PL81315B1 - - Google Patents
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- Publication number
- PL81315B1 PL81315B1 PL1970140591A PL14059170A PL81315B1 PL 81315 B1 PL81315 B1 PL 81315B1 PL 1970140591 A PL1970140591 A PL 1970140591A PL 14059170 A PL14059170 A PL 14059170A PL 81315 B1 PL81315 B1 PL 81315B1
- Authority
- PL
- Poland
- Prior art keywords
- capsules
- resistant
- gastric juice
- primer
- gastric
- Prior art date
Links
- 239000002775 capsule Substances 0.000 claims description 41
- 229920002678 cellulose Polymers 0.000 claims description 14
- 210000004051 gastric juice Anatomy 0.000 claims description 14
- 239000001913 cellulose Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 239000001828 Gelatine Substances 0.000 claims description 11
- 229920000159 gelatin Polymers 0.000 claims description 11
- 235000019322 gelatine Nutrition 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000011241 protective layer Substances 0.000 claims description 7
- -1 hydroxymethylpropyl Chemical group 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 239000000084 colloidal system Substances 0.000 claims description 4
- 239000007903 gelatin capsule Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 3
- 239000010410 layer Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 210000000813 small intestine Anatomy 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 description 13
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 108010019160 Pancreatin Proteins 0.000 description 6
- 229940055695 pancreatin Drugs 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- MPCAJMNYNOGXPB-UHFFFAOYSA-N 1,5-Anhydro-mannit Natural products OCC1OCC(O)C(O)C1O MPCAJMNYNOGXPB-UHFFFAOYSA-N 0.000 description 2
- MPCAJMNYNOGXPB-SLPGGIOYSA-N 1,5-anhydro-D-glucitol Chemical compound OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O MPCAJMNYNOGXPB-SLPGGIOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 239000001593 sorbitan monooleate Substances 0.000 description 2
- 229940035049 sorbitan monooleate Drugs 0.000 description 2
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000019626 lipase activity Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691924647 DE1924647C3 (de) | 1969-05-14 | Verfahren zur Herstellung von tnagensaftresistenten, dünndarmlöslichen Gelatinekapseln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL81315B1 true PL81315B1 (enExample) | 1975-08-30 |
Family
ID=5734215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1970140591A PL81315B1 (enExample) | 1969-05-14 | 1970-05-14 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3656997A (enExample) |
| JP (1) | JPS4928409B1 (enExample) |
| AT (1) | AT292924B (enExample) |
| BE (1) | BE750379A (enExample) |
| DK (1) | DK125957B (enExample) |
| ES (1) | ES379655A1 (enExample) |
| FI (1) | FI50834C (enExample) |
| FR (1) | FR2051528B1 (enExample) |
| GB (1) | GB1281772A (enExample) |
| IT (1) | IT974530B (enExample) |
| NL (1) | NL165054C (enExample) |
| NO (1) | NO134729C (enExample) |
| PL (1) | PL81315B1 (enExample) |
| SE (1) | SE361129B (enExample) |
| YU (1) | YU36434B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2340060A1 (de) * | 1973-08-08 | 1975-02-20 | Scherer Gmbh R P | Magensaftresistente gelatinekapseln und verfahren zu deren herstellung |
| US3922379A (en) * | 1973-12-17 | 1975-11-25 | Abbott Lab | Microencapsulation process |
| JPS50140419U (enExample) * | 1974-05-04 | 1975-11-19 | ||
| JPS6024767B2 (ja) * | 1979-08-24 | 1985-06-14 | 塩野義製薬株式会社 | 腸溶性硬カプセル剤 |
| JPS57140710A (en) * | 1981-02-24 | 1982-08-31 | Shionogi & Co Ltd | Capsule agent for rectal administration |
| GB8305693D0 (en) * | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
| DE3307353C2 (de) * | 1983-03-02 | 1985-01-31 | R.P. Scherer GmbH, 6930 Eberbach | Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung |
| IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| US4849227A (en) * | 1986-03-21 | 1989-07-18 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
| AU608756B2 (en) * | 1986-03-21 | 1991-04-18 | Eurasiam Laboratories, Inc. | Compositions for the oral administration of biologically active materials |
| AU604052B2 (en) * | 1986-08-28 | 1990-12-06 | Enzacor Properties Limited | Animal growth promotant |
| US5597564A (en) * | 1986-08-28 | 1997-01-28 | Enzacor Properties Limited | Method of administering a microgranular preparation to the intestinal region of animals |
| US5356625A (en) * | 1986-08-28 | 1994-10-18 | Enzacor Properties Limited | Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals |
| US4816259A (en) * | 1987-02-12 | 1989-03-28 | Chase Chemical Company, L.P. | Process for coating gelatin capsules |
