SG11201503369RA - Rsv f prefusion trimers - Google Patents

Rsv f prefusion trimers

Info

Publication number
SG11201503369RA
SG11201503369RA SG11201503369RA SG11201503369RA SG11201503369RA SG 11201503369R A SG11201503369R A SG 11201503369RA SG 11201503369R A SG11201503369R A SG 11201503369RA SG 11201503369R A SG11201503369R A SG 11201503369RA SG 11201503369R A SG11201503369R A SG 11201503369RA
Authority
SG
Singapore
Prior art keywords
prefusion
trimers
rsv
prefusion trimers
Prior art date
Application number
SG11201503369RA
Inventor
Andrea Carfi
Kurt Swanson
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of SG11201503369RA publication Critical patent/SG11201503369RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201503369RA 2012-11-20 2013-11-19 Rsv f prefusion trimers SG11201503369RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728498P 2012-11-20 2012-11-20
US201361890086P 2013-10-11 2013-10-11
PCT/EP2013/074169 WO2014079842A1 (en) 2012-11-20 2013-11-19 Rsv f prefusion trimers

Publications (1)

Publication Number Publication Date
SG11201503369RA true SG11201503369RA (en) 2015-06-29

Family

ID=49622826

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201503369RA SG11201503369RA (en) 2012-11-20 2013-11-19 Rsv f prefusion trimers

Country Status (13)

Country Link
US (1) US20150329597A1 (en)
EP (1) EP2922570A1 (en)
JP (1) JP2016501196A (en)
KR (1) KR20150085843A (en)
CN (1) CN104853769A (en)
AU (1) AU2013349778A1 (en)
BR (1) BR112015011389A2 (en)
CA (1) CA2890135A1 (en)
EA (1) EA201590683A1 (en)
IL (1) IL238520A0 (en)
MX (1) MX2015006377A (en)
SG (1) SG11201503369RA (en)
WO (1) WO2014079842A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220139415A (en) 2013-03-13 2022-10-14 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 Prefusion rsv f proteins and their use
US9738689B2 (en) 2013-03-13 2017-08-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Prefusion RSV F proteins and their use
EP2974739A1 (en) * 2014-07-15 2016-01-20 Novartis AG RSVF trimerization domains
US11571472B2 (en) 2014-06-13 2023-02-07 Glaxosmithkline Biologicals Sa Immunogenic combinations
WO2016061149A1 (en) * 2014-10-14 2016-04-21 Medgenics Medical Israel Ltd. Genetically-modified micro-organ secreting a therapeutic peptide and methods of use thereof
US10744193B2 (en) 2015-03-30 2020-08-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunogenic RSV polypeptides
CN108025058B (en) * 2015-06-12 2022-12-16 葛兰素史密丝克莱恩生物有限公司 Adenovirus polynucleotides and polypeptides
JO3555B1 (en) 2015-10-29 2020-07-05 Merck Sharp & Dohme Antibody neutralizing human respiratory syncytial virus
KR102136678B1 (en) 2015-12-23 2020-07-22 화이자 인코포레이티드 RSV F protein mutant
CN106119287B (en) * 2016-08-29 2019-10-11 广东华南疫苗股份有限公司 A kind of recombinant vector and method for expressing respiratory syncystial virus F protein
TWI683826B (en) * 2016-11-22 2020-02-01 國立臺灣大學 Recombinant rsv antigens
CN106946994B (en) * 2017-03-09 2019-11-26 中国医学科学院病原生物学研究所 It is a kind of inhibit infection with hepatitis C virus albumen and its application
CA3056017A1 (en) * 2017-03-23 2018-09-27 Alpha-O Peptides Ag Self-assembling protein nanoparticles with built-in six-helix bundle proteins
JP7291398B2 (en) * 2017-03-30 2023-06-15 ザ ユニバーシティー オブ クイーンズランド Chimeric molecules and uses thereof
US11192926B2 (en) 2017-04-04 2021-12-07 University Of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use
EP3932424A4 (en) * 2019-02-28 2022-10-12 KM Biologics Co., Ltd. Rsv f/g chimeric vaccine
WO2021046207A1 (en) 2019-09-04 2021-03-11 University Of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use
CN116162136B (en) * 2021-11-24 2024-08-23 成都奥达生物科技有限公司 Anti-syncytial virus membrane fusion inhibitor
WO2023187743A1 (en) * 2022-03-31 2023-10-05 The University Of Queensland Improved chimeric polypeptides and uses thereof
CN118078975A (en) * 2023-03-17 2024-05-28 成都威斯克生物医药有限公司 Vaccine against respiratory syncytial virus infection
CN117304280B (en) * 2023-11-28 2024-04-16 江苏瑞科生物技术股份有限公司 Recombinant RSV F protein and application thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149650A (en) * 1986-01-14 1992-09-22 University Of North Carolina At Chapel Hill Vaccines for human respiratory virus
US5340740A (en) 1992-05-15 1994-08-23 North Carolina State University Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process
FR2726003B1 (en) 1994-10-21 2002-10-18 Agronomique Inst Nat Rech CULTURE MEDIUM OF AVIAN TOTIPOTENT EMBRYONIC CELLS, METHOD FOR CULTURING THESE CELLS, AND AVIAN TOTIPOTENT EMBRYONIC CELLS
FR2832423B1 (en) 2001-11-22 2004-10-08 Vivalis EXOGENOUS PROTEIN EXPRESSION SYSTEM IN AN AVIAN SYSTEM
FR2836924B1 (en) 2002-03-08 2005-01-14 Vivalis AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF INTEREST SUBSTANCES
EP1528101A1 (en) 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
BRPI0821532A2 (en) * 2007-12-24 2015-06-16 Id Biomedical Corp Quebec Recombinant rsv antigens
WO2009109428A2 (en) 2008-02-01 2009-09-11 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
WO2010009065A2 (en) 2008-07-15 2010-01-21 Novartis Ag Amphipathic peptide compositions
WO2010009277A2 (en) 2008-07-15 2010-01-21 Novartis Ag Immunogenic amphipathic peptide compositions
SG172022A1 (en) 2008-12-09 2011-07-28 Novavax Inc Modified rsv f proteins and methods of their use
MX2012000036A (en) * 2009-06-24 2012-02-28 Glaxosmithkline Biolog Sa Vaccine.
WO2011008974A2 (en) 2009-07-15 2011-01-20 Novartis Ag Rsv f protein compositions and methods for making same

Also Published As

Publication number Publication date
AU2013349778A1 (en) 2015-05-28
EP2922570A1 (en) 2015-09-30
EA201590683A1 (en) 2015-11-30
JP2016501196A (en) 2016-01-18
US20150329597A1 (en) 2015-11-19
CA2890135A1 (en) 2014-05-30
BR112015011389A2 (en) 2017-08-22
CN104853769A (en) 2015-08-19
MX2015006377A (en) 2015-07-21
WO2014079842A1 (en) 2014-05-30
IL238520A0 (en) 2015-06-30
KR20150085843A (en) 2015-07-24

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