RU2016151645A - Биспецифические гетеродимерные диантитела и их применение - Google Patents
Биспецифические гетеродимерные диантитела и их применение Download PDFInfo
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- RU2016151645A RU2016151645A RU2016151645A RU2016151645A RU2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A RU 2016151645 A RU2016151645 A RU 2016151645A
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- cad
- sequence
- subdomain
- heterodimeric antibody
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Links
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 28
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 28
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 28
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 27
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 27
- 229920001184 polypeptide Polymers 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 102000000905 Cadherin Human genes 0.000 claims 13
- 108050007957 Cadherin Proteins 0.000 claims 13
- 108010086890 R-cadherin Proteins 0.000 claims 9
- 102100029758 Cadherin-4 Human genes 0.000 claims 7
- 101100123313 Mus musculus H1.8 gene Proteins 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100039875 Histone H3-7 Human genes 0.000 claims 4
- 102100038736 Histone H3.3C Human genes 0.000 claims 4
- 101001035307 Homo sapiens Histone H3-7 Proteins 0.000 claims 4
- 101001031505 Homo sapiens Histone H3.3C Proteins 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 101000897979 Homo sapiens Putative spermatid-specific linker histone H1-like protein Proteins 0.000 claims 2
- 102100021861 Putative spermatid-specific linker histone H1-like protein Human genes 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 210000003679 cervix uteri Anatomy 0.000 claims 2
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- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000004696 endometrium Anatomy 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 210000003128 head Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
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- 210000003739 neck Anatomy 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 210000000664 rectum Anatomy 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 102000008790 VE-cadherin Human genes 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 108010018828 cadherin 5 Proteins 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
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- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462019762P | 2014-07-01 | 2014-07-01 | |
| US62/019,762 | 2014-07-01 | ||
| US201562148920P | 2015-04-17 | 2015-04-17 | |
| US62/148,920 | 2015-04-17 | ||
| PCT/IB2015/054829 WO2016001810A1 (en) | 2014-07-01 | 2015-06-26 | Bispecific heterodimeric diabodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016151645A true RU2016151645A (ru) | 2018-08-03 |
| RU2016151645A3 RU2016151645A3 (Direct) | 2019-02-20 |
Family
ID=53718063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151645A RU2016151645A (ru) | 2014-07-01 | 2015-06-26 | Биспецифические гетеродимерные диантитела и их применение |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9884921B2 (Direct) |
| EP (1) | EP3164417A1 (Direct) |
| JP (1) | JP2017520575A (Direct) |
| KR (1) | KR20170010863A (Direct) |
| CN (1) | CN106661119A (Direct) |
| AU (2) | AU2015283704A1 (Direct) |
| BR (1) | BR112016030740A2 (Direct) |
| CA (1) | CA2895659A1 (Direct) |
| CO (1) | CO2017000016A2 (Direct) |
| IL (1) | IL249889A0 (Direct) |
| MX (1) | MX2016017393A (Direct) |
| PE (1) | PE20170286A1 (Direct) |
| PH (1) | PH12016502491A1 (Direct) |
| RU (1) | RU2016151645A (Direct) |
| SG (1) | SG11201609707WA (Direct) |
| TW (2) | TWI659042B (Direct) |
| WO (1) | WO2016001810A1 (Direct) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3227339T (lt) | 2014-12-05 | 2022-01-10 | Memorial Sloan-Kettering Cancer Center | Chimeriniai antigeno receptoriai, nukreipti į receptorių su prijungtu g baltymu ir jų naudojimo būdai |
| EP3227324A4 (en) * | 2014-12-05 | 2018-08-29 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
| DK3283524T3 (da) * | 2015-04-17 | 2023-05-30 | Amgen Res Munich Gmbh | BISPECIFIKKE ANTISTOFKONSTRUKTIONER MOD CDH3 og CD3 |
| WO2017008169A1 (en) * | 2015-07-15 | 2017-01-19 | Zymeworks Inc. | Drug-conjugated bi-specific antigen-binding constructs |
| US20200270363A1 (en) | 2015-12-25 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
| TW202402326A (zh) | 2016-04-28 | 2024-01-16 | 日商中外製藥股份有限公司 | 含抗體製劑 |
| WO2018021450A1 (ja) * | 2016-07-29 | 2018-02-01 | 中外製薬株式会社 | 増強されたｆｖｉｉｉ補因子機能代替活性を有する二重特異性抗体 |
| CN106496331B (zh) * | 2016-11-08 | 2020-03-13 | 北京智岭生物医药科技有限公司 | 一种FSH-Fc融合蛋白及其制备方法和用途 |
| CA3053010A1 (en) | 2017-02-08 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| EP3601345A1 (en) | 2017-03-29 | 2020-02-05 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor |
| CN110382542B (zh) * | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| US11913025B2 (en) * | 2017-03-29 | 2024-02-27 | Cytoarm Co., Ltd | Antigen-specific T cells and uses thereof |
| CN108866635B (zh) * | 2017-05-09 | 2021-11-26 | 安升（上海）医药科技有限公司 | 多特异性蛋白药物及其文库、以及制备方法和应用 |
| SG10201913194WA (en) | 2017-06-02 | 2020-03-30 | Pfizer | Recombinant robo2 proteins, compositions, methods and uses thereof |
| WO2018237341A1 (en) * | 2017-06-22 | 2018-12-27 | Development Center For Biotechnology | A TARGET CELL-DEPENDENT T CELL ENGAGING AND ACTIVATION ASYMMETRIC HETERODIMERIC Fc-ScFv FUSION ANTIBODY FORMAT FOR CANCER THERAPY |
| MY204641A (en) | 2017-09-29 | 2024-09-06 | Chugai Pharmaceutical Co Ltd | Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient |
| KR101973060B1 (ko) * | 2017-10-20 | 2019-04-26 | 주식회사 녹십자 | 항-cd3 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
| CN109706164A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人和猴cd20与效应细胞抗原的桥接分子及其应用 |
| CN109706163A (zh) * | 2017-10-26 | 2019-05-03 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接人与动物靶细胞与效应细胞的桥接分子及其应用 |
| CR20240273A (es) | 2017-11-01 | 2024-08-27 | Chugai Pharmaceutical Co Ltd | Variantes e isoformas de anticuerpos con actividad biológica reducida (divisional 2020-229) |
| DK3749346T3 (da) | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| JP2021512914A (ja) | 2018-02-08 | 2021-05-20 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ナチュラルキラー細胞を活性化する多特異的結合タンパク質を伴うがんの併用療法 |
| SG11202007945UA (en) | 2018-02-20 | 2020-09-29 | Dragonfly Therapeutics Inc | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| CA3034912A1 (en) | 2018-02-28 | 2019-08-28 | Pfizer Inc. | Il-15 variants and uses thereof |
| US20210238290A1 (en) * | 2018-05-07 | 2021-08-05 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and p-cadherin |
| PE20210127A1 (es) | 2018-05-23 | 2021-01-19 | Pfizer | Anticuerpos especificos para cd3 y sus usos |
| TWI803637B (zh) * | 2018-05-23 | 2023-06-01 | 美商輝瑞大藥廠 | 特異性針對gucy2c之抗體及其用途 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| KR20250112921A (ko) | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| EP3954707A1 (en) * | 2018-12-21 | 2022-02-16 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Protease cleavable bispecific antibodies and uses thereof |
| CN110357969B (zh) * | 2019-05-27 | 2022-03-08 | 北京志道生物科技有限公司 | 一种GLP1-EGFa异源二聚体蛋白、功能及方法 |
| US11339159B2 (en) | 2019-07-17 | 2022-05-24 | Pfizer Inc. | Toll-like receptor agonists |
| CN110669137B (zh) * | 2019-10-24 | 2021-07-16 | 高新 | 一种多特异性抗体及其制备方法和用途 |
| BR112022009723A2 (pt) | 2019-12-17 | 2022-08-09 | Pfizer | Anticorpos específicos para cd47, pd-l1, e usos dos mesmos |
| BR112022009470A2 (pt) | 2019-12-18 | 2022-08-16 | Pfizer | Regime de tratamento diário para o câncer com um inibidor de prmt5 |
| CA3174908A1 (en) | 2020-03-09 | 2021-09-16 | Pfizer Inc. | Fusion proteins and uses thereof |
