MXPA04000372A - Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa. - Google Patents
Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa.Info
- Publication number
- MXPA04000372A MXPA04000372A MXPA04000372A MXPA04000372A MXPA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A MX PA04000372 A MXPA04000372 A MX PA04000372A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- formula
- relates
- heteroaryl
- fused bicyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esta invencion se refiere a compuestos de heteroarilo biciclico fusionados substituidos con heteroarilo, tales como imidazopiridinas, imidazopirazinas, impidazopiridizinas, imidazopirimidinas e imidazotiazoles substituidos con heteroarilo, que se pueden describir por la formula I o la formula II. La invencion se refiere particularmente a tales compuestos que enlazan con alta selectividad y alta afinidad al sitio de benzodiazepina de los receptores GABAA. Esta invencion tambien se refiere a composiciones farmaceuticas que comprenden tales compuestos y al uso de tales compuestos en el tratamiento de ciertas enfermedades del sistema nervioso central (SNC). Se describen los procesos para la preparacion de compuestos de Formula I y Formula II. Esta invencion tambien se refiere al uso de bencimidazoles, piridilimidazoles y compuestos de heteroarilo biciclicos relacionados de Formula I o Formula II en combinacion con uno o mas de otros agentes del SNC, para potenciar los efectos de los otros agentes del SNC. Adicionalmente, esta invencion se refiere al uso de tales compuestos como sondas para la localizacion de los receptores GABAA en secciones de tejidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30553301P | 2001-07-13 | 2001-07-13 | |
PCT/US2002/022130 WO2003006471A1 (en) | 2001-07-13 | 2002-07-12 | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04000372A true MXPA04000372A (es) | 2004-07-23 |
Family
ID=23181185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000372A MXPA04000372A (es) | 2001-07-13 | 2002-07-12 | Compuesto biciclicos de heteroarilo fusionados sustituidos con heteroarilo como ligandos del receptor gabaa. |
Country Status (16)
Country | Link |
---|---|
US (2) | US6936617B2 (es) |
EP (1) | EP1406906A1 (es) |
JP (1) | JP2005505518A (es) |
KR (1) | KR20040015356A (es) |
CN (2) | CN101220027A (es) |
AR (1) | AR036168A1 (es) |
BR (1) | BR0211124A (es) |
CA (1) | CA2453554A1 (es) |
GT (1) | GT200200148A (es) |
IL (1) | IL159811A0 (es) |
MX (1) | MXPA04000372A (es) |
NZ (1) | NZ530992A (es) |
PA (1) | PA8550401A1 (es) |
PE (1) | PE20030292A1 (es) |
UY (1) | UY27380A1 (es) |
WO (1) | WO2003006471A1 (es) |
Families Citing this family (50)
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US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
DE60335635D1 (de) | 2002-05-22 | 2011-02-17 | Amgen Inc | Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen |
TW200410945A (en) | 2002-08-08 | 2004-07-01 | Amgen Inc | Vanilloid receptor ligands and their use in treatments" |
UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
DE10247271A1 (de) * | 2002-10-10 | 2004-08-26 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yle |
KR20060098425A (ko) * | 2003-07-25 | 2006-09-18 | 뉴로젠 코포레이션 | 이미다조-피리미딘 및 트리아졸로-피리미딘: 벤조디아제핀수용체 리간드 |
ZA200600037B (en) * | 2003-07-25 | 2007-04-25 | Neurogen Corp | Imidazo-pyrimidines and triazolo-pyrimidines: Benzodiazepine receptor ligands |
EP1880998A1 (en) * | 2003-07-25 | 2008-01-23 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
JP2007522233A (ja) | 2004-02-11 | 2007-08-09 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療におけるそれらの使用 |
