PE91198A1 - DERIVADOS PIRIDO[3,4-d]PIRIMIDINA - Google Patents

DERIVADOS PIRIDO[3,4-d]PIRIMIDINA

Info

Publication number
PE91198A1
PE91198A1 PE1997000611A PE00061197A PE91198A1 PE 91198 A1 PE91198 A1 PE 91198A1 PE 1997000611 A PE1997000611 A PE 1997000611A PE 00061197 A PE00061197 A PE 00061197A PE 91198 A1 PE91198 A1 PE 91198A1
Authority
PE
Peru
Prior art keywords
compounds
halogen
erb
preference
alkyl
Prior art date
Application number
PE1997000611A
Other languages
English (en)
Inventor
Malcolm Clive Carter
Stephen Barry Guntrip
George Stuart Cockerill
Kathryn Jane Smith
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614763.2A external-priority patent/GB9614763D0/en
Priority claimed from GBGB9625492.5A external-priority patent/GB9625492D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE91198A1 publication Critical patent/PE91198A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "X" ES N o CH; "Y" ES WCH2, CH2W o W, EN DONDE "W" ES O, S(O)m o NRa, EN DONDE m ES 0; 1 o 2; Ra ES H o ALQUILO C1-C8; R" ES DE PREFERENCIA FURANO, IMIDAZOL, TRIAZOL, PIRROLIDINA, PIPERAZINA, PIPERIDINA, ESTANDO R" OPCIONALMENTE SUSTITUIDO POR R1; n ES 0 o 1; R1 ES AMINA, H, HALOGENO, CARBOXI, 1,3-DIOXOLAN-2-ILO O METILSULFONILETILAMINO, ENTRE OTROS; p ES 0; 1; 2 o 3; O CUANDO p ES 2 o 3, DOS GRUPOS R1 ADYACENTES FORMAN CONJUNTAMENTE UN GRUPO METILENDIOXI O ETILENDIOXI; R2 ES H, HALOGENO, CF3, ALQUILO C1-C4 O ALCOXI C1-C4; "A" ES UN ANILLO HETEROCICLICO, DE PREFERENCIA PIRIDINA; "U" ES UN SISTEMA MONO- O BI- HETEROCICLICO DE 5 A 10 MIEMBROS, DE PREFERENCIA ES INDAZOLILO O INDOLILO, "U" PUEDE ESTAR SUSTITUIDO POR R6 Y R4, EN DONDE R4 ES HIDROXI O HALOGENO, ENTRE OTROS; R6 ES DE PREFERENCIA BENCILO, FLUOROBENCILO, PIRIDILMETILO O BENCENOSULFONILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS (I) Y A LOS COMPUESTOS INTERMEDIOS PARA SU OBTENCION. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO INHIBIDORES SELECTIVOS DE LAS TIROSINA CINASAS PROTEICAS, SIENDO PREFERIDAS EGFr, c-erB-2, c-erB-4, DICHA SELECTIVIDAD MINIMIZA LOS EFECTOS COLATERALES POTENCIALES, SIENDO UTILES EN EL TRATAMIENTO DEL CANCER Y PSORIASIS AL INHIBIR LA PROLIFERACION CELULAR DESCONTROLADA
PE1997000611A 1996-07-13 1997-07-11 DERIVADOS PIRIDO[3,4-d]PIRIMIDINA PE91198A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9614763.2A GB9614763D0 (en) 1996-07-13 1996-07-13 Heterocyclic compounds
GBGB9625492.5A GB9625492D0 (en) 1996-12-07 1996-12-07 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
PE91198A1 true PE91198A1 (es) 1999-01-15

Family

ID=26309694

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000611A PE91198A1 (es) 1996-07-13 1997-07-11 DERIVADOS PIRIDO[3,4-d]PIRIMIDINA

Country Status (25)

Country Link
US (2) US6174889B1 (es)
EP (2) EP1304110A3 (es)
JP (1) JP2000514445A (es)
KR (1) KR20000023812A (es)
CN (1) CN1230187A (es)
AP (1) AP9901434A0 (es)
AR (1) AR007856A1 (es)
AT (1) ATE249458T1 (es)
AU (1) AU3443997A (es)
BR (1) BR9710359A (es)
CA (1) CA2260061A1 (es)
CZ (1) CZ8999A3 (es)
DE (1) DE69724789T2 (es)
EA (1) EA199900022A1 (es)
ES (1) ES2206729T3 (es)
HR (1) HRP970371A2 (es)
ID (1) ID19403A (es)
IL (1) IL127796A0 (es)
IS (1) IS4939A (es)
NO (1) NO990124L (es)
PE (1) PE91198A1 (es)
PL (1) PL331221A1 (es)
TR (1) TR199900049T2 (es)
WO (1) WO1998002438A1 (es)
YU (1) YU1099A (es)

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