RU2014128500A - Композиции омега-3 полиненасыщенных жирных кислот в форме свободной кислоты, обогащенные DPA - Google Patents

Композиции омега-3 полиненасыщенных жирных кислот в форме свободной кислоты, обогащенные DPA Download PDF

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RU2014128500A
RU2014128500A RU2014128500A RU2014128500A RU2014128500A RU 2014128500 A RU2014128500 A RU 2014128500A RU 2014128500 A RU2014128500 A RU 2014128500A RU 2014128500 A RU2014128500 A RU 2014128500A RU 2014128500 A RU2014128500 A RU 2014128500A
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slfp
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Тимоти Дж. МЭЙНС
Бернандус Н М МАЧИЛС
Бхарат М. МЕХТА
Джеральд УАЙСЛЕР
Майкл ДЭВИДСОН
Питер Ральф ВУД
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Омтера Фармасьютикалс, Инк.
Крисалис Фарма Аг
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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Abstract

1. Фк сЕ(эк, псвфск вкпммп(аа 50%;DHA (дк, псвфск вкпммп15% (аа;DPA (дк, псвфск вкпммп1% (аа.2. Фкп п 1, вкDPA пвкпммп2% (аа.3. Фкп п 1, вкDPA пвкпммп2,5% (аа.4. Фкп п 1, вкDPA пвкпммп3% (аа.5. Фкп п 1, вкDPA пвкпммп3,5% (аа.6. Фкп п 1, вкЕпвкпммп51% (аа.7. Фкп п 1, вкЕпвкпммп52% (аа.8. Фкп п 1, вкЕпвкпммп53% (аа.9. Фкп п 1, вкЕпвкпммп54% (аа.10. Фкп п 1, вкDHA пвкпммп16% (аа.11. Фкп п 1, вкDHA пвкпммп17% (аа.12. Фкп п 1, вкЕпвкоп55% (аа дп56% (аа;DHA пвкоп19% (аа дп20% (аа; иDPA пвкоп4% (аа дп5% (аа.13. Фк сЕ псвфск вкоп50% (мм (ппмвжквк дп60% (мм;DHA, псвфск вкоп15% (мм дп25% (мм; иDPA, псвфск вкнмчп1% (мм.14. Фкп п 13, вкЕиDHA пвокоп70% (мм дп80% (мм.15. Фкп п 14, вко3 пжкпвоко80% (мм дп95% (мм.16. Фкп п 15, вко6 пжкпвокнбчп10% (мм.17. Фкп п 1, вкэ еп пвкнб чп0,1 м(чнм э18. Слф пдпв сквкипмм250 мфкп п 1.19. Слфп п 18, гвукипмм500 мф кп п 1.20. Слфп п 18, гвукип1000 мф кп п 1.21. Слфп п 18, гоксж22. Слфп п 21, гкпсмжк23. Слфп п 22, гомжкссжтА24. Слфп п 23, гомжксдксжтАто чкрвтпвнбч30 мвовп37Спхвтпмм3 мп40С25. Слфп п 23, гжомжкспмм5% сжтА26. Слфп п 23, гжомжкспмм25% сжтА27. Слфп п 26, гомжкспмм50% сжтА28. Слфп п 22, гмжкиво29. Слфп п 28, гонячкpH.30. Слфп п 29, госпам с31. Слфп п 30, гпам спсEudragit NE-30D.32. Слфп п 29, гнпсвифкрчч30 мппв33. Слфп п 32, гпсвифкпч60 мппв34. Слфп п 28, гопсзоpH эо35. Дн смслфп п 18.36. Днп п 35, спмм60 слф37. Днп п 35, спмм120 слф38. Слтг в пвфкп п 1 п иутвсипкдлнм500 мдвкивтв эдсутвсипкнудл39. Сп п 38, гэкспммп

Claims (38)

