SG11202004427TA - Kras g12c inhibitors - Google Patents
Kras g12c inhibitorsInfo
- Publication number
- SG11202004427TA SG11202004427TA SG11202004427TA SG11202004427TA SG11202004427TA SG 11202004427T A SG11202004427T A SG 11202004427TA SG 11202004427T A SG11202004427T A SG 11202004427TA SG 11202004427T A SG11202004427T A SG 11202004427TA SG 11202004427T A SG11202004427T A SG 11202004427TA
- Authority
- SG
- Singapore
- Prior art keywords
- kras
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762586775P | 2017-11-15 | 2017-11-15 | |
| PCT/US2018/061060 WO2019099524A1 (en) | 2017-11-15 | 2018-11-14 | Kras g12c inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202004427TA true SG11202004427TA (en) | 2020-06-29 |
Family
ID=66431793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202004427TA SG11202004427TA (en) | 2017-11-15 | 2018-11-14 | Kras g12c inhibitors |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10689377B2 (da) |
| EP (2) | EP3710439B1 (da) |
| JP (2) | JP7322019B2 (da) |
| KR (1) | KR20200100632A (da) |
| CN (1) | CN111989321B (da) |
| AU (1) | AU2018369759B2 (da) |
| BR (1) | BR112020009818A2 (da) |
| CA (1) | CA3082579A1 (da) |
| CL (1) | CL2020001271A1 (da) |
| CO (1) | CO2020007244A2 (da) |
| DK (1) | DK3710439T3 (da) |
| EA (1) | EA202091186A1 (da) |
| ES (1) | ES2944547T3 (da) |
| FI (1) | FI3710439T3 (da) |
| HR (1) | HRP20230377T1 (da) |
| HU (1) | HUE061599T2 (da) |
| IL (1) | IL274601B2 (da) |
| LT (1) | LT3710439T (da) |
| MX (1) | MX2020005063A (da) |
| PH (1) | PH12020550622A1 (da) |
| PL (1) | PL3710439T3 (da) |
| PT (1) | PT3710439T (da) |
| RS (1) | RS64182B1 (da) |
| SG (1) | SG11202004427TA (da) |
| SI (1) | SI3710439T1 (da) |
| TW (1) | TWI809005B (da) |
| UA (1) | UA125802C2 (da) |
| WO (2) | WO2019099524A1 (da) |
| ZA (1) | ZA202002105B (da) |
Families Citing this family (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017201161A1 (en) * | 2016-05-18 | 2017-11-23 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| HUE061599T2 (hu) * | 2017-11-15 | 2023-07-28 | Mirati Therapeutics Inc | KRas G12C inhibotorok |
| US11932633B2 (en) | 2018-05-07 | 2024-03-19 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| TW202012415A (zh) | 2018-05-08 | 2020-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| EP3844151B1 (en) * | 2018-08-31 | 2023-08-23 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| JP2022500381A (ja) * | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| EP3849536A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3849537A4 (en) * | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| CN112955137A (zh) * | 2018-09-10 | 2021-06-11 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| CN118084870A (zh) | 2018-11-09 | 2024-05-28 | 豪夫迈·罗氏有限公司 | 稠环化合物 |
| JP2022509724A (ja) | 2018-12-05 | 2022-01-24 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| JP2022517222A (ja) | 2019-01-10 | 2022-03-07 | ミラティ セラピューティクス， インコーポレイテッド | Ｋｒａｓ ｇ１２ｃ阻害剤 |
| EP3924053A1 (en) | 2019-02-12 | 2021-12-22 | Novartis AG | Pharmaceutical combination comprising tno155 and a krasg12c inhibitor |
