LU88306I2 - Felodipine (Plendil) - Google Patents

Felodipine (Plendil)

Info

Publication number
LU88306I2
LU88306I2 LU88306C LU88306C LU88306I2 LU 88306 I2 LU88306 I2 LU 88306I2 LU 88306 C LU88306 C LU 88306C LU 88306 C LU88306 C LU 88306C LU 88306 I2 LU88306 I2 LU 88306I2
Authority
LU
Luxembourg
Prior art keywords
sub
sup
och
group
compounds
Prior art date
Application number
LU88306C
Other languages
English (en)
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20335348&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU88306(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of LU88306I2 publication Critical patent/LU88306I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU88306C 1978-06-30 1993-06-16 Felodipine (Plendil) LU88306I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7807404A SE429652B (sv) 1978-06-30 1978-06-30 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester

Publications (1)

Publication Number Publication Date
LU88306I2 true LU88306I2 (fr) 1994-05-04

Family

ID=20335348

Family Applications (2)

Application Number Title Priority Date Filing Date
LU88666C LU88666I2 (fr) 1978-06-30 1979-06-12 2,6-Diméthyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylique acide,3-méthyl ester 5-ethylester à activité hypotensive son procédé de préparation et compositions pharmaceutiques le contenant
LU88306C LU88306I2 (fr) 1978-06-30 1993-06-16 Felodipine (Plendil)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU88666C LU88666I2 (fr) 1978-06-30 1979-06-12 2,6-Diméthyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylique acide,3-méthyl ester 5-ethylester à activité hypotensive son procédé de préparation et compositions pharmaceutiques le contenant

Country Status (24)

Country Link
US (1) US4264611A (fr)
EP (1) EP0007293B1 (fr)
JP (1) JPS559083A (fr)
AT (1) ATE1237T1 (fr)
AU (1) AU529116B2 (fr)
BG (1) BG61420B2 (fr)
CA (1) CA1117530A (fr)
CS (1) CS241021B2 (fr)
CY (1) CY1299A (fr)
DD (1) DD144667A5 (fr)
DE (1) DE2963150D1 (fr)
DK (1) DK148978C (fr)
FI (1) FI70573C (fr)
HK (1) HK60585A (fr)
HU (1) HU178568B (fr)
IE (1) IE48650B1 (fr)
LU (2) LU88666I2 (fr)
NL (2) NL930054I2 (fr)
NO (3) NO151965C (fr)
NZ (1) NZ190809A (fr)
SE (1) SE429652B (fr)
SG (1) SG26085G (fr)
SU (2) SU856380A3 (fr)
ZA (1) ZA792804B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
AU561213B2 (en) * 1983-06-02 1987-04-30 Teijin Limited 1, 4-dihydropyridine derivative
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
FI852359L (fi) * 1984-06-27 1985-12-28 Hoffmann La Roche Dihydropyridinderivat.
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
DE3447170A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
NZ220022A (en) * 1986-04-22 1990-04-26 Byk Gulden Lomberg Chem Fab 1,4-dihydropyridine derivatives and pharmaceutical compositions
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
JPS63255071A (ja) * 1987-04-14 1988-10-21 株式会社　岡田吾作郎商店 磁石内蔵健康棒
AT391269B (de) * 1988-12-30 1990-09-10 Burghart Kurt Pharmazeutische zubereitung
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
JPH07501551A (ja) * 1991-12-02 1995-02-16 セプラコア，インコーポレーテッド 光学的に純粋なｓ（−）フェロジピンを用いる，高血圧，狭心症および他の疾患を治療するための方法および組成物
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
ATE234286T1 (de) 1993-12-10 2003-03-15 Bayer Ag Phenyl-substituierte 1,4-dihydropyridine mit cerebraler aktivität
DE4430639A1 (de) * 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
SE9600086D0 (sv) * 1996-01-10 1996-01-10 Astra Ab New manufacturing process
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
AU8430098A (en) * 1998-07-23 2000-02-14 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6569456B2 (en) 2000-01-13 2003-05-27 Osmotica Corp. Osmotic device containing diltiazem and an ACE inhibitor or diuretic
CN100450483C (zh) * 2000-04-11 2009-01-14 三共株式会社 含有钙阻滞剂的稳定药物组合物
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
EP2266590A3 (fr) 2002-02-22 2011-04-20 Shire LLC Système d'administration de substances actives et méthodes de protection et d'administration de substances actives
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
UA82698C2 (uk) * 2003-05-30 2008-05-12 Ранбакси Лабораториз Лимитед Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20060147520A1 (en) * 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2111863B1 (fr) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Combinaison du fasudil et bosentan pour le traitement de l'hypertension artérielle pulmonaire
EP2351569B1 (fr) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire
WO2007054896A1 (fr) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Procede de preparation de sel hemicalcique d’acide (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoique
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
AR063469A1 (es) * 2006-07-14 2009-01-28 Ranbaxy Lab Ltd Formas polimorficas de ácido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3, 5-dihidroxi-heptanoico, sal hemicalcio, metodos de preparacion de las mismas, una composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8748648B2 (en) * 2007-09-06 2014-06-10 Nektar Therapeutics Oligomer-calcium channel blocker conjugates
US20090118258A1 (en) * 2007-11-07 2009-05-07 Bruce Damiano Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
WO2012123966A1 (fr) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Procédé pour la préparation de 1,4-dihydropyridines substituées en position 4
CN102827068A (zh) * 2011-06-17 2012-12-19 张锐豪 一种4-(2, 3-二氯苯基)-2, 6-二甲基-1, 4-二氢-5-甲氧基羰基-3-吡啶羧酸的制备方法
EP2747757A1 (fr) 2011-08-26 2014-07-02 Wockhardt Limited Procédés de traitement de troubles cardiovasculaires
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
CN104177286A (zh) * 2014-08-11 2014-12-03 广东东阳光药业有限公司 一种地平类药物的制备方法
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
KR101824982B1 (ko) 2015-10-07 2018-02-02 엘지전자 주식회사 차량 및 그 제어방법
CN107952483B (zh) * 2017-12-18 2020-07-28 万华化学集团股份有限公司 一种催化剂，使用该催化剂的反应器，以及一种制备β-苯乙醇的方法
CN108840819B (zh) * 2018-04-02 2021-07-30 常州瑞明药业有限公司 一种非洛地平的制备方法
WO2019241519A1 (fr) 2018-06-14 2019-12-19 Astrazeneca Uk Limited Méthodes de diminution de la tension artérielle avec une composition pharmaceutique de blocage de canal calcique de type dihydropyridine
EP3911648A4 (fr) 2019-01-18 2022-10-26 Astrazeneca AB Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof

Also Published As

Publication number Publication date
NZ190809A (en) 1982-03-09
LU88666I2 (fr) 1996-02-01
SU915799A3 (en) 1982-03-23
NL930054I1 (nl) 1993-09-01
HU178568B (en) 1982-05-28
CS241021B2 (en) 1986-03-13
NO1994026I1 (no) 1994-12-21
EP0007293B1 (fr) 1982-06-23
IE791217L (en) 1979-12-30
SE429652B (sv) 1983-09-19
NO1996006I1 (no) 1996-06-24
DD144667A5 (de) 1980-10-29
AU529116B2 (en) 1983-05-26
US4264611B1 (fr) 1984-07-17
EP0007293A1 (fr) 1980-01-23
CY1299A (en) 1985-10-18
JPS6121550B2 (fr) 1986-05-27
IE48650B1 (en) 1985-04-03
DK148978C (da) 1986-08-18
NO151965B (no) 1985-04-01
NO792112L (no) 1980-01-03
FI70573C (fi) 1986-09-24
BG61420B2 (bg) 1997-07-31
NL940012I1 (nl) 1994-08-01
ZA792804B (en) 1980-06-25
NL930054I2 (nl) 1994-02-16
SE7807404L (sv) 1979-12-31
NO151965C (no) 1985-07-10
DE2963150D1 (en) 1982-08-12
HK60585A (en) 1985-08-23
JPS559083A (en) 1980-01-22
US4264611A (en) 1981-04-28
AU4831679A (en) 1980-02-07
DK275079A (da) 1979-12-31
FI792058A (fi) 1979-12-31
FI70573B (fi) 1986-06-06
ATE1237T1 (de) 1982-07-15
CA1117530A (fr) 1982-02-02
SU856380A3 (ru) 1981-08-15
SG26085G (en) 1986-01-24
DK148978B (da) 1985-12-09

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