US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
PT971946E
(pt)
|
1997-01-21 |
2006-11-30 |
Gen Hospital Corp |
Selecção de proteínas utilizando fusões arn-proteína
|
US8207093B2
(en)
|
1997-01-21 |
2012-06-26 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
EP1801214B1
(en)
|
1997-07-07 |
2010-11-10 |
Medical Research Council |
In vitro sorting method
|
AU757955B2
(en)
|
1998-08-17 |
2003-03-13 |
Bristol-Myers Squibb Company |
Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules
|
ES2280131T3
(es)
|
1998-12-02 |
2007-09-01 |
Adnexus Therapeutics, Inc. |
Fusiones de adn-proteina y utilizaciones de las mismas.
|
JP2003500081A
(ja)
|
1999-06-01 |
2003-01-07 |
フィロス インク. |
5’核酸−タンパク質結合体の生成法
|
EP1226149A4
(en)
*
|
1999-10-01 |
2003-05-14 |
Zhongping Yu |
COMPOSITIONS AND METHODS FOR IDENTIFYING NUCLEIC ACID POLYPETIDES AND MOLECULES
|
US6489116B2
(en)
*
|
2000-01-24 |
2002-12-03 |
Phylos, Inc. |
Sensitive, multiplexed diagnostic assays for protein analysis
|
GB2360282A
(en)
*
|
2000-03-17 |
2001-09-19 |
Bioinvent Int Ab |
Making and using micro-arrays of biological materials
|
WO2002022826A2
(en)
*
|
2000-09-14 |
2002-03-21 |
Xencor, Inc. |
Methods and compositions for the construction and use of fusion libraries
|
US20030124537A1
(en)
*
|
2000-12-14 |
2003-07-03 |
Yuan-Chin Liu |
Procaryotic libraries and uses
|
AU2002251999A1
(en)
*
|
2001-02-22 |
2002-09-12 |
Xencor |
Methods and compositions for the construction and use of fusion libraries using computational protein design methods
|
US20020168640A1
(en)
*
|
2001-02-22 |
2002-11-14 |
Min Li |
Biochips comprising nucleic acid/protein conjugates
|
AU2002254134B2
(en)
|
2001-03-07 |
2006-06-01 |
Children's Medical Center Corporation |
Method to screen peptide display libraries using minicell display
|
GB0127564D0
(en)
|
2001-11-16 |
2002-01-09 |
Medical Res Council |
Emulsion compositions
|
US7842476B2
(en)
*
|
2002-09-06 |
2010-11-30 |
Isogenica Limited |
In vitro peptide expression library
|
WO2004056995A1
(en)
*
|
2002-12-23 |
2004-07-08 |
Affitech As |
Process for producing an in vitro peptide expression library
|
BRPI0406678A
(pt)
|
2003-01-07 |
2005-12-20 |
Symphogen As |
Método para produzir proteìnas policlonais recombinantes
|
EP2159285B1
(en)
|
2003-01-29 |
2012-09-26 |
454 Life Sciences Corporation |
Methods of amplifying and sequencing nucleic acids
|
US20100022414A1
(en)
|
2008-07-18 |
2010-01-28 |
Raindance Technologies, Inc. |
Droplet Libraries
|
GB0307403D0
(en)
|
2003-03-31 |
2003-05-07 |
Medical Res Council |
Selection by compartmentalised screening
|
US20060078893A1
(en)
|
2004-10-12 |
2006-04-13 |
Medical Research Council |
Compartmentalised combinatorial chemistry by microfluidic control
|
GB0307428D0
(en)
|
2003-03-31 |
2003-05-07 |
Medical Res Council |
Compartmentalised combinatorial chemistry
|
JP5183063B2
(ja)
|
2003-07-05 |
2013-04-17 |
ザ ジョンズ ホプキンス ユニバーシティ |
遺伝的変異の検出および列挙のための方法ならびに組成物
|
US20120196370A1
(en)
|
2010-12-03 |
2012-08-02 |
Fyodor Urnov |
Methods and compositions for targeted genomic deletion
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
WO2005014791A2
(en)
|
2003-08-08 |
2005-02-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
EP1660186B1
(en)
|
2003-08-18 |
2013-12-25 |
MedImmune, LLC |
Humanization of antibodies
|
US7527954B2
(en)
*
|
2003-10-01 |
2009-05-05 |
Eth Zurich |
Method for in vitro evolution of polypeptides