| WO2020238791A1 (zh) * | 2019-05-24 | 2020-12-03 | 江苏恒瑞医药股份有限公司 | 氢化吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| AU2020282473A1 (en) * | 2019-05-29 | 2022-01-06 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Nitrogen-containing heterocyclic derivative regulator, preparation method therefor and application thereof |
| CN112047939B (zh) * | 2019-06-06 | 2023-05-02 | 江苏先声药业有限公司 | 一种具有抗肿瘤活性的四氢吡啶并嘧啶类化合物 |
| CN112300153B (zh) * | 2019-07-26 | 2023-06-13 | 博瑞生物医药（苏州）股份有限公司 | 一种杂环化合物、药物组合物和用途 |
| EP4011886A4 (en) * | 2019-08-02 | 2023-07-26 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | TETRACYCLIC COMPOUND, METHOD OF PRODUCTION THEREOF AND USE THEREOF |
| CN112341457A (zh) * | 2019-08-07 | 2021-02-09 | 北京加科思新药研发有限公司 | Kras突变蛋白抑制剂 |
| CN112390788A (zh) * | 2019-08-13 | 2021-02-23 | 苏州闻天医药科技有限公司 | 一种用于抑制krasg12c突变蛋白的化合物及其制备方法和用途 |
| CN112390797A (zh) * | 2019-08-15 | 2021-02-23 | 微境生物医药科技(上海)有限公司 | 新型螺环类K-Ras G12C抑制剂 |
| CN114616232A (zh) * | 2019-09-06 | 2022-06-10 | 正大天晴药业集团南京顺欣制药有限公司 | 氮杂环庚烷并嘧啶类衍生物及其医药用途 |
| US20220402916A1 (en) * | 2019-09-18 | 2022-12-22 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| CA3152025A1 (en) * | 2019-09-24 | 2021-04-01 | David BRIERE | Combination therapies |
| WO2021057832A1 (en) * | 2019-09-25 | 2021-04-01 | Jacobio Pharmaceuticals Co., Ltd. | Kras mutant protein inhibitor |
| US20230257374A1 (en) * | 2019-10-10 | 2023-08-17 | Innovent Biologics (Suzhou) Co., Ltd. | Novel kras g12c protein inhibitor, preparation method therefor, and use thereof |
| CN112694475A (zh) * | 2019-10-23 | 2021-04-23 | 苏州泽璟生物制药股份有限公司 | 环烷基类和杂环烷基类抑制剂及其制备方法和应用 |
| AU2020372881A1 (en) | 2019-10-28 | 2022-06-09 | Merck Sharp & Dohme Llc | Small molecule inhibitors of KRAS G12C mutant |
| BR112022008375A2 (pt) * | 2019-10-30 | 2022-07-12 | Genfleet Therapeutics Shanghai Inc | Composto cíclico heterocíclico fundido substituído, método de preparação e uso farmacêutico deste |
| JP2022553857A (ja) | 2019-11-04 | 2022-12-26 | レボリューション メディシンズ インコーポレイテッド | Ｒａｓ阻害剤 |
| CN113286794B (zh) * | 2019-11-04 | 2024-03-12 | 北京加科思新药研发有限公司 | Kras突变蛋白抑制剂 |
| EP4054719A1 (en) | 2019-11-04 | 2022-09-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2021091956A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| CN112778301A (zh) * | 2019-11-07 | 2021-05-11 | 苏州泽璟生物制药股份有限公司 | 四氢吡啶并嘧啶类抑制剂及其制备方法和应用 |
| CN112824410A (zh) * | 2019-11-21 | 2021-05-21 | 苏州泽璟生物制药股份有限公司 | 氮杂七元环类抑制剂及其制备方法和应用 |
| CN114901286B (zh) | 2019-11-27 | 2024-05-10 | 特普医药公司 | 涉及二芳基巨环化合物的组合疗法 |
| JP2023505100A (ja) | 2019-11-27 | 2023-02-08 | レボリューション メディシンズ インコーポレイテッド | 共有ｒａｓ阻害剤及びその使用 |
| WO2021106231A1 (en) * | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| WO2021109737A1 (zh) * | 2019-12-02 | 2021-06-10 | 上海璎黎药业有限公司 | 一种含氧杂环化合物、其制备方法及应用 |
| TWI765448B (zh) | 2019-12-11 | 2022-05-21 | 美商美國禮來大藥廠 | Kras g12c抑制劑 |
| KR20220119088A (ko) * | 2019-12-19 | 2022-08-26 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Kras 돌연변이체 단백질 억제제 |
| CN113004269A (zh) * | 2019-12-19 | 2021-06-22 | 首药控股(北京)有限公司 | Kras-G12C抑制剂杂环化合物 |
| EP4076418A4 (en) | 2019-12-20 | 2024-01-24 | Mirati Therapeutics Inc | SOS1 INHIBITORS |
