RU2761631C2 - Белки rsv в предшествующей слиянию конформации и их применение - Google Patents

Белки rsv в предшествующей слиянию конформации и их применение Download PDF

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RU2761631C2
RU2761631C2 RU2015142981A RU2015142981A RU2761631C2 RU 2761631 C2 RU2761631 C2 RU 2761631C2 RU 2015142981 A RU2015142981 A RU 2015142981A RU 2015142981 A RU2015142981 A RU 2015142981A RU 2761631 C2 RU2761631 C2 RU 2761631C2
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rsv
protein
immunogen
polypeptide
fusion
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RU2015142981A
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Russian (ru)
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RU2015142981A3 (enExample
RU2015142981A (ru
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Питер Д. КВОНГ
Барни С. ГРЭХЭМ
Джейсон С. МАКЛЕЛЛАН
Майкл Гордон ДЖОЙС
Масару КАНЕКИЙО
Баошань ЧЖАН
Джеффри БОЙИНГТОН
Ивелин Стефанов ДЖОРДЖИВ
Мари ПАНСЕРА
Синке СОТО
Санджай СРИВАТСАН
Гийом СТЮАРТ-ДЖОНС
Лэй ЧЭНЬ
Мань ЧЭНЬ
Гво-Ю ЧУАН
Джейсон ГОРМАН
Джилад ОФЕК
Маллика САСТРИ
Йонгпинг ЯНГ
Тунцин ЧЖОУ
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Дзе Юнайтед Стэйтс Оф Америка, Эс Репрезентед Бай Дзе Секретэри, Департмент Оф Хелт Энд Хьюман Сервисиз
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
    • C07K14/135—Respiratory syncytial virus
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
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    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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RU2015142981A 2013-03-13 2014-03-13 Белки rsv в предшествующей слиянию конформации и их применение RU2761631C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361780910P 2013-03-13 2013-03-13
US61/780,910 2013-03-13
US201361798389P 2013-03-15 2013-03-15
US61/798,389 2013-03-15
US201361857613P 2013-07-23 2013-07-23
US61/857,613 2013-07-23
US201361863909P 2013-08-09 2013-08-09
US61/863,909 2013-08-09
PCT/US2014/026714 WO2014160463A1 (en) 2013-03-13 2014-03-13 Prefusion rsv f proteins and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021132097A Division RU2852571C2 (ru) 2013-03-13 2014-03-13 Белки rsv f в предшествующей слиянию конформации и их применение

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RU2015142981A RU2015142981A (ru) 2017-04-17
RU2015142981A3 RU2015142981A3 (enExample) 2018-03-14
RU2761631C2 true RU2761631C2 (ru) 2021-12-13

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US (5) US10017543B2 (enExample)
EP (2) EP4421177A3 (enExample)
JP (4) JP6703475B2 (enExample)
KR (3) KR102450375B1 (enExample)
CN (2) CN105473604B (enExample)
AU (5) AU2014243756B2 (enExample)
CA (2) CA2902877C (enExample)
DK (1) DK2970398T3 (enExample)
ES (1) ES2981623T3 (enExample)
FI (1) FI2970398T3 (enExample)
HR (1) HRP20240996T1 (enExample)
HU (1) HUE067333T2 (enExample)
LT (1) LT2970398T (enExample)
MX (2) MX385818B (enExample)
PL (1) PL2970398T3 (enExample)
PT (1) PT2970398T (enExample)
RS (1) RS65760B1 (enExample)
RU (1) RU2761631C2 (enExample)
SI (1) SI2970398T1 (enExample)
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WO (1) WO2014160463A1 (enExample)

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