|
US20050221339A1
(en)
|
2004-03-31 |
2005-10-06 |
Medical Research Council Harvard University |
Compartmentalised screening by microfluidic control
|
CA2574062A1
(en)
|
2004-07-20 |
2006-01-26 |
Symphogen A/S |
Anti-rhesus d recombinant polyclonal antibody and methods of manufacture
|
US7968287B2
(en)
|
2004-10-08 |
2011-06-28 |
Medical Research Council Harvard University |
In vitro evolution in microfluidic systems
|
AU2006227377B2
(en)
|
2005-03-18 |
2013-01-31 |
Medimmune, Llc |
Framework-shuffling of antibodies
|
CN101273141B
(zh)
|
2005-07-26 |
2013-03-27 |
桑格摩生物科学股份有限公司 |
外源核酸序列的靶向整合和表达
|
EP3913375A1
(en)
|
2006-01-11 |
2021-11-24 |
Bio-Rad Laboratories, Inc. |
Microfluidic devices and methods of use in the formation and control of nanoreactors
|
GB0605584D0
(en)
|
2006-03-20 |
2006-04-26 |
Olink Ab |
Method for analyte detection using proximity probes
|
US9562837B2
(en)
|
2006-05-11 |
2017-02-07 |
Raindance Technologies, Inc. |
Systems for handling microfludic droplets
|
EP2481815B1
(en)
|
2006-05-11 |
2016-01-27 |
Raindance Technologies, Inc. |
Microfluidic devices
|
EP2019839B1
(en)
|
2006-05-25 |
2011-12-07 |
Sangamo BioSciences, Inc. |
Methods and compositions for gene inactivation
|
WO2008021123A1
(en)
|
2006-08-07 |
2008-02-21 |
President And Fellows Of Harvard College |
Fluorocarbon emulsion stabilizing surfactants
|
AU2007284748B2
(en)
|
2006-08-11 |
2013-05-16 |
Corteva Agriscience Llc |
Zinc finger nuclease-mediated homologous recombination
|
MX2009006303A
(es)
|
2006-12-14 |
2009-10-21 |
Dow Agrosciences Llc |
Proteinas de dedo de zinc no canonicas optimizadas.
|
WO2008097559A2
(en)
|
2007-02-06 |
2008-08-14 |
Brandeis University |
Manipulation of fluids and reactions in microfluidic systems
|
JP6115801B2
(ja)
|
2007-03-27 |
2017-04-19 |
イミュノヴィア・アーベー |
腺癌の検出のための蛋白質シグネチャー/マーカー
|
WO2008130623A1
(en)
|
2007-04-19 |
2008-10-30 |
Brandeis University |
Manipulation of fluids, fluid components and reactions in microfluidic systems
|
DE602008003684D1
(de)
|
2007-04-26 |
2011-01-05 |
Sangamo Biosciences Inc |
Gezielte integration in die ppp1r12c-position
|
ATE481483T1
(de)
|
2007-05-25 |
2010-10-15 |
Symphogen As |
Verfahren zur herstellung eines rekombinanten polyklonalen proteins
|
JP5770471B2
(ja)
|
2007-07-12 |
2015-08-26 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
α−1,6−フコシルトランスフェラーゼ(FUT8)遺伝子発現を不活性化するための方法および組成物
|
US11235026B2
(en)
|
2007-09-27 |
2022-02-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating PD1
|
CN101883863B
(zh)
|
2007-09-27 |
2018-01-23 |
桑格摩生物科学股份有限公司 |
生物活性核酸酶的快速体内鉴定
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
US8399218B2
(en)
|
2007-09-27 |
2013-03-19 |
Dow Agrosciences, Llc |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
|
CA2703045C
(en)
|
2007-10-25 |
2017-02-14 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted integration
|
JP2011518555A
(ja)
|
2008-04-14 |
2011-06-30 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
標的組込みのための線形ドナーコンストラクト
|
PL2274430T3
(pl)
|
2008-04-30 |
2017-09-29 |
Sanbio Inc |
Komórki regenerujące nerwy ze zmianami w metylacji DNA
|
CA2725773C
(en)
|
2008-05-28 |
2017-12-05 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
AU2009258117B2
(en)
|
2008-06-10 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for generation of Bax- and Bak-deficient cell lines
|
JP5924937B2
(ja)
|
2008-07-25 |
2016-05-25 |