| WO2021120890A1 (en) * | 2019-12-20 | 2021-06-24 | Novartis Ag | Pyrazolyl derivatives useful as anti-cancer agents |
| CN113045565A (zh) * | 2019-12-27 | 2021-06-29 | 微境生物医药科技(上海)有限公司 | 新型K-Ras G12C抑制剂 |
| CN112094269B (zh) * | 2020-01-01 | 2021-12-07 | 上海凌达生物医药有限公司 | 一类饱和六元环并杂环类化合物、制备方法和用途 |
| CN113087700B (zh) | 2020-01-08 | 2023-03-14 | 苏州亚盛药业有限公司 | 螺环四氢喹唑啉 |
| GB202001344D0 (en) | 2020-01-31 | 2020-03-18 | Redx Pharma Plc | Ras Inhibitors |
| US20230099858A1 (en) * | 2020-02-20 | 2023-03-30 | Beta Pharma, Inc. | Pyridopyrimidine derivatives as kras inhibitors |
| CN113637005B (zh) * | 2020-02-24 | 2024-05-24 | 泰励生物科技（上海）有限公司 | 用于癌症治疗的kras抑制剂 |
| WO2021218939A1 (zh) * | 2020-04-28 | 2021-11-04 | 贝达药业股份有限公司 | 稠环化合物及其在医药上的应用 |
| TW202144349A (zh) * | 2020-04-30 | 2021-12-01 | 大陸商上海科州藥物研發有限公司 | 作為ｋｒａｓ抑制劑的雜環化合物的製備及其應用方法 |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| CN113666923A (zh) * | 2020-05-15 | 2021-11-19 | 苏州泽璟生物制药股份有限公司 | 烷氧基烷基取代杂环基类抑制剂及其制备方法和应用 |
| JP2023528623A (ja) | 2020-06-02 | 2023-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | がんを治療するための縮合環化２－アミノ－３－シアノチオフェン及び誘導体 |
| WO2021244603A1 (en) * | 2020-06-04 | 2021-12-09 | Shanghai Antengene Corporation Limited | Inhibitors of kras g12c protein and uses thereof |
| WO2021257736A1 (en) | 2020-06-18 | 2021-12-23 | Revolution Medicines, Inc. | Methods for delaying, preventing, and treating acquired resistance to ras inhibitors |
| CN115942936A (zh) | 2020-06-24 | 2023-04-07 | 勃林格殷格翰国际有限公司 | 包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法 |
| BR112022026186A2 (pt) * | 2020-06-25 | 2023-01-17 | Tolremo Therapeutics Ag | Combinação de um inibidor de bromodomínio cbp/p300 e um inibidor de kras |
| CN113912608B (zh) * | 2020-07-10 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用 |
| CN113980014B (zh) * | 2020-07-27 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 氢化吡啶并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| IL301062A (en) | 2020-09-03 | 2023-05-01 | Revolution Medicines Inc | Use of SOS1 inhibitors to treat malignancies with SHP2 mutations |
| BR112023004569A2 (pt) * | 2020-09-11 | 2023-04-04 | Mirati Therapeutics Inc | Formas cristalinas de um inibidor de kras g12c |
| EP4206201A1 (en) | 2020-09-11 | 2023-07-05 | Medshine Discovery Inc. | Crystal form of azetidine-substituted compound |
| PE20231207A1 (es) | 2020-09-15 | 2023-08-17 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer |
| US20220112204A1 (en) * | 2020-10-14 | 2022-04-14 | Accutar Biotechnology Inc. | Substituted dihydropyranopyrimidine compounds as kras inhibitors |
| WO2022087270A1 (en) * | 2020-10-23 | 2022-04-28 | Mirati Therapeutics, Inc. | Methods for treatment of lung cancers |
| WO2022089604A1 (en) * | 2020-10-30 | 2022-05-05 | Novartis Ag | New crystalline forms of a kras g12c inhibitor compound |
| TW202233188A (zh) | 2020-11-06 | 2022-09-01 | 大陸商泰勵生物科技（上海）有限公司 | 用於癌症治療的ｋｒａｓ抑制劑 |
| CN114591319A (zh) * | 2020-12-04 | 2022-06-07 | 江苏先声药业有限公司 | 四氢吡啶并嘧啶类衍生物及其用途 |
| US20230072276A1 (en) * | 2020-12-15 | 2023-03-09 | Mirati Therapeutics, Inc. | Azaquinazoline pan-KRas inhibitors |
