SE465223C5 - Moget rekombinant-humanleukocytinterferon och förfarande för dess framställning - Google Patents

Moget rekombinant-humanleukocytinterferon och förfarande för dess framställning

Info

Publication number
SE465223C5
SE465223C5 SE8104093A SE8104093A SE465223C5 SE 465223 C5 SE465223 C5 SE 465223C5 SE 8104093 A SE8104093 A SE 8104093A SE 8104093 A SE8104093 A SE 8104093A SE 465223 C5 SE465223 C5 SE 465223C5
Authority
SE
Sweden
Prior art keywords
preparation
recombinant human
human leukocyte
leukocyte interferon
mature recombinant
Prior art date
Application number
SE8104093A
Other languages
English (en)
Swedish (sv)
Other versions
SE465223B (sv
Inventor
D V N Goeddel
S Pestka
Original Assignee
D V N *Goeddel
S *Pestka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE465223(C5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by D V N *Goeddel, S *Pestka filed Critical D V N *Goeddel
Publication of SE465223B publication Critical patent/SE465223B/sv
Publication of SE465223C5 publication Critical patent/SE465223C5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SE8104093A 1980-07-01 1981-06-30 Moget rekombinant-humanleukocytinterferon och förfarande för dess framställning SE465223C5 (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (2)

Publication Number Publication Date
SE465223B SE465223B (sv) 1991-08-12
SE465223C5 true SE465223C5 (sv) 1998-02-10

Family

ID=27496622

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8104093A SE465223C5 (sv) 1980-07-01 1981-06-30 Moget rekombinant-humanleukocytinterferon och förfarande för dess framställning
SE8104093D SE8104093L (sv) 1980-07-01 1981-06-30 Interferoner och forfarande for framstellning derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8104093D SE8104093L (sv) 1980-07-01 1981-06-30 Interferoner och forfarande for framstellning derav

Country Status (36)

Country Link
EP (2) EP0211148B2 (da)
AR (1) AR242833A1 (da)
AT (3) ATE79901T1 (da)
AU (1) AU552004B2 (da)
BG (1) BG42189A3 (da)
BR (1) BR8104189A (da)
CH (2) CH657141A5 (da)
CS (1) CS273152B2 (da)
DD (3) DD202307A5 (da)
DE (3) DE3177288T3 (da)
DK (1) DK173543B1 (da)
DZ (1) DZ312A1 (da)
ES (1) ES8207514A1 (da)
FI (1) FI82712C (da)
FR (1) FR2486098B1 (da)
GB (1) GB2079291B (da)
GE (1) GEP19960519B (da)
GR (1) GR75714B (da)
HK (1) HK49285A (da)
HU (1) HU196457B (da)
IE (1) IE49255B1 (da)
IT (1) IT1137272B (da)
KE (1) KE3534A (da)
LU (1) LU83461A1 (da)
MC (1) MC1396A1 (da)
MY (1) MY8700711A (da)
NL (1) NL8103151A (da)
NO (1) NO159392C (da)
NZ (1) NZ197572A (da)
PH (1) PH18036A (da)
PL (3) PL148276B1 (da)
PT (1) PT73289B (da)
RO (1) RO87590A (da)
SE (2) SE465223C5 (da)
SU (1) SU1414319A3 (da)
YU (1) YU47700B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
FI88175C (fi) 1980-04-03 1993-04-13 Biogen Inc Rekombinant-dna-molekyler och foerfaranden foer framstaellning av polypeptider liknande humant -interferon
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
GB2150573B (en) * 1983-02-24 1987-11-11 Inst Organicheskogo Sinteza Ak Leukocytic human interferon n and method to obtain it in bacterial cells
EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (en) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Mutual separation of proteins
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
US6007805A (en) * 1994-03-07 1999-12-28 Imperial College Of Science And Technology Use of interferon subtype alpha-8 (IFN-α8) to treat viral infections of the liver
DK0679718T3 (da) * 1994-04-09 2001-10-22 Hoffmann La Roche Fremgangsmåde til fremstilling af alfa-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
CA2311681A1 (en) 1997-12-08 1999-06-17 Genentech, Inc. Human interferon-epsilon: a type i interferon
ES2361190T3 (es) 1998-08-06 2011-06-14 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso.
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
EP2292652A2 (en) * 2000-11-03 2011-03-09 Pestka Biomedical Laboratories, Inc. Interferons uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
CZ2007695A3 (cs) 2005-04-11 2008-02-27 Savient Pharmaceuticals, Inc. Variantní formy urátoxidázy a jejich použití
CA2711375C (en) * 2008-01-18 2019-04-16 F. Hoffmann-La Roche Ag Purification of not-glycosylated polypeptides
SG176897A1 (en) 2009-06-25 2012-01-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (da) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
ES8308534A1 (es) * 1980-01-08 1983-09-01 Biogen Nv Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos.
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Also Published As