| BR112022021884A2 (pt) | 2020-05-06 | 2022-12-20 | Dragonfly Therapeutics Inc | Proteínas que se ligam a nkg2d, cd16 e clec12a |
| IL298159A (en) | 2020-05-13 | 2023-01-01 | Pfizer | Treatment methods and uses for cancer treatment |
| AU2021308586A1 (en) | 2020-07-17 | 2023-03-02 | Pfizer Inc. | Therapeutic antibodies and their uses |
| WO2022053990A1 (en) | 2020-09-14 | 2022-03-17 | Pfizer Inc. | Methods, therapies and uses for treating cancer |
| WO2022121966A1 (en) * | 2020-12-10 | 2022-06-16 | Wuxi Biologics (Shanghai) Co., Ltd. | An antibody against p-cadherin and uses thereof |
| WO2022153161A1 (en) | 2021-01-14 | 2022-07-21 | Pfizer Inc. | Treatment of cancer using a prmt5 inhibitor |
| CN117222663A (zh) | 2021-03-03 | 2023-12-12 | 蜻蜓疗法股份有限公司 | 使用结合nkg2d、cd16和肿瘤相关抗原的多特异性结合蛋白治疗癌症的方法 |
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| CA3259654A1 (en) | 2022-06-17 | 2023-12-21 | Pfizer Inc. | IL-12 VARIANTS, ANTI-PD1 ANTIBODIES, FUSING PROTEINS AND THEIR USES |
| WO2024003773A1 (en) | 2022-07-01 | 2024-01-04 | Pfizer Inc. | 2,7-naphthyridine compounds as mastl inhibitors |
| KR20250029954A (ko) | 2022-07-05 | 2025-03-05 | 화이자 인코포레이티드 | 피리도[4,3-d]피리미딘 화합물 |
| WO2024074977A1 (en) | 2022-10-04 | 2024-04-11 | Pfizer Inc. | Substituted 1 h-pyrazolo-pyridine and-pyrimidine compounds |
| WO2024084364A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Compounds for the treatment of cancer |
| WO2024105563A1 (en) | 2022-11-16 | 2024-05-23 | Pfizer Inc. | Substituted bicyclic pyridone derivatives |
| CR20250413A (es) | 2023-04-05 | 2025-11-06 | Pfizer Inc | Compuestos de pirido[4,3–d]pirimidina |
| WO2024213979A1 (en) | 2023-04-10 | 2024-10-17 | Pfizer Inc. | Pyrido[4,3-d]pyrimidine compounds |
| WO2024218686A1 (en) | 2023-04-20 | 2024-10-24 | Pfizer Inc. | Pyrido[4,3-d]pyrimidine compounds |
| TW202523350A (zh) | 2023-08-10 | 2025-06-16 | 美商輝瑞股份有限公司 | 治療癌症之方法，療法及用途 |
| WO2025094035A1 (en) | 2023-11-01 | 2025-05-08 | Pfizer Inc. | Toll-like receptor agonists and conjugates thereof |
| WO2025109003A1 (en) | 2023-11-21 | 2025-05-30 | 3B Pharmaceuticals Gmbh | P-cadherin ligands |
Family Cites Families (196)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0088994B1 (en) | 1982-03-15 | 1991-06-19 | Schering Corporation | Hybrid dna, binding composition prepared thereby and processes therefor |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| WO1991001752A1 (en) | 1989-07-27 | 1991-02-21 | Fred Hutchinson Cancer Research Center | Immunosuppressive monoclonal antibodies, hybridomas and methods of transplantation |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5811267A (en) | 1990-10-29 | 1998-09-22 | Chiron Corporation | Isolated nucleic acid molecules encoding antigen binding sites of antibody molecules specific for cancer antigens |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| US6129914A (en) | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
| WO1994007921A1 (en) | 1992-09-25 | 1994-04-14 | Commonwealth Scientific And Industrial Research Organisation | Target binding polypeptide |
| WO1994012520A1 (en) | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| DE69329974T2 (de) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| JP3312357B2 (ja) | 1992-12-11 | 2002-08-05 | ザ ダウ ケミカル カンパニー | 多価の一本鎖抗体 |
| WO1994018227A2 (en) | 1993-02-04 | 1994-08-18 | Denzyme Aps | Improved method for the refolding of proteins |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
| WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
| IT1271461B (it) | 1993-12-01 | 1997-05-28 | Menarini Ricerche Sud Spa | Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5989830A (en) | 1995-10-16 | 1999-11-23 | Unilever Patent Holdings Bv | Bifunctional or bivalent antibody fragment analogue |
| CA2259966A1 (en) | 1996-07-12 | 1998-01-22 | Mcgill University | Compounds and methods for modulating cell adhesion |
