RU96112150A - Рекомбинантный аденовирусный вектор и способы его применения - Google Patents
Рекомбинантный аденовирусный вектор и способы его примененияInfo
- Publication number
- RU96112150A RU96112150A RU96112150/14A RU96112150A RU96112150A RU 96112150 A RU96112150 A RU 96112150A RU 96112150/14 A RU96112150/14 A RU 96112150/14A RU 96112150 A RU96112150 A RU 96112150A RU 96112150 A RU96112150 A RU 96112150A
- Authority
- RU
- Russia
- Prior art keywords
- protein
- pharmaceutical composition
- composition according
- tumor
- gene
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 101710012182 At1g14910 Proteins 0.000 claims 8
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 7
- 239000003937 drug carrier Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 206010010144 Completed suicide Diseases 0.000 claims 3
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 3
- 102000006601 Thymidine Kinase Human genes 0.000 claims 3
- 108020004440 Thymidine Kinase Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 230000002142 suicide Effects 0.000 claims 3
- 210000004881 tumor cells Anatomy 0.000 claims 3
- IQFYYKKMVGJFEH-XLPZGREQSA-N DEOXYTHYMIDINE Chemical class O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 230000003612 virological Effects 0.000 claims 2
- GOILPRCCOREWQE-UHFFFAOYSA-N 6-methoxy-7H-purine Chemical compound COC1=NC=NC2=C1NC=N2 GOILPRCCOREWQE-UHFFFAOYSA-N 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N Ganciclovir Chemical group O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 1
- 229960002963 Ganciclovir Drugs 0.000 claims 1
- 208000005017 Glioblastoma Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 1
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000587 Small Cell Lung Carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 claims 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasm Diseases 0.000 claims 1
- 208000008383 Wilms Tumor Diseases 0.000 claims 1
- 239000002215 arabinonucleoside Substances 0.000 claims 1
- 201000009030 carcinoma Diseases 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 201000010989 colorectal carcinoma Diseases 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000003463 hyperproliferative Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000001539 ovarian carcinoma Diseases 0.000 claims 1
- 230000001402 polyadenylating Effects 0.000 claims 1
- 230000003307 reticuloendothelial Effects 0.000 claims 1
- 201000000582 retinoblastoma Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 230000001131 transforming Effects 0.000 claims 1
- 239000000225 tumor suppressor protein Substances 0.000 claims 1
Claims (22)
1. Фармацевтическая композиция, содержащая рекомбинантный аденовирусный вектор экспрессии, который имеет частичную или полную делецию ДНК, кодирующей белок IX, и содержит ген, кодирующий чужеродный белок.
2. Фармацевтическая композиция по п.1, отличающаяся тем, что делеция последовательности гена белка IX расположена от точки, отстоящей на 3500 пар оснований от 5' - конца вирусной последовательности, до точки, отстоящей на 4000 пар оснований от 5' - конца вирусной последовательности.
3. Фармацевтическая композиция по п.2, отличающаяся тем, что аденовирусный вектор содержит делецию несущественной последовательности ДНК ранней области 3 и/или ранней области 4 в последовательности аденовируса.
4. Фармацевтическая композиция по п.2, отличающаяся тем, что аденовирусный вектор содержит делецию аденовирусных последовательностей ДНК, обозначаемых E1a и E1b.
5. Фармацевтическая композиция по п.2, отличающаяся тем, что аденовирусный вектор содержит делецию ранней области 3 и/или 4 и аденовирусных последовательностей ДНК, обозначаемых E1a и E1b.
6. Фармацевтическая композиция по п. 4 или 5, отличающаяся тем, что аденовирусный вектор содержит делецию размером до 40 нуклеотидов, расположенную в сторону 3'-конца от делеций E1a и E1b и делеции гена белка IX, а также содержит чужеродную молекулу ДНК, кодирующую сигнал полиаденилирования.
7. Фармацевтическая композиция по пп. 1 - 6, отличающаяся тем, что аденовирус относится к группе C и выбран из серотипов 1, 2, 5 или 6.
8. Фармацевтическая композиция по п.1, отличающаяся тем, что ген, кодирующий чужеродный белок, представляет собой молекулу ДНК размером до 2,6 килобаз.
9. Фармацевтическая композиция по п.1, отличающаяся тем, что ген, кодирующий чужеродный белок, представляет собой молекулу ДНК размером до 4,5 килобаз.
10. Фармацевтическая композиция по п.1, отличающаяся тем, что ген кодирует чужеродный функциональный белок или его биологически активный фрагмент.