エックス−ボディ インコーポレイテッド |
タンパク質スクリーニング法
|
KR101759586B1
(ko)
|
2008-08-22 |
2017-07-19 |
상가모 테라퓨틱스, 인코포레이티드 |
표적화된 단일가닥 분할 및 표적화된 통합을 위한 방법 및 조성물
|
US8153399B2
(en)
|
2008-10-29 |
2012-04-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for inactivating glutamine synthetase gene expression
|
US9403904B2
(en)
|
2008-11-07 |
2016-08-02 |
Fabrus, Inc. |
Anti-DLL4 antibodies and uses thereof
|
CA2745031C
(en)
|
2008-12-04 |
2018-08-14 |
Sangamo Biosciences, Inc. |
Genome editing in rats using zinc-finger nucleases
|
BRPI0922641B1
(pt)
|
2008-12-17 |
2021-10-26 |
Dow Agrosciences Llc |
Método de integração de uma ou mais sequências de ácido nucleico exógenas no genoma de uma célula vegetal
|
EP2393506B1
(en)
|
2009-02-04 |
2018-03-28 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating neuropathies
|
EP2408921B1
(en)
|
2009-03-20 |
2017-04-19 |
Sangamo BioSciences, Inc. |
Modification of cxcr4 using engineered zinc finger proteins
|
US8528589B2
(en)
|
2009-03-23 |
2013-09-10 |
Raindance Technologies, Inc. |
Manipulation of microfluidic droplets
|
WO2010117464A1
(en)
|
2009-04-09 |
2010-10-14 |
Sangamo Biosciences, Inc. |
Targeted integration into stem cells
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
CA2765488C
(en)
|
2009-06-30 |
2018-01-02 |
Sangamo Biosciences, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
CA2766123A1
(en)
|
2009-07-08 |
2011-01-13 |
Cellular Dynamics International, Inc. |
Modified ips cells having a mutant form of human immunodeficiency virus (hiv) cellular entry gene
|
EP2461819A4
(en)
|
2009-07-28 |
2013-07-31 |
Sangamo Biosciences Inc |
METHODS AND COMPOSITIONS FOR TREATING TRI-NUCLEOTIDE REPEAT DISORDERS
|
DK2462230T3
(en)
*
|
2009-08-03 |
2015-10-19 |
Recombinetics Inc |
METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION
|
CA2770312A1
(en)
|
2009-08-11 |
2011-02-17 |
Sangamo Biosciences, Inc. |
Organisms homozygous for targeted modification
|
MX2012002901A
(es)
*
|
2009-09-10 |
2012-06-27 |
Lonza Biologics Plc |
Metodo y sistema para purificacion de polipeptidos.
|
WO2011042564A1
(en)
|
2009-10-09 |
2011-04-14 |
Universite De Strasbourg |
Labelled silica-based nanomaterial with enhanced properties and uses thereof
|
EP2491127B1
(en)
|
2009-10-22 |
2017-09-20 |
Dow AgroSciences LLC |
Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
WO2011079176A2
(en)
|
2009-12-23 |
2011-06-30 |
Raindance Technologies, Inc. |
Microfluidic systems and methods for reducing the exchange of molecules between droplets
|
CA2787494C
(en)
|
2010-01-22 |
2019-09-17 |
Dow Agrosciences Llc |
Targeted genomic alteration
|
WO2011100058A1
(en)
|
2010-02-09 |
2011-08-18 |
Sangamo Biosciences, Inc. |
Targeted genomic modification with partially single-stranded donor molecules
|
JP5934657B2
(ja)
|
2010-02-12 |
2016-06-15 |
レインダンス テクノロジーズ, インコーポレイテッド |
デジタル検体分析
|
US10351905B2
(en)
|
2010-02-12 |
2019-07-16 |
Bio-Rad Laboratories, Inc. |
Digital analyte analysis
|
US9399797B2
(en)
|
2010-02-12 |
2016-07-26 |
Raindance Technologies, Inc. |
Digital analyte analysis
|
US9366632B2
(en)
|
2010-02-12 |
2016-06-14 |
Raindance Technologies, Inc. |
Digital analyte analysis
|
GB201004292D0
(en)
|
2010-03-15 |
2010-04-28 |
Olink Ab |
Assay for localised detection of analytes
|
BR112012027532A2
(pt)
|
2010-04-26 |
2020-10-13 |
Sangamo Biosciences, Inc. |
edição de genoma de um locus rosa usando nucleases de dedo de zinco.