| DE69726003T2 (de) | 1996-07-16 | 2004-08-26 | Andreas Plückthun | Immunglobulin-superfamilie domainen und fragmente mit erhöhter löslichkeit |
| AU6537798A (en) | 1997-03-14 | 1998-10-12 | Denise Casentini-Borocz | Targeted cytolysis of cancer cells |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP1027439B1 (en) | 1997-10-27 | 2010-03-17 | Bac Ip B.V. | Multivalent antigen-binding proteins |
| US6485910B1 (en) | 1998-02-09 | 2002-11-26 | Incyte Genomics, Inc. | Ras association domain containing protein |
| EP1469883A2 (en) | 1998-02-19 | 2004-10-27 | Xcyte Therapies, Inc. | Compositions and methods for regulating lymphocyte activation |
| US6783961B1 (en) | 1999-02-26 | 2004-08-31 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| HUP9900956A2 (hu) | 1998-04-09 | 2002-04-29 | Aventis Pharma Deutschland Gmbh. | Egyláncú, több antigéntkötőhely kialakítására képes molekulák, előállításuk és alkalmazásuk |
| NZ507381A (en) | 1998-04-21 | 2003-12-19 | Micromet Ag | CD19xCD3 specific polypeptides and uses thereof |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| GB9812545D0 (en) | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
| EP1100830B1 (en) | 1998-07-28 | 2003-10-01 | Micromet AG | Heterominibodies |
| DE69936927T2 (de) | 1998-10-21 | 2008-05-15 | Altor Bioscience Corp., Miramar | Polyspezifische bindemoleküle und deren verwendung |
| WO2001057188A2 (en) | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| DE19905048A1 (de) | 1999-02-08 | 2000-08-10 | Gsf Forschungszentrum Umwelt | Verwendung depletorisch oder mitogen wirkender Antikörper in der Immuntherapie |
| MXPA02010011A (es) | 2000-04-11 | 2003-04-25 | Genentech Inc | Anticuerpos multivalentes y usos para los mismos. |
| EP1284752A4 (en) | 2000-04-26 | 2004-08-18 | Elusys Therapeutics Inc | BISPECIFIC MOLECULES AND USES THEREOF |
| US20040047854A1 (en) | 2001-07-27 | 2004-03-11 | Black Roy A. | Human disintegrin protein |
| GB0025307D0 (en) | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| AU2002327164A1 (en) | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| US20040053245A1 (en) | 2001-02-05 | 2004-03-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| WO2002072141A2 (en) | 2001-03-09 | 2002-09-19 | William Herman | Targeted ligands |
| WO2002072635A2 (en) | 2001-03-13 | 2002-09-19 | University College London | Specific binding members |
| US20030194406A1 (en) | 2001-05-31 | 2003-10-16 | Chiron Corporation | P-cadherin as a target for anti-cancer therapy |
| US7189507B2 (en) | 2001-06-18 | 2007-03-13 | Pdl Biopharma, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| JP4303105B2 (ja) | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| WO2003022987A2 (en) | 2001-07-26 | 2003-03-20 | Eos Biotechnology, Inc. | Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| ES2276735T3 (es) | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
| WO2004016225A2 (en) | 2002-08-19 | 2004-02-26 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| ATE512989T1 (de) | 2002-04-15 | 2011-07-15 | Chugai Pharmaceutical Co Ltd | Verfahren zur herstellung von scdb-bibliotheken |
| EP1354600A1 (en) | 2002-04-19 | 2003-10-22 | Affimed Therapeutics AG | Antibody combination useful for tumor therapy |
| US20040018493A1 (en) | 2002-07-12 | 2004-01-29 | Anastasio Alison E. | Haplotypes of the CD3E gene |
| AU2003248081A1 (en) | 2002-07-18 | 2004-02-09 | Cellfree Sciences Co., Ltd. | Single chain antibody and utilization thereof |
| US7820166B2 (en) | 2002-10-11 | 2010-10-26 | Micromet Ag | Potent T cell modulating molecules |
| US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
| EP1560597A4 (en) * | 2002-10-29 | 2007-06-27 | Pharmacia Corp | DIFFERENTIALLY EXPRESSED CANCER GENES, POLYPEPTIDES CODED THEREIN, AND METHOD OF USE THEREOF |
| CA2504768A1 (en) | 2002-11-14 | 2004-05-27 | Adherex Technologies, Inc. | Compounds and methods for modulating functions of classical cadherins |
