BRPI0412695A - derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1 - Google Patents
derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1Info
- Publication number
- BRPI0412695A BRPI0412695A BRPI0412695-5A BRPI0412695A BRPI0412695A BR PI0412695 A BRPI0412695 A BR PI0412695A BR PI0412695 A BRPI0412695 A BR PI0412695A BR PI0412695 A BRPI0412695 A BR PI0412695A
- Authority
- BR
- Brazil
- Prior art keywords
- quinoline
- quinazoline derivatives
- receptor affinity
- affinity
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
Abstract
"DERIVADOS DE QUINOLINA E QUINAZOLINA DOTADOS DE AFINIDADE PARA RECEPTORES DO TIPO 5HT1". Os compostos de fórmula (I) e os sais farmaceuticamente aceitáveis dos mesmos são proporcionados: onde R~ 1~, m, X, R~ 2~, n, W, p, Y, Z, R~ 3~, R~ 4~, R~ 5~, e q apresentam os significados de acordo como definido na descrição. Os métodos de preparação e o uso dos mesmos em terapia, em particular para as desordens do SNC, tais como depressão ou ansiedade, são também descritos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0316915.8A GB0316915D0 (en) | 2003-07-18 | 2003-07-18 | Compounds |
PCT/EP2004/008000 WO2005014552A1 (en) | 2003-07-18 | 2004-07-15 | Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412695A true BRPI0412695A (pt) | 2006-10-03 |
Family
ID=27764115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412695-5A BRPI0412695A (pt) | 2003-07-18 | 2004-07-15 | derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1 |
Country Status (29)
Country | Link |
---|---|
US (5) | US7279481B2 (pt) |
EP (3) | EP1876174B1 (pt) |
JP (1) | JP2006528146A (pt) |
KR (1) | KR20060041242A (pt) |
CN (1) | CN100441571C (pt) |
AR (1) | AR046394A1 (pt) |
AT (2) | ATE389637T1 (pt) |
AU (1) | AU2004263268B2 (pt) |
BR (1) | BRPI0412695A (pt) |
CA (1) | CA2532452A1 (pt) |
CY (1) | CY1107974T1 (pt) |
DE (2) | DE602004024141D1 (pt) |
DK (1) | DK1646613T3 (pt) |
ES (2) | ES2336148T3 (pt) |
GB (1) | GB0316915D0 (pt) |
HK (1) | HK1089438A1 (pt) |
HR (1) | HRP20080226T3 (pt) |
IL (1) | IL173036A0 (pt) |
IS (1) | IS2744B (pt) |
MA (1) | MA27926A1 (pt) |
MX (1) | MXPA06000716A (pt) |
NO (1) | NO20060774L (pt) |
NZ (1) | NZ544586A (pt) |
PL (1) | PL1646613T3 (pt) |
PT (1) | PT1646613E (pt) |
RU (1) | RU2402533C2 (pt) |
SI (1) | SI1646613T1 (pt) |
TW (1) | TW200521115A (pt) |
WO (1) | WO2005014552A1 (pt) |
Families Citing this family (47)
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GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
MY144470A (en) * | 2004-06-17 | 2011-09-30 | Cytokinetics Inc | Compounds, compositions and methods |
KR100817538B1 (ko) * | 2006-07-05 | 2008-03-27 | 한국화학연구원 | 신규 치환된―1h―퀴나졸린―2,4―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물 |
MX2009006672A (es) * | 2006-12-19 | 2009-10-26 | Univ Virginia | Efectos combinados de topiramato y ondansetron sobre el consumo de alcohol. |
US20100076006A1 (en) * | 2007-01-31 | 2010-03-25 | University Of Virginia Patent Foundation | Topiramate Plus Naltrexone for the Treatment of Addictive Disorders |
EP2016943B1 (en) | 2007-07-19 | 2011-02-23 | Laboratorios del Dr. Esteve S.A. | Substituted tetrahydro-quinoline-sulfonamide compounds, their preparation and use as medicaments |
JP2010537990A (ja) * | 2007-08-27 | 2010-12-09 | ユニバーシティ オブ バージニア パテント ファウンデーション | アルコール中毒および薬物嗜癖の処置のための医薬の組み合わせ |
DK2255184T3 (da) | 2008-02-28 | 2013-07-22 | Univ Virginia Patent Found | Serotonintransportergen og behandling af alkoholisme |