|
PL2566972T3
(pl)
|
2010-05-03 |
2020-06-29 |
Sangamo Therapeutics, Inc. |
Kompozycje do wiązania modułów z motywem palca cynkowego
|
WO2011146121A1
(en)
|
2010-05-17 |
2011-11-24 |
Sangamo Biosciences, Inc. |
Novel dna-binding proteins and uses thereof
|
GB201009798D0
(en)
|
2010-06-11 |
2010-07-21 |
Immunovia Ab |
Method,array and use thereof
|
GB201011971D0
(en)
|
2010-07-15 |
2010-09-01 |
Olink Ab |
Methods and product
|
CA2993567C
(en)
|
2010-07-21 |
2022-06-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of a t-cell receptor gene
|
CN103168101A
(zh)
|
2010-07-23 |
2013-06-19 |
西格马-奥尔德里奇有限责任公司 |
使用靶向核酸内切酶和单链核酸的基因组编辑
|
GB201014837D0
(en)
|
2010-09-07 |
2010-10-20 |
Immunovia Ab |
Biomarker signatures and uses thereof
|
US9566352B2
(en)
|
2010-09-27 |
2017-02-14 |
Sangamo Biosciences, Inc. |
Methods and compositions for inhibiting viral entry into cells
|
EP2622103B2
(en)
|
2010-09-30 |
2022-11-16 |
Bio-Rad Laboratories, Inc. |
Sandwich assays in droplets
|
ES2562421T3
(es)
|
2010-10-12 |
2016-03-04 |
The Children's Hospital Of Philadelphia |
Métodos y composiciones para tratar la hemofilia B
|
US10669569B2
(en)
|
2010-10-15 |
2020-06-02 |
Navinci Diagnostics Ab |
Dynamic range methods
|
GB201018014D0
(en)
|
2010-10-26 |
2010-12-08 |
Senzagen Ab |
Analytical methods and arrays for use in the same
|
EP2466310A1
(en)
|
2010-12-17 |
2012-06-20 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH |
Means and methods for detecting double-strand breaks
|
CA2821547A1
(en)
|
2010-12-29 |
2012-07-05 |
Sigma-Aldrich Co. Llc |
Cells having disrupted expression of proteins involved in adme and toxicology processes
|
WO2012094132A1
(en)
|
2011-01-05 |
2012-07-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
GB201101621D0
(en)
|
2011-01-31 |
2011-03-16 |
Olink Ab |
Method and product
|
EP3859011A1
(en)
|
2011-02-11 |
2021-08-04 |
Bio-Rad Laboratories, Inc. |
Methods for forming mixed droplets
|
WO2012112804A1
(en)
|
2011-02-18 |
2012-08-23 |
Raindance Technoligies, Inc. |
Compositions and methods for molecular labeling
|
GB201103726D0
(en)
|
2011-03-04 |
2011-04-20 |
Immunovia Ab |
Method, array and use thereof
|
WO2012139045A1
(en)
|
2011-04-08 |
2012-10-11 |
Gilead Biologics, Inc. |
Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
|
GB201107863D0
(en)
|
2011-05-11 |
2011-06-22 |
Olink Ab |
Method and product
|
EP3709018A1
(en)
|
2011-06-02 |
2020-09-16 |
Bio-Rad Laboratories, Inc. |
Microfluidic apparatus for identifying components of a chemical reaction
|
US8841071B2
(en)
|
2011-06-02 |
2014-09-23 |
Raindance Technologies, Inc. |
Sample multiplexing
|
CN103781900A
(zh)
|
2011-06-30 |
2014-05-07 |
西格马-奥尔德里奇有限责任公司 |
缺乏CMP-N-乙酰神经氨酸羟化酶和/或糖蛋白α-1,3-半乳糖基转移酶的细胞
|
US8658430B2
(en)
|
2011-07-20 |
2014-02-25 |
Raindance Technologies, Inc. |
Manipulating droplet size
|
EP2737063B1
(en)
|
2011-07-25 |
2016-06-01 |
Sangamo BioSciences, Inc. |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
|
AU2012312260B2
(en)
|
2011-09-21 |
2017-08-31 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of transgene expression
|
US20130090266A1
(en)
|
2011-10-11 |
2013-04-11 |
Biolauncher Ltd. |
