DK3141548T3 - Fremgangsmåder og mellemprodukter til fremstilling af azaindoler - Google Patents

Fremgangsmåder og mellemprodukter til fremstilling af azaindoler Download PDF

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Publication number
DK3141548T3
DK3141548T3 DK16190960.1T DK16190960T DK3141548T3 DK 3141548 T3 DK3141548 T3 DK 3141548T3 DK 16190960 T DK16190960 T DK 16190960T DK 3141548 T3 DK3141548 T3 DK 3141548T3
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DK
Denmark
Prior art keywords
azaindoles
intermediates
preparation
methods
Prior art date
Application number
DK16190960.1T
Other languages
English (en)
Inventor
Gerald J Tanoury
Young Chun Jung
Derek Magdziak
Adam Looker
Billie J Kline
Olmo Beatriz Dominguez
Václav Jurcík
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK3141548T3 publication Critical patent/DK3141548T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
DK16190960.1T 2011-07-05 2012-07-03 Fremgangsmåder og mellemprodukter til fremstilling af azaindoler DK3141548T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161504351P 2011-07-05 2011-07-05
US201261636296P 2012-04-20 2012-04-20
EP12735411.6A EP2729465A2 (en) 2011-07-05 2012-07-03 Processes and intermediates for producing azaindoles

Publications (1)

Publication Number Publication Date
DK3141548T3 true DK3141548T3 (da) 2020-07-06

Family

ID=46513874

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16190960.1T DK3141548T3 (da) 2011-07-05 2012-07-03 Fremgangsmåder og mellemprodukter til fremstilling af azaindoler

Country Status (19)

Country Link
US (5) US8513414B2 (da)
EP (2) EP2729465A2 (da)
JP (3) JP2014520815A (da)
KR (1) KR20140058547A (da)
CN (2) CN106432311A (da)
AR (1) AR087069A1 (da)
AU (1) AU2012279046B2 (da)
BR (1) BR112014000115A2 (da)
CA (1) CA2839937C (da)
DK (1) DK3141548T3 (da)
ES (1) ES2804528T3 (da)
MX (1) MX2013015147A (da)
NZ (2) NZ714502A (da)
PL (1) PL3141548T3 (da)
PT (1) PT3141548T (da)
RU (1) RU2014103806A (da)
TW (1) TW201321378A (da)
WO (1) WO2013006634A2 (da)
ZA (1) ZA201400049B (da)

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RS55341B1 (sr) 2009-06-17 2017-03-31 Vertex Pharma Inhibitori replikacije virusa gripa
RU2014103806A (ru) 2011-07-05 2015-08-10 Вертекс Фармасьютикалз Инкорпорейтед Способы и промежуточные соединения для получения азаиндолов
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2014201332A1 (en) 2013-06-14 2014-12-18 Vertex Pharmaceuticals Incorporated Pharmaceutical combinations useful for treating rheumatoid arthritis
KR20160045070A (ko) 2013-08-22 2016-04-26 버텍스 파마슈티칼스 인코포레이티드 동위원소 풍부 아자인돌
US9296727B2 (en) 2013-10-07 2016-03-29 Vertex Pharmaceuticals Incorporated Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
DK3421468T3 (da) * 2013-11-13 2021-01-11 Vertex Pharma Fremgangsmåder til fremstilling af inhibitorer af re-plikation af influenzavira
NZ719729A (en) 2013-11-13 2022-04-29 Vertex Pharma Inhibitors of influenza viruses replication
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
KR20180088466A (ko) * 2015-12-09 2018-08-03 선샤인 레이크 파르마 컴퍼니 리미티드 인플루엔자 바이러스 복제 저해제, 활용 방법 및 그 용도
CN105523986A (zh) * 2015-12-30 2016-04-27 江汉大学 一种外排泵抑制剂n-氢-2-芳基吲哚及其衍生物的合成方法
BR112019004091B1 (pt) 2016-09-09 2023-02-14 F. Hoffmann-La Roche Ag Processo para a preparação de 2-(6-nitropiridin-3-il)-9h-dipirido[2,3-b;3', 4'-d]pirrol
PL3558321T3 (pl) 2016-12-23 2023-10-23 Felicitex Therapeutics, Inc. Pochodne chinolin jako inhibitory kinaz dyrk1a i/lub dyrk1b
CN113121452A (zh) * 2021-05-10 2021-07-16 甘肃堡昌化工有限公司 一种硫酸法尿嘧啶的精制工艺
CN113851244A (zh) * 2021-09-18 2021-12-28 浙江爱索拓科技有限公司 一种含放射性同位素碳-14废水的处理方法
CN113896716A (zh) * 2021-10-27 2022-01-07 浙江爱索拓科技有限公司 一种放射性同位素碳-14双标记甲磺酸伏美替尼合成方法

