PH24159A - Alpha-heterocycle substituted tolunitriles - Google Patents

Alpha-heterocycle substituted tolunitriles

Info

Publication number
PH24159A
PH24159A PH34986A PH34986A PH24159A PH 24159 A PH24159 A PH 24159A PH 34986 A PH34986 A PH 34986A PH 34986 A PH34986 A PH 34986A PH 24159 A PH24159 A PH 24159A
Authority
PH
Philippines
Prior art keywords
alkyl
substd
opt
alkylene
alkylthio
Prior art date
Application number
PH34986A
Other languages
English (en)
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston Browne
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH24159(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PH24159A publication Critical patent/PH24159A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
PH34986A 1986-03-07 1987-03-06 Alpha-heterocycle substituted tolunitriles PH24159A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
PH24159A true PH24159A (en) 1990-03-22

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
PH34986A PH24159A (en) 1986-03-07 1987-03-06 Alpha-heterocycle substituted tolunitriles

Country Status (36)

Country Link
US (1) US4749713A (ko)
EP (1) EP0236940B3 (ko)
JP (1) JPH0755930B2 (ko)
KR (1) KR910000482B1 (ko)
AT (1) ATE94873T1 (ko)
BG (4) BG46598A3 (ko)
CA (1) CA1316928C (ko)
CY (1) CY1905A (ko)
CZ (3) CZ279027B6 (ko)
DD (1) DD264432A5 (ko)
DE (2) DE3787480T2 (ko)
DK (1) DK172190B1 (ko)
DZ (1) DZ1055A1 (ko)
ES (1) ES2059317T3 (ko)
FI (1) FI91857C (ko)
HK (1) HK50296A (ko)
HU (1) HU202843B (ko)
IE (1) IE61101B1 (ko)
IL (1) IL81746A (ko)
LU (1) LU90128I2 (ko)
LV (1) LV5769B4 (ko)
MA (1) MA20888A1 (ko)
MC (1) MC1805A1 (ko)
MT (1) MTP998B (ko)
MX (1) MX5496A (ko)
MY (1) MY102428A (ko)
NL (1) NL970011I2 (ko)
NO (2) NO170277C (ko)
PH (1) PH24159A (ko)
PL (2) PL152025B1 (ko)
PT (1) PT84410B (ko)
RO (2) RO101533B1 (ko)
SK (3) SK279103B6 (ko)
SU (3) SU1470184A3 (ko)
TN (1) TNSN87033A1 (ko)
ZA (1) ZA871637B (ko)

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US5352795A (en) * 1986-03-07 1994-10-04 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
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ATE135000T1 (de) * 1989-07-14 1996-03-15 Ciba Geigy Ag Substituierte benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
JP2602456B2 (ja) * 1990-04-12 1997-04-23 雪印乳業株式会社 子宮内膜症治療剤
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DE4039559A1 (de) * 1990-12-07 1992-06-11 Schering Ag Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln
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DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
EP0641785B1 (en) 1991-09-02 1999-10-27 Yamanouchi Pharmaceutical Co. Ltd. Triazolylated tertiary amine compound or salt thereof
US5223539A (en) * 1991-11-22 1993-06-29 G. D. Searle & Co. N,n-di-alkyl(phenoxy)benzamide derivatives
AU5285593A (en) * 1992-10-21 1994-05-09 Sankyo Company Limited Azole compound
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
US5426196A (en) * 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
WO1997027853A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
AU715603B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2249615A1 (en) * 1996-04-03 1997-10-09 Robert Gomez Inhibitors of farnesyl-protein transferase
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
PL392652A1 (pl) 2001-05-16 2010-12-06 Novartis Ag Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację
JP2005515207A (ja) * 2001-12-11 2005-05-26 エモリー ユニバーシティ 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール
GB0217636D0 (en) * 2002-07-30 2002-09-11 Novartis Ag Organic compounds
CA2494345C (en) * 2002-07-30 2011-11-29 Novartis Ag Combination of an aromatase inhibitor with a bisphosphonate
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
WO2005047269A1 (en) * 2003-11-14 2005-05-26 Natco Pharma Limited A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer
BRPI0417407A (pt) * 2003-12-15 2007-04-03 Theramex derivados de 1-n-fenil-amino-1h-imidazol e composições farmacêuticas contendo estes
EP1871750A1 (en) * 2005-07-06 2008-01-02 Sicor, Inc. Improved process for the preparation of letrozole
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US20090082413A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched letrozole
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
CN103298795A (zh) 2010-08-27 2013-09-11 基因里克斯(英国)有限公司 用于制备来曲唑的纯中间体
ES2613667T3 (es) 2011-09-08 2017-05-25 Mereo Biopharma 2 Limited Composiciones farmacéuticas que comprenden un inhibidor de aromatasa
MX2014014831A (es) 2012-06-08 2015-02-12 Hoffmann La Roche Selectividad de mutante y combinaciones de un compuesto inhibidor de fosfoinositida 3 cinasa y agentes quimioterapeuticos para el tratamiento de cancer.
BR112016002465B1 (pt) 2013-08-14 2022-09-20 Novartis Ag Combinação farmacêutica e seu uso
AR104068A1 (es) 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
GB201614179D0 (en) 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
WO2020023297A1 (en) 2018-07-23 2020-01-30 Genentech, Inc. Methods of treating cancer with pi3k inhibitor, gdc-0077
WO2020076432A1 (en) 2018-10-08 2020-04-16 Genentech, Inc. Methods of treating cancer with pi3k alpha inhibitors and metformin
CN114786666A (zh) 2019-12-03 2022-07-22 基因泰克公司 治疗乳腺癌的组合疗法
TW202237136A (zh) 2020-12-11 2022-10-01 美商建南德克公司 用於治療ｈｅｒ２癌症的組合療法

