PE20030292A1 - Compuestos de heteroarilo biciclicos fusionados substituidos con heteroarilo como ligandos del receptor gabaa - Google Patents
Compuestos de heteroarilo biciclicos fusionados substituidos con heteroarilo como ligandos del receptor gabaaInfo
- Publication number
- PE20030292A1 PE20030292A1 PE2002000626A PE2002000626A PE20030292A1 PE 20030292 A1 PE20030292 A1 PE 20030292A1 PE 2002000626 A PE2002000626 A PE 2002000626A PE 2002000626 A PE2002000626 A PE 2002000626A PE 20030292 A1 PE20030292 A1 PE 20030292A1
- Authority
- PE
- Peru
- Prior art keywords
- heteroaryl
- alkyl
- compounds
- gabaa
- imidazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
SE REFIERE A UN COMPUESTOS DE HETEROARILO BICICLICOS FUSIONADOS SUBSTITUIDOS CON HETEROARILO DE FORMULA I DONDE Z1 ES N, CR1; Z2 ES N, CR2; Z3 ES N, CR3; Z4 ES N, CR4; Z5 ES N, C; Z6 ES N, C SIEMPRE QUE NO MAS DE DOS Z1-Z6 SEAN N; R1-R4 SON H, HALOGENO, HIDROXI, NITRO, CIANO, AMINO, ENTRE OTROS, ALQUILO, ALCOXI, CICLOALQUILO, ALQUENILO ENTRE OTROS; R5 ES H, HALOGENO, CIANO, HALOALQUILO O R5 REPRESENTA ALQUILO, CICLOALQUILO, ARILO, ARILALQUILO, HETEROARILO, ENTRE OTROS; Q ES -C(R6)(R7), -N(ALQUILO)-, O, CON LA CONDICION DE QUE Q NO SEA O CUANDO X2 ES N; R6 Y R7 ES H, F, ALQUILO; Y ES N, C, -CH-, -CH2-; W ES ARILO, HETEROARILO. SON COMPUESTOS PREFERIDOS 6-CLORO-2-[(2-FENIL-1H-IMIDAZOL-1-IL)METIL]-3-PROPILIMIDAZO[1,2-a]PIRIDINA, 6-CLORO-2-{[2-(3-FLUOROFENIL)-1H-IMIDAZOL-1-IL]METIL}IMIDAZO[1,2-a]PIRIDINA, 6-CLORO-2-{[2-(3-CLOROFENIL)-1H-IMIDAZOL-1-IL]METIL}IMIDAZO[1,2-a]PIRIDINA, ENTRE OTROS. SE REFIERE TAMBIEN A COMPUESTOS DE HETEROARILO BICICLICOS TAL COMO IMIDAZOPIRIDINAS, IMIDAZOPIRAZINAS, IMIDAZOPIRIDAZINAS , IMIDAZOPIRIMIDINAS E IMIDAZOTIAZOLES SUBSTITUIDOS CON HETEROARILO Y DE MANERA MAS ESPECIFICA CON LOS COMPUESTOS QUE SE ENLAZAN CON ELEVADA SELECTIVIDAD Y ELEVADA AFINIDAD CON LOS LUGARES DE BENZODIAZEPINA DE LOS RECEPTORES GABAA UTIL PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30553301P | 2001-07-13 | 2001-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030292A1 true PE20030292A1 (es) | 2003-04-03 |
Family
ID=23181185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000626A PE20030292A1 (es) | 2001-07-13 | 2002-07-12 | Compuestos de heteroarilo biciclicos fusionados substituidos con heteroarilo como ligandos del receptor gabaa |
Country Status (16)
Country | Link |
---|---|
US (2) | US6936617B2 (es) |
EP (1) | EP1406906A1 (es) |
JP (1) | JP2005505518A (es) |
KR (1) | KR20040015356A (es) |
CN (2) | CN101220027A (es) |
AR (1) | AR036168A1 (es) |
BR (1) | BR0211124A (es) |
CA (1) | CA2453554A1 (es) |
GT (1) | GT200200148A (es) |
IL (1) | IL159811A0 (es) |
MX (1) | MXPA04000372A (es) |
NZ (1) | NZ530992A (es) |
PA (1) | PA8550401A1 (es) |
PE (1) | PE20030292A1 (es) |
UY (1) | UY27380A1 (es) |
WO (1) | WO2003006471A1 (es) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
MXPA04011472A (es) | 2002-05-22 | 2005-02-14 | Amgen Inc | Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor. |
WO2004014871A1 (en) | 2002-08-08 | 2004-02-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
DE10247271A1 (de) * | 2002-10-10 | 2004-08-26 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yle |
CN100457756C (zh) * | 2003-07-25 | 2009-02-04 | 神经能质公司 | 咪唑-嘧啶类及三唑-嘧啶类:苯并二氮平受体配体 |
WO2005012306A2 (en) | 2003-07-25 | 2005-02-10 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
