PL3061808T3 - Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste - Google Patents
Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzysteInfo
- Publication number
- PL3061808T3 PL3061808T3 PL16151949T PL16151949T PL3061808T3 PL 3061808 T3 PL3061808 T3 PL 3061808T3 PL 16151949 T PL16151949 T PL 16151949T PL 16151949 T PL16151949 T PL 16151949T PL 3061808 T3 PL3061808 T3 PL 3061808T3
- Authority
- PL
- Poland
- Prior art keywords
- stem cells
- organoids
- culture medium
- epithelial
- epithelial stem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14962209P | 2009-02-03 | 2009-02-03 | |
EP09151970 | 2009-02-03 | ||
EP09171831 | 2009-09-30 | ||
EP10703131.2A EP2393917B1 (en) | 2009-02-03 | 2010-02-03 | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
EP16151949.1A EP3061808B1 (en) | 2009-02-03 | 2010-02-03 | Culture medium for epithelial stem cells and organoids comprising said stem cells |
PCT/NL2010/000017 WO2010090513A2 (en) | 2009-02-03 | 2010-02-03 | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3061808T3 true PL3061808T3 (pl) | 2021-02-08 |
Family
ID=42144924
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL16151949T PL3061808T3 (pl) | 2009-02-03 | 2010-02-03 | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste |
PL10703131.2T PL2393917T3 (pl) | 2009-02-03 | 2010-02-03 | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających komórki macierzyste |
PL18182285.9T PL3441458T3 (pl) | 2009-02-03 | 2010-02-03 | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10703131.2T PL2393917T3 (pl) | 2009-02-03 | 2010-02-03 | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających komórki macierzyste |
PL18182285.9T PL3441458T3 (pl) | 2009-02-03 | 2010-02-03 | Podłoże do hodowli nabłonkowych komórek macierzystych i organoidów zawierających wspomniane komórki macierzyste |
Country Status (19)
Country | Link |
---|---|
US (3) | US8642339B2 (pl) |
EP (4) | EP3061808B1 (pl) |
JP (2) | JP5458112B2 (pl) |
KR (1) | KR101904224B1 (pl) |
CN (1) | CN102439135B (pl) |
AU (1) | AU2010211428B2 (pl) |
CA (1) | CA2751332C (pl) |
DK (2) | DK3061808T3 (pl) |
ES (2) | ES2948761T3 (pl) |
HK (1) | HK1163746A1 (pl) |
HR (2) | HRP20230650T1 (pl) |
HU (2) | HUE028647T2 (pl) |
IL (1) | IL214381A (pl) |
MX (1) | MX2011008044A (pl) |
NZ (1) | NZ594271A (pl) |
PL (3) | PL3061808T3 (pl) |
RU (1) | RU2555545C2 (pl) |
SG (1) | SG173492A1 (pl) |
WO (1) | WO2010090513A2 (pl) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
US9464275B2 (en) * | 2008-08-21 | 2016-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Ex vivo culture, proliferation and expansion of intestinal epithelium |
GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
KR101904224B1 (ko) | 2009-02-03 | 2018-10-04 | 코닌클리즈케 네덜란드세 아카데미 반 베텐샤펜 | 상피 줄기 세포용 배양 배지 및 상기 줄기 세포를 포함하는 오르가노이드 |
EP2412800A1 (en) * | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
US8563307B2 (en) | 2009-02-24 | 2013-10-22 | James Wang | Treatment of immunosuppression-related disorders |
US9345486B2 (en) | 2009-03-16 | 2016-05-24 | University Of Washington | Nanofibrous conduits for nerve regeneration |
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
CA2809979A1 (en) | 2010-09-01 | 2012-03-08 | Whitehead Institute For Biomedical Research | Compositions and methods for modulating emt and uses thereof |
JP5850419B2 (ja) * | 2010-11-11 | 2016-02-03 | 国立大学法人大阪大学 | 細胞の三次元構造体、及び、これを製造する方法 |
SG10201601434RA (en) | 2011-02-28 | 2016-03-30 | Harvard College | Cell Culture System |
GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
CN102787094B (zh) * | 2011-05-17 | 2015-09-23 | 李晖 | 培养基、细胞培养用试剂盒及细胞培养方法 |
EP2756075B1 (en) * | 2011-08-29 | 2019-10-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use |
TWI614340B (zh) | 2011-09-28 | 2018-02-11 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
