NO983376D0 - Sulfonerte aminosyrederivater og metalloproteinase inhibitorer inneholdende de samme - Google Patents

Sulfonerte aminosyrederivater og metalloproteinase inhibitorer inneholdende de samme

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Publication number
NO983376D0
NO983376D0 NO983376A NO983376A NO983376D0 NO 983376 D0 NO983376 D0 NO 983376D0 NO 983376 A NO983376 A NO 983376A NO 983376 A NO983376 A NO 983376A NO 983376 D0 NO983376 D0 NO 983376D0
Authority
NO
Norway
Prior art keywords
amino acid
same
acid derivatives
metalloproteinase inhibitors
inhibitors containing
Prior art date
Application number
NO983376A
Other languages
English (en)
Other versions
NO983376L (no
NO312665B1 (no
Inventor
Fumihiko Watanabe
Hiroshige Tsuzuki
Mitsuaki Ohtani
Original Assignee
Shionogi & Co
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Publication date
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Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO983376D0 publication Critical patent/NO983376D0/no
Publication of NO983376L publication Critical patent/NO983376L/no
Publication of NO312665B1 publication Critical patent/NO312665B1/no

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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C311/12Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
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    • C07C311/32Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/42Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C311/45Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C311/45Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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NO19983376A 1996-01-23 1998-07-22 Sulfonerte aminosyrederivater, preparater for inhibering av metalloproteinase inneholdende slike forbindelser, samt anvendelseav slike forbindelser til fremstilling av farmasöytiske preparater NO312665B1 (no)

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JP21355596 1996-08-13
PCT/JP1997/000126 WO1997027174A1 (fr) 1996-01-23 1997-01-22 Derives d'acides amines sulfones et inhibiteurs de metalloproteinases contenant ces derives

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ES2284180T3 (es) 2007-11-01
EP0950656A1 (en) 1999-10-20
CN1214041A (zh) 1999-04-14
TR199801419T2 (xx) 1998-10-21
TW200403216A (en) 2004-03-01
NO983376L (no) 1998-09-14
EP0950656A4 (en) 2003-04-16
CZ298814B6 (cs) 2008-02-13
TWI244475B (en) 2005-12-01
HUP9903687A3 (en) 2001-12-28
PL328270A1 (en) 1999-01-18
US20030139379A1 (en) 2003-07-24
EP1486207A3 (en) 2011-01-05
DE69737605T2 (de) 2008-04-03
KR100338861B1 (ko) 2003-02-20
HUP9903687A2 (hu) 2000-03-28
NO312665B1 (no) 2002-06-17
IL125378A0 (en) 1999-03-12
PL205341B1 (pl) 2010-04-30
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SK282995B6 (sk) 2003-01-09
CZ225298A3 (cs) 1998-12-16
DE69737605D1 (de) 2007-05-24
US6881727B2 (en) 2005-04-19
US6441021B1 (en) 2002-08-27
US6207698B1 (en) 2001-03-27
SK98498A3 (en) 1999-04-13
CN100413859C (zh) 2008-08-27
WO1997027174A1 (fr) 1997-07-31
KR100338857B1 (ko) 2002-05-30
ATE359264T1 (de) 2007-05-15
EP1486207A2 (en) 2004-12-15
AU1319597A (en) 1997-08-20
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BR9707010B1 (pt) 2009-05-05
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US6235768B1 (en) 2001-05-22

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