EP1880998A1 (en) * | 2003-07-25 | 2008-01-23 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
US7534798B2 (en) | 2004-02-11 | 2009-05-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
US20090023737A1 (en) * | 2004-02-12 | 2009-01-22 | Neurogen Corporation | Imidazo-Pyridazines, Triazolo-Pyridazines and Related Benzodiazepine Receptor Ligands |
WO2006052546A2 (en) * | 2004-11-04 | 2006-05-18 | Neurogen Corporation | Pyrazolylmethyl heteroaryl derivatives |
WO2006089311A1 (en) | 2005-02-15 | 2006-08-24 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
TW200800213A (en) | 2005-09-02 | 2008-01-01 | Abbott Lab | Novel imidazo based heterocycles |
US7750000B2 (en) * | 2005-09-02 | 2010-07-06 | Bayer Schering Pharma Ag | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments |
MX2008008152A (es) * | 2005-12-23 | 2008-09-12 | Ariad Pharma Inc | Compuestos heterociclicos biciclicos. |
BRPI0710328A2 (pt) * | 2006-05-08 | 2011-08-09 | Ariad Pharma Inc | composto da fórmula i, um tautomer da mesma, ou um sal farmaceuticamente aceitável, hidrato ou outro solvato do mesmo e método para o tratamento de cáncer em um mamìfero necessitado do mesmo e composição |
KR101441365B1 (ko) * | 2006-05-08 | 2014-09-18 | 어리어드 파마슈티칼스, 인코포레이티드 | 모노시클릭 헤테로아릴 화합물 |
US20080249305A1 (en) * | 2007-03-27 | 2008-10-09 | Calderwood David J | Novel imidazole based heterocycles |
EP1974729A1 (en) | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
EP2072516A1 (en) * | 2007-12-21 | 2009-06-24 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as Melancortin-4 receptor antagonists |
US8263630B2 (en) | 2008-02-12 | 2012-09-11 | Bristol-Myers Squibb Company | 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type I inhibitors |
EP2365809B8 (en) | 2008-11-12 | 2018-10-10 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
US10206921B2 (en) | 2009-06-03 | 2019-02-19 | The Regents Of The University Of California | Methods and compositions for treating a subject for central nervous system (CNS) injury |
EP2298296A1 (en) * | 2009-08-25 | 2011-03-23 | CNRS Centre National De La Recherche Scientifique | Composition and method for treating cognitive impairments in down syndrome subjects |
MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
US20130150351A1 (en) * | 2010-06-03 | 2013-06-13 | Stanley T. Carmichael | Methods and compositions for treating a subject for central nervous system (cns) injury |
KR101034040B1 (ko) * | 2010-08-16 | 2011-05-16 | 정동영 | 백업트랙터 |
BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
CN104411312B (zh) | 2012-06-26 | 2018-03-06 | 詹森药业有限公司 | 包括pde2抑制剂例如1‑芳基‑4‑甲基‑[1,2,4]三唑[4,3‑a]‑喹喔啉化合物和pde10抑制剂的用于在治疗神经病学障碍或代谢障碍中使用的组合 |
MX362197B (es) | 2012-07-09 | 2019-01-08 | Janssen Pharmaceutica Nv | Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos. |
CA3167093A1 (en) | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
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WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
WO2016007727A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
AU2015374118B2 (en) | 2014-12-29 | 2020-07-23 | The Trustees Of The University Of Pennsylvania | Small molecule inhibitors of lactate dehydrogenase and methods of use thereof |
TWI714567B (zh) | 2015-04-03 | 2021-01-01 | 美商英塞特公司 | 作為lsd1抑制劑之雜環化合物 |
CR20180152A (es) | 2015-08-12 | 2018-08-09 | Incyte Corp | Sales de un inhibidor de lsd1 |
