V J Chari
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Immunogen Inc
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Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of SG189817A1 publication Critical patent/SG189817A1/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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