EP2772534B1 (en) | 2011-10-27 | 2019-09-18 | National University Corporation Tokyo Medical and Dental University | Culturing colorectal epithelial stem cells and transplanting colorectal epithelium |
WO2013063588A1 (en) * | 2011-10-28 | 2013-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Ex vivo culture, proliferation and expansion of primary tissue organoids |
US10006904B2 (en) | 2011-12-19 | 2018-06-26 | Umc Utrecht Holding B.V. | Rapid quantitative assay to measure CFTR function in a primary intestinal culture model |
US20150017134A1 (en) * | 2012-03-01 | 2015-01-15 | Whitehead Institute For Biomedical Research | Emt-inducing transcription factors cooperate with sox9 |
JP6519851B2 (ja) * | 2012-07-06 | 2019-05-29 | 京都府公立大学法人 | 眼細胞の分化マーカーおよび分化制御 |
EP2716298A1 (en) * | 2012-10-03 | 2014-04-09 | Institut Pasteur | A nod2-dependant pathway of cytoprotection of stem cells |
TWI687519B (zh) * | 2012-12-06 | 2020-03-11 | 美商幹細胞生物科技股份有限公司 | Lgr5+體幹細胞 |
EP2746769A1 (en) | 2012-12-21 | 2014-06-25 | Stembios Technologies, Inc. | Method for evaluating effect of action on subject based on stem celldynamics |
KR20150123805A (ko) * | 2013-02-25 | 2015-11-04 | 제넨테크, 인크. | 상피 줄기 세포의 액체 배양 |
DK3702443T3 (da) * | 2013-03-14 | 2022-04-04 | Brigham & Womens Hospital Inc | Sammensætninger og fremgangsmåder til opformering og dyrkning af epiteliale stamceller |
JP6602745B2 (ja) * | 2013-03-15 | 2019-11-06 | ザ ジャクソン ラボラトリー | 非胚性幹細胞の単離とその使用 |
US20160237400A1 (en) * | 2013-03-15 | 2016-08-18 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
WO2014153294A1 (en) * | 2013-03-17 | 2014-09-25 | The Regents Of The University Of California | Method to expand and transduce cultured human small and large intestinal stem cells |
JP6253265B2 (ja) * | 2013-06-05 | 2017-12-27 | 学校法人関西医科大学 | 食道上皮幹細胞の単離方法 |
JP6437184B2 (ja) * | 2013-06-05 | 2018-12-12 | 学校法人関西医科大学 | 舌上皮幹細胞の単離方法 |
US9595180B2 (en) | 2013-08-07 | 2017-03-14 | Nike, Inc. | Activity recognition with activity reminders |
MX2016001714A (es) | 2013-08-09 | 2016-10-03 | Ardelyx Inc | Compuestos y metodos para inhibir el transporte de fosfato. |
BR102013021202B1 (pt) * | 2013-08-20 | 2022-09-06 | Ccb - Centro De Criogenia Brasil Ltda | Processo de produção de células tronco multipotentes e progenitores |
AU2014364632B2 (en) * | 2013-12-16 | 2021-04-01 | Fresenius Medical Care Deutschland G.M.B.H. | Pancreatic islet-like cell structures and a method of preparing thereof |
EP3094720B1 (en) * | 2014-01-14 | 2021-07-21 | Yale University | Compositions and methods of preparing airway cells |
JP2015149949A (ja) * | 2014-02-17 | 2015-08-24 | 学校法人明治大学 | 免疫抑制剤の評価方法、及び免疫抑制剤評価キット |
WO2015173425A1 (en) * | 2014-05-16 | 2015-11-19 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
ES2860423T3 (es) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida |
CA2953122A1 (en) | 2014-06-20 | 2015-12-23 | Rutgers, The State University Of New Jersey | Single cell-derived organoids |
CA2953524A1 (en) * | 2014-06-27 | 2015-12-30 | The Regents Of The University Of California | Cultured mammalian limbal stem cells, methods for generating the same, and uses thereof |
JP6773645B2 (ja) | 2014-09-03 | 2020-10-21 | ザ ブリガム アンド ウィミンズ ホスピタル,インコーポレイテッド | 聴覚障害の治療のための内耳毛細胞を生成するための組成物、システムおよび方法 |
EP3191526B1 (en) * | 2014-09-12 | 2023-02-22 | The Board of Trustees of the Leland Stanford Junior University | Wnt signaling agonist molecules |
AU2015331848B2 (en) * | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
US9777052B2 (en) | 2014-12-02 | 2017-10-03 | The Board Of Regents Of The University Of Oklahoma | R-spondin variants, compositions, and methods of use |
US10100285B2 (en) | 2015-04-03 | 2018-10-16 | Propagenix Inc. | Ex vivo proliferation of epithelial cells |