MX2018012901A (es) | 2016-04-22 | 2019-06-06 | Incyte Corp | Formulaciones de inhibidor de demetilasa 1 especifica para lisina (lsd1). |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN111662270A (zh) * | 2019-03-05 | 2020-09-15 | 中国医学科学院药物研究所 | 碘同位素标记苄苯醚衍生物、及其制法和药物组合物与用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001333A1 (en) * | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
WO1996034866A1 (en) * | 1995-05-01 | 1996-11-07 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors |
GB9801538D0 (en) | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
GB9805561D0 (en) | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
GB9805559D0 (en) | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
GB9805557D0 (en) | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
US6358949B1 (en) | 1999-04-02 | 2002-03-19 | Neurogen Corporation | Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors |
AU2001236471A1 (en) | 2000-01-18 | 2001-07-31 | Neurogen Corporation | Imidazopyridines and related azacyclic derivatives as selective modulators of bradykinin b2 receptors |
AU2001270297A1 (en) * | 2000-06-30 | 2002-01-14 | Neurogen Corporation | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands |
PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
-
2001
- 2001-07-12 IL IL15981101A patent/IL159811A0/xx unknown
-
2002
- 2002-07-11 GT GT200200148A patent/GT200200148A/es unknown
- 2002-07-12 NZ NZ530992A patent/NZ530992A/en unknown
- 2002-07-12 MX MXPA04000372A patent/MXPA04000372A/es active IP Right Grant
- 2002-07-12 EP EP02749983A patent/EP1406906A1/en not_active Withdrawn
- 2002-07-12 KR KR10-2004-7000563A patent/KR20040015356A/ko not_active Application Discontinuation
- 2002-07-12 PA PA20028550401A patent/PA8550401A1/es unknown
- 2002-07-12 UY UY27380A patent/UY27380A1/es not_active Application Discontinuation
- 2002-07-12 PE PE2002000626A patent/PE20030292A1/es not_active Application Discontinuation
- 2002-07-12 US US10/194,852 patent/US6936617B2/en not_active Expired - Fee Related
- 2002-07-12 AR ARP020102628A patent/AR036168A1/es unknown
- 2002-07-12 CA CA002453554A patent/CA2453554A1/en not_active Abandoned
- 2002-07-12 WO PCT/US2002/022130 patent/WO2003006471A1/en active IP Right Grant
- 2002-07-12 JP JP2003512241A patent/JP2005505518A/ja active Pending
- 2002-07-12 CN CNA2008100019411A patent/CN101220027A/zh active Pending
- 2002-07-12 CN CNB028166965A patent/CN100369912C/zh not_active Expired - Fee Related
- 2002-07-12 BR BR0211124-1A patent/BR0211124A/pt not_active IP Right Cessation
-
2005
- 2005-08-29 US US11/214,345 patent/US20060014746A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20040015356A (ko) | 2004-02-18 |
PA8550401A1 (es) | 2004-02-07 |
EP1406906A1 (en) | 2004-04-14 |
IL159811A0 (en) | 2004-06-20 |
US20030207885A1 (en) | 2003-11-06 |
CN101220027A (zh) | 2008-07-16 |
AR036168A1 (es) | 2004-08-18 |
US6936617B2 (en) | 2005-08-30 |
CN1553916A (zh) | 2004-12-08 |
NZ530992A (en) | 2005-06-24 |
GT200200148A (es) | 2003-05-15 |
JP2005505518A (ja) | 2005-02-24 |
US20060014746A1 (en) | 2006-01-19 |
BR0211124A (pt) | 2004-06-29 |
MXPA04000372A (es) | 2004-07-23 |
CN100369912C (zh) | 2008-02-20 |
CA2453554A1 (en) | 2003-01-23 |
UY27380A1 (es) | 2003-02-28 |
WO2003006471A1 (en) | 2003-01-23 |
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