US8871753B2 (en) | 2008-04-24 | 2014-10-28 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
DE602008004213D1 (de) * | 2008-05-06 | 2011-02-10 | Biedermann Motech Gmbh | Stangenförmiges Implantat, insbesondere zur dynamischen Stabilisierung der Wirbelsäule |
US20100298397A1 (en) * | 2009-05-19 | 2010-11-25 | Singh Nikhilesh N | Method of treatment of obsessive compulsive disorder with ondansetron |
CN101671336B (zh) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
EP2308850A1 (en) * | 2009-10-06 | 2011-04-13 | Laboratorios Del. Dr. Esteve, S.A. | Heterocycyl-substituted-alkylamino phenyl derivatives, their preparation and use as medicaments |
SI2801625T1 (en) | 2010-07-02 | 2018-04-30 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug addiction |
CA2844525A1 (en) * | 2011-08-09 | 2013-02-14 | Takeda Pharmaceutical Company Limited | Cyclopropaneamine compound |
EA027743B1 (ru) | 2011-09-09 | 2017-08-31 | Юниверсити Оф Вирджиния Пэтент Фаундейшн | Молекулярно-генетический подход для лечения и диагностики алкогольной и наркотической зависимости |
GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
US9951088B2 (en) * | 2012-05-09 | 2018-04-24 | Sunovion Pharmaceuticals Inc. | D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders |
CN103508927A (zh) * | 2012-06-25 | 2014-01-15 | 天津药物研究院 | 一种2-甲磺酰氨基二苯醚的制备方法 |
CA2887598A1 (en) | 2012-10-12 | 2014-04-17 | Takeda Pharmaceutical Company Limited | Cyclopropanamine compound and use thereof |
GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
DK3072884T3 (da) | 2013-11-20 | 2020-03-09 | Sanwa Kagaku Kenkyusho Co | 3-azabicyclo[3.1.0]hexanderivat og anvendelse deraf til medicinske formål |
CN106459024B (zh) | 2014-04-11 | 2019-11-05 | 武田药品工业株式会社 | 环丙胺化合物及其用途 |
WO2016075314A1 (fr) | 2014-11-13 | 2016-05-19 | Institut National De La Recherche Agronomique | Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines |
FR3028527A1 (fr) | 2014-11-13 | 2016-05-20 | Pivert | Identification de facteurs de transcription de yarrowia lipolytica |
SI3193901T1 (en) | 2014-12-23 | 2018-06-29 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
NO3065748T3 (pt) | 2014-12-23 | 2018-04-21 | ||
MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
HUE045754T2 (hu) | 2015-06-15 | 2020-01-28 | 4D Pharma Res Ltd | Blautia stercosis és wexlerae gyulladásos és autoimmun betegségek kezelésében történõ alkalmazásra |
CN107847529B (zh) | 2015-06-15 | 2022-05-03 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
PT3206700T (pt) | 2015-06-15 | 2019-08-21 | 4D Pharma Res Ltd | Composições compreendendo estirpes bacterianas |
HUE036362T2 (hu) | 2015-11-20 | 2018-07-30 | 4D Pharma Res Ltd | Baktériumtörzseket tartalmazó készítmények |
GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
PL3313423T3 (pl) | 2016-03-04 | 2019-09-30 | 4D Pharma Plc | Kompozycje zawierające szczepy bakteryjne blautia do leczenia nadwrażliwości trzewnej |
GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商4D製藥有限公司 | 包含細菌菌株之組合物 |
GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
RS61872B1 (sr) | 2017-05-22 | 2021-06-30 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
RS61210B1 (sr) | 2017-06-14 | 2021-01-29 | 4D Pharma Res Ltd | Kompozicije koje sadrže bakterijske sojeve |
AU2018283994B2 (en) | 2017-06-14 | 2021-03-18 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
