MX2010011808A - Conjugados potentes y enlazadores hidrofilicos. - Google Patents

Conjugados potentes y enlazadores hidrofilicos.

Info

Publication number
MX2010011808A
MX2010011808A MX2010011808A MX2010011808A MX2010011808A MX 2010011808 A MX2010011808 A MX 2010011808A MX 2010011808 A MX2010011808 A MX 2010011808A MX 2010011808 A MX2010011808 A MX 2010011808A MX 2010011808 A MX2010011808 A MX 2010011808A
Authority
MX
Mexico
Prior art keywords
cell
linkers
hydrophilic linkers
binding
conjugates
Prior art date
Application number
MX2010011808A
Other languages
English (en)
Inventor
Singh Rajeeva
V J Chari Ravi
D Wilhelm Sharon
Kovtun Yalena
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MX2010011808A publication Critical patent/MX2010011808A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Los enlazadores para enlazar fármacos a agentes de enlace celular son modificados para enlazadores hidrofílicos mediante la incorporación de un separador de polietilen glicol. La potencia o eficacia de los conjugados de agente de enlace celular-fármaco se mejora varias veces de modo sorprendente en una variedad tipos de célula de cáncer, que incluyen a aquellas que expresan un bajo número de antígenos en la superficie celular o células de cáncer que son resistentes a tratamiento.
MX2010011808A 2008-04-30 2009-04-30 Conjugados potentes y enlazadores hidrofilicos. MX2010011808A (es)

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