| WO2022133038A1 (en) * | 2020-12-16 | 2022-06-23 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| TWI795129B (zh) * | 2020-12-18 | 2023-03-01 | 大陸商正大天晴藥業集團股份有限公司 | 吡啶并嘧啶酮類化合物 |
| PE20240545A1 (es) | 2020-12-18 | 2024-03-19 | Amphista Therapeutics Ltd | Moleculas bifuncionales novedosas para la degradacion de proteinas dirigidas |
| US20230107642A1 (en) | 2020-12-18 | 2023-04-06 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| US20240082218A1 (en) * | 2020-12-22 | 2024-03-14 | Novartis Ag | Pharmaceutical combinations comprising a kras g12c inhibitor and uses of a kras g12c inhibitor for the treatment of cancers |
| WO2022148421A1 (en) * | 2021-01-08 | 2022-07-14 | Beigene, Ltd. | Bridged compounds as kras g12d inhibitor and degrader and the use thereof |
| TWI793999B (zh) * | 2021-02-01 | 2023-02-21 | 大陸商南京明德新藥研發有限公司 | 嘧啶並吡喃化合物 |
| WO2022171143A1 (zh) * | 2021-02-09 | 2022-08-18 | 南京明德新药研发有限公司 | 5,6,7,8-四氢吡啶[3,4-d]嘧啶化合物 |
| WO2022187527A1 (en) * | 2021-03-05 | 2022-09-09 | Nikang Therapeutics, Inc | Quinazoline nitrile derivatives as kras inhibitors |
| WO2022195355A1 (en) | 2021-03-15 | 2022-09-22 | Novartis Ag | Benzisoxazole derivatives and uses thereof |
| CN116801883A (zh) * | 2021-03-18 | 2023-09-22 | 四川科伦博泰生物医药股份有限公司 | 一类杂芳环化合物、其制备方法及用途 |
| CN115124524A (zh) * | 2021-03-26 | 2022-09-30 | 浙江海正药业股份有限公司 | 三环类衍生物及其制备方法和用途 |
| CN116157400A (zh) * | 2021-03-30 | 2023-05-23 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
| EP4319754A1 (en) | 2021-04-08 | 2024-02-14 | Mirati Therapeutics, Inc. | Combination therapies using prmt5 inhibitors for the treatment of cancer |
| CN117479942A (zh) | 2021-04-09 | 2024-01-30 | 勃林格殷格翰国际有限公司 | 抗癌疗法 |
| WO2022217042A1 (en) * | 2021-04-09 | 2022-10-13 | Ikena Oncology, Inc. | Naphthyl-substituted quinoline-4(1h)-ones and related compounds and their use in treating medical conditions |
| WO2022223020A1 (zh) * | 2021-04-23 | 2022-10-27 | 清华大学 | 靶向活化与失活态kras g12d的抑制剂 |
| WO2022235864A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| JP2024519845A (ja) * | 2021-05-19 | 2024-05-21 | ジェネンテック， インコーポレイテッド | 併用療法 |
| WO2022247760A1 (zh) * | 2021-05-22 | 2022-12-01 | 上海科州药物研发有限公司 | 作为kras抑制剂的杂环化合物，及其制备和治疗用途 |
| EP4347606A1 (en) * | 2021-05-28 | 2024-04-10 | Merck Sharp & Dohme LLC | Small molecule inhibitors of kras g12c mutant |
| WO2022250170A1 (en) * | 2021-05-28 | 2022-12-01 | Taiho Pharmaceutical Co., Ltd. | Small molecule inhibitors of kras mutated proteins |
| EP4352053A1 (en) | 2021-06-09 | 2024-04-17 | Eli Lilly and Company | Substituted fused azines as kras g12d inhibitors |
| WO2022266206A1 (en) | 2021-06-16 | 2022-12-22 | Erasca, Inc. | Kras inhibitor conjugates |
| AR126166A1 (es) * | 2021-06-18 | 2023-09-27 | Antengene Discovery Ltd | Combinación de un inhibidor de erk y un inhibidor de kras y usos de estos |
| TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途 |
| CN117751116A (zh) * | 2021-07-07 | 2024-03-22 | 微境生物医药科技(上海)有限公司 | 作为KRas G12D抑制剂的稠环化合物 |
| TW202317589A (zh) | 2021-07-14 | 2023-05-01 | 美商尼坎醫療公司 | 作為ｋｒａｓ抑制劑的伸烷基衍生物 |
| WO2023283933A1 (en) * | 2021-07-16 | 2023-01-19 | Silexon Biotech Co., Ltd. | Compounds useful as kras g12d inhibitors |
