BR112014016788A2 - composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpa - Google Patents
composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpaInfo
- Publication number
- BR112014016788A2 BR112014016788A2 BR112014016788A BR112014016788A BR112014016788A2 BR 112014016788 A2 BR112014016788 A2 BR 112014016788A2 BR 112014016788 A BR112014016788 A BR 112014016788A BR 112014016788 A BR112014016788 A BR 112014016788A BR 112014016788 A2 BR112014016788 A2 BR 112014016788A2
- Authority
- BR
- Brazil
- Prior art keywords
- dpa
- polyunsaturated fatty
- free acid
- compositions
- fatty acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 235000020660 omega-3 fatty acid Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 238000011282 treatment Methods 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 235000021323 fish oil Nutrition 0.000 abstract 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 2
- 238000007670 refining Methods 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229940127218 antiplatelet drug Drugs 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Developing Agents For Electrophotography (AREA)
- Materials For Photolithography (AREA)
Abstract
abstract of the disclosure dpa-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented. _________________________ tradução do resumo resumo patente de invenção: "composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enri-quecidas com dpa". a presente invenção refere-se a composições farmacêuticas de ácidos graxos poli-insaturados em forma de ácido livre, enri-quecidas com dpa, a métodos terapêuticos para o uso das composições e a processos para o seu refino a partir de óleo de peixe. a presente invenção também provê métodos para tratar hipertrigliceridemia (200 mg/dl - 500 mg/dl) pela administração adjuvante de uma estatina e as composições farmacêuticas descritas no pedido de patente. métodos de tratamentos adicionais incluem, entre outros, tratamentos para aumentar as razões epa:aa, tratamentos para diminuir os níveis de apociii e tratamentos para reduzir ou prevenir a resistência a inibi-dores da agregação plaquetária.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261583796P | 2012-01-06 | 2012-01-06 | |
US201261664047P | 2012-06-25 | 2012-06-25 | |
US201261669940P | 2012-07-10 | 2012-07-10 | |
US201261680622P | 2012-08-07 | 2012-08-07 | |
US201261710517P | 2012-10-05 | 2012-10-05 | |
US201261713388P | 2012-10-12 | 2012-10-12 | |
PCT/US2013/020398 WO2013103902A1 (en) | 2012-01-06 | 2013-01-04 | Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014016788A2 true BR112014016788A2 (pt) | 2017-06-13 |
BR112014016788A8 BR112014016788A8 (pt) | 2017-07-04 |
Family
ID=48744082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014016788A BR112014016788A8 (pt) | 2012-01-06 | 2013-01-04 | composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpa |
Country Status (34)
Country | Link |
---|---|
US (5) | US9050308B2 (pt) |
EP (2) | EP3348262A1 (pt) |
JP (3) | JP6399655B2 (pt) |
KR (2) | KR102153143B1 (pt) |
CN (3) | CN108524483A (pt) |
BR (1) | BR112014016788A8 (pt) |
CA (1) | CA2860512C (pt) |
CL (1) | CL2014001803A1 (pt) |
CO (1) | CO7061070A2 (pt) |
CY (1) | CY1120663T1 (pt) |
DK (1) | DK2800563T3 (pt) |
DO (1) | DOP2014000159A (pt) |
EC (1) | ECSP14012527A (pt) |
ES (1) | ES2685703T3 (pt) |
HK (2) | HK1202073A1 (pt) |
HR (1) | HRP20181418T1 (pt) |
HU (1) | HUE039659T2 (pt) |
IL (3) | IL233517A (pt) |
IN (1) | IN2014DN06125A (pt) |
LT (1) | LT2800563T (pt) |
MX (1) | MX358319B (pt) |
MY (1) | MY165048A (pt) |
NZ (1) | NZ626699A (pt) |
PE (1) | PE20142459A1 (pt) |
PH (2) | PH12014501553A1 (pt) |
PL (1) | PL2800563T3 (pt) |
PT (1) | PT2800563T (pt) |
RS (1) | RS57777B1 (pt) |
RU (2) | RU2018116572A (pt) |
SG (2) | SG10201701004RA (pt) |
SI (1) | SI2800563T1 (pt) |
UA (1) | UA114615C2 (pt) |
