AU2001270297A1 - 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands - Google Patents

2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands

Info

Publication number
AU2001270297A1
AU2001270297A1 AU2001270297A AU7029701A AU2001270297A1 AU 2001270297 A1 AU2001270297 A1 AU 2001270297A1 AU 2001270297 A AU2001270297 A AU 2001270297A AU 7029701 A AU7029701 A AU 7029701A AU 2001270297 A1 AU2001270297 A1 AU 2001270297A1
Authority
AU
Australia
Prior art keywords
phenylimidazo
new class
receptor ligands
pyridine derivatives
brain receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001270297A
Inventor
Guolin Cai
Kenneth Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of AU2001270297A1 publication Critical patent/AU2001270297A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2001270297A 2000-06-30 2001-06-29 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands Abandoned AU2001270297A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21564600P 2000-06-30 2000-06-30
US60/215,646 2000-06-30
US60215646 2000-06-30
PCT/US2001/021068 WO2002002557A2 (en) 2000-06-30 2001-06-29 2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
AU2001270297A1 true AU2001270297A1 (en) 2002-01-14

Family

ID=22803813

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001270297A Abandoned AU2001270297A1 (en) 2000-06-30 2001-06-29 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands

Country Status (3)

Country Link
US (1) US6552037B2 (en)
AU (1) AU2001270297A1 (en)
WO (1) WO2002002557A2 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286788B6 (en) * 1999-10-08 2009-05-07 Grnenthal Gmbh Bicyclic imidazo-3-yl-amine derivates, method of producing thereof and medicaments containing said substances
GB9927687D0 (en) 1999-11-23 2000-01-19 Merck Sharp & Dohme Therapeutic agents
EP1251786B1 (en) * 2000-01-18 2007-03-14 Tyco Healthcare Group Lp Anastomosis instrument
DE10050663A1 (en) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Use of amino-substituted imidazo(1,2-a)pyridine, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine derivatives as NO synthase inhibitors, e.g. in treatment of migraine and neurodegenerative diseases
US6703393B2 (en) 2001-03-27 2004-03-09 Neurogen Corporation (Oxo-pyrazolo[1,5a]pyrimidin-2-yl) alkyl-carboxamides
DE10117184A1 (en) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituted imidazole [1,2-a] pyridin-3-yl amide and amine compounds
IL159811A0 (en) * 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
US7030144B2 (en) * 2002-05-02 2006-04-18 Neurogen Corporation Substituted imidazole derivatives: GABAA receptor ligands
US6982268B2 (en) * 2002-05-08 2006-01-03 Neurogen Corporation Substituted imidazolylmethyl pyridine and pyrazine derivatives GABAA receptor ligands
AU2003237881A1 (en) * 2002-05-17 2003-12-02 Neurogen Corporation Substituted ring-fused imidazole derivates: gabaa receptor ligands
CN100579579C (en) * 2002-10-01 2010-01-13 诺华疫苗和诊断公司 Anti-cancer and anti-infectious disease compositions and methods for using same
DE10247271A1 (en) * 2002-10-10 2004-08-26 Grünenthal GmbH Use of new and known 7-(methyl or trifluoromethyl)-imidazo-(1,2-a)-pyridines as nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, neurodegenerative diseases, inflammatory pain, diabetes or cancer
CN100457756C (en) * 2003-07-25 2009-02-04 神经能质公司 Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
PT1648899E (en) * 2003-07-25 2007-03-30 Neurogen Corp Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
EP1880998A1 (en) * 2003-07-25 2008-01-23 Neurogen Corporation Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
RU2426732C2 (en) 2006-01-17 2011-08-20 Ф. Хоффманн-Ля Рош Аг ARYL-ISOXAZOL-4-YL-IMIDAZO[1,2-a]PYRIDINE SUITABLE FOR TREATING ALZHEIMER'S DISEASE THROUGH GABA RECEPTORS
EP2070927A4 (en) * 2006-09-13 2010-10-13 Kyowa Hakko Kirin Co Ltd Fused heterocyclic derivative
JP5774982B2 (en) * 2008-05-19 2015-09-09 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． Imidazo [1,2-a] pyridine compound
BR112012010752B1 (en) * 2009-11-05 2021-07-20 University Of Notre Dame Du Lac IMIDAZO[1,2-A]PYRIDINE COMPOUNDS
WO2011143660A2 (en) 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia
KR101857599B1 (en) 2010-05-14 2018-05-14 다나-파버 캔서 인스티튜트 인크. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
US9301962B2 (en) 2010-05-14 2016-04-05 Baylor College Of Medicine Male contraceptive compositions and methods of use
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
KR101735975B1 (en) 2012-11-29 2017-05-15 에프. 호프만-라 로슈 아게 Imidazopyridine derivatives
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
BR112016001457A2 (en) * 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
JP2017504653A (en) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Diaminopyrimidine benzenesulfone derivatives and uses thereof
JP2017504651A (en) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Use of diazepan derivatives
US9695172B2 (en) 2014-01-31 2017-07-04 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
US10925881B2 (en) 2014-02-28 2021-02-23 Tensha Therapeutics, Inc. Treatment of conditions associated with hyperinsulinaemia
WO2016022902A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
CA2955077A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
AU2015339511B2 (en) 2014-10-27 2020-05-14 Tensha Therapeutics, Inc. Bromodomain inhibitors
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
KR20180051576A (en) 2015-09-11 2018-05-16 다나-파버 캔서 인스티튜트 인크. Acetamide thienotriazolol diazepines and their uses
RU2750164C2 (en) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Cyanothienotriazolodiazepines and methods for their use
AU2016324598A1 (en) 2015-09-17 2018-03-15 Marvin J. Miller Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
WO2017091673A2 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibtors and uses thereof
GEP20207104B (en) 2015-12-10 2020-05-11 Bayer Pharma AG 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
US10414765B2 (en) 2015-12-10 2019-09-17 Bayer Pharma Aktiengesellschaft Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
JOP20190005A1 (en) 2016-07-20 2019-01-20 Bayer Ag Substituted diazahetero-bicyclic compounds and their use
JOP20190284A1 (en) 2017-06-14 2019-12-11 Bayer Pharma AG Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
CN110498795B (en) * 2018-05-18 2022-02-01 山东第一医科大学(山东省医学科学院) Imidazo [1,2-a ] pyridine derivative cysteine fluorescent probe and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1536351A (en) * 1967-07-03 1968-08-27 Pyridylimidazopyridines
FR2492382A1 (en) * 1980-10-22 1982-04-23 Synthelabo IMIDAZO (1,2-A) PYRIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
FR2568880B1 (en) * 1984-08-07 1986-12-12 Synthelabo IMIDAZO ACYLAMINOMETHYL-3 DERIVATIVES (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AU4859596A (en) 1995-02-15 1996-09-04 Pharmacia & Upjohn Company Imidazo{1,2-a}pyridines for the treatment of cns and cardiac diseases

