SG10201708195RA - Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue - Google Patents
Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissueInfo
- Publication number
- SG10201708195RA SG10201708195RA SG10201708195RA SG10201708195RA SG10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA SG 10201708195R A SG10201708195R A SG 10201708195RA
- Authority
- SG
- Singapore
- Prior art keywords
- cartilage
- tissue
- compositions
- methods
- lineage cells
- Prior art date
Links
- 210000000845 cartilage Anatomy 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000001612 chondrocyte Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 210000001519 tissue Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809050P | 2013-04-05 | 2013-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201708195RA true SG10201708195RA (en) | 2017-11-29 |
Family
ID=51657353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201708195RA SG10201708195RA (en) | 2013-04-05 | 2014-04-02 | Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9993504B2 (en) |
| EP (2) | EP2981606B1 (en) |
| JP (4) | JP6516724B2 (en) |
| KR (4) | KR102393716B1 (en) |
| CN (2) | CN105209607B (en) |
| AU (3) | AU2014247679A1 (en) |
| CA (1) | CA2908369C (en) |
| HK (1) | HK1219293A1 (en) |
| SG (1) | SG10201708195RA (en) |
| WO (1) | WO2014161075A1 (en) |
| ZA (1) | ZA201507731B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201509264D0 (en) * | 2015-05-29 | 2015-07-15 | Univ Leuven Kath | Novel ATMP's |
| WO2017026878A1 (en) * | 2015-08-13 | 2017-02-16 | 전북대학교 산학협력단 | Culture medium composition for inducing musculoskeletal progenitor cell, and pharmaceutical composition comprising musculoskeletal progenitor cell for preventing or treating musculoskeletal diseases |
| EP3434761B1 (en) * | 2016-03-23 | 2023-01-18 | Kyoto University | Mesoderm induction method having high blood cell differentiation capacity |
| JP7306667B2 (en) * | 2016-03-31 | 2023-07-12 | 慶應義塾 | Differentiation-promoting pluripotent stem cell and use thereof |
| EP3510146A4 (en) | 2016-09-12 | 2020-08-05 | President and Fellows of Harvard College | Transcription factors controlling differentiation of stem cells |
| WO2018062269A1 (en) * | 2016-09-30 | 2018-04-05 | 京都府公立大学法人 | Method for producing somatic cell, somatic cell, and composition |
| WO2018101466A1 (en) * | 2016-12-02 | 2018-06-07 | タカラバイオ株式会社 | Method for producing endothelial cells |
| GB201621594D0 (en) * | 2016-12-19 | 2017-02-01 | Univ Leuven Kath | Novel cell based methods for healing of bone, cartilage and joint disorders |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| CN107365741B (en) * | 2017-06-02 | 2019-08-30 | 新乡医学院 | NCAM missing is promoting application of the BMSCs into hypertrophic chondrocyte differentiation |
| CN107354126B (en) * | 2017-06-02 | 2019-08-30 | 新乡医学院 | Application of the NCAM silencing in the cartilage cell's hypertrophic differentiation for promoting ATDC5 cell |
| EP3417888A1 (en) * | 2017-06-25 | 2018-12-26 | co.don AG | Method for producing transplantable cartilage tissue |
| WO2019004794A1 (en) | 2017-06-30 | 2019-01-03 | 코오롱생명과학 주식회사 | Pharmaceutical composition for preventing or treating osteoarthritis |
| US11696929B2 (en) | 2017-09-20 | 2023-07-11 | The Regents Of The University Of California | Methods and systems for conserving highly expanded cells |