| US4834981A (en) * | 1987-05-06 | 1989-05-30 | Monte Woodrow C | Dietary vaccine for inhibiting metabolism of methanol |
| US5146730A (en) * | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
| US6482516B1 (en) * | 1993-07-20 | 2002-11-19 | Banner Pharmacaps, Inc. | Enrobed tablet |
| US5188688A (en) * | 1990-07-20 | 1993-02-23 | Minnesota Mining And Manufacturing Company | Method of sealing a gelatin capsule |
| US5146758A (en) * | 1991-03-04 | 1992-09-15 | Herman Norman L | Process of producing soft elastic gelatin capsules |
| GB2290965A (en) * | 1994-07-11 | 1996-01-17 | Therapicon Srl | Multiple layer capsules for drugs |
| ZA974359B (en) * | 1996-05-23 | 1998-05-12 | Zeneca Ltd | Microencapsulated compositions. |
| NL1009107C2 (nl) * | 1997-11-12 | 1999-06-15 | Banner Pharmacaps Inc | Gelatine-uitspreidende doos met meervoudige, aanpasbare poortklep en meerlagig zacht gel. |
| US20030124225A1 (en) * | 1999-11-01 | 2003-07-03 | Paul West | Encapsulated alcoholic beverage |
| US20040131670A1 (en) * | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
| US20040105885A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Gelatin capsule exhibiting reduced cross-linking |
| US20040105883A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Pharmaceutical dosage form capable of maintaining stable dissolution profile upon storage |
| US20050152969A1 (en) * | 2004-01-08 | 2005-07-14 | Chiprich Timothy B. | Colored liquid-filled soft capsules and method of manufacture thereof |
| EP1876914A2 (en) * | 2005-04-04 | 2008-01-16 | Archer-Daniels-Midland Company | Lignan-containing compositions |
| US20070053972A1 (en) * | 2005-09-08 | 2007-03-08 | Cadbury Adams Usa Llc. | Gelatin capsules containing actives |
| US7925351B2 (en) * | 2007-06-13 | 2011-04-12 | Betastim, Ltd. | Gastrointestinal device for treating obesity and diabetes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2491475A (en) * | 1946-03-25 | 1949-12-20 | Parke Davis & Co | Enteric capsule |
| US2540979A (en) * | 1948-04-24 | 1951-02-06 | Smith Kline French Lab | Enteric coating |
| US2789920A (en) * | 1955-12-19 | 1957-04-23 | American Cyanamid Co | Method of coating gelatin capsules with ethyl cellulose |
| US3097144A (en) * | 1960-10-14 | 1963-07-09 | Upjohn Co | Heat-cured, polymeric, medicinal dosage film coatings containing a polyvinylpyrrolidone copolymer, polyethenoid acid, and polyethylene glycol |
| NL122039C (enExample) * | 1960-10-20 | |||
| DE1467781A1 (de) * | 1963-07-15 | 1968-12-05 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von Dragees mit verlaengerter Wirkstofffreigabe |
| US3361632A (en) * | 1964-05-08 | 1968-01-02 | Hoechst Ag | Medicinal preparations having a protracted activity and method of making them |
| US3256111A (en) * | 1964-12-04 | 1966-06-14 | Abbott Lab | Method for coating tablets |
-
1970
- 1970-05-08 YU YU01171/70A patent/YU36434B/xx unknown
- 1970-05-11 US US36458A patent/US3656997A/en not_active Expired - Lifetime
- 1970-05-12 AT AT425470A patent/AT292924B/de not_active IP Right Cessation
- 1970-05-13 FI FI701348A patent/FI50834C/fi active
- 1970-05-13 IT IT24588/70A patent/IT974530B/it active
- 1970-05-13 GB GB23150/70A patent/GB1281772A/en not_active Expired
- 1970-05-13 ES ES379655A patent/ES379655A1/es not_active Expired
- 1970-05-13 NO NO1827/70A patent/NO134729C/no unknown
- 1970-05-13 FR FR7017461A patent/FR2051528B1/fr not_active Expired
- 1970-05-13 DK DK242270AA patent/DK125957B/da unknown
- 1970-05-14 PL PL1970140591A patent/PL81315B1/pl unknown
- 1970-05-14 JP JP45040563A patent/JPS4928409B1/ja active Pending
- 1970-05-14 BE BE750379A patent/BE750379A/xx unknown
- 1970-05-14 NL NL7006993.A patent/NL165054C/xx not_active IP Right Cessation
- 1970-05-14 SE SE06650/70A patent/SE361129B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO134729B (enExample) | 1976-08-30 |
| YU117170A (en) | 1982-02-25 |
| NL165054C (nl) | 1981-03-16 |
| FR2051528A1 (enExample) | 1971-04-09 |
| DE1924647A1 (de) | 1970-11-19 |
| ES379655A1 (es) | 1973-01-16 |
| US3656997A (en) | 1972-04-18 |
| AT292924B (de) | 1971-09-10 |
| DE1924647B2 (de) | 1974-11-28 |
| IT974530B (it) | 1974-07-10 |
| NL165054B (nl) | 1980-10-15 |
| GB1281772A (en) | 1972-07-12 |
| NO134729C (enExample) | 1976-12-08 |
| NL7006993A (enExample) | 1970-11-17 |
| FR2051528B1 (enExample) | 1974-04-12 |
| SE361129B (enExample) | 1973-10-22 |
| BE750379A (fr) | 1970-10-16 |
| YU36434B (en) | 1984-02-29 |
| JPS4928409B1 (enExample) | 1974-07-26 |
| FI50834B (enExample) | 1976-04-30 |
| FI50834C (fi) | 1976-08-10 |
| DK125957B (da) | 1973-05-28 |
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