NO161740C - Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin.

Info

Publication number
NO161740C
NO161740C NO821676A NO821676A NO161740C NO 161740 C NO161740 C NO 161740C NO 821676 A NO821676 A NO 821676A NO 821676 A NO821676 A NO 821676A NO 161740 C NO161740 C NO 161740C
Authority
NO
Norway
Prior art keywords
propoxymethyl
guanine
dihydroxy
preparation
therapeutic active
Prior art date
Application number
NO821676A
Other languages
English (en)
Norwegian (no)
Other versions
NO821676L (no
NO161740B (no
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO161740(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO821676L publication Critical patent/NO821676L/no
Priority to NO874847A priority Critical patent/NO160260C/no
Priority to NO890477A priority patent/NO165026C/no
Priority to NO890476A priority patent/NO165025C/no
Publication of NO161740B publication Critical patent/NO161740B/no
Publication of NO161740C publication Critical patent/NO161740C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO821676A 1981-05-21 1982-05-19 Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin. NO161740C (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NO874847A NO160260C (no) 1981-05-21 1987-11-20 9-(1,3-dihydroksy-2-propoksymetyl)-guanin-derivater.
NO890477A NO165026C (no) 1981-05-21 1989-02-06 Analogifremgangsmaate for fremstilling av natriumsaltet 9-(1,2-dihydroksy-2-propoksymetyl)guanin.
NO890476A NO165025C (no) 1981-05-21 1989-02-06 Analogifremgangsmaate for fremstilling av natriumsaltet 9-(1,3-dihydroksy-2-propoksymetyl)guanin.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (3)

Publication Number Publication Date
NO821676L NO821676L (no) 1982-11-22
NO161740B NO161740B (no) 1989-06-12
NO161740C true NO161740C (no) 1989-09-20

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
NO821676A NO161740C (no) 1981-05-21 1982-05-19 Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin.
NO1994005C NO1994005I1 (no) 1981-05-21 1994-07-29 Ganciclovir

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1994005C NO1994005I1 (no) 1981-05-21 1994-07-29 Ganciclovir

Country Status (33)

Country Link
US (1) US4355032B2 (pl)
EP (1) EP0066208B1 (pl)
JP (2) JPS57203086A (pl)
KR (1) KR890004663B1 (pl)
AR (1) AR244227A1 (pl)
AT (1) ATE15899T1 (pl)
AU (1) AU572086B2 (pl)
BR (1) BR8202931A (pl)
CA (3) CA1305139C (pl)
CS (4) CS235018B2 (pl)
DD (2) DD203052A5 (pl)
DE (1) DE3266644D1 (pl)
DK (2) DK150304C (pl)
ES (7) ES512414A0 (pl)
FI (1) FI73682C (pl)
GR (1) GR76459B (pl)
HK (1) HK67088A (pl)
HU (2) HU188000B (pl)
IE (1) IE53731B1 (pl)
IL (1) IL65836A (pl)
IN (1) IN156469B (pl)
LU (1) LU88334I2 (pl)
MY (1) MY8700793A (pl)
NL (2) NL930022I1 (pl)
NO (2) NO161740C (pl)
NZ (1) NZ200691A (pl)
PH (1) PH17975A (pl)
PL (4) PL136637B1 (pl)
PT (1) PT74934B (pl)
RO (2) RO87387B (pl)
SG (1) SG81687G (pl)
SU (1) SU1176841A3 (pl)
ZA (1) ZA823532B (pl)

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US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
SU1537138A3 (ru) * 1982-02-01 1990-01-15 Синтекс (Ю.С.А.) Инк (Фирма) Способ получени производных пуринов или их солей
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
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US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
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US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
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US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
EP0187297B1 (en) * 1984-12-12 1991-08-21 Syntex (U.S.A.) Inc. Alkoxy methyl ether and alkoxy methyl ester derivatives
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
ATE178605T1 (de) * 1993-06-23 1999-04-15 Merrell Pharma Inc Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
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US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
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US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
IN179493B (pl) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
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US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
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Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법

