UY27380A1 - Compuestos de heteroarilo bicíclicos fusionados sustituidos con heteroarilo como ligandos del receptor gabaa - Google Patents

Compuestos de heteroarilo bicíclicos fusionados sustituidos con heteroarilo como ligandos del receptor gabaa

Info

Publication number
UY27380A1
UY27380A1 UY27380A UY27380A UY27380A1 UY 27380 A1 UY27380 A1 UY 27380A1 UY 27380 A UY27380 A UY 27380A UY 27380 A UY27380 A UY 27380A UY 27380 A1 UY27380 A1 UY 27380A1
Authority
UY
Uruguay
Prior art keywords
compounds
gabaa
heteroarilo
heteroaril
fusioned
Prior art date
Application number
UY27380A
Other languages
English (en)
Inventor
A Hutchison
G Maynard
P Albaugh
L Xie
J Yuan
S Mitchell
V Singh
M Ghosh
G Li
N Liu
K Currie
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of UY27380A1 publication Critical patent/UY27380A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Compuestos de heteroarilo fusionados sustituidos con heteroarilo de fórmula I, como imidazopiridinas, imidazopirazinas, imidazopiridazinas, imidazopirimidinas e imidazotiazoles sustituidos con heteroarilo, y más específicamente con compuestos que se enlazan con elevada selectividad y afinidad al emplazamiento de benzodiazepina de los receptores GABA. Composiciones farmacéuticas comprendiendo dichos compuestos y con su uso para tratamiento de enfermedades del sistema nervioso central (CNS). Uso de compuestos referidos así como con los relacionados en combinación con uno o más de otros agentes con el fin de potenciar los efectos de otros agentes para el CNS. Uso de ellos como sondas para ubicación de los receptores GABAa en secciones de tejido.
UY27380A 2001-07-13 2002-07-12 Compuestos de heteroarilo bicíclicos fusionados sustituidos con heteroarilo como ligandos del receptor gabaa UY27380A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30553301P 2001-07-13 2001-07-13

Publications (1)

Publication Number Publication Date
UY27380A1 true UY27380A1 (es) 2003-02-28

Family

ID=23181185

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27380A UY27380A1 (es) 2001-07-13 2002-07-12 Compuestos de heteroarilo bicíclicos fusionados sustituidos con heteroarilo como ligandos del receptor gabaa

Country Status (16)

Country Link
US (2) US6936617B2 (es)
EP (1) EP1406906A1 (es)
JP (1) JP2005505518A (es)
KR (1) KR20040015356A (es)
CN (2) CN101220027A (es)
AR (1) AR036168A1 (es)
BR (1) BR0211124A (es)
CA (1) CA2453554A1 (es)
GT (1) GT200200148A (es)
IL (1) IL159811A0 (es)
MX (1) MXPA04000372A (es)
NZ (1) NZ530992A (es)
PA (1) PA8550401A1 (es)
PE (1) PE20030292A1 (es)
UY (1) UY27380A1 (es)
WO (1) WO2003006471A1 (es)

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DE602004004143T2 (de) * 2003-07-25 2007-10-11 Neurogen Corp., Branford Imidazopyrimidine und triazolopyrimidine: benzodiazepinrezeptorliganden
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CA2556239A1 (en) 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
WO2005080355A1 (en) * 2004-02-12 2005-09-01 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
US20080004269A1 (en) * 2004-11-04 2008-01-03 Yuelian Xu Pyrazolylmethy Heteroaryl Derivatives
WO2006089311A1 (en) 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US7709468B2 (en) * 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
US7750000B2 (en) * 2005-09-02 2010-07-06 Bayer Schering Pharma Ag Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
PL2495016T3 (pl) 2005-12-23 2020-06-01 Ariad Pharmaceuticals, Inc. Bicykliczne związki heteroarylowe
WO2007133562A2 (en) * 2006-05-08 2007-11-22 Ariad Pharmaceuticals, Inc. Monocyclic heteroaryl compounds
MX2008014289A (es) 2006-05-08 2008-11-26 Ariad Pharma Inc Compuestos heteroarilicos acetilenicos.
CN101652069A (zh) * 2007-03-27 2010-02-17 艾博特公司 新的基于咪唑并的杂环化合物
EP1974729A1 (en) 2007-03-28 2008-10-01 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists
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WO2009102761A1 (en) 2008-02-12 2009-08-20 Bristol-Myers Squibb Company 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors
WO2010056311A1 (en) 2008-11-12 2010-05-20 Ariad Pharmaceuticals, Inc. Pyrazinopyrazines and derivatives as kinase inhibitors
US10206921B2 (en) 2009-06-03 2019-02-19 The Regents Of The University Of California Methods and compositions for treating a subject for central nervous system (CNS) injury
EP2298296A1 (en) * 2009-08-25 2011-03-23 CNRS Centre National De La Recherche Scientifique Composition and method for treating cognitive impairments in down syndrome subjects
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EP2575455A4 (en) * 2010-06-03 2014-01-15 Univ California METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR INJURY OF THE CENTRAL NERVOUS SYSTEM (CNS)
KR101034040B1 (ko) * 2010-08-16 2011-05-16 정동영 백업트랙터
EP2723744B1 (en) 2011-06-27 2016-03-23 Janssen Pharmaceutica, N.V. 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
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Also Published As

Publication number Publication date
US6936617B2 (en) 2005-08-30
KR20040015356A (ko) 2004-02-18
EP1406906A1 (en) 2004-04-14
US20030207885A1 (en) 2003-11-06
PE20030292A1 (es) 2003-04-03
US20060014746A1 (en) 2006-01-19
IL159811A0 (en) 2004-06-20
WO2003006471A1 (en) 2003-01-23
CA2453554A1 (en) 2003-01-23
JP2005505518A (ja) 2005-02-24
CN1553916A (zh) 2004-12-08
CN101220027A (zh) 2008-07-16
PA8550401A1 (es) 2004-02-07
NZ530992A (en) 2005-06-24
BR0211124A (pt) 2004-06-29
CN100369912C (zh) 2008-02-20
MXPA04000372A (es) 2004-07-23
AR036168A1 (es) 2004-08-18
GT200200148A (es) 2003-05-15

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