Methods and systems for optimization of peptide screening
|
US20130090247A1
(en)
|
2011-10-11 |
2013-04-11 |
Biolauncher Ltd. |
Methods and systems for identification of binding pharmacophores
|
US20130090265A1
(en)
|
2011-10-11 |
2013-04-11 |
Biolauncher Ltd. |
Systems and methods for generation of context-specific, molecular field-based amino acid substitution matrices
|
CA3099582A1
(en)
|
2011-10-27 |
2013-05-02 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of the hprt locus
|
JP6144691B2
(ja)
|
2011-11-16 |
2017-06-07 |
サンガモ セラピューティクス, インコーポレイテッド |
修飾されたdna結合タンパク質およびその使用
|
GB201122325D0
(en)
|
2011-12-23 |
2012-02-01 |
Cytoguide As |
Novel formulations
|
BR112014016614B1
(pt)
|
2012-01-11 |
2022-02-01 |
Sigma-Aldrich Co. Llc |
Métodos para produzir uma célula deficiente em manosil (alfa-1,3-)-glicoproteína beta-1,2- nacetilglucosa-miniltransferase i (mgat1) e produzir uma proteína recombinante apresentando um ou mais resíduos de manose terminal
|
CN104254337A
(zh)
|
2012-01-27 |
2014-12-31 |
桑比欧公司 |
用于调节血管生成和血管发生的方法和组合物
|
GB201201547D0
(en)
|
2012-01-30 |
2012-03-14 |
Olink Ab |
Method and product
|
CN105658792B
(zh)
|
2012-02-28 |
2020-11-10 |
西格马-奥尔德里奇有限责任公司 |
靶向组蛋白乙酰化
|
BR112014021104B1
(pt)
|
2012-02-29 |
2023-03-28 |
Sangamo Biosciences, Inc |
Proteína de fusão de ocorrência não natural compreendendo um domínio de ligação de dna de dedo de zinco manipulado que se liga a um gene htt, seu uso, método in vitro de modificação da expressão de um gene htt em uma célula, e método de geração de um sistema modelo para o estudo da doença de huntington
|
GB2500243A
(en)
*
|
2012-03-15 |
2013-09-18 |
Isogenica Ltd |
Identifying members of immobilised peptide libraries comprising protein-DNA complexes
|
GB201207297D0
(en)
|
2012-04-26 |
2012-06-06 |
Senzagen Ab |
Analytical methods and arrays for use in the same
|
NZ701060A
(en)
|
2012-05-02 |
2016-10-28 |
Sangamo Biosciences Inc |
Targeted modification of malate dehydrogenase
|
RU2650819C2
(ru)
|
2012-05-07 |
2018-04-17 |
Сангамо Терапьютикс, Инк. |
Способы и композиции для опосредованной нуклеазой направленной интеграции трансгенов
|
WO2014011237A1
(en)
|
2012-07-11 |
2014-01-16 |
Sangamo Biosciences, Inc. |
Methods and compositions for the treatment of lysosomal storage diseases
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
JP6329537B2
(ja)
|
2012-07-11 |
2018-05-23 |
サンガモ セラピューティクス, インコーポレイテッド |
生物学的薬剤の送達のための方法および組成物
|
KR102218562B1
(ko)
|
2012-08-29 |
2021-02-19 |
상가모 테라퓨틱스, 인코포레이티드 |
유전적 병태를 치료하기 위한 방법 및 조성물
|
US9937205B2
(en)
|
2012-09-04 |
2018-04-10 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
CN105264067B
(zh)
|
2012-09-07 |
2020-11-10 |
美国陶氏益农公司 |
Fad3性能基因座及相应的能够诱导靶向断裂的靶位点特异性结合蛋白
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
AU2013329186B2
(en)
|
2012-10-10 |
2019-02-14 |
Sangamo Therapeutics, Inc. |
T cell modifying compounds and uses thereof
|
JP2016500254A
(ja)
|
2012-12-05 |
2016-01-12 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
代謝疾患の調節のための方法および組成物
|
MX2015007574A
(es)
|
2012-12-13 |
2015-10-22 |
Dow Agrosciences Llc |
Gen de precision dirigido a un locus particular en el maiz.
