BR9809491A - "derivados de ergolina e seu uso como antagonista de receptor de somatostatina" - Google Patents
"derivados de ergolina e seu uso como antagonista de receptor de somatostatina"Info
- Publication number
- BR9809491A BR9809491A BR9809491-2A BR9809491A BR9809491A BR 9809491 A BR9809491 A BR 9809491A BR 9809491 A BR9809491 A BR 9809491A BR 9809491 A BR9809491 A BR 9809491A
- Authority
- BR
- Brazil
- Prior art keywords
- somatostatin receptor
- receptor antagonist
- ergoline derivatives
- formula
- ergoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE ERGOLINA E SEU USO COMO ANTAGONISTAS DE RECEPTOR DE SOMATOSTATINA"<D>. A invenção propicia compostos de fórmula I onde R~ 1~ a R~ 6~ são como definidos na descrição, e um processo para prepará-los. Os compostos de fórmula I são úteis como produtos farmacêuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9711043.1A GB9711043D0 (en) | 1997-05-29 | 1997-05-29 | Organic compounds |
PCT/EP1998/003125 WO1998054183A2 (en) | 1997-05-29 | 1998-05-27 | Ergoline derivatives and their use as somatostatin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809491A true BR9809491A (pt) | 2000-10-17 |
Family
ID=10813201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809491-2A BR9809491A (pt) | 1997-05-29 | 1998-05-27 | "derivados de ergolina e seu uso como antagonista de receptor de somatostatina" |
Country Status (24)
Country | Link |
---|---|
US (1) | US6221870B1 (pt) |
EP (1) | EP0986558A2 (pt) |
JP (1) | JP2001527580A (pt) |
KR (1) | KR20010013103A (pt) |
CN (1) | CN1259946A (pt) |
AR (1) | AR012870A1 (pt) |
AU (1) | AU727841B2 (pt) |
BR (1) | BR9809491A (pt) |
CA (1) | CA2288810A1 (pt) |
CO (1) | CO4950561A1 (pt) |
CZ (1) | CZ289466B6 (pt) |
GB (1) | GB9711043D0 (pt) |
HU (1) | HUP0002311A3 (pt) |
ID (1) | ID22916A (pt) |
IL (1) | IL132571A0 (pt) |
NO (1) | NO995482D0 (pt) |
NZ (1) | NZ500386A (pt) |
PE (1) | PE74899A1 (pt) |
PL (1) | PL336502A1 (pt) |
RU (1) | RU2191776C2 (pt) |
SK (1) | SK160899A3 (pt) |
TR (1) | TR199902848T2 (pt) |
WO (1) | WO1998054183A2 (pt) |
ZA (1) | ZA984560B (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
DE10341317B4 (de) * | 2003-09-03 | 2008-10-23 | Axxonis Pharma Ag | Transdermales therapeutisches System (TTS) zur Verabreichung von Ergolinverbindungen ausgenommen Pergolid |
DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
DE10066158B4 (de) * | 2000-08-24 | 2007-08-09 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms |
PT2062914E (pt) * | 2001-06-08 | 2014-07-18 | Ipsen Pharma Sas | Análogos quiméricos de somatostatina-dopamina |
FI20031454A0 (fi) | 2003-10-06 | 2003-10-06 | Juvantia Pharma Ltd Oy | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja |
KR101000923B1 (ko) * | 2004-01-08 | 2010-12-13 | 삼성전자주식회사 | 원격 제어기의 매크로 설정 장치 및 방법 |
US20100048549A1 (en) * | 2005-05-18 | 2010-02-25 | Siegfried Wurster | Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4 |
JP2007067096A (ja) * | 2005-08-30 | 2007-03-15 | Fujitsu Ltd | 半導体装置 |
WO2011079313A1 (en) * | 2009-12-23 | 2011-06-30 | Map Pharmaceuticals, Inc. | Novel ergoline analogs |
US8604035B2 (en) | 2011-06-23 | 2013-12-10 | Map Pharmaceuticals, Inc. | Fluoroergoline analogs |
WO2013095707A1 (en) | 2011-12-19 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel iso-ergoline derivatives |
EP2793583A4 (en) | 2011-12-21 | 2015-08-12 | Map Pharmaceuticals Inc | NOVEL NEUROMODULATORY CONNECTIONS |
US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素-多巴胺嵌合體類似物 |
JP2016503402A (ja) | 2012-11-01 | 2016-02-04 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエIpsen Pharma S.A.S. | ソマトスタチン類似体及びそのダイマー |