| EP2314676A1 (en) | 2002-11-26 | 2011-04-27 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| WO2004106381A1 (en) | 2003-05-31 | 2004-12-09 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
| DK1629011T3 (da) | 2003-05-31 | 2010-05-03 | Micromet Ag | Humane anti-humane-DC3-bindingsmolekyler |
| WO2004111089A2 (en) | 2003-06-11 | 2004-12-23 | WYETH A Corporaton of the State of Delaware | Platelet glycoprotein ib alpha variant fusion polypeptides and methods of use thereof |
| JP5091476B2 (ja) | 2003-06-27 | 2012-12-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 均質な抗体溶液の生成のための疎水性相互作用クロマトグラフィーまたはヒンジ領域改変の使用 |
| ES2315664T3 (es) | 2003-06-30 | 2009-04-01 | Domantis Limited | Anticuerpos de dominio unico (dab) pegilados. |
| US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| US20070037204A1 (en) | 2003-08-08 | 2007-02-15 | Hiroyuki ABURANTAI | Gene overexpressed in cancer |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2005028507A1 (en) | 2003-09-24 | 2005-03-31 | Monash University | CRYSTAL STRUCTURE OF CD3ϵϜ/OKT3 COMPLEX |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| DE602004021773D1 (de) | 2004-05-05 | 2009-08-13 | Micromet Ag | Herstellung eines einkettigen fv Antikörperfragments |
| MXPA06014075A (es) | 2004-06-03 | 2007-03-15 | Novimmune Sa | Anticuerpos anti-cd3 y metodos de uso de los mismos. |
| WO2006020258A2 (en) | 2004-07-17 | 2006-02-23 | Imclone Systems Incorporated | Novel tetravalent bispecific antibody |
| JP2008511337A (ja) | 2004-09-02 | 2008-04-17 | ジェネンテック・インコーポレーテッド | ヘテロ多量体分子 |
| ES2323651T3 (es) | 2005-01-05 | 2009-07-22 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. | Dominios sinteticos de inmunoglobulina con propiedades de union elaborados por ingenieria en regiones de la molecula diferentes de las regiones que determinan la complementariedad. |
| US7998695B2 (en) | 2005-02-10 | 2011-08-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| US20120237442A1 (en) | 2005-04-06 | 2012-09-20 | Ibc Pharmaceuticals, Inc. | Design and Construction of Novel Multivalent Antibodies |
| US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| ES2707152T3 (es) | 2005-04-15 | 2019-04-02 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos |
| US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| WO2012018687A1 (en) * | 2010-08-02 | 2012-02-09 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| CA2604357C (en) * | 2005-04-26 | 2012-01-17 | Pfizer Inc. | P-cadherin antibodies |
| US8603986B2 (en) | 2005-04-28 | 2013-12-10 | Mcgill University | Compounds and methods for modulating cadherin-mediated processes |
| JP5085322B2 (ja) | 2005-06-10 | 2012-11-28 | 中外製薬株式会社 | ｓｃ（Ｆｖ）２を含有する医薬組成物 |
| JP2006345852A (ja) | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
| CA2625815A1 (en) | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-cd3 antibody formulations |
| EP1940881B1 (en) | 2005-10-11 | 2016-11-30 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
| ES2595091T3 (es) | 2005-12-21 | 2016-12-27 | Amgen Research (Munich) Gmbh | Composiciones farmacéuticas con resistencia a CEA soluble |
| WO2007075672A2 (en) | 2005-12-23 | 2007-07-05 | Lankenau Institute For Medical Research | Prognostic cancer markers |
| WO2007102525A1 (en) * | 2006-02-28 | 2007-09-13 | Oncotherapy Science, Inc. | Methods for damaging cells using effector functions of anti-cdh3 antibodies |
| WO2007106507A2 (en) | 2006-03-14 | 2007-09-20 | Petrie Howard T | Detection of gene expression in mixed sample or tissue |
| EA015992B1 (ru) | 2006-03-17 | 2012-01-30 | Байоджен Айдек Эмэй Инк. | Стабилизированное антитело и многовалентная антигенсвязывающая молекула на его основе, способы получения и использования вышеназванного стабилизированного антитела |
| US8871912B2 (en) | 2006-03-24 | 2014-10-28 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
| US8535677B2 (en) | 2006-06-06 | 2013-09-17 | Oxford Biotherapeutics, Ltd. | Antibody drug conjugate treatment of colorectal cancer |