KR102598772B1 (ko) | 2015-04-03 | 2023-11-03 | 프로파제닉스 인크. | 상피 세포의 생체외 증식 |
JP6662518B2 (ja) * | 2015-04-09 | 2020-03-11 | 国立大学法人 東京医科歯科大学 | 腸上皮間リンパ球をインビトロで維持・増殖させる方法 |
CN104862272B (zh) * | 2015-05-29 | 2018-08-10 | 吉林大学 | Y-27632抑制剂在cd44阳性肠干细胞分选中的应用 |
WO2017036533A1 (en) * | 2015-09-03 | 2017-03-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids |
CA2998372A1 (en) | 2015-09-11 | 2017-03-16 | Chengkang ZHANG | Ex vivo proliferation of epithelial cells |
US20180282690A1 (en) | 2015-10-05 | 2018-10-04 | Max-Planck-Gesellschaft zur Förderung der Wissenchaften e.V. | Method and culture medium for ex vivo culturing of epidermis-derived stem cells |
JP6376578B2 (ja) | 2016-02-18 | 2018-08-22 | 学校法人慶應義塾 | 細胞培養培地、培養方法、及びオルガノイド |
GB201603569D0 (en) * | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
JP7112957B2 (ja) * | 2016-03-09 | 2022-08-04 | ベイジン パーカンズ オンコロジー カンパニー リミテッド | 腫瘍細胞懸濁培養及び関連方法 |
CN105695394A (zh) * | 2016-04-07 | 2016-06-22 | 中山大学 | 一种小鼠唾液腺类器官体的体外培养方法 |
CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
JP7367951B2 (ja) * | 2016-05-18 | 2023-10-24 | 慶應義塾 | オルガノイド培養用細胞培養培地 |
CN105950539B (zh) * | 2016-05-23 | 2020-01-07 | 华东师范大学 | 人小肠3d类器官研究p-糖蛋白模型的构建方法和应用 |
GB201610748D0 (en) * | 2016-06-20 | 2016-08-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved diffrentation method |
CN106190980A (zh) * | 2016-07-12 | 2016-12-07 | 张云霞 | 一种基于人食管癌组织用于体外培养食管癌肿瘤类器官的专用培养基及培养方法 |
EP3505620B1 (en) * | 2016-08-24 | 2023-07-26 | Keio University | 2d organoid for infection and culture of human diarrhea virus, and use of said 2d organoid |
EP3512935B1 (en) * | 2016-09-13 | 2022-02-23 | President and Fellows of Harvard College | Methods relating to intestinal organ-on-a-chip |
US11180735B2 (en) | 2016-10-28 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods to preserve tumor-stromal interactions in culture and therapeutic predictive applications thereof |
NZ753051A (en) * | 2016-11-04 | 2023-03-31 | Children’S Hospital Medical Center | Liver organoid compositions and methods of making and using same |
EP3541933A4 (en) * | 2016-11-21 | 2020-09-16 | Beijing Percans Oncology Co. Ltd. | TUMOR EPITHELIAL CELL CULTURES |
US11767515B2 (en) | 2016-12-05 | 2023-09-26 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
CN110234662A (zh) | 2017-01-26 | 2019-09-13 | 瑟罗泽恩公司 | 组织特异性wnt信号增强分子和其用途 |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CN107012116A (zh) * | 2017-05-09 | 2017-08-04 | 华东师范大学 | 一种小肠3d类器官研究bcrp介导药物转运模型的构建方法与应用 |
WO2018218344A1 (en) * | 2017-05-29 | 2018-12-06 | Stemcell Technologies Canada Inc. | Compositions and methods for obtaining organoids |
CN109136188A (zh) * | 2017-06-15 | 2019-01-04 | 上海集技生物技术有限公司 | 一种活检肠道肿瘤类器官的培养、传代、冻存和复苏方法及其应用 |
CN108118026A (zh) * | 2017-11-29 | 2018-06-05 | 宁夏医科大学总医院 | 一种人子宫内膜腺上皮细胞的分离培养方法及优化培养基 |
MX2020005668A (es) | 2017-11-30 | 2020-11-24 | Univ Kyoto | Metodo de cultivo de celulas. |
CN107841487A (zh) * | 2017-12-13 | 2018-03-27 | 章毅 | 培养味觉干细胞的方法 |
AU2018393073A1 (en) | 2017-12-19 | 2020-07-02 | Surrozen Operating, Inc. | Wnt surrogate molecules and uses thereof |
JP7317016B2 (ja) | 2017-12-19 | 2023-07-28 | スロゼン オペレーティング, インコーポレイテッド | 抗lrp5/6抗体及び使用方法 |
EP3530732A1 (en) | 2018-02-23 | 2019-08-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Ovarian cancer organoid culture |
CN110452875A (zh) * | 2018-05-07 | 2019-11-15 | 北京吉尚立德生物科技有限公司 | 一种用于培养肺癌实体瘤原代细胞的培养基 |
FR3081168B1 (fr) * | 2018-05-21 | 2022-03-11 | Univ Bordeaux | Systeme de culture cellulaire en bioreacteur |
CN110592018A (zh) * | 2018-06-13 | 2019-12-20 | 北京吉尚立德生物科技有限公司 | 一种结直肠癌实体瘤原代细胞的培养方法 |
JP7446224B2 (ja) * | 2018-08-08 | 2024-03-08 | 中外製薬株式会社 | がん組織またはがん組織に類似した組織の培養方法 |
CN109055304B (zh) * | 2018-08-16 | 2021-12-07 | 洪玥 | 一种非柱状上皮干细胞培养基及培养方法 |