Also Published As

Publication number Publication date
ES529384A0 (es) 1987-01-01
PT74934B (en) 1984-05-08
DK150304C (da) 1988-01-04
FI73682B (fi) 1987-07-31
RO87387A (ro) 1985-08-31
CA1305140C (en) 1992-07-14
ES8500276A1 (es) 1984-11-01
DK504183A (da) 1983-11-03
NL930139I1 (nl) 1993-11-01
PH17975A (en) 1985-02-22
IE821210L (en) 1982-11-21
DK149001C (da) 1988-11-28
SG81687G (en) 1989-07-07
IE53731B1 (en) 1989-02-01
CA1305141C (en) 1992-07-14
JPH046195B2 (pl) 1992-02-05
ES8505681A1 (es) 1985-06-16
ES529383A0 (es) 1986-05-16
DK504183D0 (da) 1983-11-03
JPH04217983A (ja) 1992-08-07
ES8404355A1 (es) 1984-05-01
KR830010112A (ko) 1983-12-26
AU8389282A (en) 1982-11-25
NL930139I2 (nl) 1997-07-01
DK149001B (da) 1985-12-16
MY8700793A (en) 1987-12-31
ES8701496A1 (es) 1987-01-01
ES8606869A1 (es) 1986-05-16
PL136332B1 (en) 1986-02-28
ES524900A0 (es) 1985-11-16
ES520849A0 (es) 1984-11-01
NO821676L (no) 1982-11-22
PL246770A1 (en) 1984-08-27
PL136579B1 (en) 1986-02-28
BR8202931A (pt) 1983-05-03
NO1994005I1 (no) 1994-07-29
CS235044B2 (en) 1985-04-16
AU572086B2 (en) 1988-05-05
CA1305139C (en) 1992-07-14
RO84860A (ro) 1984-09-29
FI821794A0 (fi) 1982-05-20
US4355032A (en) 1982-10-19
SU1176841A3 (ru) 1985-08-30
PL242101A1 (en) 1984-07-16
KR890004663B1 (ko) 1989-11-24
JPH0529399B2 (pl) 1993-04-30
DD203052A5 (de) 1983-10-12
ATE15899T1 (de) 1985-10-15
HU186514B (en) 1985-08-28
HK67088A (en) 1988-09-02
JPS57203086A (en) 1982-12-13
GR76459B (pl) 1984-08-10
CS235043B2 (en) 1985-04-16
CS235042B2 (en) 1985-04-16
ES8507549A1 (es) 1985-09-16
NL930022I1 (nl) 1993-05-03
EP0066208A1 (en) 1982-12-08
PT74934A (en) 1982-06-01
ZA823532B (en) 1983-03-30
IL65836A (en) 1991-04-15
AR244227A1 (es) 1993-10-29
US4355032B1 (pl) 1983-06-14
NZ200691A (en) 1986-11-12
ES524899A0 (es) 1985-09-16
LU88334I2 (fr) 1994-09-09
NO161740B (no) 1989-06-12
IN156469B (pl) 1985-08-10
DK227782A (da) 1982-11-22
IL65836A0 (en) 1982-08-31
DE3266644D1 (en) 1985-11-07
PL236521A1 (en) 1984-01-02
DD213218A5 (de) 1984-09-05
ES8601204A1 (es) 1985-11-16
ES512414A0 (es) 1984-05-01
CS235018B2 (en) 1985-04-16
PL242100A1 (en) 1984-04-24
PL136004B1 (en) 1986-01-31
RO84860B (ro) 1984-10-30
FI73682C (fi) 1987-11-09
HU188000B (en) 1986-03-28
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES533821A0 (es) 1985-06-16
RO87387B (ro) 1985-08-31
PL136637B1 (en) 1986-03-31
US4355032B2 (en) 1990-10-30

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