| TWI615403B (zh) | 2007-02-21 | 2018-02-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| AU2008234020B2 (en) | 2007-04-03 | 2013-02-07 | Amgen Research (Munich) Gmbh | Cross-species-specific CD3-epsilon binding domain |
| EP2155783B2 (en) * | 2007-04-03 | 2022-10-19 | Amgen Research (Munich) GmbH | Cross-species-specific cd3-epsilon binding domain |
| WO2008124858A2 (en) | 2007-04-11 | 2008-10-23 | F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. | Targeted receptor |
| ES2456963T3 (es) | 2007-06-04 | 2014-04-24 | Rappaport Family Institute For Research In The Medical Sciences | Agentes para el tratamiento de enfermedades inflamatorias y métodos para usar los mismos |
| KR20100058509A (ko) | 2007-07-31 | 2010-06-03 | 메디뮨 엘엘씨 | 다중특이적 에피토프 결합 단백질 및 이의 용도 |
| US9624309B2 (en) | 2007-08-15 | 2017-04-18 | Bayer Intellectual Property Gmbh | Monospecific and multispecific antibodies and method of use |
| CN104356225B (zh) | 2007-08-20 | 2018-02-13 | 肿瘤疗法科学股份有限公司 | Cdh3 肽以及含有cdh3 肽的药剂 |
| ES2667729T3 (es) | 2007-09-26 | 2018-05-14 | Ucb Biopharma Sprl | Fusiones de anticuerpos con doble especificidad |
| CA2740310A1 (en) | 2007-11-01 | 2009-05-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Altered cadherin processing in tumor cells |
| WO2009068649A2 (en) | 2007-11-30 | 2009-06-04 | Glaxo Group Limited | Antigen-binding constructs |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
| NZ588554A (en) | 2008-04-29 | 2013-03-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| RU2011103199A (ru) * | 2008-06-30 | 2012-08-10 | Онкотерапи Сайенс, Инк. (Jp) | Антитела против cdh3, меченные радиоизотопной меткой, и их применение |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| ES2604309T3 (es) | 2008-10-01 | 2017-03-06 | Amgen Research (Munich) Gmbh | Anticuerpo biespecífico de cadena sencilla PSCAxCD3, CD19xCD3, C-METxCD3, EndosialinaxCD3, EpCAMxCD3, IGF-1RxCD3 o FAPALPHA xCD3 específico entre especies |
| HRP20160684T1 (hr) | 2008-10-01 | 2016-07-15 | Amgen Research (Munich) Gmbh | Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću |
| DK2352763T4 (da) | 2008-10-01 | 2022-10-17 | Amgen Res Munich Gmbh | Bispecifikke enkeltkædede antistoffer med specificitet for højmolekylære målantigener |
| CA2738568C (en) | 2008-10-01 | 2024-02-20 | Micromet Ag | Cross-species-specific single domain bispecific single chain antibody |
| WO2010040545A1 (en) | 2008-10-06 | 2010-04-15 | Novoplant Gmbh | Proteolytically stable antibody formats |
| CN105218673A (zh) | 2008-10-10 | 2016-01-06 | 新兴产品开发西雅图有限公司 | Tcr复合物免疫治疗剂 |
| US20110020221A1 (en) | 2009-04-09 | 2011-01-27 | The Johns Hopkins University | Cancer stem cell expression patterns and compounds to target cancer stem cells |
| WO2010126137A1 (ja) | 2009-05-01 | 2010-11-04 | 国立大学法人 東京大学 | 抗カドヘリン抗体 |
| KR101431319B1 (ko) | 2009-05-27 | 2014-08-20 | 에프. 호프만-라 로슈 아게 | 삼중특이성 또는 사중특이성 항체 |
| US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| CN102612524A (zh) | 2009-09-01 | 2012-07-25 | 雅培制药有限公司 | 双重可变结构域免疫球蛋白及其用途 |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| US20110064743A1 (en) | 2009-09-09 | 2011-03-17 | Hammond Philip W | Human anti-cancer antibodies |
| WO2011030107A1 (en) | 2009-09-10 | 2011-03-17 | Ucb Pharma S.A. | Multivalent antibodies |
| AU2010298036B2 (en) | 2009-09-25 | 2015-05-21 | Xoma Technology Ltd. | Screening methods |
| EP2490714A4 (en) | 2009-10-20 | 2013-11-13 | Glaxo Group Ltd | ASSAY OF ANTI-CD3 ANTIBODIES IN AUTOIMMUNE DISEASES |
| CA2780221A1 (en) | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| WO2011071541A2 (en) | 2009-12-11 | 2011-06-16 | The Scripps Research Institute | Cadherin modulatory agents |
| EP2516458A1 (en) | 2009-12-22 | 2012-10-31 | Novartis AG | Tetravalent cd47-antibody constant region fusion protein for use in therapy |
| US20110165161A1 (en) | 2009-12-23 | 2011-07-07 | Shih-Yao Lin | Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same |