| US11135250B2 (en) * | 2017-10-25 | 2021-10-05 | Cellatoz Therapeutics, Inc. | Musculoskeletal stem cell |
| WO2019094389A1 (en) * | 2017-11-08 | 2019-05-16 | The Regents Of The University Of Colorado, A Body Corporate | Biodegradable biomimetics of growth plate cartilage for the treatment of physeal injuries |
| US11788131B2 (en) | 2018-04-06 | 2023-10-17 | President And Fellows Of Harvard College | Methods of identifying combinations of transcription factors |
| KR102121602B1 (en) * | 2018-06-27 | 2020-06-10 | 주식회사 티아라줄기세포연구소 | Crushed Stem Cell Extract(Shelled Stem Cell) Manufacturing Method Using Mass Culture Medium Composition Method and Constituent 3-low Extracting Method and A Treating Composition for Anti-Inflammatory and A Treating Composition for Cell Regeneration |
| CN110016461A (en) * | 2019-01-15 | 2019-07-16 | 深圳市第二人民医院 | A kind of cartilage cell's amplification in vitro method |
| US20220160781A1 (en) * | 2019-03-29 | 2022-05-26 | Kolon Tissuegene, Inc. | Mixed-Cell Gene Therapy |
| US20220220447A1 (en) * | 2019-05-22 | 2022-07-14 | The Cleveland Clinic Foundation | Generating dorsal foregut, and anterior domain, endoderm cells |
| WO2021037142A1 (en) * | 2019-08-27 | 2021-03-04 | The Third Hospital Of Hebei Medical University | Multipotent joint progenitor cells, compositions and methods thereof |
| WO2021054449A1 (en) * | 2019-09-18 | 2021-03-25 | 国立大学法人 岡山大学 | Lbm, cpc, opc, production and quality control methods therefor, kit, graft material, and disease model |
| EP3872168A1 (en) * | 2020-02-28 | 2021-09-01 | Cline Scientific AB | Chondrocyte differentiation |
| AU2021264726A1 (en) * | 2020-04-27 | 2022-12-01 | Nippon Zoki Pharmaceutical Co., Ltd. | Method for culturing cell population containing cartilage-derived Tie2-positive cells, and use of said method |
| CN111840514B (en) * | 2020-08-14 | 2021-07-30 | 武汉大学 | Application of CILP2 in preparation of medicine for improving heart aging and myocardial hypertrophy |
| KR20230052963A (en) | 2020-08-21 | 2023-04-20 | 젠자임 코포레이션 | FGFR3 Antibodies and Methods of Use |
| WO2023032441A1 (en) * | 2021-08-31 | 2023-03-09 | 公立大学法人横浜市立大学 | Method for creating formable cartilage tissue without requiring scaffold |
| CA3233545A1 (en) * | 2021-10-14 | 2023-04-20 | Murdoch Children's Research Institute | Methods for producing cartilage and bones |
| WO2023159062A2 (en) * | 2022-02-15 | 2023-08-24 | University Of Central Florida Research Foundation, Inc. | Anabolic drugs stimulating type ii collagen production from chondrocytes or their progenitors |
| WO2023178239A1 (en) * | 2022-03-16 | 2023-09-21 | The Children's Medical Center Corporation | Hpsc-derived articular chondrocyte compositions, systems and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| KR20060036933A (en) | 2003-10-07 | 2006-05-02 | 바이오마스터 인코포레이티드 | Cell differentiation of adipose-derived precursor cells |
| JPWO2010008100A1 (en) * | 2008-07-17 | 2012-01-05 | 国立大学法人名古屋大学 | Method for inducing skeletal muscle cells or bone cells |
| WO2010122378A1 (en) * | 2009-04-24 | 2010-10-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for chondrogenic differentiation of pluripotent or multipotent stem cells using wnt6 |
| CN102844036B (en) * | 2009-07-16 | 2016-01-20 | 生物时代股份有限公司 | For the soft osteogenetic method and composition of in vitro and in vivo |