US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
CN109207428B (zh) * | 2018-09-12 | 2022-03-22 | 上海易对医生物医药科技有限公司 | 循环肿瘤细胞的分离和培养方法 |
CN113710795A (zh) * | 2018-09-26 | 2021-11-26 | 株式会社器官再生工学 | 毛囊上皮干细胞的体外增殖方法 |
CN111197024B (zh) * | 2018-11-16 | 2023-08-18 | 杭州捷诺飞生物科技股份有限公司 | 类胰腺结构体及其构建方法与应用 |
EP3927812B1 (en) | 2019-02-19 | 2023-09-06 | Miltenyi Biotec B.V. & Co. KG | Cell culture medium and method for generation of epithelial organoids from epithelial stem cells |
CN109679913A (zh) * | 2019-02-26 | 2019-04-26 | 复旦大学附属眼耳鼻喉科医院 | 嗅觉干细胞三维培养方法 |
GB201903573D0 (en) | 2019-03-15 | 2019-05-01 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for head and neck organoids |
GB201906978D0 (en) * | 2019-05-17 | 2019-07-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method using integrin agonist |
EP3993812A4 (en) * | 2019-07-03 | 2023-08-09 | Cornell University | METHODS FOR FUNCTIONAL VASCULARIZATION OF PANCREATIC ISLETS AND BETA CELL ORGANOIDS |
EP3772538A1 (en) | 2019-08-09 | 2021-02-10 | Urosphere | Method for differentiating epithelial stem cells |
EP3789049A1 (en) * | 2019-09-06 | 2021-03-10 | QGel SA | Method for obtaining healthy intestinal organoids |
US11629385B2 (en) | 2019-11-22 | 2023-04-18 | Tempus Labs, Inc. | Tumor organoid culture compositions, systems, and methods |
CA3160708A1 (en) | 2019-12-04 | 2021-06-10 | Simone Rizzi | Method and kit for cell growth |
US11415571B2 (en) | 2019-12-05 | 2022-08-16 | Tempus Labs, Inc. | Large scale organoid analysis |
GB202004706D0 (en) | 2020-03-31 | 2020-05-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Methods and tools for studying enteroendocrine cells |
CN113528425B (zh) * | 2020-04-15 | 2023-05-30 | 合肥中科普瑞昇生物医药科技有限公司 | 一种用于乳腺上皮肿瘤细胞的培养基和培养方法 |
US11561178B2 (en) | 2020-04-20 | 2023-01-24 | Tempus Labs, Inc. | Artificial fluorescent image systems and methods |
CN111534477B (zh) * | 2020-05-13 | 2021-12-21 | 江苏省人民医院(南京医科大学第一附属医院) | 小鼠肺组织原代上皮干细胞球培养方法 |
GB202109913D0 (en) | 2021-07-09 | 2021-08-25 | Stichting Hubrecht Organoid Tech | Organoid-derived monolayers and uses thereof |
CN114134102A (zh) * | 2021-11-10 | 2022-03-04 | 杭州同创越诚基因科技有限公司 | 从结肠黏膜组织中分离隐窝并诱导产生结肠类器官的方法 |
CN114574426A (zh) * | 2022-01-25 | 2022-06-03 | 湖北省农业科学院畜牧兽医研究所 | 一种鸭小肠隐窝干细胞分离鉴定和3d类器官培养的方法 |
GB202204266D0 (en) | 2022-03-25 | 2022-05-11 | Stichting Hubrecht Organoid Tech | Methods for co-culturing genotoxic bacteria and organoids |
CN117025502A (zh) * | 2022-05-10 | 2023-11-10 | 上海赛立维生物科技有限公司 | 前列腺前体样细胞、细胞制剂及其制备方法和应用 |
CN115322948B (zh) * | 2022-07-20 | 2023-08-29 | 创芯国际生物科技(广州)有限公司 | 一种微量原代组织类器官培养前的扩增培养方法 |
Family Cites Families (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
DE69523750T2 (de) | 1994-05-04 | 2002-08-01 | Mount Sinai Hospital Corp | Modulatoren der cytokine der tgf-beta überfamilie und verfahren zu ihrer bestimmung |
US6043092A (en) | 1996-03-18 | 2000-03-28 | University Of Pittsburgh | Cell culture media for mammalian cells |
US6133027A (en) | 1996-08-07 | 2000-10-17 | City Of Hope | Inducible expression system |
US6207455B1 (en) | 1997-05-01 | 2001-03-27 | Lung-Ji Chang | Lentiviral vectors |
US6277633B1 (en) | 1997-05-13 | 2001-08-21 | The University Of North Carolina At Chapel Hill | Lentivirus-based gene transfer vectors |
US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
EP0953633A1 (en) | 1998-04-28 | 1999-11-03 | Livercell L.L.C. | Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells |
AU3859800A (en) | 1999-02-24 | 2000-09-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Artificial salivary gland |
DE19909769A1 (de) | 1999-03-05 | 2000-09-07 | Bundesrepublik Deutschland Let | Von SIVagm abgeleitete lentivirale Vektoren, Verfahren zu ihrer Herstellung und ihre Verwendung zur Genübertragung in Säugerzellen |