| US9017669B2 (en) | 2009-12-28 | 2015-04-28 | Oncotherapy Science, Inc. | Anti-CDH3 antibodies and uses thereof |
| CN102014475B (zh) | 2010-01-08 | 2012-01-04 | 华为技术有限公司 | 资源映射、码分复用方法及装置 |
| US20120294857A1 (en) | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
| AU2011215267B2 (en) | 2010-02-10 | 2016-07-07 | Pdradiopharma Inc. | Radioactive metal-labeled anti-cadherin antibody |
| ES2582001T3 (es) | 2010-02-25 | 2016-09-08 | Affimed Gmbh | Molécula que se une a antígeno y usos de la misma |
| WO2011109588A1 (en) | 2010-03-03 | 2011-09-09 | Health Research Inc. | Novel cd3 epsilon immunogens and antibodies |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究（慕尼黑）有限責任公司 | 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體 |
| CN107090045A (zh) | 2010-05-03 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 用于肿瘤诊断和治疗的组合物和方法 |
| KR20130108295A (ko) | 2010-08-13 | 2013-10-02 | 베일러 리서치 인스티튜트 | 항원-제시 세포에 항체에 대한 보조제를 직접 표적화함을 기초로 하는 신규 백신 보조제 |
| MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
| ES2537207T3 (es) | 2010-08-16 | 2015-06-03 | Novimmune S.A. | Métodos para la generación de anticuerpos multiespecíficos y multivalentes |
| CA2814040C (en) | 2010-10-08 | 2021-03-23 | Joshua Michael Donaldson | A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use |
| JP2014015396A (ja) | 2010-10-29 | 2014-01-30 | Perseus Proteomics Inc | 高い親和性を有する抗ｃｄｈ３抗体 |
| EP2634194B1 (en) | 2010-10-29 | 2018-08-15 | Perseus Proteomics Inc. | Anti-cdh3 antibody having high internalization capacity |
| EP2647707B1 (en) | 2010-11-30 | 2018-09-12 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| EP2655415A4 (en) | 2010-12-22 | 2016-03-09 | Abbvie Inc | THREE VARIABLE DOMAIN LINK PROTEINS AND USES THEREOF |
| WO2012088302A2 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Half immunoglobulin binding proteins and uses thereof |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| AR085633A1 (es) | 2011-03-08 | 2013-10-16 | Baylor Res Inst | Coadyuvantes basados en anticuerpos que son dirigidos directamente a las celulas presentadoras en antigenos |
| CA2828347A1 (en) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Bispecific three-chain antibody-like molecules |
| JP5972915B2 (ja) | 2011-03-16 | 2016-08-17 | アムジエン・インコーポレーテツド | Ｆｃ変異体 |
| IN2013MN01438A (Direct) | 2011-03-17 | 2015-06-12 | Univ Ramot | |
| EP3138581B1 (en) | 2011-03-17 | 2019-01-02 | The University of Birmingham | Re-directed immunotherapy |
| US20120244155A1 (en) | 2011-03-22 | 2012-09-27 | Baylor Research Institute | Dendritic Cells (DCs) Targeting for Tuberculosis (TB) Vaccine |
| TW201300418A (zh) | 2011-03-25 | 2013-01-01 | Baylor Res Inst | 用於抗ｃ型肝炎病毒免疫之組合物及方法 |
| TWI671315B (zh) | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| WO2012145183A2 (en) | 2011-04-19 | 2012-10-26 | Pfizer Inc. | Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer |
| RU2632647C2 (ru) | 2011-04-22 | 2017-10-06 | Аптево Рисерч Энд Девелопмент Ллс | Белки, связывающие специфический мембранный антиген простаты, и соответствующие композиции и способы |
| JP6400470B2 (ja) | 2011-05-16 | 2018-10-03 | ジェネロン（シャンハイ）コーポレイション リミテッド | 多重特異性Ｆａｂ融合タンパク質および使用法 |
| CN104080804B (zh) | 2011-05-21 | 2017-06-09 | 宏观基因有限公司 | 去免疫化的血清结合结构域及其延长血清半衰期的用途 |
| NZ703939A (en) | 2011-05-21 | 2016-01-29 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| WO2012162583A1 (en) | 2011-05-26 | 2012-11-29 | Ibc Pharmaceuticals, Inc. | Design and construction of novel multivalent antibodies |
| RS64179B1 (sr) | 2011-05-27 | 2023-05-31 | Hoffmann La Roche | Dvostruko ciljanje |
| CN103635490A (zh) | 2011-06-16 | 2014-03-12 | 诺瓦提斯公司 | 用作治疗剂的可溶性蛋白 |
| JPWO2012176765A1 (ja) | 2011-06-24 | 2015-02-23 | 株式会社ペルセウスプロテオミクス | 抗ヒトｐ−カドへリン（ｃｄｈ３）遺伝子組み換え抗体 |
| US20140242081A1 (en) | 2011-07-18 | 2014-08-28 | Micromet Ag | Dosing regimens for treatment of cea-expressing cancers |
| MX347829B (es) | 2011-07-22 | 2017-05-15 | Affimed Therapeutics Ag | Molécula fv de unión a antígeno multivalente. |