| WO2023008462A1 (ja) | 2021-07-27 | 2023-02-02 | 東レ株式会社 | 癌の治療及び／又は予防のための医薬品 |
| CN113527294A (zh) * | 2021-08-25 | 2021-10-22 | 都创(上海)医药开发有限公司 | Mrtx849化合物的晶型及其制备方法和用途 |
| WO2023031781A1 (en) | 2021-09-01 | 2023-03-09 | Novartis Ag | Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers |
| CA3231284A1 (en) * | 2021-09-09 | 2023-03-16 | Thomas SCATTOLIN | Processes and intermediates for synthesis of adagrasib |
| CN118043330A (zh) * | 2021-09-29 | 2024-05-14 | 海南先声再明医药股份有限公司 | Kras g12d抑制剂化合物及其制备方法和应用 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CA3234517A1 (en) | 2021-10-22 | 2023-04-27 | Xin Li | Nitrogen-containing tetracyclic compound, preparation method therefor, and medical use thereof |
| TW202340212A (zh) | 2021-11-24 | 2023-10-16 | 美商建南德克公司 | 治療性化合物及其使用方法 |
| TW202332429A (zh) | 2021-11-24 | 2023-08-16 | 美商建南德克公司 | 治療性化合物及其使用方法 |
| WO2023114954A1 (en) | 2021-12-17 | 2023-06-22 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| WO2023117681A1 (en) | 2021-12-22 | 2023-06-29 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds for the treatment of cancer |
| WO2023126822A1 (en) | 2021-12-28 | 2023-07-06 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and rasg12c inhibitor |
| CN114409653A (zh) * | 2021-12-31 | 2022-04-29 | 苏州闻天医药科技有限公司 | 一种桥环并嘧啶并环类化合物及其用途 |
| WO2023154528A1 (en) * | 2022-02-11 | 2023-08-17 | Wave Life Sciences Ltd. | Stereoselective technologies for chiral compounds |
| EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
| US20240043451A1 (en) | 2022-03-25 | 2024-02-08 | Eli Lilly And Company | Kras inhibitors |
| WO2023194310A1 (en) | 2022-04-04 | 2023-10-12 | Sanofi | Therapeutic combination of kras g12c inhibitor and tead inhibitor |
| WO2023199180A1 (en) | 2022-04-11 | 2023-10-19 | Novartis Ag | Therapeutic uses of a krasg12c inhibitor |
| WO2023205074A1 (en) * | 2022-04-18 | 2023-10-26 | Mirati Therapeutics, Inc. | Processes and intermediates for synthesis of adagrasib |
| WO2023205701A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
| CN114907387B (zh) * | 2022-05-26 | 2023-11-10 | 中山大学 | 嘧啶并吡咯类kras抑制剂及其制备方法与应用 |
| CN117164580A (zh) * | 2022-05-27 | 2023-12-05 | 苏州泽璟生物制药股份有限公司 | 一种kras g12c抑制剂的制备方法及其中间体 |
| CN117164526A (zh) * | 2022-05-27 | 2023-12-05 | 苏州泽璟生物制药股份有限公司 | 2-(哌嗪-2-基)乙腈类衍生物及其制备方法和应用 |
| WO2023240189A1 (en) * | 2022-06-10 | 2023-12-14 | Bristol-Myers Squibb Company | Tetrahydropyrido 3,4-d pyrimidine derivatives as kras inhibitors |
| WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2024040131A1 (en) | 2022-08-17 | 2024-02-22 | Treeline Biosciences, Inc. | Pyridopyrimidine kras inhibitors |
| GB202212641D0 (en) | 2022-08-31 | 2022-10-12 | Jazz Pharmaceuticals Ireland Ltd | Novel compounds |
| WO2024102421A2 (en) | 2022-11-09 | 2024-05-16 | Revolution Medicines, Inc. | Compounds, complexes, and methods for their preparation and of their use |
| CN116478141B (zh) * | 2023-06-20 | 2023-10-24 | 药康众拓(江苏)医药科技有限公司 | 氘代kras抑制剂药物及用途 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237060C (zh) | 2001-01-02 | 2006-01-18 | 弗·哈夫曼-拉罗切有限公司 | 用作α1A/B肾上腺素能受体拮抗剂的喹唑酮衍生物 |