CN108047143A (zh) * | 2017-12-18 | 2018-05-18 | 刘凤娟 | 一种用于治疗功能性胃肠病的5-羟色胺受体拮抗剂的合成方法 |
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CN112585139B (zh) | 2018-06-27 | 2023-12-01 | 百时美施贵宝公司 | 用作t细胞激活剂的萘啶酮化合物 |
AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
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UY27304A1 (es) * | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
GB0224084D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
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2003
- 2003-07-18 GB GBGB0316915.8A patent/GB0316915D0/en not_active Ceased
-
2004
- 2004-07-15 EP EP07118193A patent/EP1876174B1/en active Active
- 2004-07-15 AT AT04763307T patent/ATE389637T1/de active
- 2004-07-15 AT AT07118193T patent/ATE448205T1/de not_active IP Right Cessation
- 2004-07-15 PT PT04763307T patent/PT1646613E/pt unknown
- 2004-07-15 BR BRPI0412695-5A patent/BRPI0412695A/pt not_active IP Right Cessation
- 2004-07-15 DE DE602004024141T patent/DE602004024141D1/de active Active
- 2004-07-15 CA CA002532452A patent/CA2532452A1/en not_active Abandoned
- 2004-07-15 NZ NZ544586A patent/NZ544586A/en unknown
- 2004-07-15 US US10/565,066 patent/US7279481B2/en not_active Expired - Fee Related
- 2004-07-15 WO PCT/EP2004/008000 patent/WO2005014552A1/en active IP Right Grant
- 2004-07-15 ES ES07118193T patent/ES2336148T3/es active Active
- 2004-07-15 JP JP2006520756A patent/JP2006528146A/ja not_active Ceased
- 2004-07-15 DK DK04763307T patent/DK1646613T3/da active
- 2004-07-15 KR KR1020067001103A patent/KR20060041242A/ko not_active Application Discontinuation
- 2004-07-15 EP EP04763307A patent/EP1646613B1/en active Active
- 2004-07-15 MX MXPA06000716A patent/MXPA06000716A/es active IP Right Grant
- 2004-07-15 RU RU2006104993/04A patent/RU2402533C2/ru not_active IP Right Cessation
- 2004-07-15 ES ES04763307T patent/ES2302543T3/es active Active
- 2004-07-15 PL PL04763307T patent/PL1646613T3/pl unknown
- 2004-07-15 DE DE602004012564T patent/DE602004012564T2/de active Active
- 2004-07-15 AU AU2004263268A patent/AU2004263268B2/en not_active Ceased
- 2004-07-15 SI SI200430699T patent/SI1646613T1/sl unknown
- 2004-07-15 CN CNB2004800270575A patent/CN100441571C/zh not_active Expired - Fee Related
- 2004-07-15 EP EP09175186A patent/EP2145622A1/en not_active Withdrawn
- 2004-07-16 AR ARP040102527A patent/AR046394A1/es not_active Application Discontinuation
- 2004-07-16 TW TW093121227A patent/TW200521115A/zh unknown
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2006
- 2006-01-09 IL IL173036A patent/IL173036A0/en unknown
- 2006-01-18 MA MA28738A patent/MA27926A1/fr unknown
- 2006-02-15 IS IS8304A patent/IS2744B/is unknown
- 2006-02-17 NO NO20060774A patent/NO20060774L/no not_active Application Discontinuation
- 2006-09-01 HK HK06109772A patent/HK1089438A1/xx not_active IP Right Cessation
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2007
- 2007-03-16 US US11/687,098 patent/US7459456B2/en not_active Expired - Fee Related
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2008
- 2008-05-23 HR HR20080226T patent/HRP20080226T3/xx unknown
- 2008-05-29 CY CY20081100555T patent/CY1107974T1/el unknown
- 2008-07-02 US US12/166,547 patent/US7592346B2/en not_active Expired - Fee Related
-
2009
- 2009-08-13 US US12/540,452 patent/US7732600B2/en not_active Expired - Fee Related
-
2010
- 2010-04-23 US US12/766,053 patent/US20100204273A1/en not_active Abandoned
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