SE429652B - 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester - Google Patents

2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester

Info

Publication number
SE429652B
SE429652B SE7807404A SE7807404A SE429652B SE 429652 B SE429652 B SE 429652B SE 7807404 A SE7807404 A SE 7807404A SE 7807404 A SE7807404 A SE 7807404A SE 429652 B SE429652 B SE 429652B
Authority
SE
Sweden
Prior art keywords
sub
compound
dimethyl
formula
dihydropyridine
Prior art date
Application number
SE7807404A
Other languages
English (en)
Swedish (sv)
Other versions
SE7807404L (sv
Inventor
P B Berntsson
S A I Carlsson
J O Gaarder
B R Ljung
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20335348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE429652(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Haessle Ab filed Critical Haessle Ab
Priority to SE7807404A priority Critical patent/SE429652B/sv
Priority to ZA792804A priority patent/ZA792804B/xx
Priority to DE7979850057T priority patent/DE2963150D1/de
Priority to EP79850057A priority patent/EP0007293B1/en
Priority to AT79850057T priority patent/ATE1237T1/de
Priority to CY1299A priority patent/CY1299A/xx
Priority to LU88666C priority patent/LU88666I2/fr
Priority to US06/050,083 priority patent/US4264611A/en
Priority to AU48316/79A priority patent/AU529116B2/en
Priority to NO792112A priority patent/NO151965C/no
Priority to NZ190809A priority patent/NZ190809A/xx
Priority to CA000330762A priority patent/CA1117530A/en
Priority to DD79213967A priority patent/DD144667A5/de
Priority to HU79HE788A priority patent/HU178568B/hu
Priority to DK275079A priority patent/DK148978C/da
Priority to FI792058A priority patent/FI70573C/fi
Priority to SU792781817A priority patent/SU856380A3/ru
Priority to CS829181A priority patent/CS241038B2/cs
Priority to CS794585A priority patent/CS241021B2/cs
Priority to JP8206279A priority patent/JPS559083A/ja
Priority to IE1217/79A priority patent/IE48650B1/en
Publication of SE7807404L publication Critical patent/SE7807404L/xx
Priority to SU802921246A priority patent/SU915799A3/ru
Priority to SE8303617A priority patent/SE442298B/sv
Publication of SE429652B publication Critical patent/SE429652B/sv
Priority to SG260/85A priority patent/SG26085G/en
Priority to HK605/85A priority patent/HK60585A/xx
Priority to NL930054C priority patent/NL930054I2/nl
Priority to LU88306C priority patent/LU88306I2/fr
Priority to LV930684A priority patent/LV5472A3/xx
Priority to LV930698A priority patent/LV5473A3/xx
Priority to LTRP942A priority patent/LT2248B/xx
Priority to LTRP941A priority patent/LT2247B/xx
Priority to BG098595A priority patent/BG61420B2/bg
Priority to NL940012C priority patent/NL940012I1/nl
Priority to NO1994026C priority patent/NO1994026I1/no
Priority to NO1996006C priority patent/NO1996006I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
SE7807404A 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester SE429652B (sv)

Priority Applications (35)