WO (1) | WO2013103902A1 (pt) |
ZA (1) | ZA201405765B (pt) |
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GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
UA114615C2 (uk) * | 2012-01-06 | 2017-07-10 | Омтера Фармасьютікалз, Інк. | Збагачена дпк композиція омега-3 поліненасичених жирних кислот у формі вільної кислоти |
RU2645075C2 (ru) | 2012-05-07 | 2018-02-15 | Омтера Фармасьютикалс, Инк. | Композиции статинов и омега-3 жирных кислот |
CA2916208A1 (en) * | 2012-06-17 | 2013-12-27 | Matinas Biopharma, Inc. | Omega-3 pentaenoic acid compositions and methods of use |
GB201216385D0 (en) * | 2012-09-13 | 2012-10-31 | Chrysalis Pharma Ag | A pharmaceutical composition |
JP2016500055A (ja) * | 2012-10-23 | 2016-01-07 | ディーキン・ユニバーシティー | トリグリセリドを低減させる方法 |
US9629820B2 (en) | 2012-12-24 | 2017-04-25 | Qualitas Health, Ltd. | Eicosapentaenoic acid (EPA) formulations |
US10123986B2 (en) | 2012-12-24 | 2018-11-13 | Qualitas Health, Ltd. | Eicosapentaenoic acid (EPA) formulations |
GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
US9452151B2 (en) * | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
WO2015011724A2 (en) | 2013-07-22 | 2015-01-29 | Kms Health Center Pvt Ltd | A novel omega -3 fatty acid composition with a plant extract |
WO2015024055A1 (en) * | 2013-08-20 | 2015-02-26 | Deakin University | Separation of omega-3 fatty acids |
EP3738586A1 (en) | 2013-10-30 | 2020-11-18 | Patheon Softgels Inc. | Enteric soft capsules comprising polyunsaturated fatty acids |
JP2016538288A (ja) | 2013-11-15 | 2016-12-08 | ディグニティ サイエンシス リミテッド | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
CA2947741A1 (en) | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
SG11201610207WA (en) | 2014-06-04 | 2017-01-27 | Dignity Sciences Ltd | Pharmaceutical compositions comprising dgla and use of same |
US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
US9999626B2 (en) | 2014-06-18 | 2018-06-19 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of active agents |
US9895333B2 (en) | 2014-06-26 | 2018-02-20 | Patheon Softgels Inc. | Enhanced bioavailability of polyunsaturated fatty acids |
WO2016069446A1 (en) * | 2014-10-28 | 2016-05-06 | Omthera Pharmaceuticals Inc | Methods for modulating plasma levels of lipoproteins |
WO2016073335A1 (en) * | 2014-11-05 | 2016-05-12 | Omthera Pharmaceuticals Inc. | Methods of treatment |
US20160192126A1 (en) * | 2014-12-31 | 2016-06-30 | Silver Spring Networks, Inc. | System and method for tracking a device |
MA41611A (fr) | 2015-02-23 | 2018-01-02 | Omthera Pharmaceuticals Inc | Préparations en milli-capsules comprenant des acides gras polyinsaturés libres |
WO2016178066A1 (en) * | 2015-05-01 | 2016-11-10 | Mohan M Alapati | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome |
ES2851525T3 (es) | 2015-07-21 | 2021-09-07 | Afimmune Ltd | Composiciones que comprenden 15(S)-HEPE para su uso en la sensibilización de las células cancerosas a la radioterapia |
US10263794B2 (en) * | 2016-05-19 | 2019-04-16 | Linear Technology Corporation | Maintain power signature controller at power interface of PoE or PoDL system |
EP3454907B1 (en) | 2016-06-03 | 2020-07-22 | Thetis Pharmaceuticals LLC | Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation |
GB201611920D0 (en) | 2016-07-08 | 2016-08-24 | Astrazeneca Ab | Pharmaceutical compositions |
WO2019008101A1 (en) | 2017-07-06 | 2019-01-10 | Evonik Technochemie Gmbh | ENTERICALLY COATED SOLID DOSAGE FORM COMPRISING AMINO ACIDS SALTS OF OMEGA-3 FATTY ACIDS |
WO2019034698A1 (en) | 2017-08-15 | 2019-02-21 | Evonik Technochemie Gmbh | TABLET WITH HIGH ACTIVE INGREDIENT CONTENT OF OMEGA-3 FATTY ACID AMINO ACID SALTS |
EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
JP2022543283A (ja) | 2019-08-08 | 2022-10-11 | エボニック オペレーションズ ゲーエムベーハー | 多価不飽和脂肪酸塩を製造するための下流処理 |
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