NO993001L - Farmas°ytiske aminofosfonsyrederivater - Google Patents

Farmas°ytiske aminofosfonsyrederivater

Info

Publication number
NO993001L
NO993001L NO993001A NO993001A NO993001L NO 993001 L NO993001 L NO 993001L NO 993001 A NO993001 A NO 993001A NO 993001 A NO993001 A NO 993001A NO 993001 L NO993001 L NO 993001L
Authority
NO
Norway
Prior art keywords
acid derivatives
phosphonic acid
surface amino
amino phosphonic
pharmaceutical surface
Prior art date
Application number
NO993001A
Other languages
English (en)
Other versions
NO993001D0 (no
Inventor
Lan Mong Nguyen
Hieu Trung Phan
Vinh Van Dieph
Simon Floret
Raymond Azoulay
Eric Niesor
Craig Leigh Bentzen
John Robert Ife
Original Assignee
Symphar Sa
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa, Smithkline Beecham Plc filed Critical Symphar Sa
Publication of NO993001D0 publication Critical patent/NO993001D0/no
Publication of NO993001L publication Critical patent/NO993001L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Aminofosfonater alfa-substituert med fenolgrupper, med formel (I):. har lipoprotein(a)-senkende aktivitet.
NO993001A 1996-12-20 1999-06-18 Farmas°ytiske aminofosfonsyrederivater NO993001L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9626615.0A GB9626615D0 (en) 1996-12-20 1996-12-20 Novel compounds
PCT/EP1997/007161 WO1998028310A1 (en) 1996-12-20 1997-12-17 Pharmaceutical aminophosphonic acid derivatives

Publications (2)

Publication Number Publication Date
NO993001D0 NO993001D0 (no) 1999-06-18
NO993001L true NO993001L (no) 1999-06-18

Family

ID=10804837

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993001A NO993001L (no) 1996-12-20 1999-06-18 Farmas°ytiske aminofosfonsyrederivater

Country Status (31)

Country Link
US (2) US6303784B1 (no)
EP (1) EP0946572B1 (no)
JP (1) JP2001506667A (no)
KR (1) KR20000069609A (no)
CN (1) CN1105117C (no)
AP (1) AP9901546A0 (no)
AR (1) AR008541A1 (no)
AT (1) ATE255117T1 (no)
AU (1) AU5858898A (no)
BG (1) BG103574A (no)
BR (1) BR9714650A (no)
CA (1) CA2275696A1 (no)
CO (1) CO4930276A1 (no)
DE (1) DE69726449T2 (no)
DZ (1) DZ2377A1 (no)
EA (1) EA199900580A1 (no)
GB (1) GB9626615D0 (no)
HU (1) HUP0002171A3 (no)
ID (1) ID22053A (no)
IL (1) IL130334A0 (no)
MA (1) MA24427A1 (no)
NO (1) NO993001L (no)
NZ (1) NZ335884A (no)
OA (1) OA11068A (no)
PE (1) PE46799A1 (no)
PL (1) PL334189A1 (no)
SK (1) SK81099A3 (no)
TR (1) TR199901423T2 (no)
TW (1) TW434221B (no)
WO (1) WO1998028310A1 (no)
ZA (1) ZA9711431B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK287296B6 (sk) 2000-02-16 2010-06-07 Smithkline Beecham Plc Pyrimidín-4-ónové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
EP1531157B1 (en) * 2000-02-29 2008-03-19 Medicure International Inc. Cardioprotective phosphonates
ATE293119T1 (de) * 2000-02-29 2005-04-15 Medicure Int Inc Cardioprotektive phosphonate
JP2004513891A (ja) * 2000-09-27 2004-05-13 アイレックス　オンコロジー　リサーチ　エス．エイ． α−置換β−アミノエチルホスホネート
US20030114421A1 (en) * 2000-09-27 2003-06-19 Phan Hieu Trung Alpha-substituted beta-aminoethyl phosphonate derivatives
GB0024808D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0025849D0 (en) * 2000-10-23 2000-12-06 Smithkline Beecham Plc Novel compounds
JP2005529071A (ja) * 2002-02-11 2005-09-29 アイレツクス・プロダクツ・インコーポレイテツド α−置換ヘテロアリールアルキルホスホン酸エステル誘導体
WO2003070169A2 (en) * 2002-02-19 2003-08-28 Ilex Products, Inc. Aminodiphosphonate apolipoprotein e modulators
JP4824968B2 (ja) * 2005-08-18 2011-11-30 株式会社クレハ ホスホン酸誘導体及びその酸付加塩、並びにそれを用いた農園芸用病害防除剤
EP2649053B1 (en) 2010-12-06 2015-11-04 Glaxo Group Limited Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2
EP2739627A4 (en) 2011-07-27 2015-01-21 Glaxo Group Ltd 2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2
KR20140059204A (ko) 2011-07-27 2014-05-15 글락소 그룹 리미티드 비시클릭 피리미돈 화합물
LT2751094T (lt) 2011-09-01 2018-11-12 Glaxo Group Limited Naujoji kristalinė forma
EP2948457A4 (en) 2013-01-25 2016-09-07 Glaxosmithkline Ip Dev Ltd COMPOUNDS
WO2014114694A1 (en) 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
AU2014210260B2 (en) 2013-01-25 2016-08-04 Glaxosmithkline Intellectual Property Development Limited Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
MX2022005615A (es) 2019-11-09 2022-07-27 Shanghai Simr Biotechnology Co Ltd Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo.
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH683996A5 (fr) 1992-03-05 1994-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
DE4433244A1 (de) * 1994-09-19 1996-03-28 Hoechst Ag Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen
CH690264A5 (fr) 1995-06-30 2000-06-30 Symphar Sa Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
GB9626536D0 (en) 1996-12-20 1997-02-05 Symphar Sa Novel compounds

Also Published As

Publication number Publication date
MA24427A1 (fr) 1998-07-01
HUP0002171A3 (en) 2002-12-28
ID22053A (id) 1999-08-26
PE46799A1 (es) 1999-06-24
EP0946572B1 (en) 2003-11-26
CO4930276A1 (es) 2000-06-27
DE69726449D1 (en) 2004-01-08
AU5858898A (en) 1998-07-17
DE69726449T2 (de) 2004-08-26
CA2275696A1 (en) 1998-07-02
ZA9711431B (en) 1999-06-21
GB9626615D0 (en) 1997-02-05
JP2001506667A (ja) 2001-05-22
SK81099A3 (en) 1999-11-08
KR20000069609A (ko) 2000-11-25
CN1105117C (zh) 2003-04-09
OA11068A (en) 2003-03-10
TW434221B (en) 2001-05-16
WO1998028310A1 (en) 1998-07-02
NZ335884A (en) 2000-11-24
CN1240451A (zh) 2000-01-05
AR008541A1 (es) 2000-01-19
IL130334A0 (en) 2000-06-01
ATE255117T1 (de) 2003-12-15
US6303784B1 (en) 2001-10-16
BG103574A (bg) 2000-11-30
TR199901423T2 (xx) 1999-10-21
HUP0002171A2 (hu) 2001-05-28
BR9714650A (pt) 2000-10-03
PL334189A1 (en) 2000-02-14
NO993001D0 (no) 1999-06-18
EA199900580A1 (ru) 1999-12-29
EP0946572A1 (en) 1999-10-06
DZ2377A1 (fr) 2002-12-28
US20020082423A1 (en) 2002-06-27
AP9901546A0 (en) 1999-06-30

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application