|
US11466306B2
(en)
|
2013-02-14 |
2022-10-11 |
Osaka University |
Method for isolating specific genomic regions with use of molecule capable of specifically binding to endogenous DNA sequence
|
EP2958996B1
(en)
|
2013-02-25 |
2019-10-16 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
CA2906970C
(en)
|
2013-03-21 |
2021-05-18 |
Ospedale San Raffaele Srl |
Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
|
GB201305940D0
(en)
|
2013-04-02 |
2013-05-15 |
Immunovia Ab |
Methods and arrays for use in the same
|
CN105263312A
(zh)
|
2013-04-05 |
2016-01-20 |
美国陶氏益农公司 |
用于在植物基因组内整合外源序列的方法和组合物
|
US10604771B2
(en)
|
2013-05-10 |
2020-03-31 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
JP6588438B2
(ja)
|
2013-08-28 |
2019-10-09 |
サンガモ セラピューティクス, インコーポレイテッド |
Dna結合ドメインと切断ドメインとを連結するための組成物
|
US11901041B2
(en)
|
2013-10-04 |
2024-02-13 |
Bio-Rad Laboratories, Inc. |
Digital analysis of nucleic acid modification
|
US10117899B2
(en)
|
2013-10-17 |
2018-11-06 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
CN110713995B
(zh)
|
2013-10-17 |
2023-08-01 |
桑格摩生物科学股份有限公司 |
用于核酸酶介导的基因组工程改造的递送方法和组合物
|
GB201319878D0
(en)
|
2013-11-11 |
2013-12-25 |
Immunovia Ab |
Method, Array and use thereof
|
NZ719477A
(en)
|
2013-11-11 |
2022-05-27 |
Sangamo Therapeutics Inc |
Methods and compositions for treating huntington’s disease
|
SI3068881T1
(sl)
|
2013-11-13 |
2019-05-31 |
Children's Medical Center Corporation |
Z nukleazo posredovano uravnavanje izražanja genov
|
ES2813367T3
(es)
|
2013-12-09 |
2021-03-23 |
Sangamo Therapeutics Inc |
Métodos y composiciones para ingeniería genómica
|
US9944977B2
(en)
|
2013-12-12 |
2018-04-17 |
Raindance Technologies, Inc. |
Distinguishing rare variations in a nucleic acid sequence from a sample
|
WO2015103367A1
(en)
|
2013-12-31 |
2015-07-09 |
Raindance Technologies, Inc. |
System and method for detection of rna species
|
PL3102673T3
(pl)
|
2014-02-03 |
2020-11-02 |
Sangamo Therapeutics, Inc. |
Sposoby i kompozycje do leczenia talasemii beta
|
US10370680B2
(en)
|
2014-02-24 |
2019-08-06 |
Sangamo Therapeutics, Inc. |
Method of treating factor IX deficiency using nuclease-mediated targeted integration
|
SG11201607038TA
(en)
|
2014-03-04 |
2016-09-29 |
Sigma Aldrich Co Llc |
Viral resistant cells and uses thereof
|
AU2015231353B2
(en)
|
2014-03-18 |
2020-11-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
US9522936B2
(en)
|
2014-04-24 |
2016-12-20 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (TALE) proteins
|
EP3142707A4
(en)
|
2014-05-13 |
2018-02-21 |
Sangamo Therapeutics, Inc. |
Methods and compositions for prevention or treatment of a disease
|
WO2015188056A1
(en)
|
2014-06-05 |
2015-12-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease design
|
GB201410226D0
(en)
|
2014-06-09 |
2014-07-23 |
Immunovia Ab |
Methods and arrays for use in the same
|
PT3169778T
(pt)
|
2014-07-14 |
2024-01-29 |
Univ Washington State |
Knock-out de nanos que conduz à ablação de células da linha germinativa
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
US9757420B2
(en)
|
2014-07-25 |
2017-09-12 |
Sangamo Therapeutics, Inc. |
Gene editing for HIV gene therapy
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
WO2016044416A1
(en)
|
2014-09-16 |
2016-03-24 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
|
US10889834B2
(en)
|
2014-12-15 |
2021-01-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing targeted transgene integration
|
WO2016118726A2
(en)
|
2015-01-21 |