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GB9721437D0 (en) 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
US20020065270A1 (en) 1999-12-28 2002-05-30 Moriarty Kevin Joseph N-heterocyclic inhibitors of TNF-alpha expression
AU2001237041B9 (en) 2000-02-17 2005-07-28 Amgen Inc. Kinase inhibitors
UY26942A1 (es) * 2000-09-20 2002-04-26 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
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EP1506189A1 (en) 2002-04-26 2005-02-16 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
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JP4605606B2 (ja) 2004-01-30 2011-01-05 長瀬産業株式会社 軸不斉を有する光学活性な４級アンモニウム塩およびそれを用いたα−アミノ酸およびその誘導体の製造方法
UA87494C2 (en) * 2004-03-30 2009-07-27 Вертекс Фармасьютикалс Инкорпорейтед Azaindoles useful as inhibitors of jak and other protein kinases
CN101676285A (zh) 2004-03-30 2010-03-24 沃泰克斯药物股份有限公司 用作jak和其它蛋白激酶抑制剂的氮杂吲哚
WO2006038001A1 (en) * 2004-10-06 2006-04-13 Celltech R & D Limited Aminopyrimidine derivatives as jnk inhibitors
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EP2038272B8 (en) * 2006-06-30 2013-10-23 Sunesis Pharmaceuticals, Inc. Pyridinonyl pdk1 inhibitors
NZ575274A (en) * 2006-08-08 2010-11-26 Chugai Pharmaceutical Co Ltd Pyrimidine derivative as pi3k inhibitor and use thereof
MX2009006345A (es) 2006-12-14 2009-06-23 Vertex Pharma Compuestos utiles como inhibidores de proteina cinasa.
BRPI0819223A2 (pt) * 2007-11-05 2020-08-18 Novartis Ag derivados de 4-benzilamino-1-carboxiacil-piperidina como inibidores de cetp úteis para o tratamento de doenças tais como hiperlipidemia ou arteriosclerose
EP2247592B1 (en) * 2008-02-25 2011-08-31 F. Hoffmann-La Roche AG Pyrrolopyrazine kinase inhibitors
RS55341B1 (sr) 2009-06-17 2017-03-31 Vertex Pharma Inhibitori replikacije virusa gripa
RU2014103806A (ru) 2011-07-05 2015-08-10 Вертекс Фармасьютикалз Инкорпорейтед Способы и промежуточные соединения для получения азаиндолов
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
JP2014532765A (ja) 2011-11-07 2014-12-08 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 炎症性疾患を処置する方法およびそのために有用な薬学的組み合わせ物
KR20160045070A (ko) 2013-08-22 2016-04-26 버텍스 파마슈티칼스 인코포레이티드 동위원소 풍부 아자인돌

Also Published As

Publication number Publication date
US8796453B2 (en) 2014-08-05
US8946425B2 (en) 2015-02-03
US20150099884A1 (en) 2015-04-09
US20130303764A1 (en) 2013-11-14
BR112014000115A2 (pt) 2016-10-04
NZ714502A (en) 2017-04-28
ES2804528T3 (es) 2021-02-08
KR20140058547A (ko) 2014-05-14
EP3141548B1 (en) 2020-04-08
JP2017002067A (ja) 2017-01-05
JP6761448B2 (ja) 2020-09-23
TW201321378A (zh) 2013-06-01
WO2013006634A3 (en) 2013-05-10
JP2014520815A (ja) 2014-08-25
CA2839937A1 (en) 2013-01-10
JP2018162314A (ja) 2018-10-18
NZ619699A (en) 2016-03-31
US20140309421A1 (en) 2014-10-16
EP2729465A2 (en) 2014-05-14
US8513414B2 (en) 2013-08-20
AU2012279046A1 (en) 2014-01-23
EP3141548A1 (en) 2017-03-15
MX2013015147A (es) 2014-03-27
AR087069A1 (es) 2014-02-12
ZA201400049B (en) 2015-04-29
WO2013006634A2 (en) 2013-01-10
CA2839937C (en) 2020-11-03
RU2014103806A (ru) 2015-08-10
CN103702998A (zh) 2014-04-02
US9090614B2 (en) 2015-07-28
PL3141548T3 (pl) 2020-09-07
US20150284388A1 (en) 2015-10-08
EP3141548B9 (en) 2020-08-12
WO2013006634A9 (en) 2013-03-21
AU2012279046B2 (en) 2017-08-31
PT3141548T (pt) 2020-07-10
US20130102782A1 (en) 2013-04-25
CN106432311A (zh) 2017-02-22

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