RU2006115558A - Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы - Google Patents
Ингибиторы сериновых протеаз, особенно hcv ns3-ns4a протеазы Download PDFInfo
- Publication number
- RU2006115558A RU2006115558A RU2006115558/04A RU2006115558A RU2006115558A RU 2006115558 A RU2006115558 A RU 2006115558A RU 2006115558/04 A RU2006115558/04 A RU 2006115558/04A RU 2006115558 A RU2006115558 A RU 2006115558A RU 2006115558 A RU2006115558 A RU 2006115558A
- Authority
- RU
- Russia
- Prior art keywords
- ring
- aliphatic group
- cycloalkyl
- heteroaryl
- aryl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 8
- 102000012479 Serine Proteases Human genes 0.000 title claims 5
- 108010022999 Serine Proteases Proteins 0.000 title claims 5
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 claims 95
- 229910052757 nitrogen Inorganic materials 0.000 claims 65
- 125000001424 substituent group Chemical group 0.000 claims 62
- 229910052760 oxygen Inorganic materials 0.000 claims 57
- 229910052717 sulfur Inorganic materials 0.000 claims 57
- 125000005842 heteroatom Chemical group 0.000 claims 53
- 125000000623 heterocyclic group Chemical group 0.000 claims 52
- 150000001875 compounds Chemical class 0.000 claims 51
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims 49
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 49
- 125000003118 aryl group Chemical group 0.000 claims 47
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 45
- 125000004429 atom Chemical group 0.000 claims 36
- 125000001072 heteroaryl group Chemical group 0.000 claims 30
- -1 1,2-methylenedioxy Chemical group 0.000 claims 24
- 125000000165 tricyclic carbocycle group Chemical group 0.000 claims 19
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 claims 8
- 125000006721 (C5-C10) heteroaryl (C1-C6) alkyl group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000464 thioxo group Chemical group S=* 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 4
- 239000003443 antiviral agent Substances 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 4
- 239000010839 body fluid Substances 0.000 claims 4
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 230000002519 immonomodulatory effect Effects 0.000 claims 3
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 3
- 229940122604 HCV protease inhibitor Drugs 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000003996 Interferon-beta Human genes 0.000 claims 2
- 108090000467 Interferon-beta Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
- 102000007501 Thymosin Human genes 0.000 claims 2
- 108010046075 Thymosin Proteins 0.000 claims 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 2
- 229960003805 amantadine Drugs 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 229940044627 gamma-interferon Drugs 0.000 claims 2
- 229960000329 ribavirin Drugs 0.000 claims 2
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000003311 Cytochrome P-450 Enzyme Inhibitors Diseases 0.000 claims 1
- 229940122280 Cytochrome P450 inhibitor Drugs 0.000 claims 1
- 102000018832 Cytochromes Human genes 0.000 claims 1
- 108010052832 Cytochromes Proteins 0.000 claims 1
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims 1
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 1