| US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| US20080051387A1 (en) | 2006-06-09 | 2008-02-28 | Yuelian Xu | Tetrahydropyrido[3,4-d]pyrimidines and related analogues |
| US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| CA2673299C (en) | 2006-12-21 | 2016-04-12 | Sloan-Kettering Institute For Cancer Research | Pyridazinone compounds for the treatment of proliferative diseases |
| WO2008103470A2 (en) | 2007-02-21 | 2008-08-28 | Trustees Of Columbia University In The City Of New York | Oncogenic-ras-signal dependent lethal compounds |
| EP2527330A1 (en) * | 2007-03-14 | 2012-11-28 | Exelixis, Inc. | Inhibitors of the hedgehog pathway |
| US20100298289A1 (en) | 2007-10-09 | 2010-11-25 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
| US20090253693A1 (en) | 2008-04-07 | 2009-10-08 | Dmitry Koltun | 2H-BENZO[b][1,4]OXAZIN-3(4H)-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| RU2473549C2 (ru) | 2008-07-31 | 2013-01-27 | Дженентек, Инк. | Пиримидиновые соединения, композиции и способы применения |
| WO2010120996A1 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| CA2785284A1 (en) | 2009-12-25 | 2011-06-30 | Tomoyuki Kamino | Novel aryl urea derivative |
| SG181965A1 (en) | 2009-12-30 | 2012-08-30 | Avila Therapeutics Inc | Ligand-directed covalent modification of protein |
| CN104379563B (zh) | 2012-04-10 | 2018-12-21 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
| US9695133B2 (en) | 2012-07-13 | 2017-07-04 | The Trustees Of Columbia University In The City Of New York | Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| AU2014239542A1 (en) | 2013-03-15 | 2015-10-01 | Araxes Pharma Llc | Covalent inhibitors of KRas G12C |
| WO2014143659A1 (en) | 2013-03-15 | 2014-09-18 | Araxes Pharma Llc | Irreversible covalent inhibitors of the gtpase k-ras g12c |
| CN106488910B (zh) * | 2013-10-10 | 2020-07-31 | 亚瑞克西斯制药公司 | Kras g12c的抑制剂 |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| CA2950581A1 (en) | 2014-05-30 | 2015-12-03 | The Trustees Of Columbia University In The City Of New York | Multivalent ras binding compounds |
| WO2016025650A1 (en) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods |
| JO3556B1 (ar) * | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
| WO2016049524A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| WO2016049565A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Compositions and methods for inhibition of ras |
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| US10017540B2 (en) | 2015-03-11 | 2018-07-10 | California Institute Of Technology | Cyclic peptide binder against oncogenic K-Ras |
| CA2981530A1 (en) | 2015-04-10 | 2016-10-13 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| EP3283462B1 (en) | 2015-04-15 | 2020-12-02 | Araxes Pharma LLC | Fused-tricyclic inhibitors of kras and methods of use thereof |
| US10421764B2 (en) | 2015-04-24 | 2019-09-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Mutant KRas inhibitors |
