DK2756075T3 - Fremgangsmåde til fremstilling af inducerede paraksiale mesoderme progenitor (IPAM)-celler og anvendelse deraf - Google Patents
Fremgangsmåde til fremstilling af inducerede paraksiale mesoderme progenitor (IPAM)-celler og anvendelse deraf Download PDFInfo
- Publication number
- DK2756075T3 DK2756075T3 DK12753961T DK12753961T DK2756075T3 DK 2756075 T3 DK2756075 T3 DK 2756075T3 DK 12753961 T DK12753961 T DK 12753961T DK 12753961 T DK12753961 T DK 12753961T DK 2756075 T3 DK2756075 T3 DK 2756075T3
- Authority
- DK
- Denmark
- Prior art keywords
- ipam
- cells
- preparation
- mesodermal progenitor
- induced paraxial
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
- C12N2500/62—DMSO
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528348P | 2011-08-29 | 2011-08-29 | |
| EP11306080A EP2565264A1 (en) | 2011-08-29 | 2011-08-29 | Method for preparing induced paraxial mesoderm progenitor (iPAM) cells and their use |
| US201261654120P | 2012-06-01 | 2012-06-01 | |
| EP12305610 | 2012-06-01 | ||
| PCT/EP2012/066793 WO2013030243A1 (en) | 2011-08-29 | 2012-08-29 | Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2756075T3 true DK2756075T3 (da) | 2019-12-09 |
Family
ID=47755366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12753961T DK2756075T3 (da) | 2011-08-29 | 2012-08-29 | Fremgangsmåde til fremstilling af inducerede paraksiale mesoderme progenitor (IPAM)-celler og anvendelse deraf |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10240123B2 (da) |
| EP (2) | EP2756075B1 (da) |
| JP (1) | JP6570833B2 (da) |
| CA (1) | CA2847325C (da) |
| DK (1) | DK2756075T3 (da) |
| ES (1) | ES2761859T3 (da) |
| WO (1) | WO2013030243A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201708195RA (en) | 2013-04-05 | 2017-11-29 | Univ Health Network | Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue |
| AU2014268197A1 (en) * | 2014-02-11 | 2015-08-27 | Monash University | Muscle cell production |
| WO2016131137A1 (en) | 2015-02-17 | 2016-08-25 | University Health Network | Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes |
| CN108513546A (zh) | 2015-10-28 | 2018-09-07 | 克里斯珀医疗股份公司 | 用于治疗杜氏肌营养不良症的材料和方法 |
| US11318167B2 (en) | 2015-12-11 | 2022-05-03 | The Johns Hopkins University | Isolation of fusion-competent myoblasts and therapeutic applications thereof related to muscular dystrophy |
| US11390850B2 (en) | 2016-06-24 | 2022-07-19 | The Brigham And Women's Hospital, Inc. | Generation of brown adipose tissue from pluripotent stem cells in vitro |
| EP3565887A4 (en) * | 2017-01-06 | 2020-12-02 | The Regents of The University of California | METHODS ALLOWING THE PRODUCTION OF SKELETAL MUSCLE PROGENITOR CELLS |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2019092505A1 (en) | 2017-11-09 | 2019-05-16 | Casebia Therapeutics Llp | Self-inactivating (sin) crispr/cas or crispr/cpf1 systems and uses thereof |
| CN111727240A (zh) | 2017-12-29 | 2020-09-29 | 阿纳格讷斯生物技术公司 | 用于制备bap或ba细胞的方法 |
| US20210047649A1 (en) | 2019-05-08 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crispr/cas all-in-two vector systems for treatment of dmd |
| CN111282018B (zh) * | 2020-05-13 | 2020-07-31 | 优赛生命科技有限公司 | 一种用于创伤修复的脂肪干细胞组合物 |
| US20240052315A1 (en) * | 2021-03-22 | 2024-02-15 | Ramot At Tel Aviv University Ltd. | Methods for culturing and differentiating pluripotent cells into progenitor or mature muscle cells and composition comprising said cells |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1632241A4 (en) * | 2003-05-16 | 2009-07-22 | Kyowa Hakko Kirin Co Ltd | MEANS FOR THE PREVENTION AND / OR HEALING OF DISEASES IN CONNECTION WITH TISSUE DISORDER |
| US20080038820A1 (en) * | 2004-06-22 | 2008-02-14 | Rudy-Reil Diane E | Induction of pluripotent stem cells into mesodermal lineages |
| JPWO2007010858A1 (ja) * | 2005-07-15 | 2009-01-29 | 国立大学法人京都大学 | 骨格筋組織由来の単一細胞よりクローン化した多能性幹細胞 |
| JPWO2010008100A1 (ja) | 2008-07-17 | 2012-01-05 | 国立大学法人名古屋大学 | 骨格筋細胞又は骨細胞の誘導法 |
| ES2948761T3 (es) * | 2009-02-03 | 2023-09-18 | Koninklijke Nederlandse Akademie Van Wetenschappen | Combinaciones de inhibidores de la replicación del virus de la influenza |
| US20120164731A1 (en) * | 2009-07-09 | 2012-06-28 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle progenitor cells |
| KR101193541B1 (ko) | 2009-08-24 | 2012-10-22 | 한국과학기술원 | 인간 배아줄기세포에서 중간엽 줄기세포로 분화시키는 방법 |
| GB201412554D0 (en) | 2014-07-15 | 2014-08-27 | Cambridge Entpr Ltd | In vitro mesodermal differentiation |
| US10787640B2 (en) | 2015-03-03 | 2020-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Producing mesodermal cell types and methods of using the same |
-
2012
- 2012-08-29 JP JP2014527647A patent/JP6570833B2/ja active Active
- 2012-08-29 EP EP12753961.7A patent/EP2756075B1/en active Active
- 2012-08-29 WO PCT/EP2012/066793 patent/WO2013030243A1/en active Application Filing
- 2012-08-29 US US14/342,251 patent/US10240123B2/en active Active
- 2012-08-29 CA CA2847325A patent/CA2847325C/en active Active
- 2012-08-29 DK DK12753961T patent/DK2756075T3/da active
- 2012-08-29 EP EP19200815.9A patent/EP3611257A1/en not_active Withdrawn
- 2012-08-29 ES ES12753961T patent/ES2761859T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2847325A1 (en) | 2013-03-07 |
| US10240123B2 (en) | 2019-03-26 |
| JP2014525253A (ja) | 2014-09-29 |
| US20140363886A1 (en) | 2014-12-11 |
| WO2013030243A1 (en) | 2013-03-07 |
| CA2847325C (en) | 2020-01-14 |
| EP2756075A1 (en) | 2014-07-23 |
| EP3611257A1 (en) | 2020-02-19 |
| ES2761859T3 (es) | 2020-05-21 |
| EP2756075B1 (en) | 2019-10-02 |
| JP6570833B2 (ja) | 2019-09-04 |
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