FR2794473B1 (fr) | 1999-06-03 | 2003-09-26 | Centre Nat Rech Scient | Procede de multiplication de cellules souches |
CA2385628A1 (en) | 1999-09-27 | 2001-04-05 | Ammon B. Peck | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
EP1268543A2 (en) | 2000-04-05 | 2003-01-02 | Kirin Beer Kabushiki Kaisha | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
WO2002018544A2 (en) * | 2000-08-31 | 2002-03-07 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
JP2002247978A (ja) | 2001-02-23 | 2002-09-03 | Kazumori Funatsu | 肝細胞オルガノイドおよびその製造方法 |
US20030032034A1 (en) | 2001-03-05 | 2003-02-13 | Tang Y. Tom | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
US7411052B2 (en) | 2001-03-05 | 2008-08-12 | Nuvelo, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
US20030003088A1 (en) * | 2001-05-03 | 2003-01-02 | Board Of Trustees Operating Michigan State University | Human pancreatic pluripotential stem cell line |
WO2003076564A2 (en) * | 2001-05-16 | 2003-09-18 | The General Hospital Corporation | Tissue-engineered organs |
WO2003018752A2 (en) * | 2001-08-23 | 2003-03-06 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
EP2228443A1 (en) | 2001-08-30 | 2010-09-15 | ARCA biopharma, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
WO2003029437A2 (en) | 2001-10-03 | 2003-04-10 | Incyte Genomics Inc. | Secreted proteins |
JP2005506074A (ja) | 2001-10-18 | 2005-03-03 | イクシオン・バイオテクノロジー・インコーポレーテッド | 肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換 |
CN101240262A (zh) * | 2001-12-07 | 2008-08-13 | 杰龙公司 | 源自人胚胎干细胞的胰岛细胞 |
EP1504099A4 (en) | 2001-12-10 | 2006-05-10 | Nuvelo Inc | NEW NUCLEIC ACIDS AND POLYPEPTIDES |
GB0130738D0 (en) | 2001-12-21 | 2002-02-06 | Serono Internat S A | Protein |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
US20060040385A1 (en) | 2002-12-05 | 2006-02-23 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
US20070020637A1 (en) | 2003-01-21 | 2007-01-25 | Research Association For Biotechnology | Full-length cDNA |
EP1440981A3 (en) | 2003-01-21 | 2005-11-23 | Research Association for Biotechnology | Full-length human cdna |
WO2004076642A2 (en) | 2003-02-27 | 2004-09-10 | The Rockefeller University | Method for modulating epithelial stem cell lineage |
WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
US20040229355A1 (en) | 2003-05-14 | 2004-11-18 | Board Of Regents University Of Texas System | Culture medium for long-term culture of hepatocytes |
US20070010008A1 (en) | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
WO2005110009A2 (en) | 2003-07-22 | 2005-11-24 | Immunex Corporation | COMPOSITIONS AND METHODS RELATING TO TSP-30a, b, c AND d |
US20050058687A1 (en) | 2003-09-12 | 2005-03-17 | Becton, Dickinson And Company | Covalently attached collagen VI for cell attachment and proliferation |
PT2157192E (pt) | 2003-10-10 | 2013-11-28 | Deutsches Krebsforsch | Composições para diagnóstico e terapia de doenças associadas com a expressão aberrante de futrinas (r-espondinas) |
WO2005040391A1 (en) | 2003-10-27 | 2005-05-06 | Murdoch Childrens Research Institute | Compositions and methods for differentiating stem cells |
BRPI0507168A (pt) | 2004-01-27 | 2007-06-26 | Nuvelo Inc | fator proliferativo gastrointestinal e aplicações do mesmo |
SE0400974D0 (sv) | 2004-04-15 | 2004-04-15 | Cellmax Technologies Ab | Dipole design |
WO2005113751A1 (en) * | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Cell culture environments for the serum-free expansion of mesenchymal stem cells |
US20070036769A9 (en) * | 2004-06-03 | 2007-02-15 | Linheng Li | BMP pathway methods and compositions |
SE0402734D0 (sv) | 2004-11-10 | 2004-11-10 | Anders Grubb | Antimiicrobial compounds |
US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
WO2006088867A2 (en) * | 2005-02-15 | 2006-08-24 | Medistem Laboratories, Incorporated | Method for expansion of stem cells |
