KR20060130027A - 세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의억제제 - Google Patents
세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의억제제 Download PDFInfo
- Publication number
- KR20060130027A KR20060130027A KR1020067006901A KR20067006901A KR20060130027A KR 20060130027 A KR20060130027 A KR 20060130027A KR 1020067006901 A KR1020067006901 A KR 1020067006901A KR 20067006901 A KR20067006901 A KR 20067006901A KR 20060130027 A KR20060130027 A KR 20060130027A
- Authority
- KR
- South Korea
- Prior art keywords
- ring
- aliphatic
- cycloalkyl
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 C*C(*)(N*)O Chemical compound C*C(*)(N*)O 0.000 description 14
- XTEYVTGUKXNRMO-UHFFFAOYSA-N CC(C1)N(C)CC1Oc1ncncc1 Chemical compound CC(C1)N(C)CC1Oc1ncncc1 XTEYVTGUKXNRMO-UHFFFAOYSA-N 0.000 description 2
- QAKCOSQDQPYLKD-UHFFFAOYSA-N CC(C(C1)N(C)C(C2)C1c1c2cccc1)=O Chemical compound CC(C(C1)N(C)C(C2)C1c1c2cccc1)=O QAKCOSQDQPYLKD-UHFFFAOYSA-N 0.000 description 1
- CTXPLGQPAAMXDK-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CCCC2)=O Chemical compound CC(C(C1)N(C)C2C1CCCC2)=O CTXPLGQPAAMXDK-UHFFFAOYSA-N 0.000 description 1
- IQDYLKKCONHSEC-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CCNC2)=O Chemical compound CC(C(C1)N(C)C2C1CCNC2)=O IQDYLKKCONHSEC-UHFFFAOYSA-N 0.000 description 1
- MWPFJDYCOVSMJN-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CCOC2)=O Chemical compound CC(C(C1)N(C)C2C1CCOC2)=O MWPFJDYCOVSMJN-UHFFFAOYSA-N 0.000 description 1
- URANUHIETULJDJ-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CCSC2)=O Chemical compound CC(C(C1)N(C)C2C1CCSC2)=O URANUHIETULJDJ-UHFFFAOYSA-N 0.000 description 1
- HYXCPLPTPBRWBF-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CNC2)=O Chemical compound CC(C(C1)N(C)C2C1CNC2)=O HYXCPLPTPBRWBF-UHFFFAOYSA-N 0.000 description 1
- KNWUPDRXEMBTQC-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CNCC2)=O Chemical compound CC(C(C1)N(C)C2C1CNCC2)=O KNWUPDRXEMBTQC-UHFFFAOYSA-N 0.000 description 1
- LFOCDBILVXQRBW-UHFFFAOYSA-N CC(C(C1)N(C)C2C1COCC2)=O Chemical compound CC(C(C1)N(C)C2C1COCC2)=O LFOCDBILVXQRBW-UHFFFAOYSA-N 0.000 description 1
- JGAYKYAKZBATFB-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CSC2)=O Chemical compound CC(C(C1)N(C)C2C1CSC2)=O JGAYKYAKZBATFB-UHFFFAOYSA-N 0.000 description 1
- LJFMZKZMZYQOHL-UHFFFAOYSA-N CC(C(C1)N(C)C2C1CSCC2)=O Chemical compound CC(C(C1)N(C)C2C1CSCC2)=O LJFMZKZMZYQOHL-UHFFFAOYSA-N 0.000 description 1
- XAXCURSQOHSDKA-UHFFFAOYSA-N CC(C(C1)NC2C1COC2)=O Chemical compound CC(C(C1)NC2C1COC2)=O XAXCURSQOHSDKA-UHFFFAOYSA-N 0.000 description 1
- VHHZELYOBBFTEI-UHFFFAOYSA-N CC(C(CC12)N(C)C1Nc1c2cccc1)=O Chemical compound CC(C(CC12)N(C)C1Nc1c2cccc1)=O VHHZELYOBBFTEI-UHFFFAOYSA-N 0.000 description 1
- AWPUDWGAFJJTIA-UHFFFAOYSA-N CC(C(CC12)N(C)C1Oc1c2cccc1)=O Chemical compound CC(C(CC12)N(C)C1Oc1c2cccc1)=O AWPUDWGAFJJTIA-UHFFFAOYSA-N 0.000 description 1
- KXHSXQPVAKQNLH-UHFFFAOYSA-N CC(C(CC12)N(C)C1Sc1c2cccc1)=O Chemical compound CC(C(CC12)N(C)C1Sc1c2cccc1)=O KXHSXQPVAKQNLH-UHFFFAOYSA-N 0.000 description 1
- VYIKXRWKSNIFLV-UHFFFAOYSA-N CC(C1)N(C)CC1Oc1ncccc1 Chemical compound CC(C1)N(C)CC1Oc1ncccc1 VYIKXRWKSNIFLV-UHFFFAOYSA-N 0.000 description 1
- JPOMGFJKQCQCBY-UHFFFAOYSA-N CC(C1N(C)C(C2)C2C1)=O Chemical compound CC(C1N(C)C(C2)C2C1)=O JPOMGFJKQCQCBY-UHFFFAOYSA-N 0.000 description 1
- JISJZRYTTVSDFH-UHFFFAOYSA-N CC(C1N(C)C(CCC2)C2C1)=O Chemical compound CC(C1N(C)C(CCC2)C2C1)=O JISJZRYTTVSDFH-UHFFFAOYSA-N 0.000 description 1
- PRQSZHIDHVETKV-CIUDSAMLSA-N CC([C@H]1N[C@@H](CCC2)[C@@H]2C1)=O Chemical compound CC([C@H]1N[C@@H](CCC2)[C@@H]2C1)=O PRQSZHIDHVETKV-CIUDSAMLSA-N 0.000 description 1
- RLNDGFBHTWITPR-UHFFFAOYSA-N COC(C(CC(C1)(F)F)N1C(OCc1ccccc1)=O)=O Chemical compound COC(C(CC(C1)(F)F)N1C(OCc1ccccc1)=O)=O RLNDGFBHTWITPR-UHFFFAOYSA-N 0.000 description 1
- ICXGOKDOIFGMDR-UHFFFAOYSA-N OC(C(CC(C1)(F)F)N1C(OCc1ccccc1)=O)=O Chemical compound OC(C(CC(C1)(F)F)N1C(OCc1ccccc1)=O)=O ICXGOKDOIFGMDR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51015603P | 2003-10-10 | 2003-10-10 | |
| US60/510,156 | 2003-10-10 | ||
| US51376803P | 2003-10-23 | 2003-10-23 | |