Application Number Priority Date Filing Date Title
SE7807404A SE429652B (sv) 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
ZA792804A ZA792804B (en) 1978-06-30 1979-06-06 New 2,6-dimethyl-4-2,3-disubstituted phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-asymmetric disters
LU88666C LU88666I2 (fr) 1978-06-30 1979-06-12 2,6-Diméthyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylique acide,3-méthyl ester 5-ethylester à activité hypotensive son procédé de préparation et compositions pharmaceutiques le contenant
AT79850057T ATE1237T1 (de) 1978-06-30 1979-06-12 Hypotensiv wirksamer 2,6dimethyl-4-(2,3-dichlorop henyl)-1,4-dihydropyridin
EP79850057A EP0007293B1 (en) 1978-06-30 1979-06-12 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties, process for its preparation and pharmaceutical preparations containing it
DE7979850057T DE2963150D1 (en) 1978-06-30 1979-06-12 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties, process for its preparation and pharmaceutical preparations containing it
CY1299A CY1299A (en) 1978-06-30 1979-06-12 New 2,6-dimethyl-4,2,3-disubstituted phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties,as well as process for their preparation and pharmaceutical preparation containing same
US06/050,083 US4264611A (en) 1978-06-30 1979-06-19 2,6-Dimethyl-4-2,3-disubstituted phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties, as well as method for treating hypertensive conditions and pharmaceutical preparations containing same
AU48316/79A AU529116B2 (en) 1978-06-30 1979-06-22 4 phenyl-1,4-dihydropyridine derivatives
NO792112A NO151965C (no) 1978-06-30 1979-06-22 Analogifremgangsmaate til fremstilling av terapeutisk aktiv 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboksylsyre-3-metylester-5-etylester
NZ190809A NZ190809A (en) 1978-06-30 1979-06-25 2,6-dimethyl-4-(2,3-disubstituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having antihypertensive properties
CA000330762A CA1117530A (en) 1978-06-30 1979-06-28 2,6-dimethyl-4-2,3-disubstituted phenyl-1,4- dihydropyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties as well as process for their preparationand pharmaceutical preparation containing same
DD79213967A DD144667A5 (de) 1978-06-30 1979-06-28 Verfahren zur herstellung von 2,6-dimethyl-4-phenyl-1,4-dihydropyridin-3,5-dicarbonsaeurediestern
CS794585A CS241021B2 (en) 1978-06-30 1979-06-29 Method of 2,6-dimethyl-4-(i8o-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxyl acid's 3-methyl-5-ethylester production
SU792781817A SU856380A3 (ru) 1978-06-30 1979-06-29 Способ получени производных пиридина /его варианты/
DK275079A DK148978C (da) 1978-06-30 1979-06-29 Analogifremgangsmaade til fremstilling af 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyre-3-metylester-5-aetylester
FI792058A FI70573C (fi) 1978-06-30 1979-06-29 Analogifoerfarande foer framstaellning av terapeutiskt aktiv 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydro- pyridin-3,5-dikarboxylsyra-3-metylester-5-etylester
HU79HE788A HU178568B (en) 1978-06-30 1979-06-29 Process for producing new 3,5-asymmetric diesters of 2,6-dimehyl-4-bracket-2,3-disubstituted-phenyl-bracket closed-1,4-dihydro-pyridine-3,5-dicarboxylic acid
CS829181A CS241038B2 (cs) 1978-06-30 1979-06-29 Způsob výroby 3-methyl-5-ethylesteru kyseliny 2,6-dimethyl-4-(2,3-dichlorfenyl)-l,4-dihydropyridin-3,S- -dikarboxylové
JP8206279A JPS559083A (en) 1978-06-30 1979-06-30 Novel 2*66dimethyll44*2*33disubstituted phenyl**1*44dihydropyridinee3*55dicarboxylic acidd3*55asymmetric diester and its manufacture
IE1217/79A IE48650B1 (en) 1978-06-30 1979-08-08 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties,process for its preparation and pharmaceutical preparations containing it
SU802921246A SU915799A3 (en) 1978-06-30 1980-05-15 Process for producing pyridine derivatives (its modifications)
SE8303617A SE442298B (sv) 1978-06-30 1983-06-23 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyra-3-metylester-5-etylester i optisk aktiv form
SG260/85A SG26085G (en) 1978-06-30 1985-04-06 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties,process for its preparation and pharmaceutical preparations containing it
HK605/85A HK60585A (en) 1978-06-30 1985-08-15 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-methyl ester-5-ethyl ester having hypotensive properties,process for its preparation and pharmaceutical preparations containing it
NL930054C NL930054I2 (nl) 1978-06-30 1993-06-10 Nieuwe 2,6-dimethyl-4-(2,3-dichlorofenyl)-1,4-dihydropyridine-3,5-dicarbonzuur-3-methylester-5-ethylester met hypotensieve eigenschappen alsmede werkwijze voor de bereiding ervan en farmaceutische preparaten, die deze bevatten.
LU88306C LU88306I2 (fr) 1978-06-30 1993-06-16 Felodipine (Plendil)
LV930698A LV5473A3 (lv) 1978-06-30 1993-06-28 Panemiens piridina atvasinajumu iegusanai
LV930684A LV5472A3 (lv) 1978-06-30 1993-06-28 Panemiens piridina atvasinajumu iegusanai
LTRP942A LT2248B (lt) 1978-06-30 1993-09-06 Piridino dariniu gavimo budas /jo variantai/
LTRP941A LT2247B (lt) 1978-06-30 1993-09-06 Piridino dariniu gavimo budas /jo variantai/
BG098595A BG61420B2 (bg) 1978-06-30 1994-02-25 3-метилов естер 5-етилов естер на 2,6-диметил-4-(2,3- дихлорофенил)-1,4-дихидропиридин-3,5-дикарбоксиловата киселина,притежаващ хипотензивни свойства,метод за неговото получаване и фармацевтични пре парати, които ги съдържат
NL940012C NL940012I1 (nl) 1978-06-30 1994-06-29 Nieuwe 2,6-dimethyl-4-(2,3-dichlorofenyl)-1,4-dihydropyridine-3,5-dicarbonzuur-3-methylester-5-ethylester met hypotensieve eigenschappen alsmede werkwijze voor de bereiding ervan en farmaceutische preparaten die deze bevatten
NO1994026C NO1994026I1 (no) 1978-06-30 1994-12-21 Pledil/Felodipin/ 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboksylsyre-3-metylester-5-etylester
NO1996006C NO1996006I1 (no) 1978-06-30 1996-06-24 Felodipine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7807404A SE429652B (sv) 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester

Publications (2)

Publication Number Publication Date
SE7807404L SE7807404L (sv) 1979-12-31
SE429652B true SE429652B (sv) 1983-09-19

Family

ID=20335348

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7807404A SE429652B (sv) 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester

Country Status (24)

Country Link
US (1) US4264611A (xx)
EP (1) EP0007293B1 (xx)
JP (1) JPS559083A (xx)
AT (1) ATE1237T1 (xx)
AU (1) AU529116B2 (xx)
BG (1) BG61420B2 (xx)
CA (1) CA1117530A (xx)
CS (1) CS241021B2 (xx)
CY (1) CY1299A (xx)
DD (1) DD144667A5 (xx)
DE (1) DE2963150D1 (xx)
DK (1) DK148978C (xx)
FI (1) FI70573C (xx)
HK (1) HK60585A (xx)
HU (1) HU178568B (xx)
IE (1) IE48650B1 (xx)
LU (2) LU88666I2 (xx)
NL (2) NL930054I2 (xx)
NO (3) NO151965C (xx)
NZ (1) NZ190809A (xx)
SE (1) SE429652B (xx)
SG (1) SG26085G (xx)
SU (2) SU856380A3 (xx)
ZA (1) ZA792804B (xx)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
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DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
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DE3447170A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
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JPS6121550B2 (xx) 1986-05-27
AU529116B2 (en) 1983-05-26
SG26085G (en) 1986-01-24
ZA792804B (en) 1980-06-25
NO1994026I1 (no) 1994-12-21
EP0007293B1 (en) 1982-06-23
FI70573B (fi) 1986-06-06
AU4831679A (en) 1980-02-07
DD144667A5 (de) 1980-10-29
FI70573C (fi) 1986-09-24
NL930054I1 (nl) 1993-09-01
HK60585A (en) 1985-08-23
ATE1237T1 (de) 1982-07-15
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SE7807404L (sv) 1979-12-31
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SU856380A3 (ru) 1981-08-15
LU88666I2 (fr) 1996-02-01
US4264611B1 (xx) 1984-07-17
US4264611A (en) 1981-04-28
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EP0007293A1 (en) 1980-01-23
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CY1299A (en) 1985-10-18
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