Publication number Publication date
NL8103151A (nl) 1982-02-01
PH18036A (en) 1985-03-06
IE49255B1 (en) 1985-09-04
HK49285A (en) 1985-07-05
DD210305A5 (de) 1984-06-06
AT380272B (de) 1986-05-12
NO159392B (no) 1988-09-12
EP0211148A1 (en) 1987-02-25
FR2486098A1 (fr) 1982-01-08
DE3177288T3 (de) 2000-03-16
GEP19960519B (en) 1996-07-02
DE3176448D1 (en) 1987-10-22
KE3534A (en) 1985-06-07
NO812247L (no) 1982-01-04
FI82712C (fi) 1991-04-10
BR8104189A (pt) 1982-03-16
GR75714B (da) 1984-08-02
DD210304A5 (de) 1984-06-06
AU7246281A (en) 1982-01-07
DD202307A5 (de) 1983-09-07
CH651308A5 (de) 1985-09-13
PL148276B1 (en) 1989-09-30
EP0043980A3 (en) 1982-09-15
DK291081A (da) 1982-01-02
CS503781A2 (en) 1990-07-12
ATA290981A (de) 1985-09-15
CH657141A5 (de) 1986-08-15
BG42189A3 (en) 1987-10-15
NO159392C (no) 1988-12-21
IE811463L (en) 1982-01-01
ES503528A0 (es) 1982-10-01
DE3177288T2 (de) 1992-12-10
PT73289B (en) 1983-05-11
HU196457B (en) 1988-11-28
EP0043980A2 (en) 1982-01-20
EP0211148B2 (en) 1999-11-24
SU1414319A3 (ru) 1988-07-30
PL148261B1 (en) 1989-09-30
AU552004B2 (en) 1986-05-22
ATE79901T1 (de) 1992-09-15
IT8122682A0 (it) 1981-07-01
PT73289A (en) 1981-07-01
EP0211148B1 (en) 1992-08-26
RO87590A (ro) 1986-07-30
PL231940A1 (en) 1983-07-18
MY8700711A (en) 1987-12-31
NZ197572A (en) 1985-07-31
EP0043980B1 (en) 1987-09-16
AR242833A1 (es) 1993-05-31
YU47700B (sh) 1996-01-08
GB2079291A (en) 1982-01-20
GB2079291B (en) 1984-06-13
DE3125706C2 (de) 1995-05-24
PL148260B1 (en) 1989-09-30
LU83461A1 (de) 1983-04-06
CS273152B2 (en) 1991-03-12
FI82712B (fi) 1990-12-31
DE3125706A1 (de) 1982-04-15
SE465223B (sv) 1991-08-12
DE3177288D1 (de) 1992-10-01
SE8104093L (sv) 1982-01-02
ATE29727T1 (de) 1987-10-15
DZ312A1 (fr) 2004-09-13
MC1396A1 (fr) 1982-04-27
FI812067L (fi) 1982-01-02
IT1137272B (it) 1986-09-03
DK173543B1 (da) 2001-02-05
FR2486098B1 (fr) 1985-12-27
YU162281A (en) 1984-02-29
ES8207514A1 (es) 1982-10-01

Similar Documents

Publication Publication Date Title
SE465223C5 (sv) Moget rekombinant-humanleukocytinterferon och förfarande för dess framställning
GEP20074163B (en) Microbial production of mature human leukocyte interferons
FI833525A0 (fi) Humant immun-interferonprotein och dess framstaellning
GB2037296B (en) Purified proteins expecially interferon and process therefor
AU582110B2 (en) Microboal production of human fibroblast interferon
ZW6283A1 (en) Expression processing and secretion of heterologous proteins by yeast
DE2962359D1 (en) Method of purification of human fibroblast interferon
DK168190A (da) Interferonpraeparat til nasal anvendelse
MW783A1 (en) Homogeneous human immune interferon and process therefor
PH18479A (en) Homogeneous human fibrolast interferon
FI885692A (fi) Karboksimetyylisulfoetyyliselluloosa ja menetelmä sen valmistamiseksi
GB2068970B (en) Recombinant dna technique for the preparation of a protein resembling human interferon
ZA814375B (en) Interferons and process for their preparation
FI906013A0 (fi) Parkettirakenne ja menetelmä sen valmistamiseksi
AU545758B2 (en) Recombinant dna technique for the preparation of a protein resembling human interferon
GB2111527B (en) Monoclonal antibodies to human leucocyte interferon
JPS57158796A (en) Hybrid human leukocyte interferon
JPS57197224A (en) Human leucocyte interferon antibody
JPS5724400A (en) Recombination dna technique for human interferon analogue protein preparation
IE810121L (en) Protein resembling interferon
LV5676A3 (lv) Panemiens leikocitara interferona iegusanai
SE8402999A0 (sv) Spruta och förfarande för dess användning
PH25922A (en) Recombinant human immune interferon
IE800645L (en) Preparation of interferon
ZA817776B (en) Hybrid human leukocyte interferons

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8104093-3