BR9714650A - " derivados farmacêuticos de ácido aminofosfÈnico " - Google Patents

" derivados farmacêuticos de ácido aminofosfÈnico "

Info

Publication number
BR9714650A
BR9714650A BR9714650-1A BR9714650A BR9714650A BR 9714650 A BR9714650 A BR 9714650A BR 9714650 A BR9714650 A BR 9714650A BR 9714650 A BR9714650 A BR 9714650A
Authority
BR
Brazil
Prior art keywords
pharmaceutical derivatives
aminophosphonic acid
pharmaceutical
derivatives
acid
Prior art date
Application number
BR9714650-1A
Other languages
English (en)
Inventor
Lan Mong Nguyen
Hieu Trung Phan
Vinh Van Diep
Simon Floret
Raymond Azoulay
Eric Niesor
Graig Leigh Bentzen
Robert John Ife
Original Assignee
Symphar Sa
Smithkline Beechamm P L C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa, Smithkline Beechamm P L C filed Critical Symphar Sa
Publication of BR9714650A publication Critical patent/BR9714650A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Abstract

"DERIVADOS FARMACêUTICOS DE áCIDO AMINOFOSFÈNICO" Aminofosfonatos alfa substituídos por grupos fenóis, de fórmula (I) tendo atividade de diminuição de lipoproteína (a).
BR9714650-1A 1996-12-20 1997-12-17 " derivados farmacêuticos de ácido aminofosfÈnico " BR9714650A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9626615.0A GB9626615D0 (en) 1996-12-20 1996-12-20 Novel compounds
PCT/EP1997/007161 WO1998028310A1 (en) 1996-12-20 1997-12-17 Pharmaceutical aminophosphonic acid derivatives

Publications (1)

Publication Number Publication Date
BR9714650A true BR9714650A (pt) 2000-10-03

Family

ID=10804837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714650-1A BR9714650A (pt) 1996-12-20 1997-12-17 " derivados farmacêuticos de ácido aminofosfÈnico "

Country Status (31)

Country Link
US (2) US6303784B1 (pt)
EP (1) EP0946572B1 (pt)
JP (1) JP2001506667A (pt)
KR (1) KR20000069609A (pt)
CN (1) CN1105117C (pt)
AP (1) AP9901546A0 (pt)
AR (1) AR008541A1 (pt)
AT (1) ATE255117T1 (pt)
AU (1) AU5858898A (pt)
BG (1) BG103574A (pt)
BR (1) BR9714650A (pt)
CA (1) CA2275696A1 (pt)
CO (1) CO4930276A1 (pt)
DE (1) DE69726449T2 (pt)
DZ (1) DZ2377A1 (pt)
EA (1) EA199900580A1 (pt)
GB (1) GB9626615D0 (pt)
HU (1) HUP0002171A3 (pt)
ID (1) ID22053A (pt)
IL (1) IL130334A0 (pt)
MA (1) MA24427A1 (pt)
NO (1) NO993001L (pt)
NZ (1) NZ335884A (pt)
OA (1) OA11068A (pt)
PE (1) PE46799A1 (pt)
PL (1) PL334189A1 (pt)
SK (1) SK81099A3 (pt)
TR (1) TR199901423T2 (pt)
TW (1) TW434221B (pt)
WO (1) WO1998028310A1 (pt)
ZA (1) ZA9711431B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60139429D1 (de) 2000-02-16 2009-09-10 Smithkline Beecham Plc Pyrimidin-5-Onderivate als LDL-PLA2 Inhibitoren
EP1268498B1 (en) * 2000-02-29 2005-04-13 Medicure International Inc. Cardioprotective phosphonates
EP1531157B1 (en) * 2000-02-29 2008-03-19 Medicure International Inc. Cardioprotective phosphonates
US20030114421A1 (en) * 2000-09-27 2003-06-19 Phan Hieu Trung Alpha-substituted beta-aminoethyl phosphonate derivatives
CN1489596A (zh) 2000-09-27 2004-04-14 �Ʒ� α-取代的β-氨基乙基膦酸酯类化合物
GB0024808D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0025849D0 (en) * 2000-10-23 2000-12-06 Smithkline Beecham Plc Novel compounds
US20050124581A1 (en) * 2002-02-11 2005-06-09 Phan Hieu T. Alpha-substituted heteroarylalkyl phosphonate derivatives
EP1482897A2 (en) * 2002-02-19 2004-12-08 Ilex Products, Inc. Aminodiphosphonate apolipoprotein e modulators
JP4824968B2 (ja) * 2005-08-18 2011-11-30 株式会社クレハ ホスホン酸誘導体及びその酸付加塩、並びにそれを用いた農園芸用病害防除剤
TW201307324A (zh) 2010-12-06 2013-02-16 Glaxo Group Ltd 化合物
BR112014001665A2 (pt) 2011-07-27 2017-02-14 Glaxo Group Ltd compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz
TW201321382A (zh) 2011-07-27 2013-06-01 Glaxo Group Ltd 化合物
CN103906744A (zh) 2011-09-01 2014-07-02 葛兰素集团有限公司 新晶型
CA2899143A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Bicyclic pyrimidone compounds as inhibitors of lp-pla2
EP2948452B1 (en) 2013-01-25 2017-08-09 GlaxoSmithKline Intellectual Property Development Limited 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
WO2014114248A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN112778331B (zh) 2019-11-09 2022-07-05 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683996A5 (fr) 1992-03-05 1994-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
DE4433244A1 (de) * 1994-09-19 1996-03-28 Hoechst Ag Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen
CH690264A5 (fr) 1995-06-30 2000-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
GB9626536D0 (en) 1996-12-20 1997-02-05 Symphar Sa Novel compounds

Also Published As

Publication number Publication date
PL334189A1 (en) 2000-02-14
BG103574A (bg) 2000-11-30
US6303784B1 (en) 2001-10-16
AR008541A1 (es) 2000-01-19
US20020082423A1 (en) 2002-06-27
MA24427A1 (fr) 1998-07-01
NO993001D0 (no) 1999-06-18
CA2275696A1 (en) 1998-07-02
DE69726449T2 (de) 2004-08-26
EP0946572A1 (en) 1999-10-06
KR20000069609A (ko) 2000-11-25
HUP0002171A2 (hu) 2001-05-28
GB9626615D0 (en) 1997-02-05
NO993001L (no) 1999-06-18
DZ2377A1 (fr) 2002-12-28
ATE255117T1 (de) 2003-12-15
OA11068A (en) 2003-03-10
DE69726449D1 (en) 2004-01-08
TW434221B (en) 2001-05-16
CO4930276A1 (es) 2000-06-27
SK81099A3 (en) 1999-11-08
WO1998028310A1 (en) 1998-07-02
PE46799A1 (es) 1999-06-24
IL130334A0 (en) 2000-06-01
ZA9711431B (en) 1999-06-21
AU5858898A (en) 1998-07-17
EA199900580A1 (ru) 1999-12-29
HUP0002171A3 (en) 2002-12-28
EP0946572B1 (en) 2003-11-26
CN1105117C (zh) 2003-04-09
JP2001506667A (ja) 2001-05-22
AP9901546A0 (en) 1999-06-30
NZ335884A (en) 2000-11-24
CN1240451A (zh) 2000-01-05
ID22053A (id) 1999-08-26
TR199901423T2 (xx) 1999-10-21

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]