| CA2725728C (en) * | 2009-11-24 | 2014-01-28 | University Of Connecticut | Differentiation of human embryonic and induced pluripotent stem cells |
| WO2012013969A1 (en) * | 2010-07-26 | 2012-02-02 | The University Of Manchester | Targeted differentiation of stem cells |
| US20130052729A1 (en) * | 2011-08-29 | 2013-02-28 | Olivier Pourquie | Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use |
| WO2013030243A1 (en) * | 2011-08-29 | 2013-03-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use |
-
2014
- 2014-04-02 CA CA2908369A patent/CA2908369C/en active Active
- 2014-04-02 AU AU2014247679A patent/AU2014247679A1/en not_active Abandoned
- 2014-04-02 CN CN201480028250.4A patent/CN105209607B/en active Active
- 2014-04-02 WO PCT/CA2014/000312 patent/WO2014161075A1/en active Application Filing
- 2014-04-02 EP EP14778943.2A patent/EP2981606B1/en active Active
- 2014-04-02 EP EP20193958.4A patent/EP3896153A1/en active Pending
- 2014-04-02 CN CN202010058061.9A patent/CN111269880A/en active Pending
- 2014-04-02 SG SG10201708195RA patent/SG10201708195RA/en unknown
- 2014-04-02 KR KR1020217036841A patent/KR102393716B1/en active IP Right Grant
- 2014-04-02 KR KR1020237036016A patent/KR20230152164A/en not_active Application Discontinuation
- 2014-04-02 JP JP2016505658A patent/JP6516724B2/en active Active
- 2014-04-02 KR KR1020157031441A patent/KR102393715B1/en active IP Right Grant
- 2014-04-02 KR KR1020227014263A patent/KR20220057660A/en not_active Application Discontinuation
- 2014-04-02 US US14/782,070 patent/US9993504B2/en active Active
-
2015
- 2015-10-15 ZA ZA2015/07731A patent/ZA201507731B/en unknown
-
2016
- 2016-06-22 HK HK16107222.7A patent/HK1219293A1/en unknown
-
2018
- 2018-05-11 US US15/977,536 patent/US10736923B2/en active Active
-
2019
- 2019-04-16 JP JP2019077464A patent/JP2019141074A/en active Pending
-
2020
- 2020-06-18 AU AU2020204058A patent/AU2020204058A1/en not_active Abandoned
-
2021
- 2021-03-15 JP JP2021040964A patent/JP2021104021A/en active Pending
-
2022
- 2022-10-14 AU AU2022252839A patent/AU2022252839A1/en active Pending
-
2023
- 2023-01-26 JP JP2023010084A patent/JP2023061961A/en active Pending
- 2023-06-16 US US18/336,410 patent/US20230330152A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014161075A1 (en) | 2014-10-09 |
| KR102393715B1 (en) | 2022-05-02 |
| EP2981606A1 (en) | 2016-02-10 |
| US9993504B2 (en) | 2018-06-12 |
| ZA201507731B (en) | 2019-03-27 |
| CN105209607A (en) | 2015-12-30 |
| US20230330152A1 (en) | 2023-10-19 |
| JP2021104021A (en) | 2021-07-26 |
| EP3896153A1 (en) | 2021-10-20 |
| AU2020204058A1 (en) | 2020-07-09 |
| JP2023061961A (en) | 2023-05-02 |
| US20190111086A1 (en) | 2019-04-18 |
| EP2981606B1 (en) | 2020-09-02 |
| CA2908369C (en) | 2023-02-28 |
| KR20150140724A (en) | 2015-12-16 |
| KR20210138802A (en) | 2021-11-19 |
| NZ713111A (en) | 2021-10-29 |
| KR20220057660A (en) | 2022-05-09 |
| CA2908369A1 (en) | 2014-10-09 |
| CN111269880A (en) | 2020-06-12 |
| CN105209607B (en) | 2020-02-07 |
| AU2014247679A1 (en) | 2015-11-12 |
| HK1219293A1 (en) | 2017-03-31 |
| JP2016515825A (en) | 2016-06-02 |
| KR20230152164A (en) | 2023-11-02 |
| KR102393716B1 (en) | 2022-05-02 |
| JP2019141074A (en) | 2019-08-29 |
| US10736923B2 (en) | 2020-08-11 |
| JP6516724B2 (en) | 2019-05-22 |
| EP2981606A4 (en) | 2016-08-10 |
| AU2022252839A1 (en) | 2022-11-10 |
| US20160038544A1 (en) | 2016-02-11 |
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