WO2005080355A1 (en) * | 2004-02-12 | 2005-09-01 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
US20080004269A1 (en) * | 2004-11-04 | 2008-01-03 | Yuelian Xu | Pyrazolylmethy Heteroaryl Derivatives |
US7301022B2 (en) | 2005-02-15 | 2007-11-27 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
EP1928237A4 (en) * | 2005-09-02 | 2011-03-09 | Abbott Lab | NEW HETEROCYCLES BASED ON IMIDAZO |
US7750000B2 (en) * | 2005-09-02 | 2010-07-06 | Bayer Schering Pharma Ag | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments |
WO2007075869A2 (en) * | 2005-12-23 | 2007-07-05 | Ariad Pharmaceuticals, Inc. | Bicyclic heteroaryl compounds |
EP2023933A4 (en) * | 2006-05-08 | 2011-02-23 | Ariad Pharma Inc | HETEROARYL ACETYLENE COMPOUNDS |
CA2650273C (en) * | 2006-05-08 | 2016-06-07 | Ariad Pharmaceuticals, Inc. | Monocyclic heteroaryl compounds |
CN101652069A (zh) * | 2007-03-27 | 2010-02-17 | 艾博特公司 | 新的基于咪唑并的杂环化合物 |
EP1974729A1 (en) | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
EP2072516A1 (en) * | 2007-12-21 | 2009-06-24 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as Melancortin-4 receptor antagonists |
US8263630B2 (en) | 2008-02-12 | 2012-09-11 | Bristol-Myers Squibb Company | 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type I inhibitors |
US8846664B2 (en) | 2008-11-12 | 2014-09-30 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
US10206921B2 (en) | 2009-06-03 | 2019-02-19 | The Regents Of The University Of California | Methods and compositions for treating a subject for central nervous system (CNS) injury |
EP2298296A1 (en) * | 2009-08-25 | 2011-03-23 | CNRS Centre National De La Recherche Scientifique | Composition and method for treating cognitive impairments in down syndrome subjects |
ES2651296T3 (es) | 2009-10-30 | 2018-01-25 | Janssen Pharmaceutica, N.V. | Derivados de imidazo[1,2-b]piridacina y su uso como inhibidores de PDE10 |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CA2837818A1 (en) * | 2010-06-03 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for treating a subject for central nervous system (cns) injury |
KR101034040B1 (ko) * | 2010-08-16 | 2011-05-16 | 정동영 | 백업트랙터 |
WO2013000924A1 (en) | 2011-06-27 | 2013-01-03 | Janssen Pharmaceutica Nv | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
EP2863909B1 (en) | 2012-06-26 | 2020-11-04 | Janssen Pharmaceutica N.V. | Combinations comprising 4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline compounds as pde 2 inhibitors and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
CN104411314B (zh) | 2012-07-09 | 2017-10-20 | 詹森药业有限公司 | 磷酸二酯酶10的抑制剂 |
CA3022250A1 (en) | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
ES2760261T3 (es) | 2014-02-13 | 2020-05-13 | Incyte Corp | Ciclopropilaminas como inhibidores de LSD1 |
HUE045725T2 (hu) | 2014-02-13 | 2020-01-28 | Incyte Corp | Ciklopropilaminok mint LSD1 inhibitorok |
ES2672797T3 (es) | 2014-02-13 | 2018-06-18 | Incyte Corporation | Ciclopropilaminas como inhibidores de LSD1 |
WO2016007736A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines as lsd1 inhibitors |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
US9695168B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors |
EP3240785B1 (en) | 2014-12-29 | 2021-07-07 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Small molecule inhibitors of lactate dehydrogenase and methods of use thereof |
MX2017012699A (es) | 2015-04-03 | 2018-02-09 | Incyte Corp | Compuestos heterociclicos como inhibidores de demetilasa 1 especifica de lisina (lsd1). |
KR20180051523A (ko) | 2015-08-12 | 2018-05-16 | 인사이트 코포레이션 | Lsd1 저해제의 염 |