JP4964121B2 (ja) | 2005-02-23 | 2012-06-27 | 財団法人先端医療振興財団 | 血管内皮前駆細胞の生体外増幅方法 |
JP2006325444A (ja) | 2005-05-24 | 2006-12-07 | Toyobo Co Ltd | 細胞増殖培地 |
AU2006202209B2 (en) * | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
WO2007013666A2 (en) | 2005-07-26 | 2007-02-01 | Kirin Pharma Kabushiki Kaisha | Anti-tumor agents comprising r-spondins |
WO2007030290A2 (en) | 2005-09-07 | 2007-03-15 | Maine Medical Center Research | Cristin/r-spondin ligands active in the wnt signaling pathway and methods, compositions and kits relating thereto |
US20080242594A1 (en) | 2005-09-08 | 2008-10-02 | Mckay Ronald D G | Methods for Promoting Stem Cell Proliferation and Survival |
CA2623413A1 (en) | 2005-10-07 | 2007-09-07 | Nuvelo, Inc. | Stem cell factor-like protein scfa1 and uses thereof |
JP5087004B2 (ja) | 2005-10-24 | 2012-11-28 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 中胚葉、内胚葉及び中内胚葉細胞の細胞運命を指定する方法 |
JP2007116926A (ja) | 2005-10-25 | 2007-05-17 | Reprocell Inc | 体外における幹細胞の維持と純化に関する方法、組成物およびシステム |
EP1792979A1 (en) | 2005-12-01 | 2007-06-06 | Stiftung Caesar Center of Advanced European Studies and Research | Cell culture system for the enrichment and expansion of stem cells |
PL2281875T3 (pl) | 2005-12-21 | 2018-08-31 | Université Catholique de Louvain | Wyizolowane komórki macierzyste wątroby |
SG10201405107YA (en) * | 2006-02-23 | 2014-10-30 | Viacyte Inc | Compositions and methods useful for culturing differentiable cells |
US7989204B2 (en) * | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
US8741643B2 (en) * | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
EP2021462B1 (en) * | 2006-04-28 | 2019-01-09 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
WO2007149182A2 (en) * | 2006-06-19 | 2007-12-27 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
JP2008044926A (ja) | 2006-08-14 | 2008-02-28 | Trustees Of Columbia Univ In The City Of New York | Wnt信号伝達に関係した分泌タンパク質 |
JP2008061569A (ja) | 2006-09-07 | 2008-03-21 | Toyobo Co Ltd | 幹細胞の培養方法及びその培地 |
US8628964B2 (en) * | 2006-10-11 | 2014-01-14 | Drexel University | Fetal pulmonary cells and uses thereof |
CA2664828A1 (en) | 2006-10-20 | 2008-04-24 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Rspondins as modulators of angiogenesis and vasculogenesis |
RU2323252C1 (ru) | 2006-10-25 | 2008-04-27 | Антонина Ивановна Колесникова | Способ культивирования мезенхимальных стволовых клеток человека ex vivo |
US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
WO2008075796A1 (ja) | 2006-12-21 | 2008-06-26 | Kyowa Hakko Kirin Co., Ltd. | 血球回復促進剤 |
WO2008088524A2 (en) | 2006-12-28 | 2008-07-24 | Nuvelo, Inc. | Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor |
CA2676044C (en) | 2007-01-30 | 2019-10-22 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
US20080233088A1 (en) * | 2007-02-16 | 2008-09-25 | Varian Medical Systems Technologies, Inc. | Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation |
WO2008155120A2 (en) | 2007-06-20 | 2008-12-24 | Actogenix Nv | Methods and compositions for treating mucositis |
EP3009148B1 (en) | 2007-07-02 | 2018-08-22 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
MX2010000746A (es) * | 2007-07-18 | 2010-07-05 | Lifescan Inc | Diferenciacion de celulas madre embrionarias humanas. |
EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
JP2009195142A (ja) | 2008-02-20 | 2009-09-03 | Institute Of Physical & Chemical Research | 肝臓卵形細胞の取得方法 |
WO2009126310A2 (en) | 2008-04-10 | 2009-10-15 | Massachusetts Institute Of Technology | Methods for identification and use of agents targeting cancer stem cells |
