PH17975A - 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent and their pharmaceutical composition - Google Patents

9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent and their pharmaceutical composition

Info

Publication number
PH17975A
PH17975A PH27320A PH27320A PH17975A PH 17975 A PH17975 A PH 17975A PH 27320 A PH27320 A PH 27320A PH 27320 A PH27320 A PH 27320A PH 17975 A PH17975 A PH 17975A
Authority
PH
Philippines
Prior art keywords
propoxymethyl
guanine
dihydroxy
pharmaceutical composition
antiviral agent
Prior art date
Application number
PH27320A
Other languages
English (en)
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH17975(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of PH17975A publication Critical patent/PH17975A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PH27320A 1981-05-21 1982-05-20 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent and their pharmaceutical composition PH17975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (1)

Publication Number Publication Date
PH17975A true PH17975A (en) 1985-02-22

Family

ID=23017790

Family Applications (1)

Application Number Title Priority Date Filing Date
PH27320A PH17975A (en) 1981-05-21 1982-05-20 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent and their pharmaceutical composition

Country Status (33)

Country Link
US (1) US4355032B2 (pl)
EP (1) EP0066208B1 (pl)
JP (2) JPS57203086A (pl)
KR (1) KR890004663B1 (pl)
AR (1) AR244227A1 (pl)
AT (1) ATE15899T1 (pl)
AU (1) AU572086B2 (pl)
BR (1) BR8202931A (pl)
CA (3) CA1305139C (pl)
CS (4) CS235018B2 (pl)
DD (2) DD203052A5 (pl)
DE (1) DE3266644D1 (pl)
DK (2) DK150304C (pl)
ES (7) ES512414A0 (pl)
FI (1) FI73682C (pl)
GR (1) GR76459B (pl)
HK (1) HK67088A (pl)
HU (2) HU188000B (pl)
IE (1) IE53731B1 (pl)
IL (1) IL65836A (pl)
IN (1) IN156469B (pl)
LU (1) LU88334I2 (pl)
MY (1) MY8700793A (pl)
NL (2) NL930022I1 (pl)
NO (2) NO161740C (pl)
NZ (1) NZ200691A (pl)
PH (1) PH17975A (pl)
PL (4) PL136637B1 (pl)
PT (1) PT74934B (pl)
RO (2) RO87387B (pl)
SG (1) SG81687G (pl)
SU (1) SU1176841A3 (pl)
ZA (1) ZA823532B (pl)

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KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법
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US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
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US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
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US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
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SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
ATE178605T1 (de) * 1993-06-23 1999-04-15 Merrell Pharma Inc Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
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EP0976751A1 (en) * 1996-04-09 2000-02-02 Lupin Laboratories Limited A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
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US7078524B2 (en) * 2002-11-22 2006-07-18 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
SI1583542T1 (sl) * 2003-01-14 2008-12-31 Gilead Sciences Inc Sestavki in postopki za kombinacijsko antivirusnoterapijo
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
US20070129385A1 (en) * 2003-08-28 2007-06-07 Sharma Mukesh K Amorphous valganciclovir hydrochloride
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Ｔｃｍ株式会社 キャリッジ用ガタ抑制装置
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TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
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SG172361A1 (en) * 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside analogs
CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
CN102627643B (zh) * 2012-04-10 2014-01-08 常州康丽制药有限公司 更昔洛韦的精制方法
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GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법

Also Published As

Publication number Publication date
ES529384A0 (es) 1987-01-01
PT74934B (en) 1984-05-08
DK150304C (da) 1988-01-04
FI73682B (fi) 1987-07-31
RO87387A (ro) 1985-08-31
CA1305140C (en) 1992-07-14
ES8500276A1 (es) 1984-11-01
DK504183A (da) 1983-11-03
NL930139I1 (nl) 1993-11-01
IE821210L (en) 1982-11-21
DK149001C (da) 1988-11-28
SG81687G (en) 1989-07-07
NO161740C (no) 1989-09-20
IE53731B1 (en) 1989-02-01
CA1305141C (en) 1992-07-14
JPH046195B2 (pl) 1992-02-05
ES8505681A1 (es) 1985-06-16
ES529383A0 (es) 1986-05-16
DK504183D0 (da) 1983-11-03
JPH04217983A (ja) 1992-08-07
ES8404355A1 (es) 1984-05-01
KR830010112A (ko) 1983-12-26
AU8389282A (en) 1982-11-25
NL930139I2 (nl) 1997-07-01
DK149001B (da) 1985-12-16
MY8700793A (en) 1987-12-31
ES8701496A1 (es) 1987-01-01
ES8606869A1 (es) 1986-05-16
PL136332B1 (en) 1986-02-28
ES524900A0 (es) 1985-11-16
ES520849A0 (es) 1984-11-01
NO821676L (no) 1982-11-22
PL246770A1 (en) 1984-08-27
PL136579B1 (en) 1986-02-28
BR8202931A (pt) 1983-05-03
NO1994005I1 (no) 1994-07-29
CS235044B2 (en) 1985-04-16
AU572086B2 (en) 1988-05-05
CA1305139C (en) 1992-07-14
RO84860A (ro) 1984-09-29
FI821794A0 (fi) 1982-05-20
US4355032A (en) 1982-10-19
SU1176841A3 (ru) 1985-08-30
PL242101A1 (en) 1984-07-16
KR890004663B1 (ko) 1989-11-24
JPH0529399B2 (pl) 1993-04-30
DD203052A5 (de) 1983-10-12
ATE15899T1 (de) 1985-10-15
HU186514B (en) 1985-08-28
HK67088A (en) 1988-09-02
JPS57203086A (en) 1982-12-13
GR76459B (pl) 1984-08-10
CS235043B2 (en) 1985-04-16
CS235042B2 (en) 1985-04-16
ES8507549A1 (es) 1985-09-16
NL930022I1 (nl) 1993-05-03
EP0066208A1 (en) 1982-12-08
PT74934A (en) 1982-06-01
ZA823532B (en) 1983-03-30
IL65836A (en) 1991-04-15
AR244227A1 (es) 1993-10-29
US4355032B1 (pl) 1983-06-14
NZ200691A (en) 1986-11-12
ES524899A0 (es) 1985-09-16
LU88334I2 (fr) 1994-09-09
NO161740B (no) 1989-06-12
IN156469B (pl) 1985-08-10
DK227782A (da) 1982-11-22
IL65836A0 (en) 1982-08-31
DE3266644D1 (en) 1985-11-07
PL236521A1 (en) 1984-01-02
DD213218A5 (de) 1984-09-05
ES8601204A1 (es) 1985-11-16
ES512414A0 (es) 1984-05-01
CS235018B2 (en) 1985-04-16
PL242100A1 (en) 1984-04-24
PL136004B1 (en) 1986-01-31
RO84860B (ro) 1984-10-30
FI73682C (fi) 1987-11-09
HU188000B (en) 1986-03-28
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES533821A0 (es) 1985-06-16
RO87387B (ro) 1985-08-31
PL136637B1 (en) 1986-03-31
US4355032B2 (en) 1990-10-30

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