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000010241 blood sampling Methods 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 229960000311 ritonavir Drugs 0.000 claims 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical group N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 claims 1
- 229960005311 telbivudine Drugs 0.000 claims 1
- 0 CCCCC([C@@](C)CCC)[C@@]1*2(CCCC2)C1C Chemical compound CCCCC([C@@](C)CCC)[C@@]1*2(CCCC2)C1C 0.000 description 6
- ZPRZWFMMXITIEN-UHFFFAOYSA-N CC(C(C1)N(C)C(C2)C1C1C2CCCC1)=O Chemical compound CC(C(C1)N(C)C(C2)C1C1C2CCCC1)=O ZPRZWFMMXITIEN-UHFFFAOYSA-N 0.000 description 1
- PSYGDLIDUQPOKY-UHFFFAOYSA-N CC(C(C1)N(C)CC1OCc1cc(cccc2)c2cc1)=O Chemical compound CC(C(C1)N(C)CC1OCc1cc(cccc2)c2cc1)=O PSYGDLIDUQPOKY-UHFFFAOYSA-N 0.000 description 1
- MSALOQXDUIXDDG-UHFFFAOYSA-N CC(C(C1)N(C)CC1OCc1cccc2c1cccc2)=O Chemical compound CC(C(C1)N(C)CC1OCc1cccc2c1cccc2)=O MSALOQXDUIXDDG-UHFFFAOYSA-N 0.000 description 1
- DNCOHZODLHDVGD-UHFFFAOYSA-N CC(C(C1)N(C)CC1OCc1ccccc1)=O Chemical compound CC(C(C1)N(C)CC1OCc1ccccc1)=O DNCOHZODLHDVGD-UHFFFAOYSA-N 0.000 description 1
- CJJIOQWQNCHWOP-MRTLOADZSA-N CC(C(C1)N(C)C[C@@H]1[n](nc1-c2ccccc2)nc1-c1ccccc1)=O Chemical compound CC(C(C1)N(C)C[C@@H]1[n](nc1-c2ccccc2)nc1-c1ccccc1)=O CJJIOQWQNCHWOP-MRTLOADZSA-N 0.000 description 1
- WTYLAGIFKVNSEQ-UHFFFAOYSA-N CC(C(C=CC1CC2NC)N1C2=O)=O Chemical compound CC(C(C=CC1CC2NC)N1C2=O)=O WTYLAGIFKVNSEQ-UHFFFAOYSA-N 0.000 description 1
- PENAODPZFZITCT-UHFFFAOYSA-N CC(C(CC1)N(C2)C1CCC2NC)=O Chemical compound CC(C(CC1)N(C2)C1CCC2NC)=O PENAODPZFZITCT-UHFFFAOYSA-N 0.000 description 1
- PRJWZCFBRYCMOE-UHFFFAOYSA-N CC(C(CC1)N(C2=O)N1CCCN2NC)=O Chemical compound CC(C(CC1)N(C2=O)N1CCCN2NC)=O PRJWZCFBRYCMOE-UHFFFAOYSA-N 0.000 description 1
- VMTLDTWEMMJNCU-UHFFFAOYSA-N CC(C(CC12)N(C)C1NC1C2NCCC1)=O Chemical compound CC(C(CC12)N(C)C1NC1C2NCCC1)=O VMTLDTWEMMJNCU-UHFFFAOYSA-N 0.000 description 1
- UPXMTVUDVIMOMT-UHFFFAOYSA-N CC(C(CC12)N(C)C1Nc1c2cccn1)=O Chemical compound CC(C(CC12)N(C)C1Nc1c2cccn1)=O UPXMTVUDVIMOMT-UHFFFAOYSA-N 0.000 description 1
- MPZORVHGOJJCBE-UHFFFAOYSA-N CC(C(CC12)N(C)C1Nc1c2ccnc1)=O Chemical compound CC(C(CC12)N(C)C1Nc1c2ccnc1)=O MPZORVHGOJJCBE-UHFFFAOYSA-N 0.000 description 1
- APKLCLCQXYADRE-UHFFFAOYSA-N CC(C(CC12)N(C)C1Nc1c2cncc1)=O Chemical compound CC(C(CC12)N(C)C1Nc1c2cncc1)=O APKLCLCQXYADRE-UHFFFAOYSA-N 0.000 description 1
- YPQOSOMZNCTZIV-UHFFFAOYSA-N CC(C(CCC1)N(C2=O)N1CCCN2NC)=O Chemical compound CC(C(CCC1)N(C2=O)N1CCCN2NC)=O YPQOSOMZNCTZIV-UHFFFAOYSA-N 0.000 description 1
- WCWAJWJVMPOYLI-UHFFFAOYSA-N CC(C(CCC1=NC=C2NC)N1C2=O)=O Chemical compound CC(C(CCC1=NC=C2NC)N1C2=O)=O WCWAJWJVMPOYLI-UHFFFAOYSA-N 0.000 description 1
- KVVPVHPVSILHSX-UHFFFAOYSA-N CC(C(CCCC1=NC=C2NC)N1C2=O)=O Chemical compound CC(C(CCCC1=NC=C2NC)N1C2=O)=O KVVPVHPVSILHSX-UHFFFAOYSA-N 0.000 description 1
- PMGQDOGUGBNIHE-UHFFFAOYSA-N CC(C(CNC1CC2NC)N1C2=O)=O Chemical compound CC(C(CNC1CC2NC)N1C2=O)=O PMGQDOGUGBNIHE-UHFFFAOYSA-N 0.000 description 1
- JTZRPWNKLZJZFB-UHFFFAOYSA-N CC(C(COC1CC2NC)N1C2=O)=O Chemical compound CC(C(COC1CC2NC)N1C2=O)=O JTZRPWNKLZJZFB-UHFFFAOYSA-N 0.000 description 1
- AUFZRNJYCVYWAN-UHFFFAOYSA-N CC(C(CSC1CC2NC)N1C2=O)=O Chemical compound CC(C(CSC1CC2NC)N1C2=O)=O AUFZRNJYCVYWAN-UHFFFAOYSA-N 0.000 description 1
- SJEZIHPCSCLGGK-UHFFFAOYSA-N CC(C1N(C)C2NC(CCCC3)C3C2C1)=O Chemical compound CC(C1N(C)C2NC(CCCC3)C3C2C1)=O SJEZIHPCSCLGGK-UHFFFAOYSA-N 0.000 description 1
- WYVCVCNDHCXMPG-UHFFFAOYSA-N CC(C1N(C)C2NC(CCNC3)C3C2C1)=O Chemical compound CC(C1N(C)C2NC(CCNC3)C3C2C1)=O WYVCVCNDHCXMPG-UHFFFAOYSA-N 0.000 description 1
- LERQTEOOMKVSKM-UHFFFAOYSA-N CC(C1N(C)C2NC(CNCC3)C3C2C1)=O Chemical compound CC(C1N(C)C2NC(CNCC3)C3C2C1)=O LERQTEOOMKVSKM-UHFFFAOYSA-N 0.000 description 1
- GZBPEQHESSJRPW-UHFFFAOYSA-N CC(C1N(C)C2NC3NCCCC3C2C1)=O Chemical compound CC(C1N(C)C2NC3NCCCC3C2C1)=O GZBPEQHESSJRPW-UHFFFAOYSA-N 0.000 description 1
- LEWRGDPKNRUOBT-UHFFFAOYSA-N CC(C1N(C)C2Nc3cccnc3C2C1)=O Chemical compound CC(C1N(C)C2Nc3cccnc3C2C1)=O LEWRGDPKNRUOBT-UHFFFAOYSA-N 0.000 description 1
- BVVCPCIUYCENAS-UHFFFAOYSA-N CC(C1N(C)C2OC(CCCC3)C3C2C1)=O Chemical compound CC(C1N(C)C2OC(CCCC3)C3C2C1)=O BVVCPCIUYCENAS-UHFFFAOYSA-N 0.000 description 1
- FDIKJQSLNVXCGP-UHFFFAOYSA-N CC(C1N(C)C2SC(CCCC3)C3C2C1)=O Chemical compound CC(C1N(C)C2SC(CCCC3)C3C2C1)=O FDIKJQSLNVXCGP-UHFFFAOYSA-N 0.000 description 1
- UGXICRZJJBNLES-UHFFFAOYSA-N CC(C1N(C)CC2C1C1CC2CC1)=O Chemical compound CC(C1N(C)CC2C1C1CC2CC1)=O UGXICRZJJBNLES-UHFFFAOYSA-N 0.000 description 1
- AZZDJWMTNMLXTE-UHFFFAOYSA-N CC(C1N(C)CC2C1C1NC2CC1)=O Chemical compound CC(C1N(C)CC2C1C1NC2CC1)=O AZZDJWMTNMLXTE-UHFFFAOYSA-N 0.000 description 1
- DTXRKOMFJJIHQQ-UHFFFAOYSA-N CC(C1N(C)CC2C1C1SC2CC1)=O Chemical compound CC(C1N(C)CC2C1C1SC2CC1)=O DTXRKOMFJJIHQQ-UHFFFAOYSA-N 0.000 description 1
- MBYLCPNYNFPEGO-UHFFFAOYSA-N CC(C1N(C)CC2C1SCCC2)=O Chemical compound CC(C1N(C)CC2C1SCCC2)=O MBYLCPNYNFPEGO-UHFFFAOYSA-N 0.000 description 1
- OEKQXFLIHRRQRX-UHFFFAOYSA-N CC(C1N(C)Cc2c(cc3)[o]c3c12)=O Chemical compound CC(C1N(C)Cc2c(cc3)[o]c3c12)=O OEKQXFLIHRRQRX-UHFFFAOYSA-N 0.000 description 1
- NWTVYVJSHUOOCE-UHFFFAOYSA-N CC(C1N(CC(CC2)NC)C2NC1)=O Chemical compound CC(C1N(CC(CC2)NC)C2NC1)=O NWTVYVJSHUOOCE-UHFFFAOYSA-N 0.000 description 1
- APHUYPADINESLM-UHFFFAOYSA-N CC(C1N(CC(CC2)NC)C2OC1)=O Chemical compound CC(C1N(CC(CC2)NC)C2OC1)=O APHUYPADINESLM-UHFFFAOYSA-N 0.000 description 1
- ULSXBYJFOPUNQS-UHFFFAOYSA-N CC(C1N(CC(CC2)NC)C2SC1)=O Chemical compound CC(C1N(CC(CC2)NC)C2SC1)=O ULSXBYJFOPUNQS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51015603P | 2003-10-10 | 2003-10-10 | |
| US60/510,156 | 2003-10-10 | ||
| US51376803P | 2003-10-23 | 2003-10-23 | |
| US60/513,768 | 2003-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006115558A true RU2006115558A (ru) | 2007-11-20 |
Family
ID=34467967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| SK742003A3 (en) | 2000-07-21 | 2003-06-03 | Schering Corp | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |
| AR034127A1 (es) | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
| CN1498224A (zh) * | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| ES2263687T3 (es) | 2000-11-20 | 2006-12-16 | Bristol-Myers Squibb Company | Inhibidores tripeptidicos de la hepatitis c. |
| WO2002048157A2 (en) | 2000-12-13 | 2002-06-20 | Bristol-Myers Squibb Pharma Company | Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors |
| WO2002048116A2 (en) | 2000-12-13 | 2002-06-20 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
| GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
| IL159087A0 (en) | 2001-07-11 | 2004-05-12 | Vertex Pharma | Bridged bicyclic compounds and pharmaceutical compositions containing the same |
| AU2002348414B2 (en) * | 2001-10-24 | 2009-10-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system |
| CA2369970A1 (en) * | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
| AU2003223602B8 (en) * | 2002-04-11 | 2010-05-27 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4 protease |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| CA2515216A1 (en) | 2003-02-07 | 2004-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis c serine protease inhibitors |
| DE10315645B4 (de) | 2003-04-04 | 2005-07-14 | Zf Boge Elastmetall Gmbh | Hydraulisch dämpfendes Gummibuchsenlager für vertikale Montage |
| EP1636208B1 (en) * | 2003-04-11 | 2012-02-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| WO2004092161A1 (en) * | 2003-04-11 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
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-
2004
- 2004-10-08 WO PCT/US2004/033238 patent/WO2005037860A2/en not_active Ceased
- 2004-10-08 NZ NZ546663A patent/NZ546663A/en not_active IP Right Cessation
- 2004-10-08 CA CA002541634A patent/CA2541634A1/en not_active Abandoned
- 2004-10-08 CN CN201010183514A patent/CN101857631A/zh active Pending
- 2004-10-08 RU RU2006115558/04A patent/RU2006115558A/ru not_active Application Discontinuation
- 2004-10-08 JP JP2006534377A patent/JP2007532474A/ja active Pending
- 2004-10-08 KR KR1020117029638A patent/KR20120010278A/ko not_active Ceased
- 2004-10-08 TW TW093130680A patent/TW200528472A/zh unknown
- 2004-10-08 MX MXPA06004006A patent/MXPA06004006A/es active IP Right Grant
- 2004-10-08 KR KR1020067006901A patent/KR20060130027A/ko not_active Ceased
- 2004-10-08 AU AU2004282148A patent/AU2004282148A1/en not_active Abandoned
- 2004-10-08 EP EP04794554.8A patent/EP1692157B1/en not_active Expired - Lifetime
- 2004-10-08 EP EP10183579A patent/EP2361925A1/en not_active Withdrawn
- 2004-10-12 US US10/964,214 patent/US7208600B2/en not_active Expired - Fee Related
-
2006
- 2006-04-09 IL IL174863A patent/IL174863A0/en unknown
- 2006-05-10 NO NO20062101A patent/NO20062101L/no unknown
-
2007
- 2007-03-09 US US11/716,248 patent/US8039623B2/en not_active Expired - Fee Related
-
2011
- 2011-08-18 JP JP2011179106A patent/JP2011246487A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06004006A (es) | 2006-06-28 |
| CN101857631A (zh) | 2010-10-13 |
| EP2361925A1 (en) | 2011-08-31 |
| NO20062101L (no) | 2006-07-05 |
| TW200528472A (en) | 2005-09-01 |
| EP1692157A2 (en) | 2006-08-23 |
| EP1692157B1 (en) | 2013-04-17 |
| IL174863A0 (en) | 2008-02-09 |
| CA2541634A1 (en) | 2005-04-28 |
| US7208600B2 (en) | 2007-04-24 |
| WO2005037860A3 (en) | 2005-11-10 |
| NZ546663A (en) | 2010-01-29 |
| JP2011246487A (ja) | 2011-12-08 |
| KR20060130027A (ko) | 2006-12-18 |
| US20070161789A1 (en) | 2007-07-12 |
| AU2004282148A1 (en) | 2005-04-28 |
| WO2005037860A2 (en) | 2005-04-28 |
| US8039623B2 (en) | 2011-10-18 |
| JP2007532474A (ja) | 2007-11-15 |
| US20050137140A1 (en) | 2005-06-23 |
| KR20120010278A (ko) | 2012-02-02 |
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20071211 |