RU2472791C2 - Соединения, модулирующие внутриклеточный кальций - Google Patents
Соединения, модулирующие внутриклеточный кальций Download PDFInfo
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- RU2472791C2 RU2472791C2 RU2011108969/04A RU2011108969A RU2472791C2 RU 2472791 C2 RU2472791 C2 RU 2472791C2 RU 2011108969/04 A RU2011108969/04 A RU 2011108969/04A RU 2011108969 A RU2011108969 A RU 2011108969A RU 2472791 C2 RU2472791 C2 RU 2472791C2
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- compound according
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- phenyl
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- 150000001875 compounds Chemical class 0.000 title claims abstract 16
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 230000003834 intracellular effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 claims abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical group C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical group C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 claims 2
- SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical group C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 claims 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical group C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 2
- AMFYRKOUWBAGHV-UHFFFAOYSA-N 1h-pyrazolo[4,3-b]pyridine Chemical group C1=CN=C2C=NNC2=C1 AMFYRKOUWBAGHV-UHFFFAOYSA-N 0.000 claims 2
- 239000005964 Acibenzolar-S-methyl Chemical group 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical group C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 1
- 125000000355 1,3-benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical group CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- YRTCKZIKGWZNCU-UHFFFAOYSA-N furo[3,2-b]pyridine Chemical group C1=CC=C2OC=CC2=N1 YRTCKZIKGWZNCU-UHFFFAOYSA-N 0.000 claims 1
- HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical group C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical group C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- VJYJJHQEVLEOFL-UHFFFAOYSA-N thieno[3,2-b]thiophene Chemical group S1C=CC2=C1C=CS2 VJYJJHQEVLEOFL-UHFFFAOYSA-N 0.000 claims 1
- 229930192474 thiophene Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 0 Cc(cc1)c(*)c(*)c1-c1c[s]c(NC(c2nc(cccc3)c3[o]2)=O)c1C(O)=O Chemical compound Cc(cc1)c(*)c(*)c1-c1c[s]c(NC(c2nc(cccc3)c3[o]2)=O)c1C(O)=O 0.000 description 8
- ZVWZFHGXDHHQCE-UHFFFAOYSA-N OC(c1c(NC(c2ccc3nc[o]c3c2)=O)[s]cc1-c(cc1)ccc1Cl)=O Chemical compound OC(c1c(NC(c2ccc3nc[o]c3c2)=O)[s]cc1-c(cc1)ccc1Cl)=O ZVWZFHGXDHHQCE-UHFFFAOYSA-N 0.000 description 2
- PJKWZQRDKONEGL-UHFFFAOYSA-N CN(C)C(c(cc1)ccc1-c1c[s]c(NC(c2nc(cccc3)c3[o]2)=O)c1C(O)=O)=O Chemical compound CN(C)C(c(cc1)ccc1-c1c[s]c(NC(c2nc(cccc3)c3[o]2)=O)c1C(O)=O)=O PJKWZQRDKONEGL-UHFFFAOYSA-N 0.000 description 1
- VSFRIXHMZPSTMP-UHFFFAOYSA-N Cc(cc(cc1)Cl)c1-c1c[s]c(NC(c2nc3ccccc3[o]2)=O)c1C(O)=O Chemical compound Cc(cc(cc1)Cl)c1-c1c[s]c(NC(c2nc3ccccc3[o]2)=O)c1C(O)=O VSFRIXHMZPSTMP-UHFFFAOYSA-N 0.000 description 1
- LXARTSFHRVJJBD-UHFFFAOYSA-N Cc1cc(C#N)ccc1-c1c[s]c(NC(c2nc3ccccc3[o]2)=O)c1C(O)=O Chemical compound Cc1cc(C#N)ccc1-c1c[s]c(NC(c2nc3ccccc3[o]2)=O)c1C(O)=O LXARTSFHRVJJBD-UHFFFAOYSA-N 0.000 description 1
- YWENPTURSUZQOI-UHFFFAOYSA-N OC(c1c(NC(c2ccc3[s]nnc3c2)=O)[s]cc1-c(cc1)cc(Cl)c1Cl)=O Chemical compound OC(c1c(NC(c2ccc3[s]nnc3c2)=O)[s]cc1-c(cc1)cc(Cl)c1Cl)=O YWENPTURSUZQOI-UHFFFAOYSA-N 0.000 description 1
- RYPJQAPCHALZKM-UHFFFAOYSA-N OC(c1c(NC(c2ccc3nc[s]c3c2)=O)[s]cc1-c(cc1)ccc1Cl)=O Chemical compound OC(c1c(NC(c2ccc3nc[s]c3c2)=O)[s]cc1-c(cc1)ccc1Cl)=O RYPJQAPCHALZKM-UHFFFAOYSA-N 0.000 description 1
- NJFDHPKIKGVTHU-UHFFFAOYSA-N OC(c1c(NC(c2nc3ccccc3[o]2)=O)[s]cc1-c1cc(CCC2)c2cc1)=O Chemical compound OC(c1c(NC(c2nc3ccccc3[o]2)=O)[s]cc1-c1cc(CCC2)c2cc1)=O NJFDHPKIKGVTHU-UHFFFAOYSA-N 0.000 description 1
- LFTWJFWZQDZZMD-UHFFFAOYSA-N OC(c1c(NC(c2nc3ccccc3[o]2)=O)[s]cc1-c1ccc2[o]ccc2c1)=O Chemical compound OC(c1c(NC(c2nc3ccccc3[o]2)=O)[s]cc1-c1ccc2[o]ccc2c1)=O LFTWJFWZQDZZMD-UHFFFAOYSA-N 0.000 description 1
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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