AU2009274517B2 (en) | 2008-07-25 | 2015-03-26 | The University Of Georgia Research Foundation, Inc. | Compositions for Mesoderm derived ISL1+ Multipotent cells (IMPs), epicardial progenitor cells (EPCs) and multipotent CXCR4+CD56+ cells (C56Cs) and methods of use |
WO2010016766A2 (en) | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
US9464275B2 (en) * | 2008-08-21 | 2016-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Ex vivo culture, proliferation and expansion of intestinal epithelium |
WO2010049752A1 (en) | 2008-10-31 | 2010-05-06 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells |
SG171997A1 (en) | 2008-12-08 | 2011-07-28 | Soligenix Inc | Topically active steroids for use in radiation and chemotherapeutics injury |
BRPI0922572A2 (pt) | 2008-12-17 | 2019-09-24 | Scripps Research Inst | método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero. |
EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
KR101904224B1 (ko) | 2009-02-03 | 2018-10-04 | 코닌클리즈케 네덜란드세 아카데미 반 베텐샤펜 | 상피 줄기 세포용 배양 배지 및 상기 줄기 세포를 포함하는 오르가노이드 |
US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
EP2408466B1 (en) | 2009-03-18 | 2015-10-21 | The Brigham and Women's Hospital, Inc. | Dikkopf2 (Dkk2) and active fragments thereof for use in the treatment of kidney or pancreas injuries |
WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
US20120039912A1 (en) | 2009-04-15 | 2012-02-16 | Galapagos Sasu | Rspondin-3 inhibition in bone disorders |
CN102741396B (zh) | 2009-04-27 | 2017-10-20 | 威盛细胞有限公司 | 支持多能细胞生长的小分子和其方法 |
WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
EP3399026A1 (en) | 2010-06-14 | 2018-11-07 | The Scripps Research Institute | Reprogramming of cells to a new fate |
SG188666A1 (en) | 2010-09-30 | 2013-05-31 | Agency Science Tech & Res | Methods and reagents for detection and treatment of esophageal metaplasia |
AU2011349446C1 (en) | 2010-12-22 | 2016-01-21 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
CN103619168B (zh) | 2011-06-29 | 2015-09-23 | 宾州研究基金会 | 用于治疗白血病的组合物、方法和药盒 |
US20130052729A1 (en) | 2011-08-29 | 2013-02-28 | Olivier Pourquie | Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use |
US9663573B2 (en) | 2011-10-05 | 2017-05-30 | Genentech, Inc. | Methods of treating liver conditions using Notch2 antagonists |
GB201117469D0 (en) | 2011-10-10 | 2011-11-23 | Cell Guidance Systems Ltd | Culture media for pluripotent stem cells |
EP2772534B1 (en) | 2011-10-27 | 2019-09-18 | National University Corporation Tokyo Medical and Dental University | Culturing colorectal epithelial stem cells and transplanting colorectal epithelium |
US10006904B2 (en) | 2011-12-19 | 2018-06-26 | Umc Utrecht Holding B.V. | Rapid quantitative assay to measure CFTR function in a primary intestinal culture model |
WO2014066649A1 (en) | 2012-10-26 | 2014-05-01 | The Regents Of The University Of California | A strategy for engineering various 3d tissues, organoids and vasculature |
WO2014127170A1 (en) | 2013-02-13 | 2014-08-21 | Wake Forest University Health Sciences | Bioengineered liver constructs and methods relating thereto |
US20150368616A1 (en) | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
KR20230019992A (ko) | 2013-02-18 | 2023-02-09 | 유니버시티 헬스 네트워크 | 다능성 줄기세포로부터 간세포 및 담관세포의 생성 방법 |
DK3702443T3 (da) | 2013-03-14 | 2022-04-04 | Brigham & Womens Hospital Inc | Sammensætninger og fremgangsmåder til opformering og dyrkning af epiteliale stamceller |
CN110201144B (zh) | 2013-03-15 | 2024-01-02 | 得克萨斯州大学系统董事会 | 用Nutlin-3a和肽抑制肺纤维化 |
CN105324391A (zh) | 2013-04-16 | 2016-02-10 | 奥尔布森治疗学有限公司 | 多配体蛋白聚糖-2的医学用途 |
WO2015173425A1 (en) | 2014-05-16 | 2015-11-19 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
CN108064274A (zh) | 2014-07-30 | 2018-05-22 | 耶达研究及发展有限公司 | 用于培养多能干细胞的培养基 |
US20170304369A1 (en) | 2014-10-08 | 2017-10-26 | Agency For Science, Technology And Research | Methods of differentiating stem cells into liver cell lineages |
GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
JP7367951B2 (ja) | 2016-05-18 | 2023-10-24 | 慶應義塾 | オルガノイド培養用細胞培養培地 |
-
2010
- 2010-02-03 KR KR1020117020340A patent/KR101904224B1/ko active IP Right Grant
- 2010-02-03 MX MX2011008044A patent/MX2011008044A/es active IP Right Grant
- 2010-02-03 JP JP2011547839A patent/JP5458112B2/ja active Active
- 2010-02-03 DK DK16151949.1T patent/DK3061808T3/da active
- 2010-02-03 SG SG2011055399A patent/SG173492A1/en unknown
- 2010-02-03 ES ES18182285T patent/ES2948761T3/es active Active
- 2010-02-03 EP EP16151949.1A patent/EP3061808B1/en active Active
- 2010-02-03 AU AU2010211428A patent/AU2010211428B2/en active Active
- 2010-02-03 EP EP23176802.9A patent/EP4253529A3/en active Pending
- 2010-02-03 NZ NZ594271A patent/NZ594271A/en unknown
- 2010-02-03 PL PL16151949T patent/PL3061808T3/pl unknown
- 2010-02-03 HU HUE10703131A patent/HUE028647T2/en unknown
- 2010-02-03 HR HRP20230650TT patent/HRP20230650T1/hr unknown
- 2010-02-03 CN CN201080013109.9A patent/CN102439135B/zh active Active
- 2010-02-03 RU RU2011136704/10A patent/RU2555545C2/ru active
- 2010-02-03 EP EP10703131.2A patent/EP2393917B1/en active Active
- 2010-02-03 PL PL10703131.2T patent/PL2393917T3/pl unknown
- 2010-02-03 HU HUE18182285A patent/HUE062459T2/hu unknown
- 2010-02-03 EP EP18182285.9A patent/EP3441458B9/en active Active
- 2010-02-03 DK DK10703131.2T patent/DK2393917T3/en active
- 2010-02-03 PL PL18182285.9T patent/PL3441458T3/pl unknown
- 2010-02-03 CA CA2751332A patent/CA2751332C/en active Active
- 2010-02-03 US US13/147,163 patent/US8642339B2/en active Active
- 2010-02-03 WO PCT/NL2010/000017 patent/WO2010090513A2/en active Application Filing
- 2010-02-03 ES ES10703131.2T patent/ES2579909T3/es active Active
-
2011
- 2011-08-01 IL IL214381A patent/IL214381A/en active IP Right Grant
-
2012
- 2012-05-08 HK HK12104502.9A patent/HK1163746A1/zh unknown
- 2012-07-17 JP JP2012158676A patent/JP5722835B2/ja active Active
-
2013
- 2013-11-13 US US14/079,545 patent/US10947510B2/en active Active
-
2016
- 2016-07-05 HR HRP20160791TT patent/HRP20160791T1/hr unknown
-
2018
- 2018-08-27 US US16/113,445 patent/US20190100728A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1163746A1 (zh) | 種上皮幹細胞的培養基和包含所述幹細胞的類器官 | |
HK1216883A1 (zh) | 幹細胞培養 | |
GB2458863B (en) | Improved culture of stem cells | |
HK1171790A1 (zh) | 用於 蛋白表達的細胞培養基 | |
EP2440652A4 (en) | METHOD FOR CULTIVATING STEM CELLS AND PRECURSOR CELLS | |
PL2046946T3 (pl) | Hodowla pluripotencjalnych komórek macierzystych | |
FI20096288A0 (fi) | Formulations and methods for culturing stem cells | |
EP2487236A4 (en) | CULTURE SUPPORT FOR HUMAN PLURIPOTENTE STEM CELLS AND USE THEREOF | |
EP2438161B1 (en) | PROCESS FOR THE PRODUCTION OF PLURIPOTENT STEM CELLS AND THEIR CULTURE PROCESS | |
EP2155859A4 (en) | FORMULATIONS AND METHODS FOR CULTIVATING EMBRYONIC STEM CELLS | |
EP2401361A4 (en) | METHOD AND COMPOSITIONS FOR STEM CELL CULTURES | |
GB2460552B (en) | Stem cell culture media and methods | |
ZA201000715B (en) | Single pluripotent stem cell culture | |
GB0810260D0 (en) | Automated culture of stem cells | |
PL2480655T3 (pl) | Podłoże do hodowli komórkowych | |
PT3061808T (pt) | Meio de cultura para células estaminais epiteliais e organóides compreeendendo as referidas células estaminais | |
HUE050984T2 (hu) | Tenyészközeg epiteliális õssejtekhez és az õssejteket tartalmazó organoidokhoz | |
GB0810304D0 (en) | Stem cell culture media and methods | |
GB0821363D0 (en) | Stem cell culture media and methods | |
AU2009901852A0 (en) | Media and methods for cell culture | |
GB0901069D0 (en) | Stem cell culture methods | |
GB0916476D0 (en) | Stem cell culture methods | |
AU2010901922A0 (en) | Media and methods for cell culture |