| KR101723273B1 (ko) | 2011-08-23 | 2017-04-04 | 로슈 글리카트 아게 | 2 개의 ｆａｂ 단편을 포함하는 fc-부재 항체 및 이용 방법 |
| WO2013026833A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| CA2844540C (en) | 2011-08-23 | 2018-10-16 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| DK2748202T3 (en) | 2011-08-23 | 2018-09-17 | Roche Glycart Ag | BISPECIFIC ANTI-BINDING MOLECULES |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| WO2013041865A1 (en) | 2011-09-22 | 2013-03-28 | Immunocore Limited | T cell receptors |
| WO2013041687A1 (en) | 2011-09-23 | 2013-03-28 | Amgen Research (Munich) Gmbh | Bispecific binding molecules for 5t4 and cd3 |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| DK2794658T3 (en) | 2011-12-19 | 2017-06-19 | Synimmune Gmbh | BISPECIFIC ANTIBODY MOLECULE |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| MX353382B (es) | 2012-03-01 | 2018-01-10 | Amgen Res Munich Gmbh | Moleculas de union polipeptido de larga duracion. |
| AU2012376421A1 (en) | 2012-04-04 | 2014-11-13 | Perseus Proteomics Inc. | Drug conjugate comprising anti-cdh3 (p-cadherin) antibody |
| CN104487587A (zh) | 2012-04-20 | 2015-04-01 | 新兴产品开发西雅图有限公司 | Cd3结合多肽 |
| EA039663B1 (ru) * | 2012-05-03 | 2022-02-24 | Амген Инк. | Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств |
| US10647756B2 (en) * | 2015-05-18 | 2020-05-12 | Pfizer Inc. | Humanized antibodies |
-
2015
- 2015-06-26 PE PE2016002813A patent/PE20170286A1/es unknown
- 2015-06-26 MX MX2016017393A patent/MX2016017393A/es unknown
- 2015-06-26 AU AU2015283704A patent/AU2015283704A1/en not_active Abandoned
- 2015-06-26 US US14/751,704 patent/US9884921B2/en not_active Expired - Fee Related
- 2015-06-26 RU RU2016151645A patent/RU2016151645A/ru not_active Application Discontinuation
- 2015-06-26 WO PCT/IB2015/054829 patent/WO2016001810A1/en not_active Ceased
- 2015-06-26 SG SG11201609707WA patent/SG11201609707WA/en unknown
- 2015-06-26 BR BR112016030740-2A patent/BR112016030740A2/pt not_active Application Discontinuation
- 2015-06-26 CN CN201580035515.8A patent/CN106661119A/zh active Pending
- 2015-06-26 EP EP15741347.7A patent/EP3164417A1/en not_active Withdrawn
- 2015-06-26 JP JP2016575335A patent/JP2017520575A/ja active Pending
- 2015-06-26 KR KR1020167036814A patent/KR20170010863A/ko not_active Ceased
- 2015-06-26 CA CA2895659A patent/CA2895659A1/en not_active Abandoned
- 2015-06-29 TW TW104120955A patent/TWI659042B/zh not_active IP Right Cessation
- 2015-06-29 TW TW107142295A patent/TW201936638A/zh unknown
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2016
- 2016-12-13 PH PH12016502491A patent/PH12016502491A1/en unknown
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2017
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- 2017-01-03 CO CONC2017/0000016A patent/CO2017000016A2/es unknown
- 2017-12-13 US US15/840,019 patent/US20180155452A1/en not_active Abandoned
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2018
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| IL249889A0 (en) | 2017-03-30 |
| PE20170286A1 (es) | 2017-03-30 |
| TW201612194A (en) | 2016-04-01 |
| AU2015283704A1 (en) | 2016-12-15 |
| CA2895659A1 (en) | 2016-01-01 |
| TWI659042B (zh) | 2019-05-11 |
| MX2016017393A (es) | 2017-09-05 |
| SG11201609707WA (en) | 2017-01-27 |
| WO2016001810A1 (en) | 2016-01-07 |
| EP3164417A1 (en) | 2017-05-10 |
| BR112016030740A2 (pt) | 2018-02-20 |
| RU2016151645A3 (Direct) | 2019-02-20 |
| US9884921B2 (en) | 2018-02-06 |
| KR20170010863A (ko) | 2017-02-01 |
| CO2017000016A2 (es) | 2017-05-19 |
| US20160002357A1 (en) | 2016-01-07 |
| US20180155452A1 (en) | 2018-06-07 |
| AU2018274919A1 (en) | 2019-01-03 |
| CN106661119A (zh) | 2017-05-10 |
| PH12016502491A1 (en) | 2017-03-22 |
| JP2017520575A (ja) | 2017-07-27 |
| TW201936638A (zh) | 2019-09-16 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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