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Also Published As

Publication number Publication date
PT84410B (pt) 1989-10-04
ZA871637B (en) 1987-10-28
SU1549478A3 (ru) 1990-03-07
LV5769A4 (lv) 1996-12-20
SK279101B6 (sk) 1998-06-03
BG45701A3 (en) 1989-07-14
KR910000482B1 (ko) 1991-01-25
MC1805A1 (fr) 1987-12-22
PL152025B1 (en) 1990-10-31
SK736887A3 (en) 1998-06-03
FI91857C (fi) 1994-08-25
DK172190B1 (da) 1997-12-22
FI870903A (fi) 1987-09-08
IE870575L (en) 1987-09-07
MA20888A1 (fr) 1987-10-01
CZ279028B6 (en) 1994-11-16
DZ1055A1 (fr) 2004-09-13
MX5496A (es) 1993-12-01
SK151287A3 (en) 1998-06-03
CS8707367A2 (en) 1991-02-12
NO170277B (no) 1992-06-22
PL264460A1 (en) 1988-07-21
PL151490B1 (en) 1990-09-28
NO170277C (no) 1992-09-30
SU1577695A3 (ru) 1990-07-07
EP0236940B1 (en) 1993-09-22
MTP998B (en) 1987-08-21
BG46598A3 (en) 1990-01-15
IE61101B1 (en) 1994-10-05
CS8701512A2 (en) 1991-02-12
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
NO870937L (no) 1987-09-08
TNSN87033A1 (fr) 1990-01-01
NL970011I1 (nl) 1997-05-01
JPS62212369A (ja) 1987-09-18
KR870008851A (ko) 1987-10-21
SK279102B6 (sk) 1998-06-03
ES2059317T3 (es) 1994-11-16
US4749713A (en) 1988-06-07
DK117687A (da) 1987-09-08
DE3787480T2 (de) 1994-02-24
CA1316928C (en) 1993-04-27
HK50296A (en) 1996-03-29
RO101533B1 (en) 1992-06-25
AU604011B2 (en) 1990-12-06
RO101532B1 (en) 1992-11-03
LU90128I2 (fr) 1997-10-06
IL81746A0 (en) 1987-10-20
DK117687D0 (da) 1987-03-06
CZ279026B6 (en) 1994-11-16
NO1998010I1 (no) 1998-03-04
DE19775016I2 (de) 2002-02-21
BG45700A3 (en) 1989-07-14
AU6976887A (en) 1987-09-10
JPH0755930B2 (ja) 1995-06-14
BG61204B2 (bg) 1997-02-28
CS8707368A2 (en) 1991-02-12
SK736787A3 (en) 1998-06-03
NL970011I2 (nl) 1997-09-01
MY102428A (en) 1992-06-30
FI870903A0 (fi) 1987-03-02
CY1905A (en) 1987-03-05
FI91857B (fi) 1994-05-13
EP0236940B3 (en) 2011-03-23
EP0236940A3 (en) 1989-10-18
EP0236940A2 (en) 1987-09-16
LV5769B4 (lv) 1997-04-20
IL81746A (en) 1992-02-16
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
ATE94873T1 (de) 1993-10-15
CZ279027B6 (en) 1994-11-16
DD264432A5 (de) 1989-02-01
DE3787480D1 (de) 1993-10-28
SK279103B6 (sk) 1998-06-03
PT84410A (en) 1987-04-01

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