BR112022007749A2 - Construto de tgf-b, mascarado, complexo de tgf-b, heterodímero do complexo de tgf-b mascarado, um ou mais ácidos nucleicos, uso de um ou mais construtos ou complexos de tgf-b mascarados, composição, método de produção de um construto ou complexo de tgf-b mascarado e composição farmacêutica - Google Patents

Construto de tgf-b, mascarado, complexo de tgf-b, heterodímero do complexo de tgf-b mascarado, um ou mais ácidos nucleicos, uso de um ou mais construtos ou complexos de tgf-b mascarados, composição, método de produção de um construto ou complexo de tgf-b mascarado e composição farmacêutica

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Publication number
BR112022007749A2
BR112022007749A2 BR112022007749A BR112022007749A BR112022007749A2 BR 112022007749 A2 BR112022007749 A2 BR 112022007749A2 BR 112022007749 A BR112022007749 A BR 112022007749A BR 112022007749 A BR112022007749 A BR 112022007749A BR 112022007749 A2 BR112022007749 A2 BR 112022007749A2
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BR
Brazil
Prior art keywords
tgf
masked
complex
construction
complexes
Prior art date
Application number
BR112022007749A
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English (en)
Inventor
D Seidel Ronald Iii
J Chaparro Rodolfo
F Ross John
Meng Low Chee
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Cue Biopharma Inc
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Publication date
Application filed by Cue Biopharma Inc filed Critical Cue Biopharma Inc
Priority to BR122023021925-2A priority Critical patent/BR122023021925A2/pt
Publication of BR112022007749A2 publication Critical patent/BR112022007749A2/pt

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    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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Abstract

CONSTRUTO DE TGF-? MASCARADO, COMPLEXO DE TGF-?, HETERODÍMERO DO COMPLEXO DE TGF-? MASCARADO, UM OU MAIS ÁCIDOS NUCLEICOS, USO DE UM OU MAIS CONSTRUTOS OU COMPLEXOS DE TGF-? MASCARADOS, COMPOSIÇÃO, MÉTODO DE PRODUÇÃO DE UM CONSTRUTO OU COMPLEXO DE TGF-? MASCARADO E COMPOSIÇÃO FARMACÊUTICA. A presente divulgação fornece construtos e complexos polipeptídicos do Fator de Crescimento Transformador Beta (TGF-ß) que encontram uso, por exemplo, no tratamento terapêutico de doenças incluindo doenças autoimunes. Também são descritos ácidos nucleicos que codificam os construtos e complexos e métodos de preparação dos construtos e complexos em sistemas de expressão baseados em células.
BR112022007749A 2019-10-23 2020-10-22 Construto de tgf-b, mascarado, complexo de tgf-b, heterodímero do complexo de tgf-b mascarado, um ou mais ácidos nucleicos, uso de um ou mais construtos ou complexos de tgf-b mascarados, composição, método de produção de um construto ou complexo de tgf-b mascarado e composição farmacêutica BR112022007749A2 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122023021925-2A BR122023021925A2 (pt) 2019-10-23 2020-10-22 Complexo de tgf-b, seus usos, um ou mais ácidos nucleicos, composição, método para produzir uma construção ou complexo de tgf-b mascarado, composição farmacêutica, método para entrega de um polipeptídeo tgf-b e opcionalmente pelo menos um polipeptídeo mod a células que expressam em sua membrana superficial um tbr

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962925227P 2019-10-23 2019-10-23
PCT/US2020/056937 WO2021081258A1 (en) 2019-10-23 2020-10-22 TGF-β POLYPEPTIDES

Publications (1)

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BR112022007749A2 true BR112022007749A2 (pt) 2022-07-05

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BR122023021925-2A BR122023021925A2 (pt) 2019-10-23 2020-10-22 Complexo de tgf-b, seus usos, um ou mais ácidos nucleicos, composição, método para produzir uma construção ou complexo de tgf-b mascarado, composição farmacêutica, método para entrega de um polipeptídeo tgf-b e opcionalmente pelo menos um polipeptídeo mod a células que expressam em sua membrana superficial um tbr
BR112022007749A BR112022007749A2 (pt) 2019-10-23 2020-10-22 Construto de tgf-b, mascarado, complexo de tgf-b, heterodímero do complexo de tgf-b mascarado, um ou mais ácidos nucleicos, uso de um ou mais construtos ou complexos de tgf-b mascarados, composição, método de produção de um construto ou complexo de tgf-b mascarado e composição farmacêutica

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BR122023021925-2A BR122023021925A2 (pt) 2019-10-23 2020-10-22 Complexo de tgf-b, seus usos, um ou mais ácidos nucleicos, composição, método para produzir uma construção ou complexo de tgf-b mascarado, composição farmacêutica, método para entrega de um polipeptídeo tgf-b e opcionalmente pelo menos um polipeptídeo mod a células que expressam em sua membrana superficial um tbr

Country Status (12)

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US (2) US11692018B2 (pt)
EP (1) EP4034170A4 (pt)
JP (1) JP2023500066A (pt)
KR (1) KR20220087491A (pt)
CN (1) CN114728072A (pt)
AU (1) AU2020372413A1 (pt)
BR (2) BR122023021925A2 (pt)
CA (1) CA3155510A1 (pt)
IL (1) IL292253A (pt)
MX (1) MX2022004873A (pt)
TW (1) TW202130655A (pt)
WO (1) WO2021081258A1 (pt)

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JP2023500066A (ja) 2019-10-23 2023-01-04 キュー バイオファーマ，インコーポレーテッド ＴＧＦ－βポリペプチド
WO2022047220A1 (en) * 2020-08-27 2022-03-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Oncolytic viruses encoding recombinant tranforming growth factor (tgf)-beta monomers and uses thereof
JP2024096518A (ja) * 2023-01-03 2024-07-16 エフビーデー バイオロジクス リミテッド 操作されたｔｇｆｂｒｉｉバリアント及びその使用方法

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MX2022004873A (es) 2022-05-13
US11692018B2 (en) 2023-07-04
BR122023021925A2 (pt) 2024-02-27
CA3155510A1 (en) 2021-04-29
EP4034170A1 (en) 2022-08-03
JP2023500066A (ja) 2023-01-04
US20220372093A1 (en) 2022-11-24
WO2021081258A1 (en) 2021-04-29
EP4034170A4 (en) 2023-06-07
KR20220087491A (ko) 2022-06-24
CN114728072A (zh) 2022-07-08
TW202130655A (zh) 2021-08-16
IL292253A (en) 2022-06-01
AU2020372413A1 (en) 2022-06-09
US20230416322A1 (en) 2023-12-28

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