RU2015111258A - Слабительные композиции и способы лечения запора и связанных с ним желудочно-кишечных заболеваний и состояний - Google Patents
Слабительные композиции и способы лечения запора и связанных с ним желудочно-кишечных заболеваний и состояний Download PDFInfo
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- RU2015111258A RU2015111258A RU2015111258A RU2015111258A RU2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A RU 2015111258 A RU2015111258 A RU 2015111258A
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- Prior art keywords
- salt
- acetate
- cellulose
- composition
- bisoxatin
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- 239000000203 mixture Substances 0.000 title claims abstract 34
- 206010010774 Constipation Diseases 0.000 title claims 8
- 238000000034 method Methods 0.000 title claims 6
- 206010017943 Gastrointestinal conditions Diseases 0.000 title 1
- 208000018522 Gastrointestinal disease Diseases 0.000 title 1
- BPKUDUSVDVLOPY-UHFFFAOYSA-N bisoxatin Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C(=O)NC2=CC=CC=C2O1 BPKUDUSVDVLOPY-UHFFFAOYSA-N 0.000 claims abstract 15
- ZCBJDQBSLZREAA-UHFFFAOYSA-N Bisoxatin acetate Chemical compound C1=CC(OC(=O)C)=CC=C1C1(C=2C=CC(OC(C)=O)=CC=2)C(=O)NC2=CC=CC=C2O1 ZCBJDQBSLZREAA-UHFFFAOYSA-N 0.000 claims abstract 11
- 229960002875 bisoxatin Drugs 0.000 claims abstract 11
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract 3
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- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims abstract 2
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- 125000001453 quaternary ammonium group Chemical group 0.000 claims abstract 2
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- 150000003839 salts Chemical class 0.000 claims 8
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 2
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- 239000005019 zein Substances 0.000 claims 2
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- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical class OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 239000000176 sodium gluconate Substances 0.000 claims 1
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- 229940005574 sodium gluconate Drugs 0.000 claims 1
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- 230000001148 spastic effect Effects 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 150000003890 succinate salts Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 150000003892 tartrate salts Chemical class 0.000 claims 1
- 150000003567 thiocyanates Chemical class 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims 1
- 229940001496 tribasic sodium phosphate Drugs 0.000 claims 1
- 235000013337 tricalcium citrate Nutrition 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920001727 cellulose butyrate Polymers 0.000 abstract 1
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Landscapes
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| US201261723027P | 2012-11-06 | 2012-11-06 | |
| US61/723,027 | 2012-11-06 | ||
| PCT/AU2013/000973 WO2014032108A1 (en) | 2012-08-29 | 2013-08-29 | Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions |
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| RU2015111258A true RU2015111258A (ru) | 2016-10-20 |
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| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| US10166219B2 (en) | 2012-07-27 | 2019-01-01 | Redhill Bipharma Ltd. | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| JP6441890B2 (ja) | 2013-03-15 | 2018-12-19 | ブレインツリー・ラボラトリーズ，インコーポレイテッド | 硫酸塩の両用経口薬学的組成物錠剤およびその使用の方法 |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| CA2910983C (en) * | 2013-04-30 | 2021-11-02 | Thomas Julius Borody | Compositions and methods for treating microbiota-related psychotropic conditions and diseases |
| WO2015084158A1 (en) * | 2013-12-06 | 2015-06-11 | N.V. Nutricia | A pyrimidine derivative and a fatty acid source for use in the treatment of constipation |
| US10105360B2 (en) * | 2013-12-11 | 2018-10-23 | Develco Pharma Schweiz Ag | Method and composition for the treatment of opioid induced constipation |
| EP3079661B1 (de) | 2013-12-11 | 2021-05-05 | Algobate AG | Naloxon-monopräparat und mehrschichttablette |
| KR101420315B1 (ko) * | 2014-03-19 | 2014-07-17 | 남봉길 | 약학적 액제 조성물 |
| RO130546B1 (ro) * | 2014-04-28 | 2019-03-29 | Mariana Lisinschi | Unguent pentru tratamentul bolii hemoroidale |
| EP3137167A4 (en) | 2014-04-29 | 2017-12-20 | Colonaryconcepts LLC | Foods, systems, methods, and kits for providing electrolyte replacement |
| EP3193901B1 (en) | 2014-12-23 | 2018-04-04 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
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| HK1247283A1 (zh) | 2015-03-02 | 2018-09-21 | 科罗纳里康赛普茨有限责任公司 | 用於peg代谢物及peg分解产物检测的化合物及方法 |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| WO2016178578A1 (en) * | 2015-05-06 | 2016-11-10 | Polyvation B.V. | Antimicrobial compositions and methods for reducing microbial contamination |
| MA55434B1 (fr) | 2015-06-15 | 2022-02-28 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| TWI759266B (zh) | 2015-06-15 | 2022-04-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物之用途 |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| PT3307288T (pt) | 2015-06-15 | 2019-10-17 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| RU2018105869A (ru) | 2015-08-17 | 2019-09-19 | Ферринг Б.В. | Жидкие составы, содержащие пикосульфат и цитрат магния |
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| US20190000976A1 (en) * | 2016-01-28 | 2019-01-03 | Ctc Bio,Inc. | Purgative Composition |
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| CN109475544A (zh) * | 2016-03-29 | 2019-03-15 | 科罗纳里康赛普茨有限责任公司 | 用于治疗便秘的制剂 |
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| CN109906079B (zh) | 2016-06-16 | 2022-09-30 | 库蒂斯制药公司 | 用于质子泵抑制剂混悬剂的组合物和方法 |
| US20190298735A1 (en) * | 2016-07-08 | 2019-10-03 | Vanderbilt University | Treatment and prevention of clostridium difficile colitis using misoprostol |
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| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
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