SG11201809299QA (en) | 2016-04-22 | 2018-11-29 | Incyte Corp | Formulations of an lsd1 inhibitor |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN111662270A (zh) * | 2019-03-05 | 2020-09-15 | 中国医学科学院药物研究所 | 碘同位素标记苄苯醚衍生物、及其制法和药物组合物与用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001333A1 (en) * | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
WO1996034866A1 (en) * | 1995-05-01 | 1996-11-07 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors |
GB9801538D0 (en) | 1998-01-23 | 1998-03-25 | Merck Sharp & Dohme | Pharmaceutical product |
GB9805559D0 (en) | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
GB9805561D0 (en) | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
GB9805557D0 (en) | 1998-03-16 | 1998-05-13 | Merck Sharp & Dohme | A combination of therapeutic agents |
US6271241B1 (en) | 1999-04-02 | 2001-08-07 | Neurogen Corporation | Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors |
US6380210B1 (en) | 1999-04-02 | 2002-04-30 | Neurogen Corporation | Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors |
US6358949B1 (en) | 1999-04-02 | 2002-03-19 | Neurogen Corporation | Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors |
AU2001236471A1 (en) | 2000-01-18 | 2001-07-31 | Neurogen Corporation | Imidazopyridines and related azacyclic derivatives as selective modulators of bradykinin b2 receptors |
AU2001270297A1 (en) * | 2000-06-30 | 2002-01-14 | Neurogen Corporation | 2-phenylimidazo(1,2-a)pyridine derivatives: a new class of gaba brain receptor ligands |
PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
-
2001
- 2001-07-12 IL IL15981101A patent/IL159811A0/xx unknown
-
2002
- 2002-07-11 GT GT200200148A patent/GT200200148A/es unknown
- 2002-07-12 BR BR0211124-1A patent/BR0211124A/pt not_active IP Right Cessation
- 2002-07-12 CN CNA2008100019411A patent/CN101220027A/zh active Pending
- 2002-07-12 PE PE2002000626A patent/PE20030292A1/es not_active Application Discontinuation
- 2002-07-12 UY UY27380A patent/UY27380A1/es not_active Application Discontinuation
- 2002-07-12 CN CNB028166965A patent/CN100369912C/zh not_active Expired - Fee Related
- 2002-07-12 AR ARP020102628A patent/AR036168A1/es unknown
- 2002-07-12 WO PCT/US2002/022130 patent/WO2003006471A1/en active IP Right Grant
- 2002-07-12 MX MXPA04000372A patent/MXPA04000372A/es active IP Right Grant
- 2002-07-12 US US10/194,852 patent/US6936617B2/en not_active Expired - Fee Related
- 2002-07-12 CA CA002453554A patent/CA2453554A1/en not_active Abandoned
- 2002-07-12 JP JP2003512241A patent/JP2005505518A/ja active Pending
- 2002-07-12 PA PA20028550401A patent/PA8550401A1/es unknown
- 2002-07-12 NZ NZ530992A patent/NZ530992A/en unknown
- 2002-07-12 EP EP02749983A patent/EP1406906A1/en not_active Withdrawn
- 2002-07-12 KR KR10-2004-7000563A patent/KR20040015356A/ko not_active Application Discontinuation
-
2005
- 2005-08-29 US US11/214,345 patent/US20060014746A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
UY27380A1 (es) | 2003-02-28 |
CN100369912C (zh) | 2008-02-20 |
US20060014746A1 (en) | 2006-01-19 |
CN101220027A (zh) | 2008-07-16 |
WO2003006471A1 (en) | 2003-01-23 |
NZ530992A (en) | 2005-06-24 |
AR036168A1 (es) | 2004-08-18 |
CA2453554A1 (en) | 2003-01-23 |
CN1553916A (zh) | 2004-12-08 |
PA8550401A1 (es) | 2004-02-07 |
IL159811A0 (en) | 2004-06-20 |
PE20030292A1 (es) | 2003-04-03 |
BR0211124A (pt) | 2004-06-29 |
US6936617B2 (en) | 2005-08-30 |
US20030207885A1 (en) | 2003-11-06 |
JP2005505518A (ja) | 2005-02-24 |
KR20040015356A (ko) | 2004-02-18 |
EP1406906A1 (en) | 2004-04-14 |
GT200200148A (es) | 2003-05-15 |
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