CN107428745A (zh) | 2015-01-20 | 2017-12-01 | Xoc制药股份有限公司 | 麦角灵化合物及其用途 |
JP2018502889A (ja) | 2015-01-20 | 2018-02-01 | エックスオーシー ファーマシューティカルズ インコーポレイテッドXoc Pharmaceuticals, Inc | イソエルゴリン化合物およびその使用 |
WO2018223065A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
JP7099717B2 (ja) | 2019-09-30 | 2022-07-12 | 株式会社理研バイオ | ソマトスタチン受容体 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH475252A (de) * | 1966-02-08 | 1969-07-15 | Sandoz Ag | Verfahren zur Herstellung neuer Lysergsäure-Derivate |
US3592816A (en) | 1966-02-08 | 1971-07-13 | Sandoz Ltd | N-substituted piperazides of lysergic acid |
GB1188197A (en) | 1967-10-11 | 1970-04-15 | Sandoz Ltd | Lysergic Acid Derivatives |
NL6818658A (pt) * | 1968-01-18 | 1969-07-22 | ||
GB1580448A (en) * | 1976-12-06 | 1980-12-03 | Farmaceutici Italia | 8 -acetyl-6-methyl-ergoline i derivatives |
GB8501078D0 (en) * | 1985-01-16 | 1985-02-20 | Erba Farmitalia | Piperazin-1-yl-ergo-line derivatives |
TW357143B (en) | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
-
1997
- 1997-05-29 GB GBGB9711043.1A patent/GB9711043D0/en active Pending
-
1998
- 1998-05-27 AR ARP980102461A patent/AR012870A1/es unknown
- 1998-05-27 HU HU0002311A patent/HUP0002311A3/hu unknown
- 1998-05-27 SK SK1608-99A patent/SK160899A3/sk unknown
- 1998-05-27 WO PCT/EP1998/003125 patent/WO1998054183A2/en not_active Application Discontinuation
- 1998-05-27 US US09/424,377 patent/US6221870B1/en not_active Expired - Fee Related
- 1998-05-27 EP EP98932090A patent/EP0986558A2/en not_active Withdrawn
- 1998-05-27 TR TR1999/02848T patent/TR199902848T2/xx unknown
- 1998-05-27 IL IL13257198A patent/IL132571A0/xx unknown
- 1998-05-27 PE PE1998000425A patent/PE74899A1/es not_active Application Discontinuation
- 1998-05-27 NZ NZ500386A patent/NZ500386A/en unknown
- 1998-05-27 CZ CZ19994245A patent/CZ289466B6/cs not_active IP Right Cessation
- 1998-05-27 CA CA002288810A patent/CA2288810A1/en not_active Abandoned
- 1998-05-27 RU RU99127433/04A patent/RU2191776C2/ru active
- 1998-05-27 CN CN98805488A patent/CN1259946A/zh active Pending
- 1998-05-27 BR BR9809491-2A patent/BR9809491A/pt not_active IP Right Cessation
- 1998-05-27 KR KR19997011082A patent/KR20010013103A/ko active IP Right Grant
- 1998-05-27 AU AU82108/98A patent/AU727841B2/en not_active Ceased
- 1998-05-27 ID IDW991445A patent/ID22916A/id unknown
- 1998-05-27 PL PL98336502A patent/PL336502A1/xx unknown
- 1998-05-27 JP JP50023799A patent/JP2001527580A/ja active Pending
- 1998-05-28 ZA ZA984560A patent/ZA984560B/xx unknown
- 1998-05-28 CO CO98030085A patent/CO4950561A1/es unknown
-
1999
- 1999-11-09 NO NO995482A patent/NO995482D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL336502A1 (en) | 2000-07-03 |
ID22916A (id) | 1999-12-16 |
NZ500386A (en) | 2002-05-31 |
ZA984560B (en) | 1998-11-30 |
CA2288810A1 (en) | 1998-12-03 |
PE74899A1 (es) | 1999-09-14 |
US6221870B1 (en) | 2001-04-24 |
GB9711043D0 (en) | 1997-07-23 |
HUP0002311A3 (en) | 2002-08-28 |
AU727841B2 (en) | 2001-01-04 |
CZ289466B6 (cs) | 2002-01-16 |
WO1998054183A2 (en) | 1998-12-03 |
EP0986558A2 (en) | 2000-03-22 |
NO995482L (no) | 1999-11-09 |
IL132571A0 (en) | 2001-03-19 |
JP2001527580A (ja) | 2001-12-25 |
AR012870A1 (es) | 2000-11-22 |
NO995482D0 (no) | 1999-11-09 |
HUP0002311A2 (hu) | 2000-12-28 |
CO4950561A1 (es) | 2000-09-01 |
TR199902848T2 (xx) | 2000-02-21 |
SK160899A3 (en) | 2000-07-11 |
CN1259946A (zh) | 2000-07-12 |
CZ424599A3 (cs) | 2000-03-15 |
WO1998054183A3 (en) | 1999-03-04 |
RU2191776C2 (ru) | 2002-10-27 |
KR20010013103A (ko) | 2001-02-26 |
AU8210898A (en) | 1998-12-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O,7O,8O E 9O ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |