CA2541634A1 - Inhibitors of serine proteases, particularly hcv ns3-ns4a protease - Google Patents
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease Download PDFInfo
- Publication number
- CA2541634A1 CA2541634A1 CA002541634A CA2541634A CA2541634A1 CA 2541634 A1 CA2541634 A1 CA 2541634A1 CA 002541634 A CA002541634 A CA 002541634A CA 2541634 A CA2541634 A CA 2541634A CA 2541634 A1 CA2541634 A1 CA 2541634A1
- Authority
- CA
- Canada
- Prior art keywords
- ring
- aliphatic
- cycloalkyl
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 108010022999 Serine Proteases Proteins 0.000 title claims abstract description 23
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- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title claims abstract 4
- 239000003112 inhibitor Substances 0.000 title claims description 34
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- 238000000034 method Methods 0.000 claims abstract description 54
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- 229910052717 sulfur Inorganic materials 0.000 claims description 117
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 100
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P31/12—Antivirals
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Applications Claiming Priority (5)
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| US51015603P | 2003-10-10 | 2003-10-10 | |
| US60/510,156 | 2003-10-10 | ||
| US51376803P | 2003-10-23 | 2003-10-23 | |
| US60/513,768 | 2003-10-23 | ||
| PCT/US2004/033238 WO2005037860A2 (en) | 2003-10-10 | 2004-10-08 | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
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| CA2541634A1 true CA2541634A1 (en) | 2005-04-28 |
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| CA002541634A Abandoned CA2541634A1 (en) | 2003-10-10 | 2004-10-08 | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
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| EP (2) | EP2361925A1 (https=) |
| JP (2) | JP2007532474A (https=) |
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| CN (1) | CN101857631A (https=) |
| AU (1) | AU2004282148A1 (https=) |
| CA (1) | CA2541634A1 (https=) |
| IL (1) | IL174863A0 (https=) |
| MX (1) | MXPA06004006A (https=) |
| NO (1) | NO20062101L (https=) |
| NZ (1) | NZ546663A (https=) |
| RU (1) | RU2006115558A (https=) |
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| TW202334164A (zh) | 2022-01-12 | 2023-09-01 | 美商戴納立製藥公司 | （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型 |
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-
2004
- 2004-10-08 WO PCT/US2004/033238 patent/WO2005037860A2/en not_active Ceased
- 2004-10-08 KR KR1020067006901A patent/KR20060130027A/ko not_active Ceased
- 2004-10-08 RU RU2006115558/04A patent/RU2006115558A/ru not_active Application Discontinuation
- 2004-10-08 CN CN201010183514A patent/CN101857631A/zh active Pending
- 2004-10-08 CA CA002541634A patent/CA2541634A1/en not_active Abandoned
- 2004-10-08 TW TW093130680A patent/TW200528472A/zh unknown
- 2004-10-08 EP EP10183579A patent/EP2361925A1/en not_active Withdrawn
- 2004-10-08 EP EP04794554.8A patent/EP1692157B1/en not_active Expired - Lifetime
- 2004-10-08 NZ NZ546663A patent/NZ546663A/en not_active IP Right Cessation
- 2004-10-08 JP JP2006534377A patent/JP2007532474A/ja active Pending
- 2004-10-08 MX MXPA06004006A patent/MXPA06004006A/es active IP Right Grant
- 2004-10-08 AU AU2004282148A patent/AU2004282148A1/en not_active Abandoned
- 2004-10-08 KR KR1020117029638A patent/KR20120010278A/ko not_active Ceased
- 2004-10-12 US US10/964,214 patent/US7208600B2/en not_active Expired - Fee Related
-
2006
- 2006-04-09 IL IL174863A patent/IL174863A0/en unknown
- 2006-05-10 NO NO20062101A patent/NO20062101L/no unknown
-
2007
- 2007-03-09 US US11/716,248 patent/US8039623B2/en not_active Expired - Fee Related
-
2011
- 2011-08-18 JP JP2011179106A patent/JP2011246487A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060130027A (ko) | 2006-12-18 |
| EP1692157B1 (en) | 2013-04-17 |
| NO20062101L (no) | 2006-07-05 |
| WO2005037860A3 (en) | 2005-11-10 |
| IL174863A0 (en) | 2008-02-09 |
| US20050137140A1 (en) | 2005-06-23 |
| MXPA06004006A (es) | 2006-06-28 |
| EP1692157A2 (en) | 2006-08-23 |
| US20070161789A1 (en) | 2007-07-12 |
| NZ546663A (en) | 2010-01-29 |
| CN101857631A (zh) | 2010-10-13 |
| AU2004282148A1 (en) | 2005-04-28 |
| JP2011246487A (ja) | 2011-12-08 |
| EP2361925A1 (en) | 2011-08-31 |
| KR20120010278A (ko) | 2012-02-02 |
| JP2007532474A (ja) | 2007-11-15 |
| US7208600B2 (en) | 2007-04-24 |
| RU2006115558A (ru) | 2007-11-20 |
| TW200528472A (en) | 2005-09-01 |
| WO2005037860A2 (en) | 2005-04-28 |
| US8039623B2 (en) | 2011-10-18 |
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