2016-07-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for identification of highly specific nucleases
|
ES2959608T3
(es)
|
2015-04-03 |
2024-02-27 |
Dana Farber Cancer Inst Inc |
Composición y métodos de edición del genoma de células B
|
US10179918B2
(en)
|
2015-05-07 |
2019-01-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for increasing transgene activity
|
CA2984013A1
(en)
|
2015-05-12 |
2016-11-17 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
EP3322297A4
(en)
|
2015-07-13 |
2019-04-17 |
Sangamo Therapeutics, Inc. |
RELEASE METHOD AND COMPOSITIONS FOR NUCLEASE-DERIVED GENOMINE ENGINEERING
|
EP3331355B1
(en)
|
2015-08-06 |
2024-04-03 |
The Curators of the University of Missouri |
Porcine reproductive and respiratory syndrome virus (prrsv)-resistant porcine and cells having modified cd163 genes
|
US10647981B1
(en)
|
2015-09-08 |
2020-05-12 |
Bio-Rad Laboratories, Inc. |
Nucleic acid library generation methods and compositions
|
GB201516801D0
(en)
|
2015-09-22 |
2015-11-04 |
Immunovia Ab |
Method, array and use thereof
|
US11156611B2
(en)
|
2015-09-24 |
2021-10-26 |
Abvitro Llc |
Single cell characterization using affinity-oligonucleotide conjugates and vessel barcoded polynucleotides
|
KR20180081532A
(ko)
|
2015-10-30 |
2018-07-16 |
알레타 바이오쎄라퓨틱스, 인크. |
암 치료용 조성물 및 방법
|
AU2016343805A1
(en)
|
2015-10-30 |
2018-06-07 |
Aleta Biotherapeutics Inc. |
Compositions and methods for tumor transduction
|
AU2016361350B2
(en)
|
2015-11-23 |
2023-04-06 |
Sangamo Therapeutics, Inc. |
Methods and compositions for engineering immunity
|
BR112018012235A2
(pt)
|
2015-12-18 |
2018-12-04 |
Sangamo Therapeutics Inc |
rompimento alvejado do receptor de células de mhc
|
AU2016369490C1
(en)
|
2015-12-18 |
2021-12-23 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
AU2017207818B2
(en)
|
2016-01-15 |
2024-03-28 |
Regents Of The University Of Minnesota |
Methods and compositions for the treatment of neurologic disease
|
EP3769775A3
(en)
|
2016-02-02 |
2021-03-17 |
Sangamo Therapeutics, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
BR112018069279A2
(pt)
|
2016-03-23 |
2019-01-22 |
Senzagen Ab |
métodos analíticos e matrizes para uso no mesmo
|
GB201700138D0
(en)
|
2017-01-05 |
2017-02-22 |
Senzagen Ab |
Analytical methods and arrays for use in the same
|
GB201608192D0
(en)
|
2016-05-10 |
2016-06-22 |
Immunovia Ab |
Method, array and use thereof
|
GB201609951D0
(en)
|
2016-06-07 |
2016-07-20 |
Immunovia Ab |
Biomarkers signatures and uses thereof
|
GB201609950D0
(en)
|
2016-06-07 |
2016-07-20 |
Immunovia Ab |
Biomarkers signatures and uses thereof
|
MA45491A
(fr)
|
2016-06-27 |
2019-05-01 |
Juno Therapeutics Inc |
Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
|
EP3475446A1
(en)
|
2016-06-27 |
2019-05-01 |
Juno Therapeutics, Inc. |
Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
|
EP3484870B1
(en)
|
2016-07-13 |
2022-11-16 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
JP2019520844A
(ja)
|
2016-07-21 |
2019-07-25 |
マックスサイト インコーポレーティッド |
ゲノムdnaを改変するための方法および組成物
|
KR102455249B1
(ko)
|
2016-08-24 |
2022-10-17 |
상가모 테라퓨틱스, 인코포레이티드 |
가공된 표적 특이적 뉴클레아제
|
CN110325635B
(zh)
|
2016-08-24 |
2023-12-26 |
桑格摩生物治疗股份有限公司 |
使用工程化的核酸酶调控基因表达
|
BR112019005748A2
(pt)
|
2016-09-24 |
2019-06-18 |
Abvitro Llc |
afinidade-conjugados de oligonucleotídeo e usos destes
|
MX2019004487A
(es)
|
2016-10-20 |
2020-02-07 |
Sangamo Therapeutics Inc |
Metodos y composiciones para el tratamiento de la enfermedad de fabry.