11. Фармацевтическая композиция по п.10, отличающаяся тем, что ген кодирует чужеродный функциональный белок супрессии опухолей или его биологически активный фрагмент.
12. Фармацевтическая композиция по п.1, отличающаяся тем, что ген кодирует суицидный белок или его функциональный эквивалент.
13. Применение рекомбинантного аденовирусного вектора экспрессии, содержащего частичную или полную делецию ДНК белка IX и ген, кодирующий чужеродный белок, и одного или более фармацевтически приемлемых носителей для генной терапии.
14. Применение рекомбинантного аденовирусного вектора экспрессии, содержащего частичную или полную делецию ДНК белка IX и ген, кодирующий чужеродный белок, и одного или более фармацевтически приемлемых носителей для трансформации гиперпролиферативных клеток млекопитающих.
15. Применение рекомбинантного аденовирусного вектора экспрессии, содержащего частичную или полную делецию ДНК белка IX и ген, кодирующий функциональный чужеродный белок, и одного или более фармацевтически приемлемых носителей для терапии рака.
16. Применение по п.15, отличающееся тем, что кодируемый геном функциональный чужеродный белок представляет собой белок супрессии опухолей, а раковое заболевание ассоциируется с потерей эндогенного белка супрессии опухолей дикого типа.
17. Применение по п.16, отличающееся тем, что опухоль представляет собой немелкоклеточный рак легких, мелкоклеточный рак легких, гепатокарциному, меланому, ретинобластому, рак молочной железы, колоректальную карциному, лейкоз, лимфому, цервикальную карциному, опухоль мозга, саркому, рак простаты, опухоль мочевого пузыря, опухоль ретикулоэндотелиальных тканей, опухоль Вилма, астроцитому, глиобластому, нейробластому, карциному яичников, остеосаркому, рак почки.
18. Применение рекомбинантного аденовирусного вектора экспрессии, содержащего частичную или полную делецию ДНК белка IX и ген, кодирующий суицидный белок или его функциональный эквивалент, и одного или более фармацевтически приемлемых носителей для ингибирования пролиферации опухоли у животных.
19. Применение рекомбинантного аденовирусного вектора экспрессии, содержащего частичную или полную делецию ДНК белка IX и ген, кодирующий суицидный белок или его функциональный эквивалент, эффективного количества метаболита тимидинкиназы или его функционального эквивалента и одного или более фармацевтически приемлемых носителей для уменьшения пролиферации опухолевых клеток.
20. Применение по п.19, отличающееся тем, что метаболит тимидинкиназы представляет собой ганцикловир или 6-метоксипурин арабинонуклеозид или их функциональный эквивалент.
21. Применение по п.19, отличающееся тем, что опухолевые клетки представляют собой гепатоцеллюлярную карциному.
22. Набор для уменьшения пролиферации опухолевых клеток, содержащий компоненты фармацевтической композиции по п.12, метаболит тимидинкиназы или его функциональный эквивалент, фармацевтические носители.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14266993A | 1993-10-25 | 1993-10-25 | |
US142,669 | 1993-10-25 | ||
US24600694A | 1994-05-19 | 1994-05-19 | |
US246,006 | 1994-05-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96112150A true RU96112150A (ru) | 1998-10-27 |
RU2162342C2 RU2162342C2 (ru) | 2001-01-27 |
Family
ID=26840311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96112150/14A RU2162342C2 (ru) | 1993-10-25 | 1994-10-25 | Рекомбинантный аденовирусный вектор и способы его применения |
Country Status (21)
Country | Link |
---|---|
US (5) | US20080182807A1 (ru) |
EP (3) | EP2113569A1 (ru) |
JP (1) | JP3875990B2 (ru) |
CN (1) | CN1263864C (ru) |
AT (2) | ATE314482T1 (ru) |
AU (1) | AU687117B2 (ru) |
BR (1) | BR9407956A (ru) |
CA (1) | CA2173975C (ru) |
CZ (1) | CZ291372B6 (ru) |
DE (2) | DE69435223D1 (ru) |
DK (1) | DK0797676T3 (ru) |
ES (2) | ES2256842T4 (ru) |
FI (1) | FI961755A (ru) |
HU (1) | HU223733B1 (ru) |
NO (1) | NO961639L (ru) |
NZ (1) | NZ275956A (ru) |
PL (1) | PL186073B1 (ru) |
PT (1) | PT797676E (ru) |
RU (1) | RU2162342C2 (ru) |
SK (1) | SK283703B6 (ru) |
WO (1) | WO1995011984A2 (ru) |
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