1. Фк с
Е(эк, псвфск вкпммп(аа 50%;
DHA (дк, псвфск вкпммп15% (аа;
DPA (дк, псвфск вкпммп1% (аа.
2. Фкп п 1, вк
DPA пвкпммп2% (аа.
3. Фкп п 1, вк
DPA пвкпммп2,5% (аа.
4. Фкп п 1, вк
DPA пвкпммп3% (аа.
5. Фкп п 1, вк
DPA пвкпммп3,5% (аа.
6. Фкп п 1, вк
Епвкпммп51% (аа.
7. Фкп п 1, вк
Епвкпммп52% (аа.
8. Фкп п 1, вк
Епвкпммп53% (аа.
9. Фкп п 1, вк
Епвкпммп54% (аа.
10. Фкп п 1, вк
DHA пвкпммп16% (аа.
11. Фкп п 1, вк
DHA пвкпммп17% (аа.
12. Фкп п 1, вк
Епвкоп55% (аа дп56% (аа;
DHA пвкоп19% (аа дп20% (аа; и
DPA пвкоп4% (аа дп5% (аа.
13. Фк с
Е псвфск вкоп50% (мм (ппмвжквк дп60% (мм;
DHA, псвфск вкоп15% (мм дп25% (мм; и
DPA, псвфск вкнмчп1% (мм.
14. Фкп п 13, вк
ЕиDHA пвокоп70% (мм дп80% (мм.
15. Фкп п 14, вк
о3 пжкпвоко80% (мм дп95% (мм.
16. Фкп п 15, вк
о6 пжкпвокнбчп10% (мм.
17. Фкп п 1, вк
э еп пвкнб чп0,1 м-1 (чнм э
18. Слф пдпв с
к
вкипмм250 мфкп п 1.
19. Слфп п 18, гву
кипмм500 мф кп п 1.
20. Слфп п 18, гву
кип1000 мф кп п 1.
21. Слфп п 18, гоксж
22. Слфп п 21, гкпсмжк
23. Слфп п 22, гомжкссжтА
24. Слфп п 23, гомжксдксжтАто чкрвтпвнбч30 мвовп37Спхвтпмм3 мп40С
25. Слфп п 23, гжомжкспмм5% сжтА
26. Слфп п 23, гжомжкспмм25% сжтА
27. Слфп п 26, гомжкспмм50% сжтА
28. Слфп п 22, гмжкиво
29. Слфп п 28, гонячкpH.
30. Слфп п 29, госпам с
31. Слфп п 30, гпам спсEudragit NE-30D.
32. Слфп п 29, гнпсвифкрчч30 мппв
33. Слфп п 32, гпсвифкпч60 мппв
34. Слфп п 28, гопсзоpH эо
35. Дн с
мслфп п 18.
36. Днп п 35, с
пмм60 слф
37. Днп п 35, с
пмм120 слф
38. Слтг в пвфкп п 1 п иутвсипкдлнм500 мд
вкивтв эдсутвсипкнудл39. Сп п 38, гэкспммп
RU2014128500A 2012-01-06 2013-01-04 Композиции омега-3 полиненасыщенных жирных кислот в форме свободной кислоты, обогащенные DPA RU2664429C2 (ru)

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US201261583796P 2012-01-06 2012-01-06
US61/583,796 2012-01-06
US201261664047P 2012-06-25 2012-06-25
US61/664,047 2012-06-25
US201261669940P 2012-07-10 2012-07-10
US61/669,940 2012-07-10
US201261680622P 2012-08-07 2012-08-07
US61/680,622 2012-08-07
US201261710517P 2012-10-05 2012-10-05
US61/710,517 2012-10-05
US201261713388P 2012-10-12 2012-10-12
US61/713,388 2012-10-12
PCT/US2013/020398 WO2013103902A1 (en) 2012-01-06 2013-01-04 Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form

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RU2018116572A RU2018116572A (ru) 2012-01-06 2013-01-04 Композиции омега-3 полиненасыщенных жирных кислот в форме свободной кислоты, обогащенные DPA

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