Also Published As

Publication number Publication date
US6552037B2 (en) 2003-04-22
US20020032200A1 (en) 2002-03-14
WO2002002557A2 (en) 2002-01-10
WO2002002557A3 (en) 2002-07-18

Similar Documents

Publication Publication Date Title
AU2001270297A1 (en) 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands
HUS1700009I1 (en) 2-(pyridin-2-ylamino)-pyrido [2,3-d] pyrimidin-7-ones
AU2002214505A1 (en) New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
AU5276696A (en) Imidazo{1,2-a}pyridine derivatives
WO2003101949A3 (en) Process for imidazo[4,5-c]pyridin-4-amines
AU2001291893A1 (en) Use of substituted imidazo(1,2-a)pyridine-, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments
SI1220856T1 (en) Pyrazolo(4,3-d)pyrimidine derivatives
PL348924A1 (en) Substituted 2−aryl−3−(heteroaryl)−imidazo[1,2−a
AU2002220692A1 (en) Novel pyridine-substituted pyrazolopyridine derivatives
AU2002361992A1 (en) 1,4-dihydro-1,4-diphenylpyridine derivatives
AU2881199A (en) Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
AU2217200A (en) 2-amino-9-alkylpurines: gaba brain receptor ligands
AU2002215100A1 (en) Imidazo-pyrimidine derivatives as ligands for gaba receptors
AU2003220190A1 (en) Pyrazolo(1,5-a)pyridine derivatives as neurotransmitter modulators
IL190120A0 (en) PREPARATION OF 9-AMINO OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a//1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES
MXPA03008965A (en) Use of substituted imidazo[1,2-a]-pyridine compounds as medicaments.
HK1036274A1 (en) Imidazo (1,2-a) pyridine derivatives for the treatment of gastrointestinal diseases
AU2253297A (en) Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents
PL369544A1 (en) Pyridine derivatives as nmda receptor ligands
AU2759897A (en) Pyrrolo{2,3-b}pyridine derivatives, useful as radiolabelled d4 receptor ligands
ZA200205596B (en) Octahydro-2H-Pyrido[1,2-A]pyrazine compounds, a process for their preparation and pharmaceutical compositions containing them.
IL127853A0 (en) A process for the preparation of pyridine dicarboxylate derivatives
HUP0402475A3 (en) Process for the preparation of [1,4,5]-oxadiazepine derivatives
IS5654A (en) Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one-3-pyridylsulfonyl compounds and their intermediates
AU2002366092A1 (en) 1h-pyrrolo(3,2-b)pyridine-3-carboxylic acid amides