HUP9903687A2 - Szulfonált aminosavszármazékok és az ezeket tartalmazó metalloproteináz inhibitor hatású gyógyszerkészítmények - Google Patents

Szulfonált aminosavszármazékok és az ezeket tartalmazó metalloproteináz inhibitor hatású gyógyszerkészítmények

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Publication number
HUP9903687A2
HUP9903687A2 HU9903687A HUP9903687A HUP9903687A2 HU P9903687 A2 HUP9903687 A2 HU P9903687A2 HU 9903687 A HU9903687 A HU 9903687A HU P9903687 A HUP9903687 A HU P9903687A HU P9903687 A2 HUP9903687 A2 HU P9903687A2
Authority
HU
Hungary
Prior art keywords
powder
optionally substituted
heteroaryl
aryl
hydrogen atom
Prior art date
Application number
HU9903687A
Other languages
English (en)
Inventor
Mitsuaki Ohtani
Hiroshige Tsuzuki
Fumihiko Watanabe
Original Assignee
Shionogi & Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26368369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9903687(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co. Ltd. filed Critical Shionogi & Co. Ltd.
Publication of HUP9903687A2 publication Critical patent/HUP9903687A2/hu
Publication of HUP9903687A3 publication Critical patent/HUP9903687A3/hu
Publication of HU226006B1 publication Critical patent/HU226006B1/hu

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P35/00—Antineoplastic agents
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/31—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/32—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
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    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

A találmány tárgyát az (I) általánős képletű vegyületek -, ahől R1 adőtt esetben szűbsztitűált alkil-, aril-, aralkil-, heterőaril-vagy heterőarilalkil-csőpőrt; R2 hidrőgénatőm, adőtt esetben szűbsztitűált alkil-, aril-, aralkil-,heterőaril- vagy heterőarilalkilcsőpőrt; R3 kémiai kötés, adőtt esetben szűbsztitűált arilén- vagyheterőarilén-csőpőrt; R4 kémiai kötés, -(CH2)m- általánős képletű, vinilén-, etinilén-,karbőnil- vagy diazén-diil-csőpőrt (-N=N-), -N(RA)- általánős képletű,űreilén- vagy -NH-CO- képletű csőpőrt, őxigén- vagy kénatőm, -SO2NH-,-SO2NH-N=CH- képletű vagy tetrazől-diil-csőpőrt; R5 adőtt esetben szűbsztitűált alkil-, 3-8 ciklőalkil-, aril-,heterőaril- vagy nem arőmás heterőciklűsős csőpőrt; RA hidrőgénatőm vagy kis szénatőmszámú alkilcsőpőrt; Y hidrőxi-aminő- vagy hidrőxicsőpőrt; és m = 1 vagy 2; azzal a feltétellel, hőgy R2 hidrőgénatőm, ha Y hidrőxi-aminő-csőpőrt - és őptikailag aktív származékaik, gyógyászatilagelfőgadható sóik vagy hidrátjaik, tővábbá hatóanyagként ezekettartalmazó gyógyszerkészítmények képezik. ŕ
HU9903687A 1996-01-23 1997-01-22 Thiophene-sulfonylamino carboxylic and hidroxamic acid derivatives and pharmaceutical compositions with metalloproteinase inhibitory activity containing the same HU226006B1 (en)

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HUP9903687A3 (en) 2001-12-28
CZ225298A3 (cs) 1998-12-16
EP1486207A3 (en) 2011-01-05
TW200407287A (en) 2004-05-16
US6441021B1 (en) 2002-08-27
PL328270A1 (en) 1999-01-18
US20030139379A1 (en) 2003-07-24
BR9707010A (pt) 1999-07-20
TWI244474B (en) 2005-12-01
NO983376L (no) 1998-09-14
CZ298814B6 (cs) 2008-02-13
KR19990081866A (ko) 1999-11-15
TWI244475B (en) 2005-12-01
ATE359264T1 (de) 2007-05-15
AU715764B2 (en) 2000-02-10
EP0950656A1 (en) 1999-10-20
EP1486207A2 (en) 2004-12-15
US6881727B2 (en) 2005-04-19
US6207698B1 (en) 2001-03-27
ES2284180T3 (es) 2007-11-01
EP0950656A4 (en) 2003-04-16
PL205341B1 (pl) 2010-04-30
RU2198656C2 (ru) 2003-02-20
AU1319597A (en) 1997-08-20
PL198905B1 (pl) 2008-07-31
NZ325939A (en) 2000-06-23
JP3628335B2 (ja) 2005-03-09
KR100338857B1 (ko) 2002-05-30
BR9707010B1 (pt) 2009-05-05
HU226006B1 (en) 2008-02-28
DE69737605T2 (de) 2008-04-03
TW575547B (en) 2004-02-11
IL125378A0 (en) 1999-03-12
US6235768B1 (en) 2001-05-22
EP0950656B1 (en) 2007-04-11
TW200403216A (en) 2004-03-01
WO1997027174A1 (fr) 1997-07-31
TR199801419T2 (xx) 1998-10-21
CN100413859C (zh) 2008-08-27
SK98498A3 (en) 1999-04-13
DE69737605D1 (de) 2007-05-24
SK282995B6 (sk) 2003-01-09
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CN1214041A (zh) 1999-04-14
KR100338861B1 (ko) 2003-02-20

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