|
US11020492B2
(en)
|
2016-10-31 |
2021-06-01 |
Sangamo Therapeutics, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
ES2968892T3
(es)
|
2016-12-08 |
2024-05-14 |
Univ Case Western Reserve |
Métodos y composiciones para aumentar la producción de mielina funcional
|
US20190390241A1
(en)
|
2017-01-24 |
2019-12-26 |
Sigma-Aldrich Co. Llc |
Viral resistant cells and culture systems
|
GB201706464D0
(en)
|
2017-04-24 |
2017-06-07 |
Senzagen Ab |
Analytical methods and arrays for use in the same
|
EP3619322A4
(en)
|
2017-05-03 |
2021-06-30 |
Sangamo Therapeutics, Inc. |
METHODS AND COMPOSITIONS FOR MODIFICATION OF A TRANSMEMBRANARY CONDUCTANCE REGULATORY GENE IN MUCOVISCIDOSIS (CFTR)
|
US11512287B2
(en)
|
2017-06-16 |
2022-11-29 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell and/or HLA receptors
|
KR20200079539A
(ko)
|
2017-11-09 |
2020-07-03 |
상가모 테라퓨틱스, 인코포레이티드 |
시토카인 유도성 sh2-함유 단백질 (cish) 유전자의 유전자 변형
|
US11891426B2
(en)
|
2017-12-15 |
2024-02-06 |
Aleta Biotherapeutics Inc. |
CD19 variants
|
CN111757876B
(zh)
|
2018-01-17 |
2024-03-22 |
沃泰克斯药物股份有限公司 |
Dna-pk抑制剂
|
EA202091707A1
(ru)
|
2018-01-17 |
2020-12-02 |
Вертекс Фармасьютикалз Инкорпорейтед |
Хиноксалиноновые соединения, композиции, способы и наборы для повышения эффективности редактирования генома
|
EP3740479A1
(en)
|
2018-01-17 |
2020-11-25 |
Vertex Pharmaceuticals Incorporated |
Dna-pk inhibitors
|
AU2019218118A1
(en)
|
2018-02-08 |
2020-08-13 |
Sangamo Therapeutics, Inc. |
Engineered target specific nucleases
|
JP7332622B2
(ja)
|
2018-04-18 |
2023-08-23 |
サンガモ セラピューティクス, インコーポレイテッド |
ハンチンチン(htt)の調節のためのジンクフィンガータンパク質組成物
|
US11690921B2
(en)
|
2018-05-18 |
2023-07-04 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
KR20210049124A
(ko)
|
2018-08-23 |
2021-05-04 |
상가모 테라퓨틱스, 인코포레이티드 |
조작된 표적 특이적 염기 편집기
|
CN113015741A
(zh)
|
2018-09-18 |
2021-06-22 |
桑格摩生物治疗股份有限公司 |
程序性细胞死亡1(pd1)特异性核酸酶
|
CA3123717A1
(en)
|
2019-01-03 |
2020-07-09 |
Senzagen Ab |
Method for identifying agents capable of inducing respiratory sensitization and array and analytical kits for use in the method
|
JP2022517783A
(ja)
|
2019-01-11 |
2022-03-10 |
アクイタス セラピューティクス インコーポレイテッド |
活性剤の脂質ナノ粒子送達のための脂質
|
JP2022519410A
(ja)
|
2019-02-06 |
2022-03-24 |
サンガモ セラピューティクス, インコーポレイテッド |
ムコ多糖症i型の処置のための方法
|
MA55531A
(fr)
|
2019-04-02 |
2022-02-09 |
Sangamo Therapeutics Inc |
Procédés pour le traitement de béta-thalassémie
|
WO2020252381A2
(en)
|
2019-06-13 |
2020-12-17 |
Allogene Therapeutics, Inc. |
Anti-talen antibodies and uses thereof
|
AU2021269103A1
(en)
|
2020-05-06 |
2022-12-15 |
Cellectis S.A. |
Methods to genetically modify cells for delivery of therapeutic proteins
|
US20230212613A1
(en)
|
2020-05-06 |
2023-07-06 |
Cellectis S.A. |
Methods for targeted insertion of exogenous sequences in cellular genomes
|
GB202010970D0
(en)
|
2020-07-16 |
2020-09-02 |
Immunovia Ab |
Methods, arrays and uses thereof
|
EP4182297A1
(en)
|
2020-07-16 |
2023-05-24 |
Acuitas Therapeutics, Inc. |
Cationic lipids for use in lipid nanoparticles
|
EP4204545A2
(en)
|
2020-08-25 |
2023-07-05 |
Kite Pharma, Inc. |
T cells with improved functionality
|
WO2022101641A1
(en)
|
2020-11-16 |
2022-05-19 |
Pig Improvement Company Uk Limited |
Influenza a-resistant animals having edited anp32 genes
|
TW202328201A
(zh)
|
2021-11-09 |
2023-07-16 |
美商安進公司 |
產生抗體肽軛合物的方法
|
WO2023105244A1
(en)
|
2021-12-10 |
2023-06-15 |
Pig Improvement Company Uk Limited |
Editing tmprss2/4 for disease resistance in livestock
|
WO2023168397A1
(en)
|
2022-03-04 |
2023-09-07 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the asparagine biosynthesis pathway
|
WO2024013514A2
(en)
|
2022-07-15 |
2024-01-18 |
Pig Improvement Company Uk Limited |
Gene edited livestock animals having coronavirus resistance
|
WO2024073686A1
(en)
|
2022-09-30 |
2024-04-04 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the serine biosynthesis pathway
|
WO2024073692A1
(en)
|
2022-09-30 |
2024-04-04 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the glycine-formate biosynthesis pathway
|