CA2722109A1 - Potent conjugates and hydrophilic linkers - Google Patents

Potent conjugates and hydrophilic linkers Download PDF

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Publication number
CA2722109A1
CA2722109A1 CA2722109A CA2722109A CA2722109A1 CA 2722109 A1 CA2722109 A1 CA 2722109A1 CA 2722109 A CA2722109 A CA 2722109A CA 2722109 A CA2722109 A CA 2722109A CA 2722109 A1 CA2722109 A1 CA 2722109A1
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CA
Canada
Prior art keywords
bond
cell
antibody
conjugate
binding agent
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Abandoned
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CA2722109A
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English (en)
French (fr)
Inventor
Rajeeva Singh
Yelena Kovtun
Sharon D. Wilhelm
Ravi V. J. Chari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunogen Inc
Original Assignee
Immunogen Inc
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Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of CA2722109A1 publication Critical patent/CA2722109A1/en
Abandoned legal-status Critical Current

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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