| WO2016179558A1 (en) | 2015-05-06 | 2016-11-10 | The Regents Of The University Of California | K-ras modulators |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| US20180273577A1 (en) | 2015-09-24 | 2018-09-27 | Ionis Pharmaceuticals, Inc. | Modulators of kras expression |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3356359B1 (en) | 2015-09-28 | 2021-10-20 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3364977A4 (en) | 2015-10-19 | 2019-09-04 | Araxes Pharma LLC | PROCESS FOR SCREENING INHIBITORS OF RAS |
| US10670605B2 (en) | 2015-10-22 | 2020-06-02 | The Scripps Research Institute | Cysteine reactive probes and uses thereof |
| WO2017080980A1 (en) | 2015-11-09 | 2017-05-18 | Astrazeneca Ab | Dihydropyrrolopyrazinone derivatives useful in the treatment of cancer |
| WO2017079864A1 (en) | 2015-11-12 | 2017-05-18 | Hangzhou Yier Biotech Co., Ltd. | Treatment of cancers related to chronically active ras |
| US10414757B2 (en) | 2015-11-16 | 2019-09-17 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
| US9988357B2 (en) | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| WO2017201161A1 (en) * | 2016-05-18 | 2017-11-23 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| EP3519402A1 (en) | 2016-09-29 | 2019-08-07 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10377743B2 (en) | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
| BR112019011035A2 (pt) | 2016-11-30 | 2019-10-15 | Bantam Pharmaceutical Llc | métodos de uso de compostos pirazol e pirazol substituído e para o tratamento de doenças hiperproliferativas |
| CN110603254B (zh) | 2016-11-30 | 2024-04-12 | 班塔姆制药有限责任公司 | 被取代的吡唑化合物以及使用其治疗过度增生性疾病的方法 |
| JP7191828B2 (ja) | 2016-12-15 | 2022-12-19 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | がん治療のための組成物および方法 |
| EP3878850A1 (en) | 2016-12-22 | 2021-09-15 | Boehringer Ingelheim International GmbH | Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors |
| CN110366550A (zh) | 2016-12-22 | 2019-10-22 | 美国安进公司 | 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物 |
| US10344026B2 (en) | 2017-01-18 | 2019-07-09 | Nantbio, Inc. | Compositions and methods of targeting mutant K-ras |
| US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
| WO2018140598A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused n-heterocyclic compounds and methods of use thereof |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| CN110382482A (zh) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | 稠合的杂-杂二环化合物及其使用方法 |
| US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| JOP20190186A1 (ar) | 2017-02-02 | 2019-08-01 | Astellas Pharma Inc | مركب كينازولين |
| JP2020517600A (ja) | 2017-04-20 | 2020-06-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｋ−Ｒａｓモジュレーター |
| AR112797A1 (es) | 2017-09-08 | 2019-12-11 | Amgen Inc | Inhibidores de kras g12c y métodos para utilizarlos |
| HUE061599T2 (hu) * | 2017-11-15 | 2023-07-28 | Mirati Therapeutics Inc | KRas G12C inhibotorok |
| TW201938561A (zh) | 2017-12-08 | 2019-10-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| TW201942115A (zh) | 2018-02-01 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物 |
| TW201942116A (zh) | 2018-02-09 | 2019-11-01 | 美商輝瑞股份有限公司 | 作為抗癌劑之四氫喹唑啉衍生物 |
-
2018
- 2018-11-14 HU HUE18879484A patent/HUE061599T2/hu unknown