| US60/513,768 | 2003-10-23 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117029638A Division KR20120010278A (ko) | 2003-10-10 | 2004-10-08 | 세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의 억제제 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060130027A true KR20060130027A (ko) | 2006-12-18 |
Family
ID=34467967
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067006901A Ceased KR20060130027A (ko) | 2003-10-10 | 2004-10-08 | 세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의억제제 |
| KR1020117029638A Ceased KR20120010278A (ko) | 2003-10-10 | 2004-10-08 | 세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의 억제제 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117029638A Ceased KR20120010278A (ko) | 2003-10-10 | 2004-10-08 | 세린 프로테아제, 특히 ｈｃｖ ｎｓ3-ｎｓ4ａ 프로테아제의 억제제 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7208600B2 (https=) |
| EP (2) | EP2361925A1 (https=) |
| JP (2) | JP2007532474A (https=) |
| KR (2) | KR20060130027A (https=) |
| CN (1) | CN101857631A (https=) |
| AU (1) | AU2004282148A1 (https=) |
| CA (1) | CA2541634A1 (https=) |
| IL (1) | IL174863A0 (https=) |
| MX (1) | MXPA06004006A (https=) |
| NO (1) | NO20062101L (https=) |
| NZ (1) | NZ546663A (https=) |
| RU (1) | RU2006115558A (https=) |
| TW (1) | TW200528472A (https=) |
| WO (1) | WO2005037860A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170118106A (ko) * | 2015-02-13 | 2017-10-24 | 옥스포드 드러그 디자인 리미티드 | 아미노아실-tRNA 합성효소 저해제로서 신규한 N-아실-아릴술폰아미드 유도체 |
Families Citing this family (121)
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| KR100509388B1 (ko) * | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| ES2240446T3 (es) * | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| WO2004092161A1 (en) * | 2003-04-11 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| US7176208B2 (en) | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| CN1852920B (zh) | 2003-07-18 | 2010-12-15 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
| TWI359147B (en) * | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
| EP1664091A1 (en) | 2003-09-18 | 2006-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| WO2005037860A2 (en) * | 2003-10-10 | 2005-04-28 | Vertex Pharmaceuticals Incoporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| JP2007509950A (ja) * | 2003-10-27 | 2007-04-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｈｃｖ処置の組合せ剤 |
| CN1938332B (zh) * | 2004-02-04 | 2011-10-19 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 |
| US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
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| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
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| EP2007789B1 (en) | 2006-04-11 | 2015-05-20 | Novartis AG | Spirocyclic HCV/HIV inhibitors and their uses |
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| DK2114924T3 (da) | 2007-02-27 | 2012-04-10 | Vertex Pharma | Co-krystaller og farmaceutiske sammensætninger omfattende disse |
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| JP5690286B2 (ja) | 2009-03-04 | 2015-03-25 | イデニク プハルマセウティカルス，インコーポレイテッド | ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170118106A (ko) * | 2015-02-13 | 2017-10-24 | 옥스포드 드러그 디자인 리미티드 | 아미노아실-tRNA 합성효소 저해제로서 신규한 N-아실-아릴술폰아미드 유도체 |
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| EP1692157B1 (en) | 2013-04-17 |
| NO20062101L (no) | 2006-07-05 |
| WO2005037860A3 (en) | 2005-11-10 |
| IL174863A0 (en) | 2008-02-09 |
| US20050137140A1 (en) | 2005-06-23 |
| MXPA06004006A (es) | 2006-06-28 |
| EP1692157A2 (en) | 2006-08-23 |
| US20070161789A1 (en) | 2007-07-12 |
| NZ546663A (en) | 2010-01-29 |
| CN101857631A (zh) | 2010-10-13 |
| AU2004282148A1 (en) | 2005-04-28 |
| JP2011246487A (ja) | 2011-12-08 |
| EP2361925A1 (en) | 2011-08-31 |
| KR20120010278A (ko) | 2012-02-02 |
| JP2007532474A (ja) | 2007-11-15 |
| US7208600B2 (en) | 2007-04-24 |
| CA2541634A1 (en) | 2005-04-28 |
| RU2006115558A (ru) | 2007-11-20 |
| TW200528472A (en) | 2005-09-01 |
| WO2005037860A2 (en) | 2005-04-28 |
| US8039623B2 (en) | 2011-10-18 |
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