- 2018-11-14 EP EP18879484.6A patent/EP3710439B1/en active Active
- 2018-11-14 UA UAA202003509A patent/UA125802C2/uk unknown
- 2018-11-14 BR BR112020009818-3A patent/BR112020009818A2/pt unknown
- 2018-11-14 SI SI201830912T patent/SI3710439T1/sl unknown
- 2018-11-14 RS RS20230345A patent/RS64182B1/sr unknown
- 2018-11-14 CA CA3082579A patent/CA3082579A1/en active Pending
- 2018-11-14 ES ES18879484T patent/ES2944547T3/es active Active
- 2018-11-14 KR KR1020207016494A patent/KR20200100632A/ko not_active Application Discontinuation
- 2018-11-14 WO PCT/US2018/061060 patent/WO2019099524A1/en unknown
- 2018-11-14 FI FIEP18879484.6T patent/FI3710439T3/fi active
- 2018-11-14 LT LTEPPCT/US2018/061060T patent/LT3710439T/lt unknown
- 2018-11-14 EA EA202091186A patent/EA202091186A1/ru unknown
- 2018-11-14 PT PT188794846T patent/PT3710439T/pt unknown
- 2018-11-14 US US16/191,190 patent/US10689377B2/en active Active
- 2018-11-14 MX MX2020005063A patent/MX2020005063A/es unknown
- 2018-11-14 CN CN201880086849.1A patent/CN111989321B/zh active Active
- 2018-11-14 AU AU2018369759A patent/AU2018369759B2/en active Active
- 2018-11-14 HR HRP20230377TT patent/HRP20230377T1/hr unknown
- 2018-11-14 DK DK18879484.6T patent/DK3710439T3/da active
- 2018-11-14 IL IL274601A patent/IL274601B2/en unknown
- 2018-11-14 SG SG11202004427TA patent/SG11202004427TA/en unknown
- 2018-11-14 PL PL18879484.6T patent/PL3710439T3/pl unknown
- 2018-11-14 JP JP2020526612A patent/JP7322019B2/ja active Active
- 2018-11-15 TW TW107140665A patent/TWI809005B/zh active
-
2019
- 2019-05-14 WO PCT/US2019/032249 patent/WO2020101736A1/en unknown
- 2019-05-14 JP JP2021526287A patent/JP7346565B2/ja active Active
- 2019-05-14 EP EP19886028.0A patent/EP3880208A4/en active Pending
-
2020
- 2020-05-04 ZA ZA2020/02105A patent/ZA202002105B/en unknown
- 2020-05-06 US US16/868,258 patent/US20200262837A1/en not_active Abandoned
- 2020-05-13 CL CL2020001271A patent/CL2020001271A1/es unknown
- 2020-05-13 PH PH12020550622A patent/PH12020550622A1/en unknown
- 2020-06-12 CO CONC2020/0007244A patent/CO2020007244A2/es unknown
-
2022
- 2022-10-21 US US18/048,834 patent/US20230373999A1/en active Pending
-
2023
- 2023-08-04 US US18/230,580 patent/US20240101553A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL274601A (en) | KRAS G12C inhibitors | |
| IL262867B (en) | kras g12c inhibitors | |
| EP4087573A4 (en) | KRAS G12C INHIBITORS | |
| ZA202202362B (en) | Kras g12d inhibitors | |
| IL304534A (en) | kras g12c inhibitors | |
| IL287223A (en) | kras g12c inhibitors and methods of using them | |
| IL283639A (en) | kif18a inhibitors | |
| EP3844151A4 (en) | KRAS G12C INHIBITORS | |
| EP3790551A4 (en) | KRAS G12C INHIBITORS | |
| ZA202104029B (en) | Rad51 inhibitors | |
| ZA201907136B (en) | Ip6k inhibitors | |
| IL276013A (en) | pi4kiiibeta inhibitors | |
| IL281514A (en) | O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors | |
| IL274550A (en) | Dopamine-B-hydroxylase inhibitors | |
| GB201812462D0 (en) | Inhibitors | |
| GB201721465D0 (en) | Inhibitors | |
| GB201720189D0 (en) | Dopamine-B-hydroxylase inhibitors | |
| GB201804439D0 (en) | Dopamin-b-hydroxylase inhibitors |